Works Published in 2019
Displaying works 61 - 80 of 147 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Calcium imaging of primary canine sensory neurons: Small‐diameter neurons responsive to pruritogens and algogens
Brain and Behavior.
author keywords: dorsal laminectomy dissection; dorsal root ganglia cell culture; fura-2AM; ratiometric calcium imaging
MeSH headings : Animals; Cadaver; Calcium Radioisotopes; Capsaicin / pharmacology; Cattle; Cells, Cultured; Chloroquine / pharmacology; Dogs; Ganglia, Spinal / physiopathology; Histamine / pharmacology; Humans; Laminectomy; Molecular Imaging / methods; Neurotransmitter Agents / pharmacology; Pain / physiopathology; Peptide Fragments / pharmacology; Pruritus / chemically induced; Pruritus / physiopathology; Radiopharmaceuticals; Sensory Receptor Cells / physiology; Serotonin / pharmacology; Serotonin Receptor Agonists / pharmacology; Substance P / pharmacology
TL;DR:
Rodent primary sensory neurons are commonly used for studying itch and pain neurophysiology, but translation from rodents to larger mammals and humans is not direct and requires further validation to make correlations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 1, 2019
2019 journal article
Development of canine X-chromosome inactivation pattern analysis for the detection of cell clonality by incorporating the examination of the SLIT and NTRK-like family member 4 (SLITRK4) gene
RESEARCH IN VETERINARY SCIENCE, 125, 170–175.
author keywords: Androgen receptor; Clonality; Dog; SLITRK4; XCIP
MeSH headings : Alleles; Animals; Cell Lineage; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Female; Gene Expression Regulation; Heterozygote; Male; Membrane Proteins / genetics; Membrane Proteins / metabolism; Neoplasms / genetics; Neoplasms / metabolism; Receptors, Androgen / genetics; Receptors, Androgen / metabolism; X Chromosome / physiology; X Chromosome Inactivation
TL;DR:
The availability of canine XCIP analysis was improved by incorporating the examination of the SLITRK4 gene, providing a highly useful laboratory examination system for the detection of the clonality of various cell/tissue samples in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 30, 2019
2019 journal article
Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex
CHROMOSOME RESEARCH, 27(3), 179–202.
author keywords: Histiocytic sarcoma; Chromothripsis; MMP9; Aurora kinase; Dendritic cell sarcoma
MeSH headings : Animals; Chromosome Disorders; DNA Copy Number Variations / genetics; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Genome / genetics; Histiocytic Disorders, Malignant / diagnosis; Histiocytic Disorders, Malignant / genetics; Histiocytic Disorders, Malignant / veterinary; Humans; Immunohistochemistry / methods; Matrix Metalloproteinase 9 / metabolism; Spindle Apparatus / pathology
TL;DR:
Droplet digital PCR evaluation of these regions in numerous cancer specimens effectively discriminated HM from other common round cell tumors, including lymphoma and hemangiosarcoma, resulting in a novel, rapid diagnostic aid for veterinary medicine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: September 30, 2019
2019 journal article
Lack of influence by endosymbiont Wolbachia on virus titer in the common bed bug, Cimex lectularius
PARASITES & VECTORS, 12(1).
author keywords: Cimex lectularius; Wolbachia; Endosymbiont; Cimicidae; Virus suppression; ssRNA
MeSH headings : Animals; Bedbugs / microbiology; Bedbugs / virology; Calicivirus, Feline / growth & development; Calicivirus, Feline / isolation & purification; Microbial Interactions; Viral Load; Wolbachia / growth & development
TL;DR:
It is suggested that other mechanisms are involved in virus suppression within bed bugs, independent of the influence of Wolbachia, and the need for future research is underscore.
(via Semantic Scholar)
parasitesandvectors.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 30, 2019
2019 journal article
Triclosan-selected host-associated microbiota perform xenobiotic biotransformations in larval zebrafish
Toxicological Sciences.
author keywords: microbiome; microbiota; zebrafish; triclosan; triclosan sulfate; toxicokinetics; antimicrobial; antibacterial
TL;DR:
Data support the concept that microbiota modify the toxicokinetics of xenobiotic exposure and suggest that triclosan exposure selects for microbes that harbor the capacity to biotransform tricrosan into chemical metabolites with unknown toxicity profiles.
(via Semantic Scholar)
Source: ORCID
Added: September 23, 2019
2019 journal article
Microbiota alter metabolism and mediate neurodevelopmental toxicity of 17β-estradiol
Scientific Reports, 9(1).
MeSH headings : Animals; Embryonic Development / drug effects; Estradiol / metabolism; Estradiol / pharmacology; Estrogens / metabolism; Estrogens / pharmacology; Germ-Free Life / drug effects; Larva / drug effects; Larva / metabolism; Locomotion / drug effects; Microbiota / drug effects; Microbiota / genetics; Neurogenesis / drug effects; RNA, Ribosomal, 16S / genetics; Zebrafish / embryology; Zebrafish / metabolism; Zebrafish / microbiology
TL;DR:
It is demonstrated that E2 locomotor effects in the light phase are dependent on the presence of microbiota and suggest that microbiota influence chemical E2 toxicokinetics, and the concept that microbial colonization status may influence chemical toxicity is supported.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 23, 2019
2019 journal article
Ability of positive and negative contrast computed tomographic peritoneography to delineate canine liver lobe fissures
VETERINARY SURGERY, 48(8), 1444–1449.
MeSH headings : Animals; Cadaver; Contrast Media; Cross-Sectional Studies; Dogs; Humans; Liver / diagnostic imaging; Liver / injuries; Prospective Studies; Tomography, X-Ray Computed / veterinary
TL;DR:
Positive contrast CT peritoneography improved the delineation of hepatic interlobar fissures in normal canine cadavers and may assist treatment planning in dogs with large hepatic tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 23, 2019
2019 journal article
Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.
Journal of Cell Science.
author keywords: Angiopellosis; Circulating tumor cell cluster; Tumor cell extravasation; Cancer exodus hypothesis; Metastasis
MeSH headings : Animals; Cell Count; Cell Movement / physiology; HeLa Cells; Humans; Mice; Neoplasm Metastasis; Neoplastic Cells, Circulating / metabolism
TL;DR:
Circulating tumor cell clusters spread throughout the body by using a unique method to exit blood vessels, which grants the tumor cells an increased ability to form secondary tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: September 21, 2019
2019 review
Cell and biomaterial-based approaches to uterus regeneration
[Review of ]. REGENERATIVE BIOMATERIALS, 6(3), 141–148.
author keywords: Asherman's syndrome; intrauterine adhesions; endometrium; stem cells
TL;DR:
This review is a recapitulation of the literature focused on cellular therapies for treating Asherman’s syndrome, exploring the use of cell-based therapeutics, in conjunction with biomaterials, to treat AS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 16, 2019
2019 journal article
Pharmacokinetics and pharmacodynamics of alfaxalone after a single intramuscular or intravascular injection in mallard ducks (Anas platyrhynchos)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 42(6), 713–721.
author keywords: alfaxalone; Anas platyrhynchos; mallard duck; pharmacodynamics; pharmacokinetic
MeSH headings : Anesthetics / administration & dosage; Anesthetics / blood; Anesthetics / pharmacokinetics; Animals; Area Under Curve; Ducks / blood; Female; Half-Life; Injections, Intramuscular; Injections, Intravenous; Male; Pregnanediones / administration & dosage; Pregnanediones / blood; Pregnanediones / pharmacokinetics
TL;DR:
Based on sedation levels and duration, alfaxalone administered at dosages of 10 mg/kg IV or IM in mallard ducks does not induce clinically acceptable anesthesia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 16, 2019
2019 journal article
In vivo electroretinographic differentiation of rod, short-wavelength and long/medium-wavelength cone responses in dogs using silent substitution stimuli
EXPERIMENTAL EYE RESEARCH, 185.
author keywords: dog; Silent substitution; S-Cone; L/M-cone; Rod; Photoreceptor; Electroretinogram; Congenital stationary night blindness
MeSH headings : Animals; Cone Opsins / metabolism; Dark Adaptation; Disease Models, Animal; Dogs; Electroretinography / methods; Eye Diseases, Hereditary / metabolism; Eye Diseases, Hereditary / physiopathology; Female; Genetic Diseases, X-Linked / metabolism; Genetic Diseases, X-Linked / physiopathology; Male; Myopia / metabolism; Myopia / physiopathology; Night Blindness / metabolism; Night Blindness / physiopathology; Retina / metabolism; Retina / physiopathology; Retinal Cone Photoreceptor Cells / physiology; Retinal Rod Photoreceptor Cells / physiology
TL;DR:
Methods to differentiate rod, S- and L/M-cone function in dogs using silent substitution methods have been developed and the influence of temporal frequency and mean luminance on the ERGs originating in each photoreceptor type can now be studied independently.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: September 16, 2019
2019 journal article
Novel Noninvasive Diagnostics
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 49(5), 781-+.
author keywords: Canine; Cancer; Liquid biopsy; Bladder; Prostate; BRAF; Lymphoma
MeSH headings : Animals; Carcinoma, Transitional Cell / diagnosis; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / veterinary; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / genetics; Dogs; Early Detection of Cancer / methods; Early Detection of Cancer / veterinary; Female; Humans; Leukemia / diagnosis; Leukemia / veterinary; Liquid Biopsy / methods; Liquid Biopsy / veterinary; Lymphoma / diagnosis; Lymphoma / drug therapy; Lymphoma / veterinary; Male; Molecular Targeted Therapy / veterinary; Mutation; Neoplasms / diagnosis; Neoplasms / drug therapy; Neoplasms / genetics; Neoplasms / veterinary; Urethral Neoplasms / diagnosis; Urethral Neoplasms / genetics; Urethral Neoplasms / veterinary; Urinary Bladder Neoplasms / veterinary
TL;DR:
Noninvasive/minimally invasive techniques have been described in veterinary medicine that could be referred to as liquid biopsy, which offer new opportunities for improving cancer screening, diagnosis, and monitoring the impact of therapy on the patients over time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 16, 2019
2019 journal article
Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease
Journal of Veterinary Internal Medicine.
author keywords: immunofluorescent assay; meningoencephalitis; MUE; NMDA receptor encephalitis
MeSH headings : Animals; Autoantibodies / cerebrospinal fluid; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / immunology; Central Nervous System Diseases / veterinary; Dog Diseases / cerebrospinal fluid; Dog Diseases / immunology; Dogs; Female; Fluorescent Antibody Technique, Indirect / veterinary; Humans; Male; Meningoencephalitis / cerebrospinal fluid; Meningoencephalitis / immunology; Meningoencephalitis / therapy; Neurons / immunology; Receptors, N-Methyl-D-Aspartate / immunology
TL;DR:
Defining antigenic targets associated with encephalitis in dogs might allow diagnostic categorization of MUE antemortem and further evaluation of the prevalence and clinical relevance of CSF and serum antibodies to neuronal cell surface antigens is warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: September 9, 2019
2019 journal article
Morphology of the Homo naledi femora from Lesedi
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 170(1), 5–23.
author keywords: bipedal locomotion; hominin; Rising Star; thigh
MeSH headings : Animals; Anthropology, Physical; Biological Evolution; Femur / anatomy & histology; Femur / physiology; Fossils; Hominidae / anatomy & histology; Hominidae / physiology; Humans; South Africa; Walking / physiology
TL;DR:
The Lesedi femora increase the range of variation of femoral morphology in H. naledi by preserving anatomy previously unidentified or unconfirmed in the species, including an anteroposteriorly expanded midshaft and anteriorly expanded patellar surface.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: September 3, 2019
2019 journal article
Femoral neck and shaft structure in Homo naledi from the Dinaledi Chamber (Rising Star System, South Africa)
JOURNAL OF HUMAN EVOLUTION, 133, 61–77.
author keywords: Cross-sectional geometry; Lower limb; Bipedal locomotion; Middle Pleistocene
MeSH headings : Animals; Bone Density; Diaphyses / anatomy & histology; Diaphyses / physiology; Femur / anatomy & histology; Femur / physiology; Femur Neck / anatomy & histology; Femur Neck / physiology; Fossils / anatomy & histology; Hominidae / anatomy & histology; Hominidae / physiology; South Africa
TL;DR:
H. naledi shows a unique combination of characteristics in its femur that undoubtedly indicate a species committed to terrestrial bipedalism but with a unique loading pattern of the femur possibly consequence of the unique postcranial anatomy of the species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: September 3, 2019
2019 journal article
Molecular simulation of polymers with a SAFT-gamma Mie approach
MOLECULAR SIMULATION, 45(14-15), 1223–1241.
author keywords: Polymers; molecular dynamics; SAFT-gamma Mie; equations of state; force fields
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: September 3, 2019
2019 journal article
Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System
AAPS JOURNAL, 21(5).
author keywords: biopharmaceutics drug disposition classification system; dog oral bioavailability; extended clearance classification system; human oral bioavailability; interspecies extrapolation
MeSH headings : Animals; Biological Availability; Biopharmaceutics / classification; Dogs; Drug Development / methods; Humans; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Solubility; Species Specificity
TL;DR:
It is concluded that although neither the BDDCS nor the ECCS can reliably improve the ability to determine when F will be similar in humans and dogs, the E CCS provides a mechanism to help define possible causes for observed human-canine inconsistencies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2019
2019 journal article
Antimicrobial Activity of Ceftiofur and Penicillin With Gentamicin Against Escherichia coli and Streptococcus equi Subspecies zooepidemicus in an Ex Vivo Model of Equine Postpartum Uterine Disease
JOURNAL OF EQUINE VETERINARY SCIENCE, 79, 121–126.
author keywords: E. coli; S. zooepidemicus; Postpartum mare; Antibiotic use
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cephalosporins; Drug Resistance, Bacterial; Escherichia coli; Female; Gentamicins; Horse Diseases / drug therapy; Horses; Humans; Penicillins; Postpartum Period; Streptococcus equi; Uterine Diseases / drug therapy; Uterine Diseases / veterinary
TL;DR:
The intrauterine infusion of procaine penicillin G with gentamicin in cases of postpartum uterine disease caused by E. coli or S. zooepidemicus is supported by the results of this work.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2019
2019 journal article
Nuclear envelope deformation controls cell cycle progression in response to mechanical force
EMBO REPORTS, 20(9).
author keywords: AP1; c-Jun; mechanotransduction; nuclear envelope; TEAD
MeSH headings : Cell Cycle / genetics; Cell Cycle / physiology; Cell Division / genetics; Cell Division / physiology; Cell Line; Cell Nucleus / genetics; Cell Nucleus / metabolism; Flow Cytometry; G1 Phase / genetics; G1 Phase / physiology; HeLa Cells; Humans; Mechanotransduction, Cellular / genetics; Mechanotransduction, Cellular / physiology; Microscopy, Atomic Force; Nuclear Envelope / genetics; Nuclear Envelope / metabolism; Plasmids / genetics; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; S Phase / genetics; S Phase / physiology; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
It is shown that applying compressive force on the nucleus in the absence of myosin II‐mediated tension is sufficient to restore G1 to S transition and reveal that the nuclear envelope can operate as a mechanical sensor whose deformation controls cell growth in response to tension.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2019
2019 journal article
Histological evaluation of five suture materials in the telson ligament of the American horseshoe crab (Limulus polyphemus)
PEERJ, 7.
author keywords: Limulus; Suture reaction; Telson ligament; Eugenol; Histopathology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 19, 2019
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