Works Published in 2019
Displaying works 81 - 100 of 147 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Equine urinary N-acetyl-beta-D-glucosaminidase assay validation and correlation with other markers of kidney injury
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 31(5), 688–695.
author keywords: acute kidney injury; horses; N-acetyl-beta-D-glucosaminidase; renal; urine
MeSH headings : Acetylglucosaminidase / urine; Acute Kidney Injury / diagnosis; Acute Kidney Injury / urine; Acute Kidney Injury / veterinary; Animals; Biomarkers / urine; Creatinine / blood; Female; Horse Diseases / diagnosis; Horse Diseases / urine; Horses; Humans; Male; Sodium / urine; gamma-Glutamyltransferase / urine
TL;DR:
Urine NAG can be measured in horses and shows positive correlation with 2 current renal biomarkers and additional work is needed to establish normal equine reference intervals and characterize the increase of urine NAG index in horses in relation to tubular injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 19, 2019
2019 journal article
Exome sequencing of family trios from the National Birth Defects Prevention Study: Tapping into a rich resource of genetic and environmental data
BIRTH DEFECTS RESEARCH, 111(20), 1618–1632.
author keywords: birth defects; gene-environment interaction; genetics; intestinal atresia; sequence analysis
MeSH headings : Congenital Abnormalities / genetics; Congenital Abnormalities / prevention & control; Family; Gene-Environment Interaction; Humans; Exome Sequencing
TL;DR:
Successful sequencing of exomes from well-characterized NBDPS families indicated that this unique collection can be used to investigate the roles of genetic variation and gene-environment interaction effects in birth defect etiologies, providing a valuable resource for birth defect researchers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 12, 2019
2019 journal article
Quantified water intake in laboratory cats from still, free-falling and circulating water bowls, and its effects on selected urinary parameters
JOURNAL OF FELINE MEDICINE AND SURGERY, 21(8), 682–690.
author keywords: Water intake; FLUTD; feline lower urinary tract disease; RSS; relative super saturation; urine specific gravity; urolith
MeSH headings : Animals; Animals, Laboratory; Calcium Oxalate / urine; Cats; Drinking / physiology; Drinking Water / analysis; Laboratory Animal Science / instrumentation; Struvite / urine; Urinalysis / veterinary
TL;DR:
Overall, water bowl type had no appreciable effect on water intake and alternative methods to increase water intake should be implemented beyond providing unique water bowls in patients where augmented water intake would be beneficial for disease management.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 12, 2019
2019 journal article
Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome
ADVANCED HEALTHCARE MATERIALS, 8(14).
author keywords: Asherman's syndrome; endometrial injury; hyaluronic acid; mesenchymal stem cells; secretome
MeSH headings : Animals; Disease Models, Animal; Electrocoagulation; Endometrium / injuries; Female; Gynatresia / therapy; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Hyaluronic Acid / chemistry; Hydrogels / chemistry; Mesenchymal Stem Cells / metabolism; Pregnancy; Rats, Sprague-Dawley
TL;DR:
The HA gel/MSC‐Sec treatment paradigm creates a sustained release system that repairs endometrial injury in rats and promotes viable pregnancy, and holds great potential for the treatment of AS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019
2019 journal article
Evaluation of ultrasonographically determined ratios of kidney length to aorta diameter for assessment of kidney size in healthy young dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 80(8), 764–770.
MeSH headings : Animals; Aorta / anatomy & histology; Aorta / diagnostic imaging; Dogs / anatomy & histology; Kidney / anatomy & histology; Kidney / diagnostic imaging; Observer Variation; Organ Size; Ultrasonography / veterinary
TL;DR:
1-month-old dogs have larger kidneys relative to body weight and aorta diameter than do older dogs, and interobserver variability for the youngest group of dogs indicated limited usefulness of these measurements and related ratios for neonatal dogs in clinical practice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 12, 2019
2019 journal article
Impact of epidural bupivacaine on perioperative opioid requirements, recovery characteristics, and duration of hospitalization in dogs undergoing cystotomy: A retrospective study of 56 cases
VETERINARY SURGERY, 48(7), 1330–1337.
MeSH headings : Analgesia, Epidural / veterinary; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / therapeutic use; Anesthesia, Epidural; Anesthetics, Local / administration & dosage; Animals; Bupivacaine / administration & dosage; Bupivacaine / therapeutic use; Cross-Sectional Studies; Cystotomy / adverse effects; Cystotomy / veterinary; Dog Diseases / surgery; Dogs; Female; Hospitalization; Humans; Male; Morphine / administration & dosage; Morphine / therapeutic use; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Retrospective Studies
TL;DR:
Perioperative lumbosacral epidural with bupivacaine reduced intraoperative opioids consumption in dogs anesthetized for cystotomy and may reduce intraoperative opioid requirements without affecting return of bladder function or DOH.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 12, 2019
2019 journal article
The US Opioid Epidemic and Its Impact on US General Practice Veterinarians
FRONTIERS IN VETERINARY SCIENCE, 6.
author keywords: opioid; veterinary; shortage; pain management; anesthesia
TL;DR:
Veterinarians' ability to provide opioids for their patients has been impacted by the opioid shortage, with a greater impact on full mu opioid agonists as compared to drugs like butorphanol, buprenorphine, and tramadol.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 22, 2019
2019 journal article
Oral reserpine administration in horses results in low plasma concentrations that alter platelet biology
EQUINE VETERINARY JOURNAL, 51(4), 537–543.
author keywords: horse; reserpine; pharmacokinetics; tranquilisation; platelets; hypercoagulability
MeSH headings : Administration, Oral; Adrenergic Uptake Inhibitors / administration & dosage; Adrenergic Uptake Inhibitors / blood; Adrenergic Uptake Inhibitors / pharmacokinetics; Adrenergic Uptake Inhibitors / pharmacology; Animals; Area Under Curve; Blood Platelets / drug effects; Female; Half-Life; Horses / blood; Male; Reserpine / administration & dosage; Reserpine / blood; Reserpine / pharmacokinetics; Reserpine / pharmacology
TL;DR:
Oral reserpine demonstrates low plasma concentrations and a prolonged half-life in horses and is likely due to serotonin release and re-uptake which primes platelets for activation and thromboxane B2 release.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 22, 2019
2019 journal article
Vangl2 coordinates cell rearrangements during gut elongation
DEVELOPMENTAL DYNAMICS, 248(7), 569–582.
author keywords: Vangl2; endoderm; gut; Xenopus; morphogenesis; elongation
MeSH headings : Animals; Body Patterning; Cell Adhesion; Cell Movement; Cell Polarity; Endoderm / cytology; Intestines / anatomy & histology; Intestines / growth & development; Membrane Proteins / metabolism; Membrane Proteins / physiology; Morphogenesis; Xenopus Proteins / metabolism; Xenopus Proteins / physiology; Xenopus laevis / growth & development
TL;DR:
The embryonic gut tube undergoes extensive lengthening to generate the surface area required for nutrient absorption across the digestive epithelium in Xenopus, a process that concomitantly opens the gut lumen and facilitates epithelial morphogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 22, 2019
2019 journal article
Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women
CELL, 178(1), 190-+.
MeSH headings : Cohort Studies; Disease Progression; Female; Glycosylation; HIV / genetics; HIV Infections / immunology; HIV Infections / transmission; HIV Infections / virology; Humans; Immunoglobulin Fc Fragments / metabolism; Immunoglobulin G / blood; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Malawi; Placenta / metabolism; Pregnancy; Pregnancy Complications, Infectious / immunology; Pregnancy Complications, Infectious / virology; Receptors, IgG / metabolism; United States; Viral Load / genetics
TL;DR:
It is suggested that Fc region characteristics modulate the selective placental transfer of IgG, with implications for maternal vaccine design and infant health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019
2019 journal article
Interferon-lambda 3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 8(1), 1–20.
author keywords: Cryptosporidiosis; Cytokine; Enterocyte; Protozoa
MeSH headings : Animals; Cell Line; Cryptosporidiosis / genetics; Cryptosporidiosis / immunology; Cryptosporidiosis / parasitology; Cryptosporidium parvum / physiology; Cytokines / genetics; Cytokines / metabolism; Disease Models, Animal; Gene Expression Profiling; Intestinal Mucosa / immunology; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Swine; Up-Regulation
TL;DR:
These studies identify IFN-λ2/3 as a key epithelial defense mechanism against C parvum infection and Priming of IECs with recombinant human IFn-λ3 promoted cellular defense against CParvum infections and abrogated C parVum–induced loss of barrier function by decreasing paracellular permeability to sodium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019
2019 review
Chemical Engineering of Cell Therapy for Heart Diseases
[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 52(6), 1687–1696.
MeSH headings : Animals; Biocompatible Materials / chemistry; Biomimetics / methods; Cardiomyopathy, Dilated / therapy; Cell- and Tissue-Based Therapy / methods; Chemical Engineering / methods; Exosomes; Humans; Hydrogels / chemistry; Myocardial Infarction / therapy; Stem Cells / chemistry; Stem Cells / metabolism
TL;DR:
The third generation of therapeutic strategies are developed, which utilize cell-free approaches for cardiac cell therapies, and it is hoped that the designs will promote the use of chemical engineering approaches to transform, transport, and fabricate cell- free systems as novel cardiac cell therapeutic agents for clinical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019
2019 journal article
Exact and efficient hybrid Monte Carlo algorithm for accelerated Bayesian inference of gene expression models from snapshots of single-cell transcripts
The Journal of Chemical Physics.
Contributors: Y. Lin * & N. Buchler n
MeSH headings : Algorithms; Bayes Theorem; Gene Expression; Models, Genetic; Monte Carlo Method; Single-Cell Analysis
TL;DR:
It is shown that time-dependent mRNA distributions of discrete-state models of gene expression are dynamic Poisson mixtures, whose mixing kernels are characterized by a piecewise deterministic Markov process, and Bayesian evidence selects the true model and outperforms approximate metrics typically used for model selection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: July 10, 2019
2019 journal article
Plasma Bleomycin Concentrations during Electrochemotherapeutic Treatment of Fibropapillomas in Green Turtles Chelonia mydas
JOURNAL OF AQUATIC ANIMAL HEALTH, 31(2), 186–192.
MeSH headings : Animals; Bleomycin / blood; Electrochemotherapy / statistics & numerical data; Electrochemotherapy / veterinary; Papilloma / therapy; Papilloma / veterinary; Plasma / chemistry; Turtles / blood
TL;DR:
This study adds further support that electrochemotherapy with bleomycin has the potential to be used as an effective alternative treatment for this complex disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 8, 2019
2019 journal article
Evaluation of the anesthetic and cardiorespiratory effects of intramuscular alfaxalone administration and isoflurane in budgerigars (Melopsittacus undulatus) and comparison with manual restraint
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 254(12), 1427–1435.
MeSH headings : Anesthetics / pharmacology; Animals; Injections, Intramuscular / veterinary; Isoflurane; Melopsittacus / physiology; Pregnanediones
TL;DR:
Alfaxalone administered IM at 10 mg/kg produced effective sedation in healthy budgerigars and may be a viable alternative to isoflurane and manual restraint for brief, minimally invasive procedures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 1, 2019
2019 journal article
Ammonium tetrathiomolybdate treatment of copper-associated hepatopathy in dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(3), 1336–1343.
author keywords: chelation; copper toxicosis; hepatitis; Labrador Retrievers; molybdenum
MeSH headings : Anemia / veterinary; Animals; Biopsy; Chelating Agents / therapeutic use; Copper / analysis; Copper / metabolism; Dog Diseases / drug therapy; Dogs; Female; Hepatitis, Chronic / drug therapy; Hepatitis, Chronic / veterinary; Liver / chemistry; Liver / surgery; Male; Molybdenum / adverse effects; Molybdenum / analysis; Molybdenum / therapeutic use; Prospective Studies; Thrombocytopenia / veterinary
TL;DR:
Results suggest that TTM can effectively decrease [Cu]H in some dogs with CAH and how it compares with current treatments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 1, 2019
2019 journal article
Computed Tomography for the Diagnosis and Characterization of Dermoid Sinuses in Two Dogs
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 55(4).
MeSH headings : Animals; Dermoid Cyst / diagnosis; Dermoid Cyst / pathology; Dermoid Cyst / surgery; Dermoid Cyst / veterinary; Dog Diseases / diagnosis; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Laminectomy / veterinary; Male; Spinal Neoplasms / diagnosis; Spinal Neoplasms / pathology; Spinal Neoplasms / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR:
These cases show that single-phase contrast CT was accurate in characterizing the extent of the dermoid sinus without adjunctive tests or more invasive diagnostics, avoiding the risks associated with myelography or fistulography and the expense of MRI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 1, 2019
2019 journal article
Epigenome-wide meta-analysis of DNA methylation and childhood asthma
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(6), 2062–2074.
author keywords: Epigenetics; methylation; asthma; childhood; newborn; drug development
MeSH headings : Asthma / genetics; Child; CpG Islands / genetics; Cross-Sectional Studies; DNA Methylation; ERG1 Potassium Channel / genetics; Epigenesis, Genetic; Epigenome / genetics; Genome-Wide Association Study; Humans; Infant, Newborn; Interleukin-5 Receptor alpha Subunit / genetics
TL;DR:
Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age, and Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 24, 2019
2019 journal article
microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential
JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237–2250.
MeSH headings : Animals; Exosomes / genetics; Exosomes / metabolism; Exosomes / pathology; Female; Heart / physiology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Human Umbilical Vein Endothelial Cells / metabolism; Human Umbilical Vein Endothelial Cells / pathology; Humans; Male; Mice; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Regeneration; Signal Transduction; Stromal Cells / metabolism; Stromal Cells / pathology
TL;DR:
The heart failure pathological condition altered the miR cargos of cardiac-derived exosomes and impaired their regenerative activities, and mechanistic studies revealed that miR-21-5p augmented Akt kinase activity through the inhibition of phosphatase and tensin homolog.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2019
2019 journal article
The role of cellular contact and TGF-beta signaling in the activation of the epithelial mesenchymal transition (EMT)
CELL ADHESION & MIGRATION, 13(1), 63–75.
author keywords: EMT; TGF-; cellular adhesion; epithelial; mesenchymal; breast carcinoma; colon carcinoma
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Cell Adhesion; Cell Movement; Colorectal Neoplasms / metabolism; Colorectal Neoplasms / pathology; Epithelial-Mesenchymal Transition / drug effects; Female; Humans; Signal Transduction; Transforming Growth Factor beta / pharmacology; Tumor Cells, Cultured
TL;DR:
Examination of the dual influence of the TGF-β pathway and intercellular contact on the activation of EMT in colon (SW480) and breast (MCF7) carcinoma cells highlights that, while EMT is induced by the synergy of multiple signals, this activation varies across cell types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 24, 2019
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