Works Published in 2011
Displaying works 21 - 40 of 46 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
PLOS ONE, 6(10).
MeSH headings : Bile Acids and Salts / metabolism; Cholesterol, LDL / blood; Demography; Female; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / metabolism; Gastrointestinal Tract / microbiology; Humans; Liver-Specific Organic Anion Transporter 1; Male; Metabolomics; Metagenome / drug effects; Middle Aged; Models, Biological; Organic Anion Transporters / genetics; Pharmacogenetics; Polymorphism, Single Nucleotide / genetics; Simvastatin / pharmacology; Treatment Outcome
TL;DR:
Interactions between genome, gut microbiome and environmental influences should be considered in the study and management of cardiovascular disease and metabolic profiles could provide valuable information about treatment outcomes and could contribute to a more personalized approach to therapy.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Pharmacogenomic characterization of US FDA-approved cytotoxic drugs
PHARMACOGENOMICS, 12(10), 1407–1415.
author keywords: cancer; cell line; chemotherapy; cytotoxicity; pharmacogenetics; pharmacogenomic; QTL
MeSH headings : Antineoplastic Agents / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Approval; Genetic Linkage; Humans; Pharmacogenetics; Quantitative Trait Loci / genetics; United States; United States Food and Drug Administration
TL;DR:
The results of this systematic study highlight the variable role that genetics plays in response to cytotoxic drugs, and inform the prioritization of chemotherapeutic drugs with a sizable genetic response component for future investigation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Forecasting the future of biodiversity: a test of single- and multi-species models for ants in North America
ECOGRAPHY, 34(5), 836–847.
TL;DR:
It is suggested that warm rather than cold regions potentially could experience the greatest changes in ant fauna under climate change and that multi-species models may represent an important complement to SDMs, particularly in analyses involving large numbers of rare or poorly-sampled species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: Beyond aspirin and clopidogrel
THROMBOSIS RESEARCH, 128(4), 335–340.
MeSH headings : Adult; Aspirin / administration & dosage; Aspirin / adverse effects; Bleeding Time; Blood Platelets / drug effects; Chi-Square Distribution; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Omega-3 / administration & dosage; Fatty Acids, Omega-3 / adverse effects; Female; Hemorrhage / chemically induced; Humans; Male; Middle Aged; North Carolina; Pilot Projects; Platelet Aggregation / drug effects; Platelet Aggregation Inhibitors / administration & dosage; Platelet Aggregation Inhibitors / adverse effects; Platelet Function Tests; Predictive Value of Tests; Surface Properties; Ticlopidine / administration & dosage; Ticlopidine / adverse effects; Ticlopidine / analogs & derivatives; Time Factors
TL;DR:
The results suggest that omega-3 PUFA increase the total platelet surface charge and, therefore, attenuate platelet activation, even among patients taking aspirin or aspirin plus clopidogrel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart
GENES CHROMOSOMES & CANCER, 50(11), 859–874.
MeSH headings : Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Comparative Genomic Hybridization; Core Binding Factor Alpha 1 Subunit / genetics; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Gene Dosage; Genomic Instability; Humans; In Situ Hybridization, Fluorescence; Male; Membrane Proteins / genetics; Osteosarcoma / genetics; Osteosarcoma / veterinary; PTEN Phosphohydrolase / genetics; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Tumor Suppressor Proteins / genetics
TL;DR:
Large scale screening of genomic imbalance in canine OS further validates the use of the dog as a suitable model for human cancers, supporting the idea that dysregulation discovered in canine cancers will provide an avenue for complementary study in human counterparts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Genomic Profiling in CEPH Cell Lines Distinguishes between the Camptothecins and Indenoisoquinolines
MOLECULAR CANCER THERAPEUTICS, 10(10), 1839–1845.
MeSH headings : Antineoplastic Agents, Phytogenic / pharmacology; Camptothecin / pharmacology; Cell Line; Drug Evaluation, Preclinical / methods; Gene Expression Profiling; Genomics / methods; Humans; Isoquinolines / pharmacology; Oligonucleotide Array Sequence Analysis; Quantitative Trait Loci; Topoisomerase I Inhibitors / pharmacology
TL;DR:
In vitro sensitivity of the same panel of CEPH cell lines to the indenisoquinolones, a structurally distinct class of Top1 inhibitors, is characterized, revealing a pattern of 7 quantitative trait loci (QTL) shared by all of the camptothecins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Evolution of the Max and Mlx Networks in Animals
GENOME BIOLOGY AND EVOLUTION, 3, 915–937.
author keywords: protein evolution; basic-helix-loop-helix-leucine zipper (bHLHZ) domain; Myc/Max/Mad network; Mlx and Mondo Network; phylogenetic tree; discriminant analysis
MeSH headings : Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / chemistry; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics; Basic-Leucine Zipper Transcription Factors / classification; Basic-Leucine Zipper Transcription Factors / genetics; Binding Sites; Evolution, Molecular; Gene Expression Regulation; Gene Regulatory Networks / genetics; Humans; Molecular Sequence Data; Multigene Family; Phylogeny; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Synteny / genetics
TL;DR:
These analyses on Max and Mlx network members provide a model for characterizing the evolution of TFs involved in essential networks, and identify clear relationships among protein families with distinct points of radiation and divergence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Studying Gene and Gene-Environment Effects of Uncommon and Common Variants on Continuous Traits: A Marker-Set Approach Using Gene-Trait Similarity Regression
AMERICAN JOURNAL OF HUMAN GENETICS, 89(2), 277–288.
MeSH headings : Chromosomes, Human, Pair 21 / genetics; Computer Simulation; Databases, Genetic; Environment; Genes / genetics; Genetic Markers; Humans; Models, Genetic; Mutation / genetics; Quantitative Trait, Heritable; Regression Analysis
TL;DR:
A similarity-based regression method for assessing the main genetic and interaction effects of a group of markers on quantitative traits and is an ideal tool for evaluating associations between phenotype and marker sets defined by linkage disequilibrium blocks, genes, or pathways in whole-genome analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Quality of reporting on randomised controlled trials of auriculotherapy for pain
ACUPUNCTURE IN MEDICINE, 29(2), 122–126.
MeSH headings : Auriculotherapy; Cluster Analysis; Guidelines as Topic; Humans; Pain Management; Peer Review, Research / standards; Principal Component Analysis; Publishing / standards; Quality Improvement; Randomized Controlled Trials as Topic / standards
TL;DR:
Quality of reporting for studies of auriculotherapy for pain appears to have generally improved since the implementation of STRICTA and CONSORT guidelines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Urban areas may serve as habitat and corridors for dry-adapted, heat tolerant species; an example from ants
URBAN ECOSYSTEMS, 14(2), 135–163.
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Identification of alternative splice variants in Aspergillus flavus through comparison of multiple tandem MS search algorithms
BMC Genomics, 12.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Architecture of energy balance traits in emerging lines of the Collaborative Cross
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(6), E1124–E1134.
author keywords: genetics; wheel running; adiposity; body weight; quantitative trait loci
MeSH headings : Alleles; Analysis of Variance; Animals; Body Fat Distribution; Body Weight / genetics; Body Weight / physiology; Chromosome Mapping; Chromosomes / genetics; Crosses, Genetic; Eating / genetics; Eating / physiology; Energy Metabolism / genetics; Energy Metabolism / physiology; Genotype; Linkage Disequilibrium; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Motor Activity / physiology; Phenotype; Physical Conditioning, Animal / physiology; Quantitative Trait Loci; Running / physiology; Sample Size
TL;DR:
The results suggest that the CC will be a powerful, high-precision tool for examining the genetic architecture of complex traits such as those involved in regulation of energy balance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Variation in genome-wide mutation rates within and between human families
Nature Genetics, 43(7), 712–137.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Shift work in nurses: Contribution of phenotypes and genotypes to adaptation
PLoS One, 6(4).
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
RNAi Effector Diversity in Nematodes
PLOS NEGLECTED TROPICAL DISEASES, 5(6).
Contributors: J. Dalzell*, P. McVeigh *, N. Warnock*, M. Mitreva *, D. Bird n , P. Abad *, C. Fleming*, T. Day*
MeSH headings : Animals; Conserved Sequence; Gene Expression Profiling; Helminth Proteins / biosynthesis; Helminth Proteins / genetics; Nematoda / genetics; RNA Interference
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Global diversity in light of climate change: the case of ants
DIVERSITY AND DISTRIBUTIONS, 17(4), 652–662.
author keywords: Aridity; biodiversity; biogeography; Formicidae; species richness; temperature
UN Sustainable Development Goal Categories
13. Climate Action
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Biological pathway selection through nonlinear dimension reduction
BIOSTATISTICS, 12(3), 429–444.
author keywords: Dimension reduction; Generalized additive model; Kernel methods; Pathway selection; Sliced inverse regression
MeSH headings : Computational Biology / methods; Computer Simulation; Data Interpretation, Statistical; Gene Expression Profiling / methods; Glioblastoma / genetics; Humans; Models, Genetic; Models, Statistical; Oligonucleotide Array Sequence Analysis / methods; Principal Component Analysis
TL;DR:
This article proposes a 2-step procedure for identifying pathways that are related to and influence the clinical phenotype, and proposes a nonlinear dimension reduction method, which permits flexible within-pathway gene interactions as well as nonlinear pathway effects on the response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Variation in above-ground forest biomass across broad climatic gradients
Global Ecology and Biogeography, 20(5), 744–754.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
LEUKEMIA & LYMPHOMA, 52(7), 1321–1335.
author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
MeSH headings : Aneuploidy; Animals; Breeding; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Copy Number Variations / genetics; Dogs; Gene Expression Regulation, Neoplastic; Genomics; Immunophenotyping; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / pathology
TL;DR:
It is hypothesized that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior
BMC Cancer, 11.
Source: NC State University Libraries
Added: August 6, 2018
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