Works Published in 2016
Displaying works 21 - 40 of 59 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
Genetic predictors of cardiovascular mortality during intensive glycemic control in type 2 diabetes: Findings from the ACCORD clinical trial
Diabetes Care, 39(11), 1915–1924.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Genetic Drift, Not Life History or RNAi, Determine Long-Term Evolution of Transposable Elements
GENOME BIOLOGY AND EVOLUTION, 8(9), 2964–2978.
Contributors: A. Szitenberg *, S. Cha n, C. Opperman n, D. Bird n , M. Blaxter * & D. Lunt *
author keywords: nematoda; transposable elements evolution; RNA interference; mating system; parasitism
TL;DR:
Although statistical power to detect selection is demonstrated, there is no evidence that variation in these factors influence genomic TE loads across extended periods of time, and the effects of genetic drift appear to persist and control TE variation among species.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Comprehensive genomic characterization of five canine lymphoid tumor cell lines
BMC Veterinary Research, 12.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
A genetic response score for hydrochlorothiazide use insights from genomics and metabolomics integration
Hypertension, 68(3), 621-.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Advancing toxicology research using in vivo high throughput toxicology with small fish models.
ALTEX, 33(4), 435–452.
Contributors: A. Planchart n , C. Mattingly n , D. Allen *, P. Ceger *, W. Casey *, D. Hinton *, J. Kanungo *, S. Kullman n
author keywords: aquatic models; 21st century toxicology; alternatives
TL;DR:
The recommendations formulated by workshop participants to enhance the utility of small fish species in toxicology studies are summarized, as well as many of the advances in the field of toxicology that resulted from usingSmall freshwater fish species, including advances in developmental toxicology, cardiovascular toxicologists, neurotoxicology, and immunotoxicology are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2016 journal article
Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database
ENVIRONMENTAL HEALTH PERSPECTIVES, 124(10), 1592–1599.
Contributors: C. Grondin n, A. Davis n, T. Wiegers n, B. King *, J. Wiegers n, D. Reif n , J. Hoppin n , C. Mattingly n
TL;DR:
Curation and integration of exposure data within the CTD provides researchers with new opportunities to correlate exposures with human health outcomes, to identify underlying potential molecular mechanisms, and to improve understanding about the exposome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
Nature Genetics, 48(9), 1055-.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Using toxcast™ data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure
Environmental Health Perspectives, 124(7), 910–919.
Contributors: I. Shah *, R. Woodrow Setzer*, J. Jack n, K. Houck *, R. Judson *, T. Knudsen *, J. Liu *, M. Martin*
MeSH headings : Environmental Pollutants / toxicity; High-Throughput Screening Assays; Membrane Potential, Mitochondrial; Risk Assessment; Toxicity Tests / methods
TL;DR:
These findings show the utility of HCI data for reconstructing cell state trajectories and provide insight into the adaptation and resilience of in vitro cellular systems based on tipping points.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2016 journal article
TreeScaper: Visualizing and Extracting Phylogenetic Signal from Sets of Trees
MOLECULAR BIOLOGY AND EVOLUTION, 33(12), 3314–3316.
author keywords: TreeScaper; visualization; community detection; phylogenetic trees
MeSH headings : Computer Simulation; Databases, Nucleic Acid; Evolution, Molecular; Phylogeny; Sequence Analysis, DNA / methods; Software
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Mitochondrial Genome Sequences and Structures Aid in the Resolution of Piroplasmida phylogeny
PLOS ONE, 11(11).
Contributors: M. Schreeg n, H. Marr n, J. Tarigo n, L. Cohn*, D. Bird n , E. Scholl n, M. Levy n, B. Wiegmann n , A. Birkenheuer n
MeSH headings : DNA, Protozoan / genetics; Genome, Mitochondrial; Humans; Phylogeny; Piroplasmida / classification; Piroplasmida / genetics; Protozoan Infections / parasitology
TL;DR:
Phylogenetic analysis of concatenated mitochondrial and 18S sequences as well as cox1 amino acid sequence identified five distinct Piroplasmida groups, each of which possesses a unique mitochondrial genome structure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants
Translational Psychiatry, 6(9), e894–e894.
MeSH headings : Adult; Arginine / metabolism; Citrulline / metabolism; Depressive Disorder, Major / drug therapy; Depressive Disorder, Major / metabolism; Depressive Disorder, Treatment-Resistant / drug therapy; Depressive Disorder, Treatment-Resistant / metabolism; Excitatory Amino Acid Antagonists / therapeutic use; Female; Glutamic Acid / metabolism; Humans; Indoleacetic Acids / metabolism; Infusions, Intravenous; Ketamine / therapeutic use; Male; Metabolomics; Methionine / metabolism; Middle Aged; Ornithine / metabolism; Phenotype; Phospholipids / metabolism; Tryptophan / metabolism; Urea / metabolism
TL;DR:
Changes in glutamate and circulating phospholipids that were significantly associated with decreases in depression severity are observed, providing new insights into the mechanism underlying the rapid antidepressant effects of ketamine and esketamine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2016 review
Embracing integrative multiomics approaches
[Review of ]. International Journal of Genomics.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes
METABOLOMICS, 12(11).
Contributors: C. Scott Chialvo *, R. Che n, D. Reif n , A. Motsinger-Reif n & L. Reed *
author keywords: Eigenvector metabolite analysis; Linkage analyses; Environment; Enrichment analyses
TL;DR:
Eigenvector Metabolite Analysis provides a simple method to identify correlations between metabolites, gene expression, and phenotypes, which can allow us to partition multivariate datasets into meaningful biological modules and identify under-studied metabolites and unannotated gene transcripts that may be central to important biological processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
ToxEvaluator: an integrated computational platform to aid the interpretation of toxicology study-related findings
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.
MeSH headings : Animals; Computational Biology / methods; Computer Simulation; Database Management Systems; Databases, Factual; Humans; Mice; Toxicogenetics / methods; User-Computer Interface
TL;DR:
ToxEvaluator was developed jointly by Pfizer and the Comparative Toxicogenomics Database as an in silico platform to facilitate interpretation of toxicity findings in light of prior knowledge and rapidly identified direct and indirect linkages between cerivastatin and myopathy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 review
Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast (TM) High-Throughput Data
[Review of ]. ENVIRONMENTAL HEALTH PERSPECTIVES, 124(8), 1141–1154.
Contributors: S. Auerbach *, D. Filer*, D. Reif n , V. Walker *, A. Holloway *, J. Schlezinger *, S. Srinivasan *, D. Svoboda*
MeSH headings : Databases, Factual; Diabetes Mellitus / chemically induced; Diabetes Mellitus / epidemiology; Environment; Environmental Exposure / statistics & numerical data; Environmental Pollutants / standards; Environmental Pollutants / toxicity; High-Throughput Screening Assays; Humans; Obesity / chemically induced; Obesity / epidemiology; Outcome Assessment, Health Care; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR:
The results of this screening-level analysis suggest that the spectrum of environmental chemicals to consider in research related to diabetes and obesity is much broader than indicated by research papers and reviews published in the peer-reviewed literature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females
G3-GENES GENOMES GENETICS, 6(5), 1409–1416.
author keywords: meiosis; recombination; aging
MeSH headings : Animals; Crossing Over, Genetic; Drosophila melanogaster / genetics; Female; Genetic Background; Genetic Loci; Genome, Insect; Genomics / methods; Male; Meiosis / genetics; Models, Genetic; Recombination, Genetic
TL;DR:
The hypothesis that maternal age influences rates of crossing over in a genotypic-specific manner is tested and a new role of genotype by maternal age interactions in mediating recombination rate is revealed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial
PHARMACOGENOMICS JOURNAL, 16(3), 243–248.
MeSH headings : Adenosine Triphosphatases / genetics; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Carboplatin / adverse effects; Cation Transport Proteins / genetics; Copper-Transporting ATPases; Docetaxel; Female; Gastrointestinal Diseases / chemically induced; Gastrointestinal Diseases / diagnosis; Gastrointestinal Diseases / genetics; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Kaplan-Meier Estimate; NAV1.8 Voltage-Gated Sodium Channel / genetics; Ovarian Neoplasms / drug therapy; Ovarian Neoplasms / mortality; Pharmacogenetics; Pharmacogenomic Variants / genetics; Phenotype; Polymorphism, Single Nucleotide; Proportional Hazards Models; Risk Factors; Scotland; Severity of Illness Index; Taxoids / adverse effects; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A / genetics
TL;DR:
The SCOTROC1 data provide potential targets for modulation/inhibition of GI toxicity in ovarian cancer patients, and seven single-nucleotide polymorphisms in the ATP7B, GSR, VEGFA and SCN10A genes are identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
BioCreative V CDR task corpus: a resource for chemical disease relation extraction
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.
MeSH headings : Computational Biology / methods; Data Mining / methods; Databases, Factual; Disease; Humans; Toxicogenetics / methods
TL;DR:
The BC5CDR corpus was successfully used for the BioCreative V challenge tasks and should serve as a valuable resource for the text-mining research community.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Assessing the state of the art in biomedical relation extraction: overview of the BioCreative V chemical-disease relation (CDR) task
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.
MeSH headings : Biomedical Research; Data Mining / methods; Databases, Factual; Disease; Humans; Statistics as Topic; Time Factors
TL;DR:
This task was found to be successful in engaging the text-mining research community, producing a large annotated corpus and improving the results of automatic disease recognition and CDR extraction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Alarms about structural alerts
GREEN CHEMISTRY, 18(16), 4348–4360.
TL;DR:
It is demonstrated that contrary to the common perception of QSAR models as "black boxes" they can be used to identify statistically significant chemical substructures (QSAR-based alerts) that influence toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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