Works Published in 2015
Displaying works 101 - 120 of 154 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant
Immunogenetics, 67(9), 501–513.
author keywords: Teleost; MHC class I; Evolution; Polymorphism; Haplotype
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Chromosome Mapping; Chromosome Walking; Evolution, Molecular; Female; Gene Expression Profiling; Genotype; Genotyping Techniques; Haplotypes / genetics; Histocompatibility Antigens Class I / classification; Histocompatibility Antigens Class I / genetics; Male; Molecular Sequence Data; Polymorphism, Genetic / genetics; Zebrafish / genetics; Zebrafish / immunology
TL;DR:
Two MHC class I U lineage genes are described that map to chromosome 22 in zebrafish and are likely to play a nonclassical role as they lack conservation of key peptide binding residues, display limited polymorphic variation, and exhibit tissue-specific expression.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Variation in the Microbiota of Ixodes Ticks with Regard to Geography, Species, and Sex
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81(18), 6200–6209.
MeSH headings : Animals; Bacteria / classification; Bacteria / genetics; Biota; Cluster Analysis; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Ribosomal / chemistry; DNA, Ribosomal / genetics; Geography; Ixodes / microbiology; Molecular Sequence Data; Phylogeny; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA; Sex Factors; United States
TL;DR:
Analysis of the microbiota of ticks captured in 19 locations suggests substantial variations in the Ixodes microbiota in association with geography, species, and sex.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Prediction of human population responses to toxic compounds by a collaborative competition
Nature Biotechnology, 33(9), 933–172.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Practicing the science of sustainability: the challenges of transdisciplinarity in a developing world context
Sustainability Science, 10(4), 581–599.
author keywords: Sustainability science; Integration; Transdisciplinarity; Interdisciplinarity; Multidisciplinarity; Water security; South Africa
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Geographic clustering of elevated blood heavy metal levels in pregnant women
BMC PUBLIC HEALTH, 15.
author keywords: Cadmium; Lead; Mercury; Arsenic; Spatial analysis
MeSH headings : Adult; Arsenic / blood; Cadmium / blood; Female; Humans; Lead / blood; Maternal Exposure / statistics & numerical data; Mercury / blood; Metals, Heavy / blood; Pregnancy; Pregnancy Complications / blood; Pregnancy Complications / epidemiology; Prenatal Care / statistics & numerical data; Prenatal Exposure Delayed Effects / prevention & control; Rural Population / statistics & numerical data; United States / epidemiology; Urban Population / statistics & numerical data; Young Adult
TL;DR:
Elevated blood concentrations of Cd and Pb are spatially clustered in this urban environment compared to the surrounding areas and cluster membership was associated with lower education levels and higher pre-pregnancy BMI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1849(10), 1277–1288.
author keywords: Nrf2; Histone; Epigenetic; Arsenic; HO-1; Antioxidant response element
MeSH headings : Animals; Antioxidant Response Elements / genetics; Arsenites / pharmacology; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1 / biosynthesis; Heme Oxygenase-1 / genetics; Heme Oxygenase-1 / metabolism; Histones / genetics; Histones / metabolism; Humans; Keratinocytes / metabolism; Mice; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / genetics; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Signal Transduction; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR:
It is proposed that Nrf2 may influence H3S10 phosphorylation at the HO-1 ARE and additional promoter regions, which highlights the complex interplay between NRF2 and H 3S10osphorylation in arsenite-activatedHO-1 transcription.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Tissue concentrations of sulfamethazine and tetracycline hydrochloride of swine (Sus scrofa domestica) as it relates to withdrawal methods for international export
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 71(3), 590–596.
author keywords: Swine; Tetracycline; Sulfa methazine; Pharmacokinetics; Population; Monte Carlo method; FDA tolerance limit method; Maximum residue limit; Withdrawal interval; Withdrawal time
MeSH headings : Administration, Oral; Age Factors; Animal Husbandry; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Consumer Product Safety; Drug Administration Schedule; Drug Residues / pharmacokinetics; Food Contamination / analysis; Food Supply; Red Meat / analysis; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Sus scrofa / metabolism; Tetracycline / administration & dosage; Tetracycline / pharmacokinetics; Tissue Distribution; Water Supply
TL;DR:
The TLM may not always provide adequate WDT for foreign export markets especially when MRLs differ from tolerance levels approved for US markets, however, PopPK methods can provide conservative WDIs in situations with considerable variability in medication exposure such as with administration in water.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
The human transcriptome across tissues and individuals
Science, 348(6235), 660–665.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
Science, 348(6235), 648–660.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Pesticide Use and Relative Leukocyte Telomere Length in the Agricultural Health Study
PLOS ONE, 10(7), e0133382.
Ed(s): T. Nawrot
MeSH headings : Acetamides / poisoning; Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / diagnosis; Agricultural Workers' Diseases / genetics; Health Occupations / statistics & numerical data; Humans; Iowa; Leukocytes / drug effects; Leukocytes / metabolism; Malathion; Male; Middle Aged; North Carolina; Occupational Exposure / analysis; Organophosphate Poisoning / diagnosis; Organophosphate Poisoning / genetics; Pesticides / poisoning; Prospective Studies; Surveys and Questionnaires; Telomere / drug effects; Telomere / genetics; Telomere Homeostasis / drug effects; Telomere Shortening / drug effects
TL;DR:
Ass associations between occupational pesticide use reported at three time points and relative telomere length (RTL) in the Agricultural Health Study are examined, suggesting that leukocyte TL may be impacted by cumulative use and recent use of certain pesticides.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Molecular Cloning, Functional Characterization, and Evolutionary Analysis of Vitamin D Receptors Isolated from Basal Vertebrates
PLOS ONE, 10(4).
Contributors: E. Kollitz n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n
MeSH headings : Animals; Base Sequence; Cloning, Molecular; Computational Biology; Electrophoretic Mobility Shift Assay; Evolution, Molecular; Fishes / genetics; Likelihood Functions; Models, Genetic; Molecular Sequence Data; Petromyzon / genetics; Phylogeny; Protein Binding; Protein Interaction Mapping; Receptors, Calcitriol / genetics; Sequence Analysis, DNA; Skates, Fish / genetics; Species Specificity; Two-Hybrid System Techniques
TL;DR:
This study compares molecular activities of vitamin D receptors (VDR) from basal species that diverged at key points in vertebrate evolution in order to infer derived and ancestral VDR functions of teleost paralogs and suggests that 1, 25D3 acts as a partial agonist in basal species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Immune Deficiency Influences Juvenile Social Behavior and Maternal Behavior
BEHAVIORAL NEUROSCIENCE, 129(3), 331–338.
author keywords: immunodeficiency; social recognition; maternal behavior; SCID; sex differences
MeSH headings : Animals; Animals, Newborn; Behavior, Animal / physiology; Disease Models, Animal; Female; Gene-Environment Interaction; Habituation, Psychophysiologic / physiology; Immunologic Deficiency Syndromes / psychology; Immunologic Deficiency Syndromes / therapy; Male; Maternal Behavior / physiology; Mice, Inbred C57BL; Mice, SCID; Ovariectomy; Perception / physiology; Psychological Tests; Random Allocation; Recognition, Psychology / physiology; Social Behavior; Spleen / cytology; Spleen / transplantation
TL;DR:
The data indicate that Gene × Environment interactions influence social interactions in immune deficient mice and that partial immune restoration could normalize behaviors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization
CHROMOSOME RESEARCH, 23(2), 171–186.
author keywords: Canine; Oral melanoma; Cytogenetics; Array; Comparative genomic hybridization
MeSH headings : Animals; Chromosome Aberrations; Cluster Analysis; Comparative Genomic Hybridization; Computational Biology; DNA Copy Number Variations; Dogs; Female; Humans; In Situ Hybridization, Fluorescence; Male; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mouth Neoplasms / genetics; Mouth Neoplasms / pathology; Penetrance; Skin Neoplasms
TL;DR:
This study suggests that in concordance with what is known for human melanomas, canine melanomas of the oral mucosa and cutaneous epithelium are discrete and initiated by different molecular pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Canine urothelial carcinoma: genomically aberrant and comparatively relevant
CHROMOSOME RESEARCH, 23(2), 311–331.
author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
MeSH headings : Animals; Biopsy; Carcinoma / veterinary; Chromosome Aberrations; Comparative Genomic Hybridization; Computational Biology / methods; DNA Copy Number Variations; Dogs; Female; Genetic Loci; Genomics / methods; Humans; In Situ Hybridization, Fluorescence; Male; Urologic Neoplasms / veterinary
TL;DR:
It is proposed that common aberrations found in primary canine UC biopsies are indicative of an evolutionarily conserved mechanism of pathogenesis and harbor genes key to urothelial neoplasia, warranting investigation for diagnostic, prognostic, and therapeutic applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
An allergic lung microenvironment suppresses carbon nanotube-induced inflammasome activation via STAT6-dependent inhibition of caspase-1
PLoS One, 10(6).
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice
BIOLOGY OF SEX DIFFERENCES, 6.
author keywords: Growth hormone; Sex differences; Estradiol; Sex chromosomes; Hypothalamus; Cerebellum; Growth hormone-releasing hormone; Obesity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Multi-Institutional Collaboration for a Shared Renewable Energy Assessment Curriculum
Natural Sciences Education, 44.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2015 journal article
Maternal cadmium, iron and zinc levels, DNA methylation and birth weight
BMC Pharmacology & Toxicology, 16.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes
CELL DEATH & DISEASE, 6.
MeSH headings : Animals; Apoptosis / genetics; Apoptosis / radiation effects; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cell Line; Cell Proliferation / genetics; Cell Proliferation / radiation effects; DNA Damage / genetics; DNA Damage / radiation effects; Gene Expression Regulation / radiation effects; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / radiation effects; Mice; RNA, Long Noncoding / biosynthesis; RNA, Long Noncoding / genetics; Skin / metabolism; Skin / pathology; Skin / radiation effects; Skin Neoplasms / genetics; Skin Neoplasms / pathology; Tumor Suppressor Protein p53 / genetics; Ultraviolet Rays
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST
TOXICOLOGY IN VITRO, 29(3), 544–550.
author keywords: DNA methylation; Epigenetics; Insulin-like growth factor 2 (IGF2); Paternally expressed gene 1/mesoderm specific transcript (PEG1/MEST); Lead acetate; Bisulfite pyrosequencing
MeSH headings : DNA Methylation / drug effects; Gene Expression Regulation / drug effects; HEK293 Cells; Humans; Insulin-Like Growth Factor II / biosynthesis; Insulin-Like Growth Factor II / genetics; Lead / toxicity; Organometallic Compounds / toxicity; Proteins / genetics; Proteins / metabolism
TL;DR:
Pb exposure below reportable/actionable levels increased expression of PEG1/MEST concomitant with decreased methylation, suggesting that Pb exposure can stably alter the regulatory capacity of multiple imprints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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