Works Published in 2006
Displaying works 41 - 54 of 54 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2006 journal article
Substitutions of prolines examine their role in kinetic trap formation of the caspase recruitment domain (CARD) of RICK
PROTEIN SCIENCE, 15(3), 395–409.
author keywords: caspase recruitment domain; RICK; Greek key; folding kinetics; equilibrium folding; folding intermediates; kinetic traps
MeSH headings : Amino Acid Substitution; Binding Sites; Caspase 1; Caspases / chemistry; Caspases / metabolism; Circular Dichroism; Enzyme Precursors / chemistry; Enzyme Precursors / metabolism; Kinetics; Models, Molecular; Proline / chemistry; Proline / genetics; Protein Folding; Protein Serine-Threonine Kinases / chemistry; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Protein Structure, Tertiary; Receptor-Interacting Protein Serine-Threonine Kinase 2; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / chemistry; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / genetics; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism
TL;DR:
The results show that P85 is critical for maintaining the function of the protein and that all mutations decrease the stability, and the complex folding pathway, especially formation of kinetically trapped species, is not due to prolyl isomerism.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Removal of divalent cations induces structural transitions in Red clover necrotic mosaic virus, revealing a potential mechanism for RNA release
JOURNAL OF VIROLOGY, 80(21), 10395–10406.
MeSH headings : Amino Acid Sequence; Calcium / metabolism; Capsid / metabolism; Capsid / ultrastructure; Capsid Proteins / genetics; Capsid Proteins / metabolism; Capsid Proteins / ultrastructure; Cations, Divalent / metabolism; Cryoelectron Microscopy; Image Processing, Computer-Assisted; Magnesium / metabolism; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes; RNA, Viral / genetics; RNA, Viral / metabolism; Sequence Homology, Amino Acid; Species Specificity; Static Electricity; Tombusviridae / genetics; Tombusviridae / metabolism; Tombusviridae / ultrastructure
TL;DR:
Results indicate that divalent cations play a central role in capsid dynamics and suggest a mechanism for the release of viral RNA in low-divalent-cation environments such as those found within the cytoplasm of a cell.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Polycations globally enhance binding of 14-3-3 omega to target proteins in spinach leaves
PLANT AND CELL PHYSIOLOGY, 47(6), 764–771.
author keywords: divalent cations; far-Western overlay; nitrate reductase; 14-3-3 protein; spermine; Spinacia oleracea
MeSH headings : 14-3-3 Proteins / analysis; 14-3-3 Proteins / metabolism; Adenosine Monophosphate / pharmacology; Arabidopsis Proteins / analysis; Arabidopsis Proteins / metabolism; Digoxigenin; Light; Magnesium / pharmacology; Nitrate Reductase / analysis; Nitrate Reductase / metabolism; Phosphorylation; Photoperiod; Plant Leaves / chemistry; Plant Leaves / metabolism; Plant Proteins / analysis; Plant Proteins / metabolism; Polyamines / pharmacology; Polyelectrolytes; Protein Binding; Spermine / pharmacology; Spinacia oleracea / chemistry; Spinacia oleracea / metabolism
TL;DR:
The results suggest that the binding of 14-3-3s to targets in addition to pNR may also be regulated by polycations and 5'-AMP.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 article
Efficacy of ronidazole for treatment of feline Tritrichomonas foetus infection
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 20, pp. 536–543.
author keywords: colitis; diarrhea; metronidazole; nitroimidazole; tinidazole
TL;DR:
Oral administration of RDZ at 30 to 50 mg/kg PO q12h for 14 days resolved diarrhea and eradicated infection in 1 naturally infected cat and 10 experimentally inoculated cats receiving a different isolate of T foetus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Diffraction enhanced imaging of controlled defects within bone, including bone-metal gaps
Physics in Medicine & Biology, 51(12), 3283–3300.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training
ATHEROSCLEROSIS, 185(1), 65–69.
author keywords: apolipoprotein A1; single nucleotide polymorphism; high density lipoprotein; subtraction; aerobic exercise
MeSH headings : Adolescent; Adult; Aged; Apolipoprotein A-I / genetics; Biomarkers / blood; Cardiovascular Diseases / blood; Cardiovascular Diseases / genetics; Cholesterol, HDL / blood; DNA / genetics; Exercise / physiology; Follow-Up Studies; Genotype; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Polymorphism, Single Nucleotide; Reference Values
TL;DR:
Results show that genetic variation at the APOA1 gene promoter is associated with HDL subfraction redistribution resulting from exercise training.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker
Protein Expression and Purification, 47(1), 311–318.
author keywords: caspase-3; fusion protein; protein expression; proteolysis
MeSH headings : Amino Acid Sequence; Caspase 3 / metabolism; Caspase 3 / physiology; Glutathione Transferase / genetics; Histidine / genetics; Hydrolysis; Molecular Sequence Data; Peptide Fragments / chemistry; Peptide Fragments / genetics; Peptide Fragments / metabolism; Protein Structure, Tertiary / genetics; Proteins / genetics; Proteins / isolation & purification; Proteins / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / isolation & purification; Recombinant Fusion Proteins / metabolism
TL;DR:
A glutathione S-transferase-fusion protein vector with a caspase-3 consensus cleavage sequence located between the N-terminal GST tag and a target protein is designed and it is shown that the enzyme efficiently cleaves the fusion protein without leaving excess amino acids on the target protein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2006 journal article
Crystalline cyclodextrin inclusion compounds formed with aromatic guests: Guest-dependent stoichiometries and hydration-sensitive crystal structures
CRYSTAL GROWTH & DESIGN, 6(5), 1113–1119.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Multiple solvent crystal structures: Probing binding sites, plasticity and hydration
JOURNAL OF MOLECULAR BIOLOGY, 357(5), 1471–1482.
author keywords: elastase; solvent mapping; organic solvents; protein binding sites; multiple solvent crystal structures
MeSH headings : Animals; Binding Sites; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Pancreatic Elastase / chemistry; Pancreatic Elastase / metabolism; Protein Conformation; Solvents; Swine; Water / chemistry
TL;DR:
The MSCS method allows probing of hot spots, plasticity and hydration simultaneously, providing a powerful complementary strategy to guide computational methods currently in development for binding site determination, ligand docking and design.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Controlled encapsidation of gold nanoparticles by a viral protein shell
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(14), 4502–4503.
MeSH headings : Capsid Proteins / chemistry; Capsid Proteins / genetics; DNA, Viral / chemistry; DNA, Viral / genetics; Gold / chemistry; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; RNA, Viral / chemistry; RNA, Viral / genetics; Tombusviridae / chemistry; Tombusviridae / genetics
TL;DR:
Covalent linkage of the OAS to Au functions as a trigger for specific encapsidation and demonstrates that foreign cargo can be packaged into Red clover necrotic mosaic virus virions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Single and multiple deletions in the transmembrane domain of the Sindbis virus E2 glycoprotein identify a region critical for normal virus growth
VIROLOGY, 347(1), 199–207.
author keywords: Sindis virus; E2 glycoprotein; transmembrane domain; virus assembly; compensatory mutations
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Cricetinae; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Sequence Deletion; Sindbis Virus / genetics; Sindbis Virus / growth & development; Sindbis Virus / physiology; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / genetics; Virus Replication / genetics
TL;DR:
Results suggest that the position of the deletion and the length of the C terminal region of the E2 transmembrane domain is vital for normal virus production, and deletion mutants resulting in decreased infectivity produce particles that appear to be processed and transported correctly suggesting a role involved in virus entry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Structural characterization of the E2 glycoprotein from Sindbis by lysine biotinylation and LC-MS/MS
VIROLOGY, 348(1), 216–223.
author keywords: Sindbis; mass spectrometry; surface labeling; Alphavirus; glycoprotein
MeSH headings : Amino Acid Sequence; Animals; Biotin / metabolism; Cell Line; Cricetinae; Lysine / metabolism; Mass Spectrometry / methods; Microscopy, Electron, Transmission; Molecular Sequence Data; Protein Structure, Quaternary; Sindbis Virus / chemistry; Sindbis Virus / physiology; Sindbis Virus / ultrastructure; Staining and Labeling / methods; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / ultrastructure; Viral Plaque Assay; Virion / chemistry; Virion / ultrastructure
TL;DR:
The organization of the E2 glycoprotein was probed by surface biotinylation of intact virions and it was confirmed that the E1 protein is almost completely buried in the virus structure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Mutations in the endodomain of Sindbis virus glycoprotein E2 define sequences critical for virus assembly
JOURNAL OF VIROLOGY, 80(9), 4458–4468.
MeSH headings : Amino Acid Sequence; Animals; Capsid Proteins / genetics; Capsid Proteins / metabolism; Cell Line; Cricetinae; Gene Deletion; Microscopy, Electron, Transmission; Molecular Sequence Data; Mutation / genetics; Protein Structure, Tertiary; Sequence Alignment; Sindbis Virus / physiology; Sindbis Virus / ultrastructure; Tyrosine / genetics; Tyrosine / metabolism; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / genetics; Viral Envelope Proteins / metabolism; Virus Assembly
TL;DR:
Submo acid substitutions and deletions in a region of the E2 tail (E2 amino acids 408 to 415) that is initially integrated into the endoplasmic reticulum are produced to define protein interactions critical for virus assembly and suggest a fundamental difference between Sindbis virus assembly in mammalian and insect cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Measurement of multisite oxidation kinetics reveals an active site conformational change in Spo0F as a result of protein oxidation
BIOCHEMISTRY, 45(20), 6260–6266.
MeSH headings : Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; Circular Dichroism; Kinetics; Mass Spectrometry; Methionine / metabolism; Models, Molecular; Oxidation-Reduction; Phosphorylation; Protein Conformation; Structure-Activity Relationship
TL;DR:
It is found that oxidation causes a three-stage conformational change in Spo0F, a regulator of sporulation in Bacillus subtilis, and the dramatic structural changes affect only the region surrounding the active site, while the remainder of the structure remains relatively unperturbed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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