Works Published in 2020
Displaying works 21 - 40 of 41 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 article
The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: monitoring county level vulnerability
Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y., Wright, F. A., … Reif, D. M. (2020, August 13). (Vol. 8). Vol. 8.
TL;DR:
The Pandemic Vulnerability Index (PVI) presents a visual synthesis of county-level vulnerability indicators that can be compared in a regional, state, or nationwide context to enable more effective and coordinated action to combat the pandemic.
(via Semantic Scholar)
doi.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 21, 2020
2020 journal article
Novel peptide ligands for antibody purification provide superior clearance of host cell protein impurities
JOURNAL OF CHROMATOGRAPHY A, 1625.
author keywords: Peptide affinity ligands; Protein A; mAb purification; Affinity chromatography; Peptide design
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal / isolation & purification; Antibodies, Monoclonal / metabolism; CHO Cells; Chromatography, Affinity / methods; Cricetinae; Cricetulus; Immunoglobulin G / isolation & purification; Immunoglobulin G / metabolism; Ligands; Peptides / chemical synthesis; Peptides / chemistry; Peptides / metabolism; Protein Binding; Staphylococcal Protein A / chemistry; Staphylococcal Protein A / metabolism
TL;DR:
WQRHGI-WorkBeads resin was finally characterized by purification of a monoclonal antibody from a Chinese Hamster Ovary cell culture harvest, affording a remarkable HCP LRV of 2.7, and consistent product yield and purity over 100 chromatographic cycles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 10, 2020
2020 journal article
Genetic and environmental risk for lymphoma in boxer dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(5), 2068–2077.
author keywords: canine; detoxification; exposure; lymphosarcoma
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Genetic Predisposition to Disease; Genotype; Lymphoma / genetics; Lymphoma / veterinary; Risk Factors
TL;DR:
Proximity to nuclear power plants, chemical suppliers, and crematoria were significant risk factors for lymphoma in this population of boxers and support the hypothesis that aggregate exposures to environmental chemicals and industrial waste may contribute to lymphoma risk in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 3, 2020
2020 journal article
Infection by cyst nematodes induces rapid remodelling of developing xylem vessels in wheat roots
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Animals; Cell Wall / metabolism; Cysts / metabolism; Gene Expression Regulation, Plant / genetics; Giant Cells / cytology; Infections; Microscopy, Confocal / methods; Nematoda / metabolism; Nematode Infections / metabolism; Nematode Infections / physiopathology; Plant Diseases / parasitology; Plant Roots / metabolism; Plant Roots / parasitology; Triticum / metabolism; Triticum / parasitology; Tylenchoidea / parasitology; Tylenchoidea / physiology; Xylem / cytology
TL;DR:
By interfering with a developmental program that normally leads to programmed cell death, H. avenae may permit xylem vessel elements to remain alive for later exploitation by the parasite.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 20, 2020
2020 journal article
Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(12), 7409–7419.
MeSH headings : Animals; Biomarkers; Dogs; Environmental Monitoring; Humans; Organophosphates; Silicones
TL;DR:
Exposures among pet dogs and their owners using silicone dog tags and wristbands were evaluated to determine if contaminant levels were correlated with validated biomarkers and the value of using silicone bands with dogs to investigate health impacts on humans from shared exposures is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: July 13, 2020
2020 journal article
The influence of packed cell volume versus plasma proteins on thromboelastographic variables in canine blood
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 30(4), 418–425.
MeSH headings : Animals; Blood Coagulation Tests / veterinary; Blood Proteins / physiology; Cell Size; Dogs / blood; Female; Fibrinogen / metabolism; Hematocrit / veterinary; Male; Thrombelastography / veterinary
TL;DR:
In an ex vivo model, plasma proteins but not PCV impacted TEG variables, suggesting that TEG changes noted with anemia are imparted by changes in available fibrinogen in a fixed microenvironment rather than artifact of anemia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 13, 2020
2020 article
QSAR without borders (vol 10, pg 531, 2020)
Muratov, E. N., Bajorath, J., Sheridan, R. P., Tetko, I. V., Filimonov, D., Poroikov, V., … Tropsha, A. (2020, June 7). CHEMICAL SOCIETY REVIEWS, Vol. 49, pp. 3716–3716.
TL;DR:
This research presents a novel probabilistic procedure called QSAR without borders, which can be used to assess the severity of the impact of natural disasters on the response of the immune system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 6, 2020
2020 review
QSAR without borders
[Review of ]. CHEMICAL SOCIETY REVIEWS, 49(11), 3525–3564.
MeSH headings : Algorithms; Animals; Artificial Intelligence; Chemistry, Pharmaceutical / methods; Databases, Factual; Drug Design; Drug-Related Side Effects and Adverse Reactions / metabolism; History, 20th Century; History, 21st Century; Humans; Models, Molecular; Pharmaceutical Preparations / chemistry; Quantitative Structure-Activity Relationship; Quantum Theory; Reproducibility of Results
TL;DR:
This Perspective summarizes recent technological advances in QSAR modeling but it also highlights the applicability of algorithms, modeling methods, and validation practices developed inQSAR to a wide range of research areas outside of traditional QSar boundaries including synthesis planning, nanotechnology, materials science, biomaterials, and clinical informatics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 6, 2020
2020 journal article
Nonlinear Dose-Response Modeling of High-Throughput Screening Data Using an Evolutionary Algorithm
DOSE-RESPONSE, 18(2).
author keywords: evolutionary algorithm; hillslope model; parameter estimation; nonlinear regression; model selection
TL;DR:
This work proposes the use of an EA for dose–response modeling for a range of potential response model functional forms that can not only fit the most commonly used nonlinear dose– response models but also select the best model if no model assumption is made, which is especially useful in the case of high-throughput curve fitting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: June 15, 2020
2020 journal article
Inductive transfer learning for molecular activity prediction: Next-Gen QSAR Models with MolPMoFiT
JOURNAL OF CHEMINFORMATICS, 12(1).
author keywords: Transfer learning; Neural networks; Self-supervised learning; QSPR; QSAR
TL;DR:
The Molecular Prediction Model Fine-Tuning approach is proposed, an effective transfer learning method based on self-supervised pre-training + task-specific fine-tuning for QSPR/QSAR modeling for smaller chemical datasets with specific endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 18, 2020
2020 journal article
In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish
Journal of Immunotoxicology, 17(1), 94–104.
author keywords: Chemical screen; high throughput; phagocyte; reactive oxygen species (ROS); polycyclic aromatic hydrocarbons (PAH); endocrine disrupting compounds (EDC); lead
MeSH headings : Animals; Animals, Genetically Modified; Benzo(a)pyrene / adverse effects; Blood Cell Count; Cytotoxicity Tests, Immunologic / methods; Embryo, Nonmammalian; Estradiol / adverse effects; Feasibility Studies; High-Throughput Screening Assays / methods; Immunity, Innate / drug effects; Macrophages / drug effects; Macrophages / immunology; Methoxychlor / adverse effects; Neutrophils / drug effects; Neutrophils / immunology; Organometallic Compounds / adverse effects; Phenanthrenes / adverse effects; Reactive Oxygen Species / analysis; Reactive Oxygen Species / metabolism; Respiratory Burst / drug effects; Respiratory Burst / immunology; Zebrafish
TL;DR:
The utility of zebrafish larvae as a vertebrate model for identifying compounds that impact innate immune function at non-teratogenic levels is demonstrated and validates measuring ROS production and phagocyte numbers as metrics for monitoring how xenobiotic exposure alters the innate immune system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: May 15, 2020
2020 journal article
Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(3), 897–906.
author keywords: Asthma; food allergy; invariant natural killer T cells; metabolomics; metabolites; secondary bile acids; sphingolipids; tryptophan
MeSH headings : Asthma / blood; Biomarkers / blood; Child; Child, Preschool; Female; Food Hypersensitivity / blood; Humans; Male; Metabolome; Metabolomics / methods; Pilot Projects
TL;DR:
Children with FA display a disease-specific metabolomic profile that is informative of disease mechanisms and severity, and which dominates in the presence of asthma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 27, 2020
2020 journal article
SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides
JOURNAL OF CHEMINFORMATICS, 12(1).
author keywords: Macrolides; PKS enumerator; In silico chemical library software; Polyketides
TL;DR:
A new cheminformatics enumeration technology—SIME, synthetic insight-based macrolide enumerator—a new and improved software technology that can enumerate fully assembled macrolides with synthetic feasibility by utilizing the constitutional and structural knowledge extracted from biosynthetic aspects of macrolided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 27, 2020
2020 journal article
Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells
SMALL, 16(21).
author keywords: nanotoxicity; silver nanoparticles; transcriptomics
MeSH headings : Gene Expression / drug effects; Hepatocytes / drug effects; Humans; Metal Nanoparticles / chemistry; Silver; Surface Properties; Time Factors
TL;DR:
Universal to all surface coatings, AgNP-treated cells responded by inactivating proliferation and enabling cell cycle checkpoints, which provide a foundation for understanding hepatic response to low-dose AgNPs for future risk assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 14, 2020
2020 journal article
CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity
ENVIRONMENTAL HEALTH PERSPECTIVES, 128(2).
MeSH headings : Androgens; Computer Simulation; Databases, Factual; Endocrine Disruptors; High-Throughput Screening Assays; Humans; Receptors, Androgen; United States; United States Environmental Protection Agency
TL;DR:
The Collaborative Modeling Project for Androgen Receptor Activity (CoMPARA) efforts are described, which follows the steps of the Collaborative Estrogen Recept Activity Prediction Project (CERAPP).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 30, 2020
2020 journal article
Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function
ARCHIVES OF TOXICOLOGY, 94(2), 469–484.
author keywords: Neurotoxicity; Screening; ToxCast
MeSH headings : Animals; Cell Culture Techniques / instrumentation; Cell Culture Techniques / methods; Databases, Chemical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical / methods; Machine Learning; Microelectrodes; Nerve Net / drug effects; Neural Networks, Computer; Neurons / drug effects; Neurotoxicity Syndromes / pathology; Rats, Long-Evans; Toxicity Tests / methods
TL;DR:
It is demonstrated that multivariate MEA activity patterns can efficiently screen for diverse chemical activities relevant to neurotoxicity, and that response patterns may have predictive value related to chemical structural features.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020
2020 journal article
Hierarchical Quantitative Structure-Activity Relationship Modeling Approach for Integrating Binary, Multiclass, and Regression Models of Acute Oral Systemic Toxicity
CHEMICAL RESEARCH IN TOXICOLOGY, 33(2), 353–366.
MeSH headings : Administration, Oral; Algorithms; Animals; Models, Molecular; Molecular Structure; Organic Chemicals / administration & dosage; Organic Chemicals / toxicity; Quantitative Structure-Activity Relationship; Rats; Regression Analysis
TL;DR:
A novel, dual-layer hierarchical modeling method to fully integrate regression and classification QSAR models for assessing rat acute oral systemic toxicity, with respect to regulatory classifications of concern is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 30, 2020
2020 journal article
HGBEnviroScreen: Enabling Community Action through Data Integration in the Houston–Galveston–Brazoria Region
International Journal of Environmental Research and Public Health, 17(4), 1130.
author keywords: environmental justice; geographic information systems; vulnerable populations; community; public health; data; screening; enviroscreen
MeSH headings : Accidents, Occupational; Community Participation; Disasters; Environmental Exposure; Floods; Humans; Public Health; Risk Assessment; Risk Factors; Vulnerable Populations
TL;DR:
HGBEnviroScreen is not only helping identify communities of greatest overall vulnerability but is also providing insights into which domains would most benefit from improved planning, policy, and action in order to reduce future vulnerability.
(via Semantic Scholar)
Source: ORCID
Added: February 15, 2020
2020 journal article
A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes
CLINICAL PHARMACOLOGY & THERAPEUTICS, 107(6), 1383–1393.
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacology; Child; Child, Preschool; Female; Gene Expression Regulation / genetics; Genetic Variation; Genome-Wide Association Study; Genotype; Humans; Hypolipidemic Agents / pharmacology; Infant; Liver / metabolism; Male; Middle Aged; Phenotype; Proprotein Convertase 9 / genetics; Quantitative Trait Loci / genetics; Receptors, G-Protein-Coupled / genetics; Sex Factors; Young Adult
TL;DR:
Translational relevance of these results is evidenced by linking DPYD eQTLs to differences in safety of chemotherapy, linking the sex‐biased regulation of PCSK9 expression to anti‐lipid therapy, and identifying the G‐protein coupled receptor GPR180 as a novel drug target for hypertriglyceridemia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: February 10, 2020
2020 journal article
A Single, Shared Triploidy in Three Species of Parasitic Nematodes
G3-GENES GENOMES GENETICS, 10(1), 225–233.
Contributors: A. Schoonmaker*, Y. Hao*, D. Bird* & G. Conant n
author keywords: polyploidy; evolutionary model; root-knot nematode
MeSH headings : Animals; Evolution, Molecular; Genome, Helminth; Phylogeny; Triploidy; Tylenchoidea / classification; Tylenchoidea / genetics
TL;DR:
Three root-knot nematodes of the genus Meloidogyne descend from a single common hybridization event that yielded triplicated genomes with three distinguishable subgenomes, and ancestral loci where two of the three gene copies have been lost are less likely to have orthologs in Caenorhabditis elegans that are lethal when knocked down than are ancestral locu with surviving duplicate copies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 21, 2020
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