Works Published in 2008
Displaying works 61 - 80 of 112 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
Gene Silencing in Mammalian Cells with Light-Activated Antisense Agents
ChemBioChem, 9(18), 2937–2940.
author keywords: Antisense agents; caged compounds; DNA; gene regulation; RNA
MeSH headings : Animals; Base Sequence; Gene Silencing; Genes, Reporter; Light; Luciferases, Renilla / chemistry; Mice; NIH 3T3 Cells; Oligonucleotides, Antisense / chemistry; Oligonucleotides, Antisense / metabolism; Oligonucleotides, Antisense / radiation effects; Phosphorothioate Oligonucleotides / chemistry; Phosphorothioate Oligonucleotides / metabolism; Transfection
TL;DR:
Detailed knowledge of the external regulation of gene func-tion is a fundamental necessity in order to annotate sequencedgenomes and to understand biological processes in single cells and multicellular organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis
CYTOGENETIC AND GENOME RESEARCH, 122(2), 110–121.
MeSH headings : Animals; Chromosomes / genetics; Comparative Genomic Hybridization; Cytogenetics; Databases, Nucleic Acid; Dogs; Genome / genetics; In Situ Hybridization, Fluorescence; Neoplasms / genetics; Oligonucleotide Array Sequence Analysis
TL;DR:
The dog genome sequence assembly is used to identify a framework panel of 2,097 bacterial artificial chromosome (BAC) clones, selected at intervals of approximately one megabase, which has enormous potential for aiding gene discovery through a comparative approach to molecular oncology.
(via Semantic Scholar)
www.karger.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 chapter
Animal skin morphology and dermal absorption
In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment (2nd ed., pp. 17–35). New York: Informa Healthcare.
Ed(s): M. Roberts & K. Walters
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Magnetic resonance imaging of live freshwater mussels (Unionidae)
INVERTEBRATE BIOLOGY, 127(4), 396–402.
author keywords: MRI; morphology; bivalve; soft tissue; unionid
TL;DR:
This study clarifies the body plan of unionid mussels and demonstrates the efficacy of magnetic resonance imaging technology for in vivo evaluation of the structure, function, and integrity of mussel soft tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 review
Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus
[Review of ]. NEUROTOXICOLOGY, 29(6), 988–997.
author keywords: Genistein; Equal; Soy; Isoflavones; Gonadotropin; Puberty; Development; Endocrine disruption; DPN; PPT
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrous Cycle / drug effects; Female; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Kisspeptins; Nerve Fibers / metabolism; Phenols / pharmacology; Proteins / metabolism; Pyrazoles / pharmacology; Rats; Receptors, Estrogen / agonists; Reproductive Physiological Phenomena / drug effects
TL;DR:
The data suggest that neonatal exposure to EDCs can suppress GnRH activity in adulthood, and that ERalpha plays a pivotal role in this process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 article
A solvatochromatic approach to quantifying formulation effects on dermal permeability
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, Vol. 19, pp. 615–630.
author keywords: mixtures; skin; membrane-coated fiber; solvation energy
MeSH headings : Animals; Ethanol / metabolism; Models, Theoretical; Permeability / drug effects; Phenol / metabolism; Skin Physiological Phenomena; Solvents / metabolism; Swine; Toxicology / methods; Water / metabolism
TL;DR:
This research demonstrated that formulation-specific strength coefficients predicted changes in the dermal permeability of phenolic compounds when formulated with commercial metal-working fluid formulations or 50% ethanol and that these effects can be modeled within the context of a linear solvation energy relationship (LSER).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
TAK1-binding Protein 1, TAB1, Mediates Osmotic Stress-induced TAK1 Activation but Is Dispensable for TAK1-mediated Cytokine Signaling
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(48), 33080–33086.
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Line; Cytokines / metabolism; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Enzyme Activation / physiology; Fibroblasts / cytology; Fibroblasts / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Osmotic Pressure / physiology; Protein Structure, Tertiary / physiology; Signal Transduction / physiology
TL;DR:
It is found that TAK1 is spontaneously activated when the concentration is increased and that it is totally dependent on TAB1, and that the C-terminal 68 amino acids of TAB 1 were sufficient to mediate osmotic stress-induced TAK 1 activation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling
Blood, 112(12), 4694–4698.
MeSH headings : Antineoplastic Agents / therapeutic use; Cells, Cultured; Enzyme Inhibitors / therapeutic use; Farnesyltranstransferase / antagonists & inhibitors; Female; Humans; Hypertension, Pulmonary / drug therapy; Hypertension, Pulmonary / etiology; K562 Cells; Leukemia, Large Granular Lymphocytic / complications; Leukemia, Large Granular Lymphocytic / drug therapy; Leukemia, Large Granular Lymphocytic / genetics; Middle Aged; Quinolones / therapeutic use; Receptors, Natural Killer Cell / genetics; Signal Transduction / genetics; Treatment Outcome
TL;DR:
A genetic approach demonstrated that killing of pulmonary endothelial cells by patient NK cells was mediated by dysregulated balance in activating and inhibitory NK-receptor signaling, and suggested a causal relationship between the expanded lymphocyte population and these clinical manifestations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(38), 26161–26168.
MeSH headings : Animals; Antioxidants / metabolism; Cytochromes c / metabolism; Gene Expression Regulation; Inflammation; Keratinocytes / cytology; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Transgenic; Models, Biological; NF-kappa B / metabolism; Oxidative Stress; Proto-Oncogene Proteins c-jun / metabolism; Reactive Oxygen Species; Skin / metabolism
TL;DR:
It is shown that, in an in vivo setting, the antioxidant treatment could reduce an inflammatory condition in keratinocyte-specific Tak1 deletion mice and regulate ROS partially through c-Jun, which is important for preventing ROS-induced skin inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Novel arthropod repellent, BioUD, is an efficacious alternative to deet
JOURNAL OF MEDICAL ENTOMOLOGY, 45(5), 891–898.
author keywords: BioUD; deet; insect repellent; mosquitoes; ticks
TL;DR:
Based on studies in toto, BioUD is an efficacious alternative to deet in its repellent activity and was more efficacious than 25 and 30% deet, respectively, in these studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
C/EBP beta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf)
CELL DEATH AND DIFFERENTIATION, 15(11), 1734–1744.
author keywords: apoptosis; p53; C/EBP beta; p19(Arf); DNA damage; keratinocytes
MeSH headings : Animals; Apoptosis / drug effects; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / metabolism; Carcinogens / toxicity; Cell Survival / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cyclophosphamide / administration & dosage; Cyclophosphamide / pharmacology; DNA Damage; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Injections, Intraperitoneal; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Mice; Oncogene Protein p21(ras) / metabolism; Protein Processing, Post-Translational / drug effects; Repressor Proteins / metabolism; Transcriptional Activation / drug effects; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR:
Results suggest that inhibition of C/EBPβ may be a target for cancer cotherapy to increase the efficacy of alkylating chemotherapeutic agents and suggest that p19Arf represses p53 to promote cell survival downstream of DNA damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2008 journal article
Effects of temperature and molecular oxygen on the use of atmospheric pressure plasma as a novel method for insect control
JOURNAL OF ECONOMIC ENTOMOLOGY, 101(2), 302–308.
author keywords: atmospheric pressure plasma; insect control; quarantine; dielectric barrier discharge; oxygenated helium plasma
TL;DR:
It seems that increases in temperature and the introduction of oxygen even at low levels can increase the insecticidal activity of plasma to varying degrees depending on the insect species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 review
Pulmonary applications and toxicity of engineered nanoparticles
[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 295(3), L400–L411.
author keywords: nanotechnology; nanomaterials; respiratory system; lung
MeSH headings : Animals; Drug Delivery Systems; Humans; Lung / drug effects; Lung / metabolism; Models, Biological; Nanoparticles / therapeutic use; Nanoparticles / toxicity; Nanotechnology; Tissue Distribution
TL;DR:
An overview of the potential usefulness of nanoparticles and nanotechnology in respiratory research and medicine is provided and important issues and recent data pertaining to nanoparticle-related pulmonary toxicity are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Enhancement of extra chromosomal recombination in somatic cells by affecting the ratio of homologous recombination (HR) to non-homologous end joining (NHEJ)
ANIMAL BIOTECHNOLOGY, 19(1), 6–21.
author keywords: extra chromosomal; homologous recombination; somatic cells
MeSH headings : Acetyltransferases / genetics; Animals; Cell Physiological Phenomena; Chromosomes / genetics; DNA Primers; DNA Repair; Plasmids; Recombination, Genetic; Swine; Tumor Suppressor Protein p53 / genetics
TL;DR:
Results show that attempts at reducing NHEJ by use of Mre11 or anti-Ku aptamers were unsuccessful, and cell synchrony via thymidine incorporation does increase the ratio of HR/NHEJ and this indicates that this approach may be of use to facilitate targeting in somatic cells by reducing the numbers of colonies that need to be analyzed before a HR is identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Generation of a conditional mutant allele for Tab1 in mouse
GENESIS, 46(8), 431–439.
author keywords: conditional gene knockout; MAP kinase; BMP; Tab1; TGF-beta
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Animals; Exons; Gene Targeting; Integrases / metabolism; Mice; Mutation
TL;DR:
It is demonstrated that Cre‐mediated recombination using Sox2‐Cre, a Cre line expressed in the epiblast during early embryogenesis, results in deletion of the gene and protein and homozygous Cre‐recombined null embryos display an identical phenotype to conventional null embryos.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 51(3), 324–331.
author keywords: PBPK; melamine; rat; porcine; meat withdrawal time; feed contaminants
MeSH headings : Animal Feed / adverse effects; Animal Feed / analysis; Animals; Drug Administration Schedule; Drug Residues / analysis; Food Contamination / prevention & control; Male; Meat Products; Models, Biological; Rats; Rats, Inbred F344; Reproducibility of Results; Resins, Synthetic / pharmacokinetics; Swine; Time Factors; Triazines / pharmacokinetics
TL;DR:
A physiologically based pharmacokinetic model for melamine was developed for rats and extrapolated to pigs, providing evidence of the usefulness in species extrapolation over a range of dosing scenarios and can be used to protect the food supply after accidental exposure in the face of little in the target species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappa B
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(28), 19245–19254.
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Motifs / genetics; Amino Acid Substitution; Humans; I-kappa B Kinase / genetics; I-kappa B Kinase / metabolism; Interleukin-1beta / metabolism; MAP Kinase Kinase 3 / genetics; MAP Kinase Kinase 3 / metabolism; MAP Kinase Kinase 6 / genetics; MAP Kinase Kinase 6 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mutation, Missense; NF-kappa B / genetics; NF-kappa B / metabolism; Phosphorylation; Protein Binding / genetics; Protein Structure, Tertiary / genetics; Signal Transduction / physiology; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Ubiquitin / genetics; Ubiquitin / metabolism; p38 Mitogen-Activated Protein Kinases / genetics; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
The results show that TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK 1-TAB1, which activates IKK signaling to NF-κB.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis
JOURNAL OF IMMUNOLOGY, 181(2), 1143–1152.
MeSH headings : Animals; Apoptosis; Colitis / immunology; Colitis / metabolism; Enterocytes / cytology; Enterocytes / immunology; Enterocytes / metabolism; Ileitis / immunology; Ileitis / metabolism; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Mice, Mutant Strains; Signal Transduction; Tumor Necrosis Factor-alpha / immunology; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Enterocyte apoptosis and intestinal inflammation were strongly attenuated when enterocyte-specific constitutive TAK1-deleted mice were crossed to TNF receptor 1−/− mice, and it is proposed that aberration in Tak1 signaling might disrupt intestinal homeostasis and favor the development of inflammatory disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains
BMC Evolutionary Biology, 8(1), 177.
MeSH headings : Amino Acid Sequence; Animals; Conserved Sequence; Evolution, Molecular; Fish Proteins / genetics; Fish Proteins / immunology; Genetic Variation; Immunoglobulin Variable Region / genetics; Models, Genetic; Molecular Sequence Data; Multigene Family; Oryzias / genetics; Phylogeny; Protein Structure, Tertiary / genetics; Receptors, Immunologic / genetics; Species Specificity; Synteny; Zebrafish / genetics; Zebrafish / immunology
TL;DR:
Comprehensive phylogenetic analyses between the complete datasets of NITRs from medaka and zebrafish indicate multiple species-specific expansions of different families of NITS, consistent with recent birth-and-death events.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 39(1), 45–52.
author keywords: fibrosis; bleomycin; sex; respiratory mechanics
MeSH headings : Animals; Bleomycin / toxicity; Collagen / metabolism; Dihydrotestosterone / pharmacology; Estradiol / deficiency; Female; Inflammation / chemically induced; Inflammation / physiopathology; Lung Compliance / drug effects; Lung Compliance / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Orchiectomy; Ovariectomy; Polymerase Chain Reaction; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / physiopathology; RNA / genetics; Respiratory Function Tests; Sex Characteristics
TL;DR:
The data indicate that androgens play an exacerbating role in decreased lung function after bleomycin administration, and traditional measures of fibrosis may miss critical differences in lung function between the sexes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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