Works Published in 2014
Displaying works 81 - 100 of 143 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Endocrine regulation of predator-induced phenotypic plasticity
Oecologia, 176(3), 625–635.
MeSH headings : Animals; Daphnia / anatomy & histology; Daphnia / genetics; Daphnia / growth & development; Daphnia / physiology; Ecdysone / metabolism; Endocrine System / metabolism; Food Chain; Gene Expression Regulation; Juvenile Hormones / metabolism; Phenotype; Real-Time Polymerase Chain Reaction
TL;DR:
This research synthesizes detail about predator-induced defenses and the physiological regulation of arthropod somatic growth and morphology, leading to a clear prediction that morphological defences are regulated by juvenile hormone and life-history plasticity by ecdysone and juvenile hormone.
(via Semantic Scholar)
link.springer.com (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
Atomic Layer Deposition Coating of Carbon Nanotubes with Aluminum Oxide Alters Pro-Fibrogenic Cytokine Expression by Human Mononuclear Phagocytes In Vitro and Reduces Lung Fibrosis in Mice In Vivo
PLOS ONE, 9(9).
MeSH headings : Aluminum Oxide / pharmacology; Animals; Cell Death / drug effects; Cell Line; Cytokines / metabolism; Humans; Inflammation / pathology; Interleukin-1beta / biosynthesis; Interleukin-6 / metabolism; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Macrophages / drug effects; Macrophages / metabolism; Macrophages / ultrastructure; Mice, Inbred C57BL; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / ultrastructure; Osteopontin / metabolism; Phagocytes / drug effects; Phagocytes / metabolism; Pulmonary Fibrosis; Soot / pharmacology; Surface Properties; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Findings indicate that ALD thin film coating of MWCNTs with Al2O3 reduces fibrosis in mice and that in vitro phagocyte expression of IL-6, TNF-α, and OPN, but not IL-1β, predict M WCNT-induced fibrosisIn the lungs of mice in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
A Novel Model for Neuroendocrine Toxicology: Neurobehavioral Effects of BPA Exposure in a Prosocial Species, the Prairie Vole (Microtus ochrogaster)
ENDOCRINOLOGY, 155(10), 3867–3881.
MeSH headings : Affect / drug effects; Animals; Arvicolinae / physiology; Arvicolinae / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Defense Mechanisms; Endocrine Disruptors / toxicity; Environmental Exposure; Environmental Pollutants / toxicity; Female; Male; Models, Animal; Motor Activity / drug effects; Neurosecretory Systems / drug effects; Phenols / toxicity; Social Behavior; Toxicity Tests
TL;DR:
The hypothesis that BPA alters affective behaviors, potentially via disruption of OT/AVP pathways, is supported in the prairie vole, which is more prosocial than lab rats or mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
2,4-D adsorption to biochars: Effect of preparation conditions on equilibrium adsorption capacity and comparison with commercial activated carbon literature data
WATER RESEARCH, 62, 20–28.
Contributors: J. Kearns *, L. Wellborn*, R. Summers * & D. Knappe n
author keywords: Pesticide; Herbicide; Water treatment; Charcoal; Low-cost adsorbent
TL;DR:
Economic analysis showed that high temperature chars can be a cost-effective alternative to ACs for water treatment applications and increase pyrolysis intensity by increasing temperature and duration was found to positively influence adsorption capacity yield.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Unraveling secrets of telomeres: One molecule at a time
DNA REPAIR, 20, 142–153.
author keywords: Telomeres; Single-molecule imaging; Atomic force microscopy; Fluorescence microscopy; FRET; Laser tweezers; Magnetic tweezers; Protein DNA interactions
MeSH headings : Animals; Fluorescence Resonance Energy Transfer / methods; Humans; Microscopy, Atomic Force / methods; Microscopy, Fluorescence / methods; Optical Tweezers; Telomere / chemistry; Telomere / metabolism; Telomere-Binding Proteins / chemistry; Telomere-Binding Proteins / metabolism
TL;DR:
This review presents a brief overview of the principles of single-molecule imaging and manipulation techniques and highlights results obtained from applying these single- molecule techniques for studying structure, dynamics and functions of G-quadruplexes, telomerase, and shelterin proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Synthetic organic water contaminants in developing communities: an overlooked challenge addressed by adsorption with locally generated char
JOURNAL OF WATER SANITATION AND HYGIENE FOR DEVELOPMENT, 4(3), 422–436.
Contributors: J. Kearns *, D. Knappe n & R. Summers *
author keywords: biochar; charcoal; drinking water; herbicide; pesticide; Thailand
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus
TOXICOLOGICAL SCIENCES, 140(1), 190–203.
author keywords: brain; endocrine disruptor; endocrine disruption; hypothalamus; development; subchronic exposure; sexually dimorphic; ethinyl estradiol; bisphenol A
MeSH headings : Aging / metabolism; Animals; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / genetics; Ethinyl Estradiol / toxicity; Female; Gene Expression / drug effects; Hypothalamus / drug effects; Hypothalamus / embryology; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / metabolism; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Sex Characteristics
TL;DR:
The impact of subchronic exposure from gestation to adulthood to oral doses of BPA below the current no-observed-adverse-effect level (NOAEL) of 5 mg/kg body weight (bw)/day on estrogen receptor (ESR) expression in sexually dimorphic brain regions of prepubertal and adult female rats is examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort
EPIGENETICS, 9(8), 1120–1130.
author keywords: birth weight; DNA methylation; imprinted genes; folate; epidemiology; epigenetics
MeSH headings : Adolescent; Adult; Birth Weight / genetics; Cohort Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Erythrocytes / metabolism; Ethnicity; Female; Folic Acid / blood; Genomic Imprinting; Humans; Infant, Newborn; Male; Pregnancy; Racial Groups; Young Adult
TL;DR:
The data suggest that, with respect to birth weight, no additional benefits may be derived from increased maternal folate concentrations, especially in non-obese women, and support epigenetic plasticity as a key mechanistic response to folate availability during early fetal development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus)
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 31(9), 1506–1521.
author keywords: flunixin; PBPK models; withdrawal intervals; route of administration; cattle (Bos taurus)
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle / blood; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Drug Residues; Liver / chemistry; Liver / metabolism; Milk / chemistry; Models, Biological; Sensitivity and Specificity; Software; Uncertainty
TL;DR:
A physiologically based pharmacokinetic (PBPK) model was developed to predict plasma, liver and milk concentrations of flunixin in cattle following intravenous, intramuscular or subcutaneous administration for use as a tool to determine factors that may affect the withdrawal time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 conference paper
Single-molecule imaging reveals DNA-binding properties of cohesin proteins SA1 and SA2.
Environmental and Molecular Mutagenesis, 55, S29–29.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Peptidoglycan recognition protein genes and risk of Parkinson's disease
Movement Disorders, 29(9), 1171–1180.
Contributors: S. Goldman*, F. Kamel*, G. Ross*, S. Jewell*, C. Marras *, J. Hoppin n , D. Umbach *, G. Bhudhikanok*
author keywords: Parkinson's disease; peptidoglycan; PGLYRP; microbiome; gut
MeSH headings : Adult; Aged; Aged, 80 and over; Carrier Proteins / genetics; Case-Control Studies; Female; Genetic Association Studies; Genetic Predisposition to Disease / genetics; Genotype; Humans; Logistic Models; Male; Microbiota / genetics; Middle Aged; Odds Ratio; Parkinson Disease / genetics; Polymorphism, Single Nucleotide / genetics
TL;DR:
Common variants in PGLYRP genes are associated with PD risk in two independent studies and are consistent with hypotheses of a causative role for the gut microbiota and gastrointestinal immune response in PD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018
2014 journal article
Metabolomic, behavioral, and reproductive effects of the aromatase inhibitor fadrozole hydrochloride on the unionid mussel Lampsilis fasciola
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 206, 213–226.
author keywords: Glochidia; Bivalve; Metabolomics; Aromatase inhibitor; Unionid
MeSH headings : Animals; Aromatase Inhibitors / pharmacology; Behavior, Animal / drug effects; Fadrozole / pharmacology; Female; Larva / drug effects; Male; Metabolome / drug effects; Reproduction / drug effects; Unionidae / drug effects; Unionidae / physiology
TL;DR:
Both sexes revealed significant reductions in fadrozole-induced metabolic effects in gill tissue sampled after 12 Days, indicating time-dependent mechanisms of disruptions in metabolic pathways and homeostatic processes to compensate for such disruptions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Canine Prostate Cancer Cell Line (Probasco) Produces Osteoblastic Metastases In Vivo
PROSTATE, 74(13), 1251–1265.
author keywords: prostate cancer; osteoblastic metastases; canine; dog
MeSH headings : Animals; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Bone Neoplasms / genetics; Bone Neoplasms / metabolism; Bone Neoplasms / secondary; Carcinoma / genetics; Carcinoma / metabolism; Carcinoma / secondary; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dogs; Male; Mice; Mice, Nude; Neoplasm Transplantation; Osteoblasts / metabolism; Osteoblasts / pathology; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology
TL;DR:
This study established and characterized a novel canine prostate cancer cell line that will contribute to the understanding of prostate cancer pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
A stressful shortness of breath: molting disrupts breathing in the mayfly Cloeon dipterum
FRESHWATER SCIENCE, 33(3), 695–699.
author keywords: respirometry; temperature; thermal biology; molting; oxygen consumption; Ephemeroptera
TL;DR:
The insect molt appears to be a previously unappreciated route by which warming conditions may affect aquatic insects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
A Bayesian Network Model for Assessing Natural Estrogen Fate and Transport in a Swine Waste Lagoon
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, 10(4), 511–521.
MeSH headings : Animals; Bayes Theorem; Estrogens / chemistry; Models, Theoretical; Sewage / chemistry; Swine; Waste Disposal, Fluid; Water Pollutants, Chemical / chemistry
TL;DR:
Management scenario evaluations demonstrated that the best possible management options to reduce estrogen levels in the lagoon are either to adjust the estrogen input loading from swine barn facilities or to effectively enhance estrogen bonding with suspended solids through the use of organic polymers or inorganic coagulants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Transport of Steroid Hormones, Phytoestrogens, and Estrogenic Activity across a Swine Lagoon/Sprayfield System
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 48(19), 11600–11609.
MeSH headings : Agriculture / methods; Androgens / chemistry; Androstenedione / chemistry; Animals; Diet / veterinary; Environmental Monitoring / methods; Equol / chemistry; Estrogens / chemistry; Estrone / chemistry; Feces / chemistry; Genistein / chemistry; Hormones / chemistry; Isoflavones / chemistry; Phytoestrogens / chemistry; Progesterone / chemistry; Steroids / chemistry; Swine; Urine / chemistry
TL;DR:
This investigation encompasses the most comprehensive suite of natural hormone and phytoestrogen analytes examined to date across a livestock lagoon/sprayfield and provides global insight into the fate of these analytes in this widely used waste management system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 review
TAK1 control of cell death
[Review of ]. CELL DEATH AND DIFFERENTIATION, 21(11), 1667–1676.
MeSH headings : Animals; Apoptosis / physiology; Cell Death; Cell Survival; Homeostasis; Humans; MAP Kinase Kinase Kinases / metabolism; Mice; Mitogen-Activated Protein Kinases / metabolism; NF-kappa B / metabolism; Necrosis / metabolism; Signal Transduction
TL;DR:
This review summarizes the consequences of TAK1 deficiency in different cell and tissue types from the perspective of cell death and also focuses on the mechanism by which Tak1 complex inhibits or promotes programmed cell death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Phylogeny and Size Differentially Influence Dissolved Cd and Zn Bioaccumulation Parameters among Closely Related Aquatic Insects
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 48(9), 5274–5281.
MeSH headings : Animals; Aquatic Organisms / classification; Aquatic Organisms / metabolism; Cadmium / metabolism; Insecta / classification; Insecta / metabolism; Kinetics; Phylogeny; Solubility; Species Specificity; Water Pollutants, Chemical / metabolism; Zinc / metabolism
TL;DR:
The findings suggest that intrafamily variability can be profound and have important practical implications in that the authors need to better understand how well "surrogate species" represent their fellow congeners and family members.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Genetic Regulation of Zfp30, CXCL1, and Neutrophilic Inflammation in Murine Lung
GENETICS, 198(2), 735–U376.
author keywords: asthma; CXCL1; neutrophil; expression quantitative trait locus (eQTL); systems genetics; complex traits; Multiparent Advanced Generation Inter-Cross (MAGIC); multiparental populations; MPP
MeSH headings : Animals; Chemokine CXCL1 / genetics; Chemokine CXCL1 / metabolism; DNA-Binding Proteins / physiology; Gene Expression; Gene Expression Regulation / immunology; Lung / immunology; Lung / pathology; Male; Mice, Transgenic; Neutrophil Infiltration; Pneumonia / genetics; Quantitative Trait Loci; Trachea / immunology; Trachea / pathology; Transcription Factors / physiology
TL;DR:
It is shown that Zfp30 is expressed in airway epithelia in the normal mouse lung and that altering ZFP30 expression in vitro affects CXCL1 responses to an immune stimulus, providing strong evidence that Z FP30 is a novel regulator of neutrophilic airway inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels
CELLULAR SIGNALLING, 26(12), 2702–2709.
author keywords: Hypoxia; Cobalt chloride; Hypoxia inducible factor (HIF); Iron regulatory protein (IRP); Nrf2; Ferritin
MeSH headings : Apoferritins / genetics; Cell Line, Tumor; Cobalt / pharmacology; Ferritins / genetics; Gene Expression Regulation / genetics; Humans; Hypoxia / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Iron-Regulatory Proteins / genetics; Protein Processing, Post-Translational / drug effects; Protein Processing, Post-Translational / genetics; RNA, Messenger / genetics; Transcription, Genetic / drug effects; Transcription, Genetic / genetics; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR:
It is demonstrated that hypoxia and cobalt chloride regulate ferritin heavy chain (ferritin H) expression by two distinct mechanisms through the interplay between DNA and mRNA elements at the transcriptional and post-transcriptional levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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