Works Published in 2019
Displaying works 21 - 40 of 147 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
A Simple Methodology for Discerning Item Construction Flaws in Health Professions Examinations
Health Professions Education, 5(1), 82–89.
TL;DR:
The methodology was evidenced to be robust, as multiple items containing item construction flaws were identified by inflated success rates for a group of examinees who had no prior training in the subject matter.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Source: Crossref
Added: February 21, 2020
2019 journal article
Biomechanical Function and Size of the Anteromedial and Posterolateral Bundles of the ACL Change Differently with Skeletal Growth in the Pig Model
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 477(9), 2161–2174.
MeSH headings : Aging / physiology; Animals; Anterior Cruciate Ligament / physiology; Biomechanical Phenomena; Cadaver; Models, Animal; Musculoskeletal Development / physiology; Range of Motion, Articular / physiology; Rotation; Swine; Tibia / physiology; Torque
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: February 17, 2020
2019 review
Canine vector-borne disease: mapping and the accuracy of forecasting using big data from the veterinary community
[Review of ]. ANIMAL HEALTH RESEARCH REVIEWS, 20(1), 47–60.
author keywords: Anaplasma; canine vector-borne disease; Ehrlichia; epidemiology; forecast; heartworm; Lyme; One Health
MeSH headings : Aging; Animals; Big Data; Dog Diseases / epidemiology; Dog Diseases / parasitology; Dog Diseases / prevention & control; Dogs; Humans; Immunocompromised Host; Pets; Risk Factors; Vector Borne Diseases / epidemiology; Vector Borne Diseases / veterinary; Zoonoses
TL;DR:
A review summarizes the fidelity of VBD forecasts and illustrates the practical use of CAPC pathogen prevalence maps and forecast data in the practice of veterinary medicine and client education.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 3, 2020
2019 journal article
Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells
ADVANCED THERAPEUTICS, 2(10).
author keywords: bispecific antibodies; immunotherapy; myocardial infarction; stem cells
TL;DR:
In vivo studies in a mouse model with heart ischemia/reperfusion injury demonstrate the safety and therapeutic potency of SCRD BsAb, which supports cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020
2019 journal article
In Situ Joint Stiffness Increases During Skeletal Growth but Decreases Following Partial and Complete Anterior Cruciate Ligament Injury
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 141(12).
TL;DR:
This work furthers the understanding of the interaction between joint biomechanics and ACL function throughout growth and the impact of ACL injury in the skeletally immature joint.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: January 27, 2020
2019 journal article
Veterinary Student Stress, the Benefit of Canine Pets, and Potential Institutional Support of Dog Ownership
JOURNAL OF VETERINARY MEDICAL EDUCATION, 46(4), 438–448.
author keywords: student services; wellness; dog ownership; veterinary student stress
MeSH headings : Animals; Dogs; Education, Veterinary; Humans; Ownership; Pets / psychology; Prospective Studies; Schools, Veterinary / statistics & numerical data; Students, Medical / psychology; Surveys and Questionnaires
TL;DR:
Providing on-site boarding and care options for student-owned dogs can play an important role in both recruiting prospective veterinary students and enhancing the well-being of those currently in the program.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 27, 2020
2019 article
What is your diagnosis? Lymphocytes engulfing erythrocytes in a cat
Mochizuki, H., Sherrick, E., Mastromauro, M., & Stowe, D. M. (2019, December). VETERINARY CLINICAL PATHOLOGY, Vol. 48, pp. 768–770.
author keywords: cell cannibalism; chronic lymphocytic leukemia; erythrophagia; feline; lymphoma
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / pathology; Cats; Female; Leukemia, Lymphoid / diagnosis; Leukemia, Lymphoid / pathology; Leukemia, Lymphoid / veterinary; Lymphocytes
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 21, 2020
2019 journal article
Progesterone inhibits cytokine/TNF-α production by porcine CL macrophages via the genomic progesterone receptor
Domestic Animal Endocrinology, 12, 106426.
author keywords: Pig; Corpus luteum; Progesterone; TNF-alpha; Macrophages; Cytokines
MeSH headings : Animals; Cells, Cultured; Cytokines / genetics; Cytokines / metabolism; Dose-Response Relationship, Drug; Gene Expression Regulation / drug effects; Genomics; Macrophages / drug effects; Macrophages / metabolism; Progesterone / administration & dosage; Progesterone / pharmacology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Progesterone / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Swine; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
The hypothesis that P4 acting via the genomic P4 receptor (PGR) inhibits CL MAC TNF-α and thus plays a key role in regulating LS during the pig estrous cycle is examined and it is suggested that progesterone, acting via PGR, plays a critical physiological role in the control of T NF-α production by CL MACs and LS During the pig Estrous cycle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 14, 2020
2019 journal article
Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression
MOLECULAR CELL, 76(6), 909-+.
Contributors: G. Gowans*, J. Bridgers*, J. Zhang*, R. Dronamraju*, A. Burnetti n, D. King*, A. Thiengmany*, S. Shinsky*
MeSH headings : Acyl Coenzyme A / metabolism; Energy Metabolism / genetics; Fatty Acids / metabolism; Gene Expression Regulation, Fungal; Histones / genetics; Histones / metabolism; Homeostasis; Lysine; Oxidation-Reduction; Protein Processing, Post-Translational; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Signal Transduction; Transcription Factor TFIID / genetics; Transcription Factor TFIID / metabolism; Transcription, Genetic
TL;DR:
These findings expose an unexpected link between metabolic flux and transcription and demonstrate that histone crotonylation and Taf14 participate in the repression of energy-demanding gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: NC State University Libraries, Web Of Science, ORCID
Added: January 6, 2020
2019 journal article
Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma
MOLECULAR CANCER RESEARCH, 17(12), 2410–2421.
MeSH headings : Animals; Blood Vessels / pathology; Breast / metabolism; Breast / pathology; Class I Phosphatidylinositol 3-Kinases / genetics; Class Ia Phosphatidylinositol 3-Kinase / genetics; Cyclin-Dependent Kinase Inhibitor p15 / genetics; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Dogs; Female; Genome / genetics; Genomics; Hemangiosarcoma / genetics; Hemangiosarcoma / pathology; Humans; Mutation / genetics; Tumor Suppressor Protein p53 / genetics; Viscera / metabolism; Viscera / pathology; Exome Sequencing
TL;DR:
Canine hemangiosarcoma closely models the genomic landscape of human angiosarComa of the breast and viscera, and is a powerful tool for investigating the pathogenesis of this devastating disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 30, 2019
2019 journal article
Endocrine Disruption and Reproductive Pathology
TOXICOLOGIC PATHOLOGY, 47(8), 1049–1071.
author keywords: endocrine disrupters; environmental toxicology; fish pathology; hormonal carcinogenesis; reproductive system; nonhuman primate; rodent pathology
MeSH headings : Animals; Congresses as Topic; Endocrine Disruptors / toxicity; Female; Fetal Development / drug effects; Heart / drug effects; Heart / embryology; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / metabolism; Prenatal Exposure Delayed Effects / pathology; Receptors, Androgen / genetics; Receptors, Androgen / metabolism; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Reproduction / drug effects; Species Specificity; Testis / drug effects; Testis / embryology; Testis / pathology; Uterus / drug effects; Uterus / embryology; Uterus / pathology
TL;DR:
Investigations involving endocrine active substances and reproductive toxicity have dominated the landscape of ecotoxicological research, and it is now recognized that anthropomorphic substances may also adversely affect the nervous and immune systems via hormonal mechanisms and play substantial roles in metabolic diseases, such as type 2 diabetes and obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: December 30, 2019
2019 journal article
Epigenetic switching as a strategy for quick adaptation while attenuating biochemical noise
PLOS COMPUTATIONAL BIOLOGY, 15(10).
Contributors: M. Gomez-Schiavon * & N. Buchler *
MeSH headings : Adaptation, Physiological / genetics; Animals; Biological Evolution; Computer Simulation; Environment; Epigenesis, Genetic / genetics; Epigenesis, Genetic / physiology; Epigenomics / methods; Gene Regulatory Networks / genetics; Genotype; Humans; Models, Genetic; Models, Theoretical; Mutation; Phenotype; Selection, Genetic / genetics
TL;DR:
This work uses computer simulations to evolve a mechanistic, biophysical model of a self-activating genetic circuit, which can both adapt genetically through mutation and exhibit epigenetic switching, and shows a trade-off between either minimizing the adaptation time or increasing the robustness of the phenotype to biochemical noise.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 30, 2019
2019 journal article
Population Pharmacokinetics of Danofloxacin After Single Intramuscular Dose Administration in California Brown Pelicans (Pelecanus occidentalis californicus)
JOURNAL OF AVIAN MEDICINE AND SURGERY, 33(4), 361–368.
author keywords: danofloxacin; pharmacokinetics; avian; brown pelican; Pelecanus occidentalis californicus
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Birds / metabolism; Chromatography, High Pressure Liquid / veterinary; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Intramuscular / veterinary; Intramuscular Absorption; Microbial Sensitivity Tests / veterinary; Nonlinear Dynamics; Pectoralis Muscles / metabolism
TL;DR:
The intramuscular injection of danofloxacin in pelicans at this dose produced plasma concentrations that meet therapeutic targets for bacteria with a minimum inhibitory concentration of ≤0.25 µg/mL, which can be used for future studies to evaluate the efficacy of dan ofloxicin for treating susceptible bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019
2019 journal article
Effects of Regulatory T Cell Depletion on NK Cell Responses against Listeria monocytogenes in Feline Immunodeficiency Virus Infected Cats
VIRUSES-BASEL, 11(11).
author keywords: feline immunodeficiency virus; NK cells; regulatory T cells; innate immunity; Treg depletion
MeSH headings : Animals; Cats; Dendritic Cells / immunology; Feline Acquired Immunodeficiency Syndrome / complications; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Killer Cells, Natural / immunology; Listeria monocytogenes / immunology; Listeria monocytogenes / physiology; Listeriosis / immunology; Listeriosis / microbiology; Listeriosis / veterinary; Lymph Nodes / immunology; Lymphocyte Depletion; Opportunistic Infections / immunology; Opportunistic Infections / microbiology; Opportunistic Infections / veterinary; T-Lymphocytes, Regulatory / immunology
TL;DR:
Treg depletion failed to improve the innate immune response of FIV-infected cats against Lm and this may be due to dendritic cell dysfunction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 30, 2019
2019 review
Evolutionary innovation, fungal cell biology, and the lateral gene transfer of a viral KilA-N domain
[Review of ]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 58-59, 103–110.
Contributors: E. Medina *, E. Walsh n & N. Buchler n
MeSH headings : DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Evolution, Molecular; Fungi / genetics; Fungi / metabolism; Gene Transfer, Horizontal / physiology; Membrane Proteins / chemistry; Membrane Proteins / genetics; Membrane Proteins / metabolism; Nuclear Proteins / chemistry; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phylogeny; Protein Conformation; Protein Domains / genetics; Repressor Proteins / chemistry; Repressor Proteins / genetics; Repressor Proteins / metabolism; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Schizosaccharomyces pombe Proteins / chemistry; Schizosaccharomyces pombe Proteins / genetics; Schizosaccharomyces pombe Proteins / metabolism; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism; Viral Regulatory and Accessory Proteins / genetics
TL;DR:
A family of fungal transcription factors derived from the lateral gene transfer of a KilA-N domain commonly found in prokaryotic and eukaryotic DNA viruses play central roles in cell cycle, morphogenesis, sexual differentiation, and quiescence.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 16, 2019
2019 journal article
Diagnostic utility of clinical and laboratory test parameters for differentiating between sudden acquired retinal degeneration syndrome and pituitary-dependent hyperadrenocorticism in dogs
VETERINARY OPHTHALMOLOGY, 22(6), 842–858.
author keywords: biomarker; dog; hyperadrenocorticism; retina; sudden acquired retinal degeneration syndrome
MeSH headings : Animals; Case-Control Studies; Dog Diseases / diagnosis; Dogs; Electroretinography / veterinary; Female; Male; Pituitary ACTH Hypersecretion / diagnosis; Pituitary ACTH Hypersecretion / veterinary; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / veterinary; Tomography, Optical Coherence / veterinary
TL;DR:
This work provides the basis for future studies that could identify and examine dogs with SARDS prior to vision loss, which may extend the potential therapeutic window for SARDS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: December 16, 2019
2019 journal article
Mist1 Expression Is Required for Paneth Cell Maturation
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 8(4), 549–560.
author keywords: MIST1; Paneth Cells; Intermediate Cells
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / biosynthesis; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Cell Differentiation / physiology; Cell Division / physiology; Cell Lineage; Endoplasmic Reticulum Stress; Endoplasmic Reticulum, Rough / physiology; Epithelium / metabolism; Female; Intestinal Mucosa / metabolism; Intestine, Small / physiology; Intestines / physiology; Mice; Mice, Knockout; Paneth Cells / metabolism; Paneth Cells / physiology; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Transcriptome
TL;DR:
MIST1 plays an important role in organization of the Paneth cell secretory apparatus and managing endoplasmic reticulum stress, which occurs downstream ofPaneth cell lineage allocation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 16, 2019
2019 journal article
Molecular Dynamics Simulations of Kir2.2 and Cholesterol Reveal State- and Concentration-Dependent Binding Sites
Biophysical Journal, 116(3), 41a.
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019
2019 journal article
Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis.
EBioMedicine.
author keywords: Enteric glial cells; Colon cancer stem cells; Colorectal cancer: Tumor microenvironment; PGE2
MeSH headings : Animals; Carcinogenesis / metabolism; Carcinogenesis / pathology; Cell Line; Colonic Neoplasms / pathology; Dinoprostone / metabolism; Epithelial Cells / metabolism; Epithelial Cells / pathology; Female; Humans; Interleukin-1 / metabolism; Male; Mice, SCID; Models, Biological; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology; Neuroglia / pathology; Phenotype; Receptors, Prostaglandin E, EP4 Subtype / metabolism; Signal Transduction; Tumor Microenvironment
TL;DR:
Results show that EGCs, once activated by the tumor, acquire a pro-tumorigenic phenotype and stimulate CSC-driven tumorigenesis via a PGE2/EP4/EGFR-dependent pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: December 3, 2019
2019 journal article
Itch-associated Neuropeptides and Their Receptor Expression in Dog Dorsal Root Ganglia and Spinal Cord
ACTA DERMATO-VENEREOLOGICA, 99(12), 1131–1135.
author keywords: dog; canine atopic dermatitis; somatostatin; NPPB; NMB; GRP
MeSH headings : Animals; Calcium Signaling; Cells, Cultured; Dogs; Female; Ganglia, Spinal / metabolism; Ganglia, Spinal / physiopathology; Gene Expression Regulation; Male; Neuropeptides / genetics; Neuropeptides / metabolism; Pruritus / genetics; Pruritus / metabolism; Pruritus / physiopathology; Receptors, Neuropeptide / genetics; Receptors, Neuropeptide / metabolism; Spinal Cord / metabolism; Spinal Cord / physiopathology
TL;DR:
The results provide the first evidence that dogs use similar pruritogenic pathways to those characterized in mice and thus identify multiple targets for the future treatment of itch in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 2, 2019
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