Works Published in 2012
Displaying works 61 - 80 of 112 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Construction and Immunological Evaluation of Dual Cell Surface Display of HIV-1 Gag and Salmonella enterica Serovar Typhimurium FliC in Lactobacillus acidophilus for Vaccine Delivery
CLINICAL AND VACCINE IMMUNOLOGY, 19(9), 1374–1381.
MeSH headings : AIDS Vaccines / administration & dosage; AIDS Vaccines / genetics; AIDS Vaccines / immunology; Administration, Oral; Animals; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Cell Surface Display Techniques / methods; Cells, Cultured; Dendritic Cells / immunology; Female; Flagellin / genetics; Flagellin / immunology; HIV-1 / genetics; HIV-1 / immunology; Humans; Intestinal Mucosa / immunology; Lactobacillus acidophilus / genetics; Leukocytes, Mononuclear / immunology; Mice; Mice, Inbred BALB C; Salmonella typhimurium / genetics; Salmonella typhimurium / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology; gag Gene Products, Human Immunodeficiency Virus / genetics; gag Gene Products, Human Immunodeficiency Virus / immunology
TL;DR:
Results suggested that the Gag-displaying L. acidophilus elicited specific immune responses and the coexistence of FliC conferred an adjuvant effect on local IgA production.
(via Semantic Scholar)
cvi.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Application of a Multi-Route Physiologically Based Pharmacokinetic Model for Manganese to Evaluate Dose-Dependent Neurological Effects in Monkeys
TOXICOLOGICAL SCIENCES, 129(2), 432–446.
author keywords: manganese; neurotoxicity; dose response; physiologically based pharmacokinetic modeling
MeSH headings : Animals; Cebus; Dose-Response Relationship, Drug; Manganese / pharmacokinetics; Models, Biological; Risk Assessment
TL;DR:
A physiologically based pharmacokinetic model that accurately accounts for the dose dependencies of Mn distribution was used to estimate increases in brain Mn concentrations in monkeys following Mn exposure and provides strong evidence of a dose-dependent transition in the mode of action for the neurological effects of Mn that needs to be considered in risk assessments for this essential metal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
WNT7B in fibroblastic foci of idiopathic pulmonary fibrosis
RESPIRATORY RESEARCH, 13.
author keywords: Myofibroblasts; Alveolar epithelium; Interstitial lung disease
MeSH headings : Aged; Aged, 80 and over; Basement Membrane / pathology; Female; Fibroblasts / pathology; Humans; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Macrophages / pathology; Male; Middle Aged; Muscle, Smooth / pathology; Respiratory Mucosa / pathology; Respiratory System / blood supply; Respiratory System / pathology; Severity of Illness Index; Wnt Proteins / analysis; Wnt Proteins / metabolism
TL;DR:
Tissue samples from the Lung Tissue Research Consortium of 39 patients diagnosed with mild to severe IPF/usual interstitial pneumonia and 19 normal patients were examined for the immunolocalization of Wnt7B, demonstrating Wnt 7B to be expressed at high concentrations in regions of active hyperplasia, metaplasia and fibrotic change in IPF patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 review
The outdoor air pollution and brain health workshop
[Review of]. NeuroToxicology, 33(5), 972–984.
Source: NC State University Libraries
Added: August 6, 2018
2012 conference paper
Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts
Reproduction in Domestic Animals, 47, 418–419.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(5), 452–459.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Bacteria / drug effects; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Subcutaneous; Microbial Sensitivity Tests; Swine / blood
TL;DR:
It is demonstrated that the concentration of biologically active enrofloxacin in tissues exceeds the concentration predicted by the unbound fraction in pig plasma, and is sufficient for the pathogens that cause respiratory infections in pigs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Array-based comparative genomic hybridization-guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1335–1343.
MeSH headings : Animals; Comparative Genomic Hybridization / methods; Comparative Genomic Hybridization / standards; Comparative Genomic Hybridization / veterinary; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Gene Dosage; Histiocytic Sarcoma / genetics; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Immunohistochemistry; Lymphoma / genetics; Lymphoma / pathology; Lymphoma / veterinary; Osteosarcoma / genetics; Osteosarcoma / pathology; Osteosarcoma / veterinary; RNA, Neoplasm / chemistry; RNA, Neoplasm / genetics; Real-Time Polymerase Chain Reaction / methods; Real-Time Polymerase Chain Reaction / standards; Real-Time Polymerase Chain Reaction / veterinary; Reference Standards
TL;DR:
Results of the present study indicated LOC611555 may be a useful RT-qPCR assay reference gene for multiple tissue types, such as lymphomas, osteosarcomas, or histiocytic sarcomas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Acute myeloblastic leukemia with associated BCR-ABL translocation in a dog
VETERINARY CLINICAL PATHOLOGY, 41(3), 362–368.
author keywords: Cytogenetics; FISH; immunophenotyping; Raleigh chromosome
MeSH headings : Animals; Bone Marrow / pathology; Cytogenetic Analysis / veterinary; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Fusion Proteins, bcr-abl / genetics; Hematologic Tests / veterinary; Immunophenotyping / veterinary; In Situ Hybridization, Fluorescence / veterinary; Leukemia, Myeloid, Acute / genetics; Leukemia, Myeloid, Acute / immunology; Leukemia, Myeloid, Acute / pathology; Leukemia, Myeloid, Acute / veterinary; Male; Translocation, Genetic / genetics
TL;DR:
This is the first report of AML with a BCR-ABL translocation in a domestic animal and large multinucleated cells were observed frequently, supporting megakaryocytic lineage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Over-expression of human endosulfatase-1 exacerbates cadmium-induced injury to transformed human lung cells in vitro
TOXICOLOGY AND APPLIED PHARMACOLOGY, 265(1), 27–42.
author keywords: Cadmium; HSulf-1; Lung epithelial injury; 6-O-sulfate
MeSH headings : Adenoviridae / genetics; Apoptosis / drug effects; Blotting, Western; Cadmium / toxicity; Cell Count; Cell Line, Tumor; Cell Survival / drug effects; Cell Transformation, Neoplastic / drug effects; Coloring Agents; Down-Regulation / drug effects; Heparan Sulfate Proteoglycans / pharmacology; Humans; In Situ Nick-End Labeling; Lac Operon / genetics; Lung / pathology; Polymerase Chain Reaction; Respiratory Mucosa / pathology; Sulfotransferases / biosynthesis; Sulfotransferases / physiology; Tetrazolium Salts; Thiazoles; Transduction, Genetic; Up-Regulation / drug effects
TL;DR:
The finding that HSulf-1 sensitizes these cancer cells and intensifies the injury induced by cadmium suggests that 6-O-sulfate groups on HSPGs may play important roles in protection against certain environmental toxicants, such as heavy metals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Isolation and characterization of neural progenitor cells from adult canine brains
American Journal of Veterinary Research, 73(12), 1963–1968.
MeSH headings : Animals; Cell Culture Techniques / veterinary; Cell Differentiation; Cell Lineage; Dogs; Female; Hippocampus / cytology; Hippocampus / metabolism; Immunohistochemistry / veterinary; Lateral Ventricles / cytology; Lateral Ventricles / metabolism; Male; Neural Stem Cells / cytology; Neural Stem Cells / physiology; RNA / analysis; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Results suggested the persistence of SOX2- Positive, nestin-positive, GFAP- positive,GFAP-Positive, OCT4-negative, and NANOG-negative neural progenitor cells in the SVZ and SGZ regions of mature canine brains, which are capable of producing multiple cell lineages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2012 journal article
Surface modifications on InAs decrease indium and arsenic leaching under physiological conditions
APPLIED SURFACE SCIENCE, 261, 842–850.
author keywords: InAs; Zebrafish; Toxicity; Passivation; Surface modifications; ICP-MS
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
OPTIMIZATION OF CONTRAST-ENHANCED MULTIDETECTOR ABDOMINAL COMPUTED TOMOGRAPHY IN SEDATED CANINE PATIENTS
VETERINARY RADIOLOGY & ULTRASOUND, 53(5), 507–512.
author keywords: Computed tomography technique; Multidetector; Sedated dogs; Rapid examination
MeSH headings : Animals; Artifacts; Conscious Sedation / veterinary; Contrast Media; Dogs / anatomy & histology; Liver / diagnostic imaging; Multidetector Computed Tomography / veterinary; Phantoms, Imaging / veterinary; Radiographic Image Enhancement; Radiography, Abdominal / veterinary; Spleen / diagnostic imaging
TL;DR:
Scanning under sedation was well tolerated in all patients, and sedated CT examination is a promising tool for screening abdominal disease in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin
FEBS LETTERS, 586(20), 3681–3691.
author keywords: Autotaxin; Transcription; Neuroblastoma; AP-1; SP; Internally initiated SP3; Curcumin
MeSH headings : Cell Line, Tumor; Curcumin / pharmacology; Cyclic AMP / genetics; Gene Deletion; Genes, Reporter / genetics; Humans; Neuroblastoma / pathology; Phosphoric Diester Hydrolases / deficiency; Phosphoric Diester Hydrolases / genetics; Proto-Oncogene Proteins c-myc / metabolism; Response Elements / drug effects; Response Elements / genetics; Sp Transcription Factors / metabolism; Transcription Factor AP-1 / metabolism; Transcription, Genetic / drug effects; Transcriptional Activation / drug effects
TL;DR:
A novel Atx transcriptional mechanism is characterised, utilised by both cell lines, that is restricted to the first 285 bp of the Atx promoter and involves AP‐1 and SP transcription factors, acting through a CRE/AP‐1‐like element at position −142 to −149 and a GAbox relative to the AtX translational start site.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Cell trafficking through the choroid plexus
CELL ADHESION & MIGRATION, 6(5), 390–396.
author keywords: cerebrospinal fluid; pleocytosis; monocytes; macrophages; dendritic cells; T cells; inflammation; adhesion molecules; chemokines
MeSH headings : Animals; Biological Transport; Blood-Brain Barrier / metabolism; Cell Movement; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / metabolism; Central Nervous System Diseases / pathology; Cerebral Ventricles / metabolism; Cerebral Ventricles / pathology; Chemokines / cerebrospinal fluid; Choroid Plexus / blood supply; Choroid Plexus / metabolism; Choroid Plexus / pathology; Dendritic Cells / metabolism; Epithelium / metabolism; Humans; Inflammation / cerebrospinal fluid; Intercellular Adhesion Molecule-1 / metabolism; Macrophages / metabolism; Stromal Cells / metabolism; T-Lymphocytes / metabolism; Vascular Cell Adhesion Molecule-1 / metabolism
TL;DR:
The choroid plexus is a multifunctional organ that sits at the interface between the blood and cerebrospinal fluid and is in an excellent position to provide continuous immune surveillance by CD4+ T cells, macrophages and dendritic cells and to regulate immune cell trafficking in response to disease and trauma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Calpain and MARCKS protein regulation of airway mucin secretion
PULMONARY PHARMACOLOGY & THERAPEUTICS, 25(6), 427–431.
author keywords: Airway; Mucin; MARCKS; Calpain; Secretion
MeSH headings : Bronchi / cytology; Bronchi / metabolism; Calpain / antagonists & inhibitors; Calpain / metabolism; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells / metabolism; Fluorescence; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides / administration & dosage; Oligopeptides / pharmacology; Protein Kinase C / metabolism; Tetradecanoylphorbol Acetate / pharmacology
TL;DR:
Cleavage of MARCKS by Calpain may have an important role in regulation of the PKC/MARCKS pathway regulating airway mucin secretion, as opposed to the original hypothesis, inactivating Calpain caused a decrease rather than an increase in secretion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
COMPARISON OF ABDOMINAL COMPUTED TOMOGRAPHY AND ABDOMINAL ULTRASOUND IN SEDATED DOGS
VETERINARY RADIOLOGY & ULTRASOUND, 53(5), 513–517.
author keywords: comparison with ultrasound; multidetector CT; sedated dogs
MeSH headings : Abdomen / diagnostic imaging; Animals; Conscious Sedation / veterinary; Contrast Media; Dog Diseases / diagnostic imaging; Dogs; Iohexol; Multidetector Computed Tomography / veterinary; Radiography, Abdominal / veterinary; Ultrasonography
TL;DR:
It appears that CT has an advantage in lesion detection in dogs greater than 25 kg, making it a better screening test for abdominal disease in these patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Premature translational termination products are rapidly degraded substrates for MHC class I presentation
PLoS One, 7(12).
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Pharmacokinetics of lidocaine and its active metabolite monoethylglycinexylidide after a single intravenous administration in chickens (Gallus domesticus) anesthetized with isoflurane
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(6), 604–607.
MeSH headings : Anesthesia, Inhalation; Anesthetics, Inhalation / pharmacology; Anesthetics, Local / administration & dosage; Anesthetics, Local / blood; Anesthetics, Local / metabolism; Anesthetics, Local / pharmacokinetics; Animals; Area Under Curve; Chickens / blood; Female; Half-Life; Injections, Intravenous; Isoflurane / pharmacology; Lidocaine / administration & dosage; Lidocaine / analogs & derivatives; Lidocaine / blood; Lidocaine / metabolism; Lidocaine / pharmacokinetics
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Pharmacokinetics of diminazene diaceturate in healthy cats
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(6), 608–610.
MeSH headings : Animals; Antiprotozoal Agents / blood; Antiprotozoal Agents / pharmacokinetics; Area Under Curve; Cats / blood; Chromatography, High Pressure Liquid; Diminazene / analogs & derivatives; Diminazene / blood; Diminazene / pharmacokinetics; Female; Half-Life; Male
TL;DR:
The pharmacokinetic profile of diminazene diaceturate in cats was characterized and it was found that this drug, if found to be effective for the treatment of C. felis, would offer advantages both in practicality of dosing and in cost.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
VESICULOBULLOUS SKIN REACTION TEMPORALLY RELATED TO FIROCOXIB TREATMENT IN A WHITE RHINOCEROS (CERATOTHERIUM SIMUM)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 43(1), 186–189.
author keywords: Adverse drug reaction; Ceratotherium simum; firocoxib; vesiculobullous dermatitis; white rhinoceros
MeSH headings : 4-Butyrolactone / adverse effects; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Drug Eruptions / veterinary; Female; Lameness, Animal / drug therapy; Perissodactyla; Skin Diseases, Vesiculobullous / chemically induced; Skin Diseases, Vesiculobullous / veterinary; Sulfones / adverse effects; Sulfones / therapeutic use
TL;DR:
Findings in the lesions of chronic nail-bed abscesses in a 40 yr-old female white rhinoceros are similar to those seen in some drug reactions in people; therefore an adverse drug reaction to the firocoxib was suspected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.