Works Published in 2004
Displaying works 81 - 100 of 102 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2004 patent
Neutralization-sensitive epitopes of Cryptosporidium parvum
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues
MOLECULAR AND CELLULAR BIOLOGY, 24(17), 7538–7547.
MeSH headings : Animals; Cell Cycle / physiology; Cell Cycle Proteins / metabolism; Cell Division / physiology; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases / antagonists & inhibitors; Cyclin-Dependent Kinases / genetics; Cyclin-Dependent Kinases / metabolism; Cyclins / metabolism; Epidermal Cells; Epidermis / metabolism; Epidermis / pathology; Epithelium / metabolism; Epithelium / pathology; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Tumor Suppressor Proteins / metabolism
TL;DR:
Results show that CDK4 mediates the proliferative and oncogenic activities of Myc in vivo through a mechanism that involves the sequestration of specific CDK inhibitors.
(via Semantic Scholar)
mcb.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 article
In vitro prediction of canine urolith mineral composition using computed tomographic mean beam attenuation measurements
VETERINARY RADIOLOGY & ULTRASOUND, Vol. 45, pp. 189–197.
author keywords: beam attenuation; calcium oxalate; computed tomography; dog; Hounsfield units; struvite; uric acid; urolith
MeSH headings : Animals; Calcium Oxalate / chemistry; Dog Diseases / diagnostic imaging; Dogs; Magnesium Compounds / chemistry; Phosphates / chemistry; Predictive Value of Tests; Sensitivity and Specificity; Struvite; Tomography, X-Ray Computed / veterinary; Uric Acid / chemistry; Urinary Calculi / chemistry; Urinary Calculi / diagnostic imaging; Urinary Calculi / veterinary
TL;DR:
HU could be used to differentiate three types of uroliths of pure mineral composition in vitro and further studies are needed to determine the predictive value of HU in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Hyperglycemia-induced TGF beta and fibronectin expression in embryonic mouse heart
DEVELOPMENTAL DYNAMICS, 231(1), 179–189.
author keywords: hyperglycemia; TGF beta; fibronectin; embryonic heart; protein; mRNA
MeSH headings : Animals; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Fibronectins / metabolism; Hyperglycemia / metabolism; Mice; Myocardium / cytology; Myocardium / metabolism; RNA, Messenger / metabolism; Transforming Growth Factor beta / metabolism; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Transforming Growth Factor beta3
TL;DR:
It is proposed that TGFβ1 and fibronectin may play a role in diabetes‐induced cardiac dysmorphogenesis and is characterized in the organogenesis‐stage mouse heart.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Epigenetic and genomic imprinting analysis in nuclear transfer derived Bos gaurus/Bos taurus hybrid fetuses
Biology of Reproduction, 71(2), 470–478.
MeSH headings : Animals; Cattle; Chimera / genetics; Cloning, Organism; DNA Methylation; DNA, Satellite; Embryonic Development; Epidermis / physiology; Epigenesis, Genetic / genetics; Exons; Female; Fibroblasts / physiology; Genomic Imprinting / genetics; Genotype; Insulin-Like Growth Factor II / genetics; Keratins / genetics; Nuclear Transfer Techniques; Placenta; Pregnancy; Promoter Regions, Genetic; Proteins / genetics; RNA, Long Noncoding; RNA, Untranslated / genetics
TL;DR:
The use of a bovine interspecies model for the assessment and characterization of epigenetic modifications and genomic imprinting in Day 40-old female NT-derived fetuses and placenta indicates that the nuclear transfer process affects gene expression patterns in the trophectoderm- and inner cell mass-derived tissues to different extents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2004 journal article
Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 20(5), 477–489.
author keywords: tumours; hyperthermia; sodium nitroprusside; CGRP
MeSH headings : Animals; Blood Pressure / drug effects; Calcitonin Gene-Related Peptide / therapeutic use; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / physiopathology; Dog Diseases / radiotherapy; Dog Diseases / therapy; Dogs; Hyperthermia, Induced; Nitroprusside / therapeutic use; Sarcoma / drug therapy; Sarcoma / radiotherapy; Sarcoma / therapy; Sarcoma / veterinary; Soft Tissue Neoplasms / drug therapy; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / therapy; Soft Tissue Neoplasms / veterinary; Vasodilator Agents / therapeutic use
TL;DR:
There is little justification for translation of this approach to human trials using conventional local hyperthermia treatment of SNP, and a significant increase was seen in tumour but not normal subcutaneous tissue temperatures, which was not sufficient to improve the likelihood of increased response rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Allometric analysis of ciprofloxacin and enrofloxacin pharmacokinetics across species
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(3), 139–146.
MeSH headings : Animals; Anti-Infective Agents / pharmacokinetics; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones / pharmacokinetics; Humans; Models, Biological; Quinolones / pharmacokinetics; Species Specificity; Veterinary Drugs / pharmacokinetics
TL;DR:
Results of the current analyses indicate it is possible to use allometry to predict pharmacokinetic variables of enrofloxacin or ciprofl oxacin based on body size of species, which could provide information on appropriate doses of ciprafloxACin and enro FLX for all species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 article
Hypoglycemia-induced changes in cell death and cell proliferation in the organogenesis-stage embryonic mouse heart (Retracted article. See vol 76, pg 278, 2006)
Ghatnekar, G. S., Barnes, J. A., Dow, J. L., & Smoak, I. W. (2004, March). BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, Vol. 70, pp. 121–131.
author keywords: embryonic heart; hypoglycemia; apoptosis; cell proliferation; flow cytometry; caspase-3; p53; PCNA
MeSH headings : Animals; Caspase 3; Caspases / metabolism; Cell Death; Cell Division; Flow Cytometry; Heart / embryology; Hypoglycemia / metabolism; Hypoglycemia / pathology; Immunohistochemistry; Mice; Organogenesis; Proliferating Cell Nuclear Antigen / metabolism; Tumor Suppressor Protein p53 / metabolism
TL;DR:
Hypoglycemia reduces embryonic viability, induces significant cell death, and reduces cell proliferation in the E9.5 mouse heart, and these processes may involve active caspase-3 and p53.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Heparin affects signaling pathways stimulated by fibroblast growth factor-1 and-2 in type II cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 287(1), L191–L200.
author keywords: extracellular matrix; basement membrane; receptor tyrosine kinase phosphorylation; ERK pathway; fibroblast growth factor signaling
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Heparin / administration & dosage; Heparin / pharmacology; Mitogen-Activated Protein Kinases / metabolism; Phosphorylation / drug effects; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-akt; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Pulmonary Alveoli / physiology; Rats; Rats, Inbred Strains; Signal Transduction / drug effects; Sulfates / metabolism; Thymidine / metabolism; Time Factors
TL;DR:
The data suggest that heparin's known capacity to alter DNA synthesis and, possibly, other biological end points is realized via cross talk between multiple signaling pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 patent
Anti-cryptosporidium parvum preparations
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Cloning and transgenesis in mammals: Implications for xenotransplantation
AMERICAN JOURNAL OF TRANSPLANTATION, 4, 43–50.
MeSH headings : Animals; Animals, Genetically Modified; Cloning, Organism; Embryo, Mammalian / cytology; Graft Rejection / etiology; Graft Rejection / immunology; Graft Rejection / prevention & control; Humans; Immune Tolerance; Immunosuppression Therapy; Nuclear Transfer Techniques; Stem Cells / cytology; Swine; Transplantation, Heterologous / immunology; Transplantation, Heterologous / methods; Transplantation, Heterologous / trends
TL;DR:
Advances in transgenic manipulation and cloning in swine are reviewed and how the development of these two technologies is critical to the eventual utilization of the pig as a human organ donor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma
NATURE MEDICINE, 10(2), 193–196.
MeSH headings : Animals; Asthma / metabolism; Bronchi / cytology; Bronchi / metabolism; Bronchi / pathology; Bronchial Provocation Tests; Cytoplasmic Granules / metabolism; Cytoplasmic Granules / ultrastructure; Disease Models, Animal; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mucins / metabolism; Mucus / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Ovalbumin / administration & dosage; Ovalbumin / immunology; Peptide Fragments / administration & dosage; Peptide Fragments / chemistry; Peptide Fragments / pharmacology; Peptides / administration & dosage; Peptides / chemistry; Peptides / pharmacology; Proteins / chemistry; Proteins / genetics; Proteins / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism
TL;DR:
It is shown that the intratracheal instillation of this peptide blocks mucus hypersecretion in a mouse model of asthma, and a pivotal role for MARCKS protein, specifically its N-terminal region, in modulating this secretory process in mammalian airways is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Use of artificial androgen receptor coactivators to alter myoblast proliferation
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 91(3), 111–119.
author keywords: androgen receptor; muscle growth; coactivators
MeSH headings : Animals; Base Sequence; Cell Division / drug effects; DNA Primers; HeLa Cells; Humans; Muscle, Skeletal / cytology; Muscle, Skeletal / drug effects; Mutagenesis, Site-Directed; Rats; Receptors, Androgen / drug effects; Receptors, Androgen / metabolism
TL;DR:
The ability of the mutated AR to act as an artificial coactivator to up-regulate androgen responsive genes is a useful tool for understanding the interaction of androgens and muscle growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(5), 337–341.
MeSH headings : Administration, Oral; Animals; Antitussive Agents / administration & dosage; Antitussive Agents / blood; Antitussive Agents / pharmacokinetics; Antitussive Agents / pharmacology; Area Under Curve; Biological Availability; Cross-Over Studies; Dextromethorphan / administration & dosage; Dextromethorphan / blood; Dextromethorphan / pharmacokinetics; Dextromethorphan / pharmacology; Dextrorphan / blood; Dogs / metabolism; Female; Injections, Intravenous / veterinary; Male; Muscle, Skeletal / drug effects; Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
TL;DR:
The short half-life, rapid clearance, and poor bioavailability of dextromethorphan limit its potential use as a chronic orally administered therapeutic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Somatic cell cloning: The ultimate form of nuclear reprogramming?
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 15(5), 1140–1144.
MeSH headings : Animals; Cloning, Molecular / methods; Humans; Kidney Failure, Chronic / therapy; Stem Cell Transplantation / methods; Stem Cells / physiology
TL;DR:
To make this a reality, techniques associated with cloning and genetic modifications in somatic cells need to be continued to be developed and optimized and have an effect beyond the area of nuclear transfer and assist with better methods for transdifferentiation of mammalian cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 article
Pharmackokinetics of enrofloxacin in neonatal kittens
Seguin, M. A., Papich, M. G., Sigle, K. J., Gibson, N. M., & Levy, J. K. (2004, March). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 65, pp. 350–356.
MeSH headings : Administration, Oral; Age Factors; Animals; Cats / metabolism; Ciprofloxacin / blood; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Injections, Subcutaneous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics; Time Factors
TL;DR:
Doses may need to be increased to achieve therapeutic drug concentrations in 6- to 8-week-old kittens and oral administration of enrofloxacin resulted in poor bioavailability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Peptide mapping of feline immunodeficiency virus by IFN-gamma elispot
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 100(1-2), 49–59.
author keywords: feline; peptide; ELISPOT; feline immunodeficiency virus; T-cell
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal / immunology; Antibody Specificity / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Gene Products, env / immunology; Gene Products, gag / immunology; Immunodeficiency Virus, Feline / immunology; Immunoenzyme Techniques / methods; Immunoenzyme Techniques / veterinary; Interferon-gamma / genetics; Interferon-gamma / immunology; Molecular Sequence Data; Peptide Fragments / immunology; Peptide Library; Peptide Mapping; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA-Directed DNA Polymerase / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary
TL;DR:
This work has developed a feline IFN-γ ELISPOT assay and used it to determine FIV-specific T-cell epitopes recognized by infected cats and its results will be useful in assessing cell-mediated responses to experimental FIV vaccines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Orchitis in two dogs with Rocky Mountain spotted fever
VETERINARY RADIOLOGY & ULTRASOUND, 45(5), 458–465.
author keywords: orchitis; rickettsia; testicle; ultrasound
MeSH headings : Animals; Diagnosis, Differential; Dog Diseases / diagnostic imaging; Dogs; Male; Orchitis / complications; Orchitis / diagnostic imaging; Orchitis / veterinary; Rocky Mountain Spotted Fever / complications; Rocky Mountain Spotted Fever / veterinary; Ultrasonography
TL;DR:
Two dogs with testicular swelling were sonographically diagnosed with orchitis and were subsequently diagnosed with Rocky Mountain spotted fever (RMSF) and should be considered in any dog with vascular insult to the testes, especially when other signs of systemic illness are involved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Imaging diagnosis: Biliopleural fistula in a dog
Veterinary Radiology & Ultrasound, 45(1), 70–72.
MeSH headings : Animals; Biliary Fistula / diagnosis; Biliary Fistula / etiology; Biliary Fistula / veterinary; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs / injuries; Gallbladder / injuries; Lung Injury; Male; Pleural Effusion / diagnosis; Pleural Effusion / etiology; Pleural Effusion / veterinary; Radiography; Respiratory Tract Fistula / diagnosis; Respiratory Tract Fistula / etiology; Respiratory Tract Fistula / veterinary; Ultrasonography; Wounds, Gunshot / complications; Wounds, Gunshot / veterinary
Source: NC State University Libraries
Added: August 6, 2018
2004 review
Ganaxolone: a prospective overview
[Review of ]. DRUGS OF THE FUTURE, 29(3), 227–242.
TL;DR:
As a novel GABA a receptor modulator with unique, broad-spectrum protective efficacy, ganaxolone may have additional therapeutic potential in alcohol and cocaine withdrawal seizures, as well as in the treatment of anxiety and other mood disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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