Biomedical Engineering

Works Published in 2016

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Displaying works 161 - 173 of 173 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2016 journal article

Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 20(2), 351–359.

By: J. Koh *, J. Hogue*, Y. Wang  n, M. DiSalvo  n, N. Allbritton n, Y. Shi *, J. Olson*, J. Sosa *

author keywords: hyperparathyroidism; parathyroid; adenoma; calcium; single-cell analysis
MeSH headings : Adenoma / metabolism; Calcium / metabolism; Calcium Signaling / physiology; Cell Line; Humans; Hyperparathyroidism, Primary / metabolism; Parathyroid Neoplasms / metabolism; Receptors, Calcium-Sensing / metabolism; Single-Cell Analysis / methods
TL;DR: Calcium EC50 values from a series of parathyroid adenomas revealed that the tumours segregated into two distinct categories, indicating the existence of a previously unappreciated biochemical sub‐classification of PHPT tumours, possibly reflecting distinct etiological mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Predicting standard-dose PET image from low-dose PET and multimodal MR images using mapping-based sparse representation

Physics in Medicine and Biology, 61(2), 791–812.

By: Y. Wang *, P. Zhang *, L. An *, G. Ma *, J. Kang*, F. Shi *, X. Wu *, J. Zhou * ...

author keywords: positron emission tomography (PET); sparse representation; mapping-based sparse representation; incremental refinement; standard-dose PET prediction; multimodal MR images
MeSH headings : Brain / diagnostic imaging; Brain Mapping / methods; Humans; Image Processing, Computer-Assisted / methods; Magnetic Resonance Imaging / methods; Multimodal Imaging / methods; Positron-Emission Tomography / methods; Radiation Dosage
TL;DR: Inspired by the success of patch-based sparse representation (SR) in super-resolution image reconstruction, a mapping-based SR (m-SR) framework is proposed for standard-dose PET image prediction and can outperform benchmark methods in both qualitative and quantitative measures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 journal article

Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration

ACS NANO, 10(1), 1292–1299.

By: D. Shi *, X. Xu *, Y. Ye n, K. Song *, Y. Cheng, J. Di n, Q. Hu n, J. Li ...

author keywords: drug delivery; tissue engineering; hydrogel; regenerative medicine; nanoparticles
TL;DR: The effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology makes the chondrogenesis efficient and persistent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 article

Elastic drug delivery: could treatments be triggered by patient movement?

NANOMEDICINE, Vol. 11, pp. 323–325.

By: Y. Zhang n, J. Yu n, Y. Zhu n & Z. Gu n

author keywords: drug delivery; mechanical-responsive; nanoparticle; wearable devices
MeSH headings : Drug Delivery Systems; Elasticity; Humans; Movement; Patients
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

NANO LETTERS, 16(2), 1118–1126.

By: Q. Hu n, W. Sun n, Y. Lu n, H. Bomba n, Y. Ye n, T. Jiang *, A. Isaacson*, Z. Gu n

author keywords: Drug delivery; stimuli-responsive; tumor microenvironment; apoptosis; antiangiogenesis
MeSH headings : Angiogenesis Inhibitors / administration & dosage; Angiogenesis Inhibitors / chemistry; Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Drug Delivery Systems; Endosomes / drug effects; Gene Transfer Techniques; Humans; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / chemistry; Mice; Snake Venoms / administration & dosage; Snake Venoms / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; Tumor Microenvironment / drug effects; Xenograft Model Antitumor Assays
TL;DR: Equipped with an acid-degradable modality, the resulting CS-NG can substantially release combinational anticancer drugs-tumor necrosis factor-related apoptosis inducing ligand and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 review

Recent advances of cocktail chemotherapy by combination drug delivery systems

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 98, 19–34.

By: Q. Hu n, W. Sun n, C. Wang n & Z. Gu n

author keywords: Chemotherapy; Combination; Cancer; Nanocarriers; Drug delivery
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Drug Delivery Systems; Humans; Nanoparticles / administration & dosage; Nanoparticles / therapeutic use; Neoplasms / drug therapy
TL;DR: This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers and highlights the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Rational Design of a Dephosphorylation-Resistant Reporter Enables Single-Cell Measurement of Tyrosine Kinase Activity

ACS CHEMICAL BIOLOGY, 11(2), 355–362.

By: A. Turner, M. Lebhae, A. Proctor, Q. Wang, D. Lawrence & N. Allbritton n

MeSH headings : Cell Line, Tumor; Enzyme Assays / methods; ErbB Receptors / chemistry; ErbB Receptors / metabolism; Humans; Phosphorylation; Single-Cell Analysis / methods; Tetrahydroisoquinolines / chemistry; Tetrahydroisoquinolines / metabolism; Tyrosine / chemistry; Tyrosine / metabolism
TL;DR: This work describes a peptidic reporter that, upon phosphorylation by the epidermal growth factor receptor (EGFR), is resistant to dephosphorylation both in vitro and in cellulo, and contains a conformationally constrained phosphorylatable moiety. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Odor Assessment of Automobile Cabin Air With Field Asymmetric Ion Mobility Spectrometry and Photoionization Detection

IEEE SENSORS JOURNAL, 16(2), 409–417.

By: J. Li  n, R. Hodges n, R. Gutierrez-Osuna*, G. Luckey, J. Crowell, S. Schiffman n , H. Nagle n 

author keywords: Air quality; machine olfaction; odor assessment; field asymmetric ion mobility spectrometry; photoionization detection; multidimensional scaling; linear regression
TL;DR: The results support the feasibility of replacing human panel assessments by objective instrumental means for quality control tasks in the production process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Microneedle-based sensors for medical diagnosis

JOURNAL OF MATERIALS CHEMISTRY B, 4(8), 1379–1383.

By: P. Miller*, R. Narayan n & R. Polsky*

TL;DR: A general overview of recent progress in microneedle-based sensing research is provided, including: (a) glucose monitoring, (b) ex vitro microneedsle diagnostic systems for general health monitoring with an emphasis on sensor construction, and (c) in vivo use of microneEDle sensors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model

CARTILAGE, 7(2), 174–184.

By: M. Fisher n, N. Belkin*, A. Milby*, E. Henning*, N. Soeegaard, M. Kim*, C. Pfeifer *, V. Saxena* ...

author keywords: cartilage; repair; mesenchymal stem cells; TGF-3; animal models
TL;DR: At this early healing time point, treatment with TGF-β3 promoted the formation of collagen type II within the defect, while allogeneic MSCs had little benefit. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Design, Fabrication, and Characterization of a Bifrequency Colinear Array

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 63(2), 266–274.

By: Z. Wang n, S. Li n, T. Czernuszewicz n, C. Gallippi n, R. Liu *, X. Geng *, X. Jiang n

author keywords: Bifrequency ultrasound; colinear array; composite transducer
TL;DR: The results of this study suggest that bifrequency colinear arrays are potential aids for wideband fundamental imaging and harmonic/subharmonic imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 article

ATP-Responsive Drug Delivery Systems

Sun, W., & Gu, Z. (2016, March 3). EXPERT OPINION ON DRUG DELIVERY, Vol. 13, pp. 311–314.

By: W. Sun n & Z. Gu n

MeSH headings : Adenosine Triphosphate / metabolism; Drug Carriers / chemistry; Drug Delivery Systems; Humans
TL;DR: An emerging strategy utilizing the “molecular unit of currency” in biological energy transfer - ATP - as a trigger for therapeutic delivery is discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

A Novel Ultrasound Technique for Non-Invasive Assessment of Cell Differentiation

IEEE SENSORS JOURNAL, 16(1), 61–68.

By: W. Huang *, J. Kim n, K. Kim n, S. Bakshi n, J. Williams n, P. Matthieu n, E. Loboa n, K. Shung*, Q. Zhou *, X. Jiang n

author keywords: Lead magnesium niobate-lead titanate piezoelectric resonator; in-situ cell differentiation monitoring; electrical impedance measurement; osteogenic differentiation
TL;DR: A novel technique for the characterization of mammalian cells during cell culture was studied using a lead magnesium niobate-lead titanate single crystal piezoelectric resonator to observe changes in material properties of human adipose derived stem cells during both proliferation and osteogenic differentiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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