Works Published in 2005
Displaying works 81 - 100 of 113 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2005 journal article
Iron alters glutamate secretion by regulating cytosolic aconitase activity
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 288(5), C1117–C1124.
author keywords: retinal pigment epithelial cells; lens epithelial cells
MeSH headings : Aconitate Hydratase / antagonists & inhibitors; Aconitate Hydratase / metabolism; Animals; Cells, Cultured; Citric Acid / metabolism; Cytosol / metabolism; Dogs; Enzyme Activation / drug effects; Glutamates / metabolism; Iron / metabolism; Isocitrates / metabolism; Membrane Transport Proteins / metabolism; Oxalates / pharmacology; Pigment Epithelium of Eye / drug effects; Pigment Epithelium of Eye / enzymology; Riluzole / pharmacology; Vesicular Glutamate Transport Protein 1
TL;DR:
The results are the first to provide a functional link between these two physiologically important substances by demonstrating a significant role for iron in the regulation of glutamate production and secretion in mammalian cells resulting from iron regulation of aconitase activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Investigating hookworm genomes by comparative analysis of two Ancylostoma species
BMC Genomics, 6.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Induction of serum and mucosal FIV-specific immune responses by intranasal immunization with p24Gag
VACCINE, 23(12), 1471–1478.
author keywords: feline immunodeficiency virus (FIV); intranasal; LT(R192G); mucosal adjuvant
MeSH headings : Adjuvants, Immunologic / administration & dosage; Administration, Intranasal; Animals; Antibodies, Viral / blood; Bacterial Toxins / administration & dosage; Cats; Enterotoxins / administration & dosage; Escherichia coli Proteins / administration & dosage; Female; Gene Products, gag / administration & dosage; Gene Products, gag / immunology; Immunodeficiency Virus, Feline / immunology; Immunoglobulin A / analysis; Immunoglobulin G / blood; Lentivirus Infections / prevention & control; Saliva / immunology; T-Lymphocytes / immunology; Vagina / immunology; Vaginal Douching; Viral Vaccines / administration & dosage; Viral Vaccines / immunology
TL;DR:
It is demonstrated that nasal immunization of cats can be a relevant and effective route for the delivery of candidate vaccines, however, development of strong systemic and mucosal immune responses requires co-administration of a mucosal adjuvant, such as LT(R192G).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Cloning and expression of feline interleukin 15
CYTOKINE, 29(2), 77–83.
author keywords: feline; feline immunodeficiency virus; interleukin 15
MeSH headings : Animals; Antibodies / immunology; Base Sequence; Blotting, Western; Cats; Cell Line; Cloning, Molecular; Cross Reactions; DNA Primers; DNA, Complementary; Humans; Immunohistochemistry; Interleukin-15 / genetics; Interleukin-15 / immunology; Plasmids; T-Lymphocytes / immunology
TL;DR:
A cDNA encoding feline interleukin 15 (IL15) was cloned from the lymph node of a cat infected with feline infectious peritonitis virus and was shown to sustain primary feline lymphocytes, a feline T cell line, and mouse CTLL-2 cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Anxiolytic activity of progesterone in progesterone receptor knockout mice
NEUROPHARMACOLOGY, 48(1), 14–24.
author keywords: progesterone; progesterone receptor; allopregnanolone; finasteride; GABA(A) receptor; neurosteroid; anxiety; elevated plus maze
MeSH headings : Analysis of Variance; Animals; Anxiety / drug therapy; Behavior, Animal / drug effects; Brain / metabolism; Chromatography, High Pressure Liquid / methods; Dose-Response Relationship, Drug; Female; Finasteride / pharmacology; Genotype; Immunohistochemistry / methods; Male; Maze Learning / drug effects; Mice; Mice, Knockout; Pregnanolone / blood; Pregnanolone / pharmacology; Progesterone / pharmacology; Progesterone / therapeutic use; Receptors, Progesterone / deficiency; Receptors, Progesterone / genetics; Receptors, Progesterone / metabolism; Time Factors
TL;DR:
Progesterone knockout mice bearing a targeted null mutation of the PR gene that abrogates the function of both PR-A and PR-B subtypes were utilized to determine the requirement for PRs in the anxiolytic actions of progesterone, demonstrating that allopregnanolone (or other 5alpha-reduced metabolites of progestersone) accounts for the response to the parent steroid hormone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 interview
An interview with... Dr. Donald E. Thrall
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 171(4), 305–314.
author keywords: bronchitis; emphysema; human bronchial epithelial cells; mucin
MeSH headings : Acrolein / pharmacology; Blotting, Western; Cells, Cultured; ErbB Receptors / drug effects; ErbB Receptors / metabolism; Glutathione / metabolism; Humans; Metalloproteases / metabolism; Mitogen-Activated Protein Kinases / metabolism; Mucin 5AC; Mucins / drug effects; Mucins / genetics; Mucins / metabolism; Oxidative Stress / physiology; Polymerase Chain Reaction / methods; RNA, Messenger / biosynthesis; RNA, Messenger / drug effects; Up-Regulation / drug effects
TL;DR:
Together, data suggest that acrolein induces MUC5AC expression via an initial ligand-dependent activation of EGFR mediated by ADAM17 and MMP9 and TIMP3 transcription, and that a prolonged effect of acrole in NCI-H292 cells may be mediated by altering MMP 9 and TIMp3 transcription.
(via Semantic Scholar)
citeseerx.ist.psu.edu (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis
Cancer Research, 65(3), 887–897.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Evaluation of endogenous reference genes for real-time PCR quantification of gene expression in Ancylostoma caninum
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 143(2), 241–244.
author keywords: Ancylostoma hookworms; real-time PCR; validation; reference gene
MeSH headings : Ancylostoma / genetics; Animals; Gene Expression; Gene Expression Profiling / methods; Genes, Helminth; Quality Control; Reference Standards; Reverse Transcriptase Polymerase Chain Reaction / standards
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Differential degradation of ferritin H- and L-chains: Accumulation of L-chain-rich ferritin in lens epithelial cells
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 46(10), 3521–3529.
MeSH headings : Aging / physiology; Animals; Apoferritins; Cells, Cultured; Cysteine Proteinase Inhibitors / pharmacology; Dogs; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Iron / metabolism; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Lysosomes / metabolism; Methionine / metabolism; Plasmids; Transfection
TL;DR:
The formation of inclusion bodies in older lens epithelial cells, as demonstrated in the current investigation, is intriguing and could point to possible involvement of cytoplasmic L-chain-enriched ferritin aggregates in the formation of age-related cataract.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
The physiological and behavioural impacts of and preference for an enriched environment in the eastern box turtle (Terrapene carolina carolina)
APPLIED ANIMAL BEHAVIOUR SCIENCE, 92(4), 353–365.
author keywords: turtle; enrichment; preference tests; housing
TL;DR:
Turtles in enriched enclosures had a significantly lower heterophil to lymphocyte ratio (H/L) at the end of the treatment period and spent significantly less time engaged in escape behaviour.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism
CELLULAR SIGNALLING, 17(2), 153–166.
author keywords: sumoylation; trichostatin A; SP3; PML; transcriptional regulation; trans-activation; trans-repression
MeSH headings : Amino Acid Substitution; Animals; Blotting, Western; COS Cells; Cell Line; Cell Line, Tumor; Cell Nucleus / chemistry; Cell Nucleus / metabolism; Chlorocebus aethiops; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Enzyme Inhibitors / pharmacology; Ethylmaleimide / chemistry; Humans; Hydroxamic Acids / pharmacology; Immunohistochemistry; Lysine / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Promoter Regions, Genetic / genetics; Promyelocytic Leukemia Protein; Prostate-Specific Antigen / genetics; Protein Isoforms / genetics; Protein Isoforms / metabolism; SUMO-1 Protein / genetics; SUMO-1 Protein / metabolism; Sp1 Transcription Factor / chemistry; Sp1 Transcription Factor / metabolism; Sp3 Transcription Factor; Tetrahydrofolate Dehydrogenase / genetics; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism; Transcriptional Activation / drug effects; Transfection; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Ubiquitin-Conjugating Enzymes / metabolism
TL;DR:
It is concluded that Sp3 isoforms are sumoylated in vivo and this post-translational modification plays an important role in the regulation of Sp3-mediated transcription.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 article
Pharmacokinetics and tissue distribution of itraconazole after oral and intravenous administration to horses
Davis, J. L., Salmon, J. H., & Papich, M. G. (2005, October). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 66, pp. 1694–1701.
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Horses / metabolism; Injections, Intravenous / veterinary; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Protein Binding
TL;DR:
Itraconazole administered orally as a solution had higher, more consistent absorption than orally administered capsules and attained plasma concentrations that are inhibitory against fungi that infect horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Gene expression profiles associated with the transition to parasitism in Ancylostoma caninum larvae
Molecular and Biochemical Parasitology, 143(1), 39–48.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Effects of recombinant equine growth hormone on in vitro biomechanical properties of the superficial digital flexor tendon of Standardbred yearlings in training
VETERINARY SURGERY, 34(3), 253–259.
author keywords: recombinant equine growth hormone; mechanical testing; superficial digital flexor tendon; Standardbred; horse
MeSH headings : Animals; Biomechanical Phenomena; Forelimb / physiology; Growth Hormone / administration & dosage; Growth Hormone / pharmacology; Horses / physiology; Injections, Intramuscular / veterinary; Physical Conditioning, Animal; Tendons / drug effects; Treatment Outcome
TL;DR:
REGH, administered at the manufacturer's recommended dose rates to maturing Standardbred horses in training, does not significantly augment the in vitro biomechanical properties of the forelimb SDFT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Cross-species pharmacologic evaluation of plasmin as a direct-acting thrombolytic agent: Ex vivo evaluation for large animal model development
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 16(3), 369–377.
MeSH headings : Analysis of Variance; Animals; Cattle; Fibrinolysin / pharmacology; Fibrinolytic Agents / pharmacology; Humans; Microscopy, Electron; Sheep; Species Specificity; Swine; Tissue Plasminogen Activator / pharmacology
TL;DR:
Ovine clots treated with plasmin most closely resemble the lysis observed with human clots, and is an effective direct-acting thrombolytic agent that is capable of lysing fibrin from several species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Basal and reovirus-induced beta interferon (IFN-beta) and IFN-beta-stimulated gene expression are cell type specific in the cardiac protective response
JOURNAL OF VIROLOGY, 79(5), 2979–2987.
MeSH headings : Animals; Base Sequence; DNA / genetics; DNA-Binding Proteins / genetics; Fibroblasts / immunology; Fibroblasts / virology; Gene Expression Regulation; Humans; Interferon Regulatory Factor-7; Interferon-beta / genetics; Mammalian orthoreovirus 3 / immunology; Mammalian orthoreovirus 3 / pathogenicity; Mice; Mice, Knockout; Myocarditis / genetics; Myocarditis / immunology; Myocarditis / virology; Myocytes, Cardiac / immunology; Myocytes, Cardiac / virology; Orthoreovirus, Mammalian / immunology; Orthoreovirus, Mammalian / pathogenicity; Receptors, Interferon / deficiency; Receptors, Interferon / genetics; Reoviridae Infections / genetics; Reoviridae Infections / immunology; Reoviridae Infections / virology; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
It is suggested that the higher basal IFN-β and ISG expression in myocytes may play an important protective role in cardiac myocytes, and reovirus replicates to higher titers in cardiac fibroblasts than in cardiacMyocytes, suggesting that theIFN- β response controls reov virus replication equivalently in the two cell types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Antimicrobial drug use in veterinary medicine
JOURNAL OF VETERINARY INTERNAL MEDICINE, 19(4), 617–629.
author keywords: antibacterial; antibiotic; prudent use; resistance
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Analysis of diltiazem in Lipoderm (R) transdermal gel using reversed-phase high-performance liquid chromatography applied to homogenization and stability studies
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 38(1), 60–65.
author keywords: diltiazem; reverse-phase liquid chromatography; transdermal gel; drug stability; compounded drug analysis
MeSH headings : Calcium Channel Blockers / analysis; Chromatography, High Pressure Liquid / methods; Diltiazem / analysis; Drug Stability; Gels; Pharmaceutical Preparations / chemistry; Reference Standards; Reproducibility of Results
TL;DR:
A simple and novel method for the extraction and quantification of diltiazem hydrochloride was developed and applied to homogenization and stability studies and showed excellent linearity from 50 to 250 mg/ml in undiluted gel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Toll-like receptor expression in feline lymphoid tissues
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 106(3-4), 229–237.
author keywords: toll-like receptors; feline; feline immunodeficiency virus; innate immunity
MeSH headings : Animals; Base Sequence; Cat Diseases / genetics; Cat Diseases / immunology; Cats / genetics; Cats / immunology; Cell Line; Cloning, Molecular; DNA Primers / genetics; Gene Expression; Immunodeficiency Virus, Feline / pathogenicity; Lentivirus Infections / genetics; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Lymphocyte Subsets / immunology; Lymphoid Tissue / immunology; Membrane Glycoproteins / genetics; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cell Surface / genetics; Tissue Distribution; Toll-Like Receptors
TL;DR:
Results demonstrate that tissue distribution of TLRs is associated with the immunological role of a particular tissue, that lymphocytes may also express these 'innate immune' receptors, and that FIV infection can alter TLR expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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