Works Published in 2012
Displaying works 81 - 100 of 112 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Thermal dose fractionation affects tumour physiological response
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 28(5), 431–440.
author keywords: thermal dosimetry; tumor oxygenation; microenvironment
MeSH headings : Animals; Antigens, Neoplasm / metabolism; Carbonic Anhydrases / metabolism; Caspase 3 / metabolism; Dogs; Hyperthermia, Induced; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Sarcoma / metabolism; Sarcoma / pathology; Sarcoma / therapy; Soft Tissue Neoplasms / metabolism; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / therapy; Tumor Burden; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
There was a greater reduction in tumour volume and water diffusion at the end of therapy in tumours receiving one hyperthermia fraction per week, and response data pointed to a one per week prescription being superior.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
TWO ANATOMIC RESOURCES OF CANINE PELVIC LIMB MUSCLES BASED ON CT AND MRI
VETERINARY RADIOLOGY & ULTRASOUND, 53(3), 266–272.
author keywords: 3D Computer model; anatomic modeling; anatomy; muscle
MeSH headings : Animals; Computer Simulation; Dogs / anatomy & histology; Magnetic Resonance Imaging / veterinary; Muscle, Skeletal / anatomy & histology; Muscle, Skeletal / diagnostic imaging; Pelvis; Tomography, X-Ray Computed / veterinary
TL;DR:
The Diagnostic Atlas is an interactive, multiplanar, web-based MR atlas of the canine pelvic limb musculature that was created by manually segmenting clinically analogous MR sequences and the 3D Model serves as a resource for students of gross anatomy, encouraging integrative learning with its highly interactive and selective display capabilities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells
EPIGENETICS, 7(5), 429–431.
author keywords: genomic imprinting; PRIM2; pseudogene; placenta; WBC; SNP; sequencing
MeSH headings : Alleles; DNA Primase / genetics; DNA Primase / metabolism; DNA Replication; Databases, Nucleic Acid; Female; Gene Frequency; Genetic Loci; Genome, Human; Genomic Imprinting; Heterozygote; Humans; Leukocytes / cytology; Leukocytes / enzymology; Molecular Sequence Annotation; Placenta / cytology; Placenta / enzymology; Polymorphism, Single Nucleotide; Pregnancy; Pseudogenes; RNA, Messenger / genetics; RNA, Messenger / metabolism; Transcription, Genetic
TL;DR:
It is reported here their failure to confirm imprinting of the PRIM2 locus in human placenta or WBC, and the discordance between results and those of others is likely due to an incorrectly annotatedPRIM2 pseudogene found in the human genome database.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 article
Effects of acepromazine maleate on platelet function assessed by use of adenosine diphosphate activated- and arachidonic acid-activated modified thromboelastography in healthy dogs
Conner, B. J., Hanel, R. M., Hansen, B. D., Motsinger-Reif, A. A., Asakawa, M., & Swanson, C. R. (2012, May). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 595–601.
MeSH headings : Acepromazine / administration & dosage; Acepromazine / adverse effects; Adenosine Diphosphate / chemistry; Animals; Arachidonic Acid / chemistry; Blood Platelets / drug effects; Blood Platelets / physiology; Cross-Over Studies; Dogs / physiology; Female; Hemostasis / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / adverse effects; Injections, Intravenous / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
TL;DR:
Platelet function in dogs, as assessed by use of a modified thromboelastography assay, was not inhibited by acepromazine at doses of 0.05 or 0.1 mg/kg, IV, in contrast to previous reports in which it was suggested that ace Promazine may alter platelet function via inhibition of ADP and AA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Ciprofloxacin pharmacokinetics and oral absorption of generic ciprofloxacin tablets in dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(7), 1085–1091.
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Biological Availability; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Cross-Over Studies; Dogs / metabolism; Drugs, Generic / administration & dosage; Drugs, Generic / analysis; Drugs, Generic / pharmacokinetics; Half-Life; Random Allocation; Tablets
TL;DR:
Inconsistent oral absorption of ciprofloxacin in some dogs may be formulation dependent and affected by tablet dissolution in the small intestine, as well as pharmacokinetic-pharmacodynamic target concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
A Small Molecule Inhibitor Partitions Two Distinct Pathways for Trafficking of Tonoplast Intrinsic Proteins in Arabidopsis
PLOS ONE, 7(9).
MeSH headings : Acyltransferases / genetics; Acyltransferases / physiology; Aquaporins / genetics; Aquaporins / physiology; Arabidopsis / drug effects; Arabidopsis / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Arabidopsis Proteins / physiology; Brefeldin A / pharmacology; Cell Membrane / metabolism; Golgi Apparatus / metabolism; Green Fluorescent Proteins / metabolism; Hypocotyl / metabolism; Microscopy, Confocal / methods; Models, Biological; Promoter Regions, Genetic; Protein Transport; Seedlings; Vacuoles / metabolism
TL;DR:
It is shown that members of the TIP family are targeted to the vacuole via at least two distinct pathways, and the bioactivity of a novel inhibitor that can differentiate between them is characterized and mediated in part by common mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Transmigration of macrophages across the choroid plexus epithelium in response to the feline immunodeficiency virus
CELL AND TISSUE RESEARCH, 347(2), 443–455.
author keywords: HIV; FIV; Monocytes; T cells; Cerebrospinal fluid; Brain; Blood-brain barrier; Trafficking
MeSH headings : Animals; Blood-Brain Barrier / immunology; Blood-Brain Barrier / virology; Cats; Cell Movement; Choroid Plexus / cytology; Choroid Plexus / metabolism; Choroid Plexus / virology; Endothelial Cells / metabolism; Epithelium / metabolism; Immunodeficiency Virus, Feline / metabolism; Leukocytes, Mononuclear / metabolism; Macrophages / cytology; Macrophages / metabolism; Macrophages / virology; T-Lymphocytes / cytology; T-Lymphocytes / metabolism
TL;DR:
FIV significantly enhanced translocation of macrophages and T cells indicating that the choroid plexus epithelium is likely to be an active site of immune cell trafficking in response to infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Transgenic Stra8-EYFP pigs: a model for developing male germ cell technologies
TRANSGENIC RESEARCH, 21(2), 383–392.
author keywords: Pig; Transgenic; Stra8; Spermatogonia; Marker gene
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Blotting, Western; Cells, Cultured; Cloning, Molecular; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Regulation, Developmental; Genes, Reporter; Germ Cells / cytology; Germ Cells / metabolism; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Immunohistochemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Mice; Microscopy, Fluorescence / methods; Mitochondria / genetics; Mitochondria / metabolism; Nuclear Transfer Techniques; Plasmids / genetics; Plasmids / metabolism; Promoter Regions, Genetic; Proteins / genetics; Proteins / metabolism; Swine; Testis / cytology; Testis / metabolism; Transfection; Transgenes; Tretinoin / pharmacology
TL;DR:
Transgenic pigs expressing mitochondrial localized enhanced yellow fluorescent protein (EYFP-mito) under control of the germ cell specific Stimulated by Retinoic Acid 8 (Stra8) promoter indicates that these pigs will be useful by providing labelled cells for use in such technologies such as germ cell transplantation and in vitro spermatogenic studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification
GENES CHROMOSOMES & CANCER, 51(6), 569–578.
MeSH headings : Adult; Aged; Aged, 80 and over; Comparative Genomic Hybridization; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / genetics; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, myc; Hemangiosarcoma / chemistry; Hemangiosarcoma / genetics; Hemangiosarcoma / metabolism; Humans; In Situ Hybridization, Fluorescence; Male; MicroRNAs / biosynthesis; MicroRNAs / genetics; Middle Aged; Proto-Oncogene Proteins c-myc / biosynthesis; Proto-Oncogene Proteins c-myc / genetics; RNA, Long Noncoding; Sequence Analysis, RNA; Thrombospondin 1 / biosynthesis; Thrombospondin 1 / genetics; Transcription Factors / biosynthesis; Transcription Factors / genetics; Vascular Neoplasms / chemistry; Vascular Neoplasms / genetics; Vascular Neoplasms / metabolism
TL;DR:
MyC amplification may play a crucial role in the angiogenic phenotype of AS through upregulation of the miR‐17‐92 cluster, which subsequently downregulates THBS1, a potent endogenous inhibitor of angiogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Chronic treatment in vivo with beta-adrenoceptor agonists induces dysfunction of airway beta(2)-adrenoceptors and exacerbates lung inflammation in mice
BRITISH JOURNAL OF PHARMACOLOGY, 165(7), 2365–2377.
author keywords: beta-adrenoceptor; beta-agonist; receptor desensitization; airway remodelling; airway inflammation; asthma; loss of bronchoprotection; mouse
MeSH headings : Administration, Inhalation; Adrenergic beta-2 Receptor Agonists / administration & dosage; Adrenergic beta-2 Receptor Agonists / adverse effects; Animals; Anti-Asthmatic Agents / administration & dosage; Anti-Asthmatic Agents / adverse effects; Asthma / complications; Asthma / drug therapy; Bronchoconstriction / drug effects; Disease Models, Animal; Humans; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin / administration & dosage; Ovalbumin / immunology; Pneumonia / etiology; Pneumonia / pathology; Pneumonia / physiopathology; Receptors, Adrenergic, beta-2 / deficiency; Receptors, Adrenergic, beta-2 / drug effects; Receptors, Adrenergic, beta-2 / genetics
TL;DR:
A mouse model was aimed to develop a mouse model that demonstrated functional β‐agonist‐induced β2‐adrenoceptor desensitization in the context of allergic inflammatory airway disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Species identification of trichomonads and associated coinfections in dogs with diarrhea and suspected trichomonosis
VETERINARY PARASITOLOGY, 187(1-2), 319–322.
author keywords: Pentatrichomonas hominis; Tritrichomonas foetus; Polymerase chain reaction
MeSH headings : Animals; Coinfection / veterinary; Diarrhea / parasitology; Diarrhea / veterinary; Dog Diseases / parasitology; Dogs; Feces / parasitology; Female; Male; Trichomonas Infections / complications; Trichomonas Infections / parasitology; Trichomonas Infections / veterinary
TL;DR:
Results suggest that P. hominis infection is more frequently identified than T. foetus infection in diarrheic dogs with trichomonosis and that concurrent enteropathogen infection is common in this population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Pharmacokinetics and distribution of minocycline in mature horses after oral administration of multiple doses and comparison with minimum inhibitory concentrations
EQUINE VETERINARY JOURNAL, 44(4), 453–458.
author keywords: horse; minocycline; pharmacokinetics; synovial fluid; cerebral spinal fluid; aqueous humour; minimum inhibitory concentrations
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Aqueous Humor / chemistry; Area Under Curve; Bacteria / drug effects; Drug Administration Schedule; Female; Half-Life; Horses / blood; Horses / cerebrospinal fluid; Horses / metabolism; Male; Microbial Sensitivity Tests; Minocycline / administration & dosage; Minocycline / chemistry; Minocycline / pharmacokinetics; Pilot Projects; Synovial Fluid / chemistry; Tissue Distribution
TL;DR:
The use of orally administered minocycline at a dose of 4 mg/kg bwt every 12 h for the treatment of nonocular infections caused by susceptible (MIC ≤ 0.25 µg/ml) organisms in horses is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Longitudinal study comparing the dynamics of Clostridium difficile in conventional and antimicrobial free pigs at farm and slaughter
VETERINARY MICROBIOLOGY, 157(1-2), 172–178.
author keywords: Clostridium difficile; Antimicrobial resistance; Swine; Toxinotyping; Toxins; Farm; Slaughter
MeSH headings : Animal Husbandry / methods; Animals; Anti-Bacterial Agents / administration & dosage; Clostridioides difficile / classification; Clostridioides difficile / drug effects; Clostridioides difficile / isolation & purification; Drug Resistance, Multiple, Bacterial; Longitudinal Studies; Microbial Sensitivity Tests; Prevalence; Sus scrofa / microbiology; Swine / microbiology; Swine Diseases / microbiology
TL;DR:
It is concluded that the unique production practices employed in conventional and ABF production systems have no impact on the pathogen population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Hypocalcemia and Hypovitaminosis D in Dogs with Induced Endotoxemia
JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(2), 244–251.
author keywords: Animal model; Calcium; Magnesium; Parathyroid hormone; Sepsis; Vitamin D
MeSH headings : Animals; Blood Gas Analysis / veterinary; Blood Pressure; Body Temperature; Calcium / blood; Calcium / urine; Cross-Over Studies; Dog Diseases / blood; Dog Diseases / metabolism; Dogs; Endotoxemia / blood; Endotoxemia / complications; Endotoxemia / metabolism; Endotoxemia / veterinary; Hypocalcemia / blood; Hypocalcemia / complications; Hypocalcemia / metabolism; Hypocalcemia / veterinary; Magnesium / blood; Magnesium / urine; Male; Parathyroid Hormone / blood; Vitamin D / analogs & derivatives; Vitamin D / blood
TL;DR:
Hypocalcemia occurs during endotoxemia in dogs and is associated with hypovitaminosis D, and hypomagnesemia, hypoparathyroidism, alkalosis, and increased calciuresis are not associated with HypocalCEmia in endotoxemic dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family
Genomics, 99(5), 282–291.
author keywords: Zebrafish; Innate immunity; Lipid binding
MeSH headings : Alternative Splicing; Amino Acid Sequence; Animals; Binding Sites / genetics; Chromosome Mapping; Cloning, Molecular; DNA, Complementary / chemistry; DNA, Complementary / genetics; Genetic Variation; Genomics / methods; Immunoglobulins / chemistry; Immunoglobulins / genetics; Models, Molecular; Molecular Sequence Data; Multigene Family / genetics; Phospholipids / chemistry; Phospholipids / metabolism; Phylogeny; Protein Binding; Protein Isoforms / chemistry; Protein Isoforms / genetics; Protein Isoforms / metabolism; Protein Structure, Tertiary; Receptors, Immunologic / chemistry; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Zebrafish / genetics; Zebrafish Proteins / chemistry; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
These findings suggest that novel multigene families encoding diversified immune receptors have arisen in different vertebrate lineages and affect parallel patterns of ligand recognition that potentially impact species-specific advantages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Drug solubility classification in the dog
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35, 87–91.
MeSH headings : Administration, Oral; Animals; Dogs; Dosage Forms; Gastrointestinal Tract / physiology; Humans; Solubility; Veterinary Drugs / administration & dosage; Veterinary Drugs / chemistry; Veterinary Drugs / pharmacokinetics; Veterinary Drugs / pharmacology
TL;DR:
The impact of body size vs. administered dose and gastric volume on the estimated gastric drug concentration that needs to be considered and the human pH criteria for evaluating drug Solubility can be used when evaluating drug solubility of oral medications in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
USEFULNESS OF A HALF-FOURIER ACQUISITION SINGLE-SHOT TURBO SPIN-ECHO PULSE SEQUENCE IN IDENTIFYING ARACHNOID DIVERTICULA IN DOGS
VETERINARY RADIOLOGY & ULTRASOUND, 53(2), 157–161.
author keywords: acquisition; arachnoid diverticulum; magnetic resonance imaging; single-shot; turbo spin echo
MeSH headings : Animals; Arachnoid Cysts / diagnosis; Arachnoid Cysts / veterinary; Dog Diseases / diagnosis; Dogs; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary
TL;DR:
Although sensitivity in this study was likely artificially low, the significantly increased detection rate of arachnoid diverticula when using HASTE imaging indicates that this sequence is a valuable addition to MR imaging protocols for the canine spine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Suppression of Immunodeficiency Virus-Associated Neural Damage by the p75 Neurotrophin Receptor Ligand, LM11A-31, in an In Vitro Feline Model
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 7(2), 388–400.
author keywords: Dementia; Encephalitis; Inflammation; Therapy; HIV; FIV
MeSH headings : Animals; Astrocytes / drug effects; Astrocytes / pathology; Astrocytes / virology; Cats; Cells, Cultured; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Immunodeficiency Virus, Feline; Immunohistochemistry; In Vitro Techniques; Isoleucine / analogs & derivatives; Isoleucine / pharmacology; Ligands; Microglia / drug effects; Microglia / pathology; Microglia / virology; Morpholines / pharmacology; Neurons / drug effects; Neurons / pathology; Neurons / virology; Neuroprotective Agents / pharmacology; Real-Time Polymerase Chain Reaction; Receptor, Nerve Growth Factor / agonists
TL;DR:
The strong neuroprotection afforded by LM11A-31 in an infectious in vitro model indicates that LM11a-31 may have excellent potential for the treatment of HIV-associated neurodegeneration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Modelling defined mixtures of environmental oestrogens found in domestic animal and sewage treatment effluents using an in vitro oestrogen-mediated transcriptional activation assay (T47D-KBluc)
International Journal of Andrology, 35(3), 397–406.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
In Vivo Assessment of Natural Killer Cell Responses during Chronic Feline Immunodeficiency Virus Infection
PLOS ONE, 7(5).
MeSH headings : Animals; Apoptosis; Cats; Cell Proliferation; Female; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / pathogenicity; Immunophenotyping; Killer Cells, Natural / immunology; Lentivirus Infections / immunology; Lentivirus Infections / virology; Leukocytes, Mononuclear / immunology; Male
TL;DR:
The failure of the NK cell response against Lm challenge in the draining lymph node of FIV-infected cats correlates with the delayed control and clearance of this opportunistic bacterial pathogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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