Works Published in 2011
Displaying works 41 - 60 of 71 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Inference on treatment effects from a randomized clinical trial in the presence of premature treatment discontinuation: the SYNERGY trial
BIOSTATISTICS, 12(2), 258–269.
author keywords: Dynamic treatment regime; Inverse probability weighting; Potential outcomes; Proportional hazards model
MeSH headings : Acute Coronary Syndrome / drug therapy; Algorithms; Computer Simulation; Endpoint Determination; Enoxaparin / administration & dosage; Enoxaparin / adverse effects; Enoxaparin / therapeutic use; Hemorrhage / etiology; Heparin / administration & dosage; Heparin / adverse effects; Heparin / therapeutic use; Humans; Intention to Treat Analysis; Models, Statistical; Monte Carlo Method; Mortality; Multicenter Studies as Topic; Probability; Proportional Hazards Models; Randomized Controlled Trials as Topic / methods; Survival Analysis; Treatment Outcome; Withholding Treatment / statistics & numerical data
TL;DR:
The Superior Yield of the New Strategy of Enoxaparin, Revascularization, and GlYcoprotein IIb/IIIa inhibitors (SYNERGY) was a randomized, open-label, multicenter clinical trial comparing 2 anticoagulant drugs on the basis of time-to-event endpoints.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
History Can Matter: Non-Markovian Behavior of Ancestral Lineages
SYSTEMATIC BIOLOGY, 60(3), 276–290.
author keywords: Ancestral lineage; ancestral process; Hill-Robertson effect; population genetics
MeSH headings : Computer Simulation; Evolution, Molecular; Genetic Fitness; Genetic Variation; Markov Chains; Models, Genetic; Polymorphism, Genetic; Selection, Genetic
TL;DR:
This work used the Wright-Fisher model of population genetics to simulate very many generations of mutation, natural selection, and genetic drift to show that the process by which a nonrecombining sequence changes over time can markedly deviate from the Markov assumption that is ubiquitous in molecular phylogenetics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Group-specific comparison of four lactobacilli isolated from human sources using differential blast analysis
GENES AND NUTRITION, 6(3), 319–340.
author keywords: In silico analysis; PAU; Adhesion; Stress response; Bacteriophage
TL;DR:
A comparative genomic analysis of four completely sequenced Lactobacillus strains, isolated from the human gastrointestinal tract, versus 25 lactic acid bacterial genomes present in the public database at the time of analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Architecture of energy balance traits in emerging lines of the Collaborative Cross
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(6), E1124–E1134.
author keywords: genetics; wheel running; adiposity; body weight; quantitative trait loci
MeSH headings : Alleles; Analysis of Variance; Animals; Body Fat Distribution; Body Weight / genetics; Body Weight / physiology; Chromosome Mapping; Chromosomes / genetics; Crosses, Genetic; Eating / genetics; Eating / physiology; Energy Metabolism / genetics; Energy Metabolism / physiology; Genotype; Linkage Disequilibrium; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Motor Activity / physiology; Phenotype; Physical Conditioning, Animal / physiology; Quantitative Trait Loci; Running / physiology; Sample Size
TL;DR:
The results suggest that the CC will be a powerful, high-precision tool for examining the genetic architecture of complex traits such as those involved in regulation of energy balance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Variation in genome-wide mutation rates within and between human families
Nature Genetics, 43(7), 712–137.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Genetic analysis of complex traits in the emerging Collaborative Cross
GENOME RESEARCH, 21(8), 1213–1222.
MeSH headings : Animals; Crosses, Genetic; Female; Gene Expression; Genetic Association Studies; Genome; Haplotypes; Male; Mice; Phenotype; Quantitative Trait Loci
TL;DR:
It is demonstrated that the genetic diversity of the CC, which derives from random mixing of eight founder strains, results in high phenotypic diversity and enhances the ability to map causative loci underlying complex disease-related traits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Functional dissection of Odorant binding protein genes in Drosophila melanogaster
GENES BRAIN AND BEHAVIOR, 10(6), 648–657.
author keywords: Behavioral genetics; chemoreception; olfaction; proteomics; RNAi
MeSH headings : Animals; Behavior, Animal; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Gene Expression; Proteomics; Receptors, Odorant / genetics; Smell / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 article
Walter M. Fitch (1929-2011)
Atchley, W. R. (2011, May 13). SCIENCE, Vol. 332, pp. 804–804.
MeSH headings : Evolution, Molecular; History, 20th Century; History, 21st Century; Periodicals as Topic / history; Societies, Scientific / history; Societies, Scientific / organization & administration; United States
TL;DR:
Walter Monroe Fitch, founder of the field of molecular phylogenetics and strongly promoted the widespread teaching of evolution, passed away in Irvine, California, on 10 March at the age of 81.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 article
The Impact of Omic Technologies on the Study of Food Microbes
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 2, Vol. 2, pp. 353–371.
author keywords: sequencing; genome; probiotic; pathogen; microbiome; transcriptome
MeSH headings : Animals; Bioengineering; Food Microbiology / methods; Foodborne Diseases / prevention & control; Gene Expression Profiling; Genomics / methods; Gram-Negative Bacteria / classification; Gram-Negative Bacteria / genetics; Gram-Negative Bacteria / isolation & purification; Gram-Negative Bacteria / metabolism; Gram-Positive Bacteria / classification; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / isolation & purification; Gram-Positive Bacteria / metabolism; High-Throughput Nucleotide Sequencing; Humans; Metagenomics / methods; Molecular Typing; Proteomics / methods; Transcriptome
TL;DR:
This review outlines advances in omic technologies and how these have impacted food microbiology through providing examples of recently published landmark work.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
The Effects of Weak Genetic Perturbations on the Transcriptome of the Wing Imaginal Disc and Its Association With Wing Shape in Drosophila melanogaster
GENETICS, 187(4), 1171–U314.
MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Insect; Genetic Variation; Genome, Insect; Genotype; Heterozygote; Linear Models; Multigene Family; Mutation; Phenotype; Transcriptional Activation; Wings, Animal / growth & development
TL;DR:
Weak mutational perturbations in genes affecting wing development in Drosophila melanogaster that influence wing shape relative to a co-isogenic wild type are used to examine overall patterns of covariation between phenotypic variables of interest and underlying aspects of gene activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Starch Self-Processing in Transgenic Sweet Potato Roots Expressing a Hyperthermophilic alpha-Amylase
BIOTECHNOLOGY PROGRESS, 27(2), 351–359.
author keywords: hyperthermophilic enzymes; starch conversion; transgenic plants; sweet potato; biofuels
MeSH headings : Crops, Agricultural / genetics; Hot Temperature; Ipomoea batatas / genetics; Ipomoea batatas / metabolism; Plant Roots / metabolism; Plants, Genetically Modified / enzymology; Plants, Genetically Modified / metabolism; Southeastern United States; Starch / metabolism; Thermotoga maritima / enzymology; alpha-Amylases / genetics; alpha-Amylases / physiology
TL;DR:
The results presented here demonstrate that engineering plants with hyperthermophilic glycoside hydrolases can facilitate cost effective starch conversion to fermentable sugars and the use of sweet potato as an alternative near‐term energy crop should be considered.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Joint analysis of transcriptional and post-transcriptional brain tumor data: searching for emergent properties of cellular systems
BMC Bioinformatics, 12.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Analysis of the ArcA regulon in anaerobically grown Salmonella enterica sv. Typhimurium
BMC MICROBIOLOGY, 11.
MeSH headings : Anaerobiosis; Animals; Female; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Metabolic Networks and Pathways / genetics; Mice; Mice, Inbred C57BL; Microarray Analysis; Regulon; Repressor Proteins / genetics; Repressor Proteins / metabolism; Salmonella typhimurium / genetics; Salmonella typhimurium / growth & development; Salmonella typhimurium / metabolism
TL;DR:
The results demonstrated that in S. Typhimurium, ArcA serves as a transcriptional regulator coordinating cellular metabolism, flagella biosynthesis, and motility, and a set of 120 genes whose regulation was shared with the anaerobic redox regulator, Fnr.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
A recombineering-based gene tagging system for Arabidopsis
PLANT JOURNAL, 66(4), 712–723.
Contributors: R. Zhou n, L. Benavente n, A. Stepanova n & J. Alonso n
author keywords: Arabidopsis; recombineering; Aux; IAA; gene tagging; fluorescent; proteins
MeSH headings : Agrobacterium tumefaciens / genetics; Agrobacterium tumefaciens / metabolism; Arabidopsis / genetics; Arabidopsis / metabolism; Chromosomes, Artificial, Bacterial / genetics; DNA Primers / genetics; Escherichia coli; Gene Expression Profiling / methods; Genetic Engineering / methods; Genetic Vectors; Green Fluorescent Proteins / metabolism; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism; Point Mutation; Recombination, Genetic
TL;DR:
It is suggested that recombineering-based gene tagging should be the gold standard for gene expression studies in Arabidopsis because it has several advantages compared to other classical strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: ORCID, Web Of Science
Added: August 6, 2018
2011 journal article
grassy tillers1 promotes apical dominance in maize and responds to shade signals in the grasses
Proceedings of the National Academy of Sciences of the United States of America, 108(33), E506–512.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Phylogeny-based developmental analyses illuminate evolution of inflorescence architectures in dogwoods (Cornus s. l., Cornaceae)
NEW PHYTOLOGIST, 191(3), 850–869.
Contributors: C. Feng n, Q. Xiang n & R. Franks n
author keywords: ancestral character state reconstruction; Cornus; evolutionary development; inflorescence evolution; umbels and heads
MeSH headings : Biological Evolution; Cornus / genetics; Cornus / growth & development; Cornus / ultrastructure; Inflorescence / genetics; Inflorescence / growth & development; Inflorescence / ultrastructure; Meristem / genetics; Meristem / growth & development; Meristem / ultrastructure; Organogenesis / genetics; Phylogeny; Reproduction / physiology
TL;DR:
The results indicate that heads and umbels evolved independently in Cornus from elongated forms via an umbellate dichasium ancestor and this process involved several independent changes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Genes of the Unfolded Protein Response Pathway Harbor Risk Alleles for Primary Open Angle Glaucoma
PLOS ONE, 6(5).
MeSH headings : Aged; Alleles; Female; Genotype; Glaucoma, Open-Angle / genetics; Haplotypes / genetics; Humans; Inhibitor of Apoptosis Proteins / genetics; Linkage Disequilibrium / genetics; Male; Polymorphism, Single Nucleotide / genetics; Protein Disulfide-Isomerases / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Unfolded Protein Response / genetics; Unfolded Protein Response / physiology
TL;DR:
Combating genomics approach demonstrates that effectiveness of the UPR in response to accumulation of misfolded or aggregated proteins may contribute to the pathogenesis of POAG and provide targets for early therapeutic intervention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
The Collaborative Cross: A Recombinant Inbred Mouse Population for the Systems Genetic Era
ILAR JOURNAL, 52(1), 24–31.
author keywords: aging; Collaborative Cross (CC); mouse model; recombinant inbred mice; systems genetics; genetic reference population
MeSH headings : Aging / genetics; Aging / physiology; Animals; Crosses, Genetic; Mice; Models, Animal
TL;DR:
The Collaborative Cross (CC) is a large panel of recently established multiparental recombinant inbred mouse lines specifically designed to overcome the limitations of existing mouse genetic resources for analysis of phenotypes caused by combinatorial allele effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Efficient germ-line transformation of the economically important pest species Lucilia cuprina and Lucilia sericata (Diptera, Calliphoridae)
Insect Biochemistry and Molecular Biology, 41(1), 70–75.
author keywords: Lucilia cuprina; Lucilia sericata; PiggyBac; Transformation; Transgenesis; Maggot therapy; Flystrike
MeSH headings : Animals; Animals, Genetically Modified / metabolism; Australia; Diptera / genetics; Female; Gene Expression Regulation; Gene Transfer Techniques; Genes, Insect; Germ Cells / metabolism; Green Fluorescent Proteins / analysis; Heat-Shock Proteins / genetics; Heat-Shock Proteins / metabolism; Humans; Larva / genetics; Larva / metabolism; New Zealand; Pest Control, Biological / methods; Plasmids / genetics; Plasmids / metabolism; Sheep; Transformation, Genetic; Transposases / genetics; Transposases / metabolism; Wounds and Injuries / therapy
TL;DR:
An efficient and reliable method for germ-line transformation of Lucilia cuprina using new piggyBac vector and helper plasmids containing the strong promoter from the L. cuprina hsp83 gene to drive expression of the transposase and fluorescent protein marker gene is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2011 journal article
Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 4623–4630.
author keywords: antiinflammatory; lactobacilli; Toll-like receptor 2; innate immunity
MeSH headings : Animals; Autoimmunity / immunology; CD4-Positive T-Lymphocytes / immunology; Colitis / chemically induced; Colitis / immunology; Colitis / microbiology; DNA Primers / genetics; Dextran Sulfate / toxicity; Flow Cytometry; Fluorescent Antibody Technique; Gene Deletion; Gene Expression Regulation / immunology; Homeodomain Proteins / genetics; Interleukin-10 / genetics; Lactobacillus acidophilus / metabolism; Lipopolysaccharides / deficiency; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88 / genetics; Polymerase Chain Reaction; Teichoic Acids; Transferases (Other Substituted Phosphate Groups) / genetics
TL;DR:
Directed alteration of cell surface components of L. acidophilus NCFM establishes a potential strategy for the treatment of inflammatory intestinal disorders and significantly mitigated dextran sulfate sodium and CD4+CD45RBhighT cell-induced colitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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