Molecular Education, Technology and Research Innovation Center

Works Published in 2015

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Displaying works 21 - 40 of 52 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2015 journal article

New Models for Regulation of Vinculin by Actin and Phospholipids

Biophysical Journal, 108(2), 508a–509a.

By: P. Thompson* , H. Lee*, L. Kim *, S. Ramachandran *, A. Tandon*, R. Mendez-Giraldez*, G. Alushin *, N. Dokholyan*, S. Campbell *

TL;DR: A sub-nanometer resolution reconstruction of the Vt/actin complex is obtained which sheds light on actin-induced conformational changes necessary for vinculin dimerization and actin filament bundling. (via Semantic Scholar)
Source: ORCID
Added: December 10, 2019

2015 journal article

Solvate Structures and Computational/Spectroscopic Characterization of LiPF6 Electrolytes

The Journal of Physical Chemistry C, 119(16), 8492–8500.

By: S. Han  n, S. Yun, O. Borodin, D. Seo n, R. Sommer , V. Young, W. Henderson  n

UN Sustainable Development Goal Categories
Source: ORCID
Added: November 12, 2019

2015 journal article

ChemInform Abstract: Crystalline and Liquid Structure of Zinc Chloride Trihydrate: A Unique Ionic Liquid.

ChemInform, 46(16), no-no.

By: R. Wilcox*, B. Losey*, J. Folmer*, J. Martin *, M. Zeller * & R. Sommer* 

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: November 12, 2019

2015 journal article

Self-Assembly of n-Alkyl-and Aryl-Side Chain Ureas and Their Derivatives as Evidenced by SEM and X-ray Analysis

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2015(34), 7511–7518.

By: O. Kulikov *, D. Siriwardane*, G. McCandless*, C. Barnes*, Y. Sevryugina *, J. DeSousa*, J. Wu*, R. Sommer n , B. Novak*

author keywords: Supramolecular chemistry; Self-assembly; Gelation; Nanofibers; Ureas
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Intramolecular C-H activation by air-stable Pt(II) phosphite complexes

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 799-800, 201–207.

By: K. Grice *, J. Kositarut*, A. Lawando* & R. Sommer n 

author keywords: Organoplatinum(II) complexes; Phosphite ligands; X-ray crystallography; Cyclometallation
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Ferromagnetic coupling in d(1)-d(3) linear oxido-bridged heterometallic complexes: ground-state models of metal-to-metal charge transfer excited states

DALTON TRANSACTIONS, 44(43), 18937–18944.

By: T. Huang n, X. Wu n, X. Song n, H. Xu  n, T. Smirnova n , W. Weare n, R. Sommer n 

TL;DR: A model that links either ferromagnetic or antiferromagentic exchange coupling with long excited state lifetimes in metal-to-metal charge transfer (MMCT) chromophores is proposed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Synthesis of 7-norbornenols via Diels-Alder cycloadditions of cyclopentadienol generated by decomposition of ferrocenium cation

TETRAHEDRON LETTERS, 56(44), 6038–6042.

By: S. Allen *, T. Lathrop*, S. Patel*, D. Moody*, R. Sommer n  & T. Coombs *

author keywords: Cyclopentadienol; Norbornenol; Ferrocenium; Ferrocene cation; Diels-Alder reaction
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Influence of C-Trap Ion Accumulation Time on the Detectability of Analytes in IR-MALDESI MSI

ANALYTICAL CHEMISTRY, 87(20), 10483–10490.

By: E. Rosen n, M. Bokhart n, M. Nazari n & D. Muddiman n 

MeSH headings : Ions / chemistry; Lasers; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Infrared; Time Factors; Xenobiotics / analysis
TL;DR: Reducing the C-trap ion accumulation time resulted in increased ion abundance by up to 3 orders of magnitude for analytes ranging from xenobiotics to endogenous lipids, and facilitated the reduction of voxel-to-voxel variability by more than 3-fold. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

In-depth LC-MS/MS analysis of the chicken ovarian cancer proteome reveals conserved and novel differentially regulated proteins in humans

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(22), 6851–6863.

By: A. Nepomuceno n, H. Shao *, K. Jing, Y. Ma*, J. Petitte n , M. Idowu*, D. Muddiman n , X. Fang *, A. Hawkridge *

author keywords: Mass spectrometry; Proteomics; Ovarian Cancer; Chicken; Ovostatin 2; OVOS2
MeSH headings : Amino Acid Sequence; Animals; Chickens; Chromatography, Liquid / methods; Conserved Sequence; Female; Gene Expression Regulation, Neoplastic; Humans; Mass Spectrometry / methods; Molecular Sequence Data; Neoplasm Proteins / metabolism; Ovarian Neoplasms / metabolism; Proteome / chemistry; Proteome / metabolism; Species Specificity
TL;DR: Analysis of the ovarian cancer proteome of the chicken provides the first evidence for involvement of OVOS2 in the pathogenesis of both chicken and human ovarian cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Global Proteomic Analysis of Functional Compartments in Immature Avian Follicles Using Laser Microdissection Coupled to LC-MS/MS

JOURNAL OF PROTEOME RESEARCH, 14(9), 3912–3923.

By: A. Nepomuceno n, D. Muddiman n  & J. Petitte n 

author keywords: microdissection; proteomics; ovary; follicle; avian; chicken; yolk; steroidogenesis; vitellogenin
MeSH headings : Animals; Avian Proteins / analysis; Avian Proteins / chemistry; Chickens; Chromatography, Liquid; Female; Laser Capture Microdissection / methods; Ovarian Follicle / chemistry; Proteome / analysis; Proteome / chemistry; Proteomics / methods; Tandem Mass Spectrometry
TL;DR: A global proteome for SWF, white yolk, and ovarian stroma of the avian ovary is provided that can be used as a baseline for future studies and verifies that the coupling of LMD with proteomic analysis can be use to evaluate proteins from small, physiologically functional compartments of complex tissue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples

JOURNAL OF PROTEOME RESEARCH, 14(10), 4394–4401.

By: E. Hecht*, E. Scholl*, S. Walker*, A. Taylor, W. Cliby *, A. Motsinger-Reif*, D. Muddiman* 

author keywords: N-linked glycosylation; INLIGHT; ovarian cancer; relative quantification; cancer biomarker; human plasma
MeSH headings : Biomarkers, Tumor / blood; Carbohydrate Sequence; Case-Control Studies; Chromatography, Liquid / methods; Female; Fucose / blood; Glycosylation; Humans; Hydrazines / chemistry; Molecular Sequence Data; Neoplasm Staging; Ovarian Neoplasms / blood; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / pathology; Polysaccharides / blood; Sialic Acids / blood; Staining and Labeling / methods; Tandem Mass Spectrometry / methods
TL;DR: For all N-glycans, the vectors of the effects from stages II-IV were sequentially reversed, suggesting potential biological changes in OVC morphology or in host response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Mechanisms of Egg Yolk Formation and Implications on Early Life History of White Perch (Morone americana)

PLOS ONE, 10(11).

By: J. Schilling n, P. Loziuk n, D. Muddiman n , H. Daniels n & B. Reading n 

MeSH headings : Animals; Bass / metabolism; Blotting, Western; Chromatography, Liquid; Egg Proteins / metabolism; Egg Yolk / metabolism; Female; Immunohistochemistry; Oocytes / cytology; Oocytes / metabolism; Ovary / cytology; Receptors, Cell Surface / metabolism; Sexual Maturation; Staining and Labeling; Tandem Mass Spectrometry; Vitellogenins / metabolism
TL;DR: The three white perch vitellogenins were quantified accurately and precisely in the liver, plasma, and ovary during pre-vitellogenic oocyte growth using protein cleavage-isotope dilution mass spectrometry (PC-IDMS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Elucidation of Xylem-Specific Transcription Factors and Absolute Quantification of Enzymes Regulating Cellulose Biosynthesis in Populus trichocarpa

JOURNAL OF PROTEOME RESEARCH, 14(10), 4158–4168.

By: P. Loziuk n, J. Parker  n, W. Li n, C. Lin n, J. Wang n , Q. Li *, R. Sederoff n, V. Chiang n, D. Muddiman n 

author keywords: shotgun discovery proteomics; absolute quantification; PC-IDMS; cellulose biosynthesis; transcription factor; targeted mass spectrometiry; SRM
MeSH headings : Carbohydrate Metabolism; Cellulose / biosynthesis; Cellulose / genetics; Chromatography, Liquid; Gene Expression Regulation, Plant; Molecular Sequence Annotation; Plant Proteins / genetics; Plant Proteins / isolation & purification; Plant Proteins / metabolism; Populus / genetics; Populus / metabolism; Proteome / genetics; Proteome / isolation & purification; Proteome / metabolism; Proteomics; Tandem Mass Spectrometry; Transcription Factors / genetics; Transcription Factors / isolation & purification; Transcription Factors / metabolism; Wood / chemistry; Wood / metabolism; Xylem / genetics; Xylem / metabolism
TL;DR: The study described herein sought to identify the proteins directly involved in cellulose biosynthesis during wood formation in Populus trichocarpa along with known xylem-specific transcription factors involved in regulating these key proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Elaboration of an unexplored substitution site in synthetic bacteriochlorins

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 19(7), 887–902.

By: N. Zhang n, K. Reddy n, J. Jiang n, M. Taniguchi n , R. Sommer n  & J. Lindsey n 

author keywords: hydroporphyrin; dioxepine; chlorophyllone; bacteriochlorophyllone; auxochrome; artificial photosynthesis
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Definitive Screening Design Optimization of Mass Spectrometry Parameters for Sensitive Comparison of Filter and Solid Phase Extraction Purified, INLIGHT Plasma N-Glycans

ANALYTICAL CHEMISTRY, 87(14), 7305–7312.

By: E. Hecht n, J. McCord n & D. Muddiman n 

MeSH headings : Animals; Chickens; Equipment Design; Mass Spectrometry / instrumentation; Polysaccharides / blood; Polysaccharides / isolation & purification; Solid Phase Extraction / instrumentation
TL;DR: High-throughput, quantitative processing of N-linked glycans would facilitate large-scale studies correlating the glycome with disease and open the field to basic and applied researchers by coupling filter-aided-N-glycan separation to the individuality normalization when labeling with glycan hydrazide tags (INLIGHT) for analysis of plasma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Influence of Desorption Conditions on Analyte Sensitivity and Internal Energy in Discrete Tissue or Whole Body Imaging by IR-MALDESI

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 26(6), 899–910.

By: E. Rosen n, M. Bokhart n, H. Ghashghaei  n & D. Muddiman n 

author keywords: IR-MALDESI; Mass spectrometry imaging; Laser desorption whole body imaging; Lipids; Xenobiotics
MeSH headings : Anesthetics, Local / analysis; Anesthetics, Local / pharmacokinetics; Animals; Cocaine / analysis; Cocaine / pharmacokinetics; Infrared Rays; Lipid Metabolism; Lipids / analysis; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Whole Body Imaging / methods
TL;DR: Optimized desorption conditions have been used to conduct an untargeted lipidomic analysis of whole body sagittal sections of neonate mouse, with enhanced lipid coverage received by varying the laser wavelength used for mass spectrometry imaging (MSI). (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Activin/Nodal Signaling Switches the Terminal Fate of Human Embryonic Stem Cell-derived Trophoblasts

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(14), 8834–8848.

By: P. Sarkar n, S. Randall n, T. Collier n, A. Nero n, T. Russell n, D. Muddiman n , B. Rao n

MeSH headings : Activins / metabolism; Base Sequence; Cell Differentiation; Cell Lineage; DNA Methylation; DNA Primers; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Ephrin-B2 / genetics; Humans; Nodal Protein / metabolism; Polymerase Chain Reaction; Promoter Regions, Genetic; Signal Transduction; Trophoblasts / cytology; Trophoblasts / metabolism
TL;DR: It is shown that activin/nodal signaling switches the terminal fate of these hESC-derived trophoblasts, providing a model system that allows for targeted derivation of extravillous trophoblast and syncytiotrophoblasts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Machine learning reveals sex-specific 17-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins

PROTEOMICS, 15(15), 2678–2690.

By: J. Schilling n, A. Nepomuceno n, A. Planchart n , J. Yoder n , R. Kelly n , D. Muddiman n , H. Daniels n, N. Hiramatsu*, B. Reading n 

author keywords: Animal proteomics; Endocrine disrupting compounds; Machine learning; Plasma; Semiquantitative proteomics; Support vector machines
MeSH headings : Animals; Bass / metabolism; Blood Proteins / metabolism; Blotting, Western; Chromatography, Liquid; Estradiol / pharmacology; Estrogens / pharmacology; Female; Fish Proteins / metabolism; Kininogens / metabolism; Male; Nanotechnology / methods; Proteome / drug effects; Proteome / metabolism; Proteomics / methods; Sex Factors; Support Vector Machine; Tandem Mass Spectrometry; Vitellogenins / metabolism
TL;DR: This is the first report that Eltd1 and Kng1 may be E2‐responsive proteins in fishes and therefore may be useful indicators of estrogen induction in fishes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Long-Lived LMCT in a d(0) Vanadium(V) Complex by Internal Conversion to a State of 3d(xy) Character

JOURNAL OF PHYSICAL CHEMISTRY C, 119(30), 17029–17038.

By: S. Choing*, A. Francis n, G. Clendenning*, M. Schuurman *, R. Sommer n , I. Tamblyn *, W. Weare n, T. Cuk *

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Determining the Conformational Landscape of a and pi Coupling Using para-Phenylene and "Aviram-Ratner" Bridges

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(29), 9222–9225.

By: D. Stasiw n, J. Zhang n, G. Wang  n, R. Dangi*, B. Stein *, D. Shultz n , M. Kirk *, L. Wojtas*, R. Sommer n 

TL;DR: The torsional dependence of donor-bridge-acceptor (D-B-A) electronic coupling matrix elements and the pairwise exchange interactions are further illuminated in three-dimensional, "Ramachandran-type" plots that relate D-B and B-A torsions to both electronic and exchange couplings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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