Works Published in 2023
Displaying works 21 - 40 of 40 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2023 article
Development of an object-based image analysis tool for mass spectrometry imaging ion classification
Eisenberg, S. M., Knizner, K. T., & Muddiman, D. C. (2023, May 24). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 5.
author keywords: IR-MALDESI; Object-based image analysis; Mass spectrometry imaging; Image segmentation; Image classification; MATLAB
TL;DR:
The utility of an ion classification tool (ICT) developed using object-based image analysis in MATLAB is presented, which was able to accurately classify 45/50 ions as on-tissue or background.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 3, 2023
2023 article
Predicting Sialic Acid Content of N-Linked Glycans Using the Isotopic Pattern of Chlorine
Palomino, T. V., & Muddiman, D. C. (2023, June 8). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 6.
author keywords: N-linked glycans; sialic acid; chlorine; IR-MALDESI
MeSH headings : Humans; N-Acetylneuraminic Acid; Chlorine; Polysaccharides / chemistry; Sialic Acids / analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
A new rule is described that can predict the number of sialic acids on a glycan and grants confident glycan annotations and compositions beyond accurate mass measurements, thereby further improving the capability of IR-MALDESI to study sialylated N-linked glycans within biological tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 26, 2023
2023 article
Automatic z-Axis Correction for IR-MALDESI Mass Spectrometry Imaging of Uneven Surfaces
Xi, Y., Knizner, K. T. T., Garrard, K. P. P., & Muddiman, D. C. C. (2023, June 12). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 6.
author keywords: mass spectrometry imaging; nonflat surfaces; IR-MALDESI; automatic z-axis correction
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 26, 2023
2023 journal article
Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach
MICROBIAL CELL FACTORIES, 22(1).
Contributors: D. Durmusoglu n, I. Al’Abri n, Z. Li n, T. Islam Williams n, L. Collins n , J. Martínez *, N. Crook n
MeSH headings : Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces boulardii / genetics; Saccharomyces boulardii / metabolism; Saccharomyces / genetics; Saccharomyces / metabolism; Probiotics / metabolism; Endopeptidases / metabolism
TL;DR:
A quadruple protease-deficient Sb strain is constructed that produces 5045 mg/L secretory NPA, an improvement of tenfold over wild-type Sb and highlights the ability of proteomics to highlight under-explored mediators of this process.
(via Semantic Scholar)
doi.org (publisher)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023
2023 journal article
Histone malonylation is regulated by SIRT5 and KAT2A
ISCIENCE, 26(3).
TL;DR:
The role of histone malonylation in ribosomal gene expression is highlighted by mass spectrometry and it is reported that availability of malonyl-co-enzyme A (malonyL-CoA), an endogenous provider ofmalonyl groups, affects lysinemalonylation, and that the deacylase SIRT5 selectively reduces malonylated of histones.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 12, 2023
2023 article
Time of acquisition and high spatial resolution mass spectrometry imaging (vol 58, e4911, 2023)
Muddiman, D. C. (2023, May). JOURNAL OF MASS SPECTROMETRY, Vol. 58.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 15, 2023
2023 article
On the importance of color in mass spectrometry imaging (vol 57, e4898, 2022)
Muddiman, D. C. (2023, May). JOURNAL OF MASS SPECTROMETRY, Vol. 58.
Sources: Web Of Science, NC State University Libraries
Added: May 15, 2023
2023 article
Achieving Sub-Parts-per-Million Mass Measurement Accuracy on an Orbitrap Mass Spectrometry Imaging Platform without Automatic Gain Control
Kibbe, R. R., & Muddiman, D. C. (2023, April 25). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 4.
author keywords: centroid; mass measurement accuracy; IR-MALDESI; mass spectrometry imaging; Orbitrap; automatic gain control
MeSH headings : Animals; Mice; Mass Spectrometry / methods; Data Accuracy; Lipids
TL;DR:
There is support that natively collecting centroid MS data significantly improves MMA to sub-ppm levels without AGC and reduces false positive annotations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 15, 2023
2023 journal article
Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates
Molecular & Cellular Proteomics.
MeSH headings : Animals; Humans; Chlorocebus aethiops; SARS-CoV-2; COVID-19; Cerebrospinal Fluid Proteins; Proteome; Macaca mulatta
TL;DR:
The results indicate that CSF proteome changes after infection resolution correspond with bronchial virus abundance during early infection and revealed substantial differences between the infected NHPs and their age-matched uninfected controls, suggesting these differences could reflect altered secretion of CNS factors in response to SARS-CoV-2-induced neuropathology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2023 article
Lipidomic Analysis of Mouse Brain to Evaluate the Efficacy and Preservation of Different Tissue Preparatory Techniques by IR-MALDESI-MSI
Wang, M. F., Sohn, A. L., Samal, J., Erning, K., Segura, T., & Muddiman, D. C. (2023, March 29). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 3.
author keywords: IR-MALDESI; mass spectrometry imaging; sucrose; PFA
MeSH headings : Mice; Animals; Spectrometry, Mass, Electrospray Ionization / methods; Lipidomics; Ice; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ions / chemistry; Lipids / analysis; Brain
TL;DR:
Evidence from these investigations supports sucrose-embedding without ice matrix as an alternative preparatory technique for IR-MALDESI-MSI, and demonstrates improved spatial distribution of ions resulting from the cryo-protective property of sucrose and paraformaldehyde fixation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 24, 2023
2023 journal article
Chronic BMAA exposure combined with TDP-43 mutation elicits motor neuron dysfunction phenotypes in mice
NEUROBIOLOGY OF AGING, 126, 44–57.
author keywords: BMAA; TDP-43; ALS; Mass-spectrometry; Guam; Parkinsonism
MeSH headings : Animals; Mice; Amyotrophic Lateral Sclerosis / chemically induced; Amyotrophic Lateral Sclerosis / genetics; Amyotrophic Lateral Sclerosis / metabolism; Neurodegenerative Diseases / complications; Motor Neurons / pathology; Phenotype; Amino Acids, Diamino / toxicity; Amino Acids, Diamino / genetics; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease Models, Animal
TL;DR:
A multihit model based on low expression of a dominant familial ALS TDP-43 mutation and chronic low-dose BMAA exposure showed a motor phenotype absent from either lesion alone, and Elevated BMAA levels in liver were associated with dysregulation of the unfolded protein response (UPR) pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 11, 2023
2023 article
Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut
Foley, M. H., Walker, M. E., Stewart, A. K., O'Flaherty, S., Gentry, E. C., Patel, S., … Theriot, C. M. (2023, March 13). NATURE MICROBIOLOGY.
MeSH headings : Animals; Mice; Humans; Clostridioides difficile; Clostridioides; Bile Acids and Salts; Amidohydrolases; Clostridium Infections
TL;DR:
Insight is provided into the structural basis of BSH mechanisms that shape the BA landscape and promote colonization resistance against C. difficile in vitro and in pre-clinical in vivo models of CDI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: April 4, 2023
2023 article
Impact of wavelength and spot size on laser depth of focus: Considerations for mass spectrometry imaging of non-flat samples
Joignant, A. N. N., Xi, Y., & Muddiman, D. C. C. (2023, March 14). JOURNAL OF MASS SPECTROMETRY, Vol. 3.
author keywords: depth of focus; laser wavelength; mass spectrometry imaging; spatial resolution; surface roughness
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023
2023 article
Discovery Proteomics and Absolute Protein Quantification Can Be Performed Simultaneously on an Orbitrap-Based Mass Spectrometer
Williams, T. I., Kowalchyk, C., Collins, L. B., & Reading, B. J. (2023, March 22). ACS OMEGA, Vol. 3.
Contributors: T. Williams n , C. Kowalchyk*, L. Collins n & B. Reading n
TL;DR:
A comparative study on data-dependent acquisition (DDA) and PRM-based workflows to quantify egg yolk protein precursors or vitellogenins (VTGs) Aa, Ab, and C in striped bass (Morone saxatilis) concludes that DDA is able to deliver both discovery data and absolute quantification data in the same experiment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 23, 2023
2023 journal article
SMART: A data reporting standard for mass spectrometry imaging
JOURNAL OF MASS SPECTROMETRY, 58(2).
author keywords: data reporting standards; mass spectrometry imaging
MeSH headings : Research Design; Mass Spectrometry / methods; Ions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
The goal of this tutorial is to discuss the necessity of establishing a uniform reporting system to communicate MSI data in publications and presentations in a simple format to readily interpret the parameters and baseline outcomes of the data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023
2023 journal article
Metabolic engineering of the anthocyanin biosynthetic pathway in Artemisia annua and relation to the expression of the artemisinin biosynthetic pathway
PLANTA, 257(3).
author keywords: Anthocyanin; Artemisinin; Artemisinic acid; Arteannuin b; Artemisia annua; Plant tissue culture
MeSH headings : Artemisia annua / chemistry; Anthocyanins / metabolism; Biosynthetic Pathways; Metabolic Engineering; Reactive Oxygen Species / metabolism; Tandem Mass Spectrometry; Artemisinins / chemistry; Artemisinins / metabolism
TL;DR:
The engineering of anthocyanins does not eliminate the biosynthesis of artemisinin in cells and a new hypothesis that enzymes catalyze the formation of art Artemisinin from dihydroartemisinic acid in non-GT cells is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 13, 2023
2023 journal article
Quasi-continuous infrared matrix-assisted laser desorption electrospray ionization source coupled to a quadrupole time-of-flight mass spectrometer for direct analysis from well plates
JOURNAL OF MASS SPECTROMETRY, 58(1).
author keywords: ambient ionization; direct analysis; IR-MALDESI; Q-TOF mass spectrometer
TL;DR:
An infrared matrix‐assisted laser desorption electrospray ionization (IR‐MALDESI) source coupled directly to an Agilent 6545 for direct analysis from well plates and is a proof of concept for HTS applications using IR‐MAL DESI coupled to a different MS platform.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 13, 2023
2023 journal article
Salinity-induced ionoregulatory changes in the gill proteome of the mayfly, Neocloeon triangulifer
ENVIRONMENTAL POLLUTION, 316.
author keywords: Proteomics; Salinity; Mayfly; Gill biology; Ion transport; Osmoregulation
MeSH headings : Animals; Ephemeroptera; Gills / metabolism; Salinity; Proteome / metabolism; Sodium Chloride / metabolism; Proteomics; Calcium Chloride; Water Pollutants, Chemical / metabolism; Aquatic Organisms / metabolism; Sodium-Potassium-Exchanging ATPase / metabolism; Ions / metabolism; Water / metabolism
TL;DR:
The breadth of physiological functions in gills is demonstrated by exploring non-transport related pathways found in the dataset, including ATP synthesis, calcium signaling, and oxidative stress response, and the challenges of working with non-model species without fully sequenced and annotated genomes are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 30, 2023
2023 journal article
Transforming a Mid-infrared Laser Profile from Gaussian to a Top- Hat with a Diffractive Optical Element for Mass Spectrometry Imaging
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 34(1), 10–16.
author keywords: diffractive optical element; top-hat; infrared; IR-MALDESI; 3D MSI
MeSH headings : Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectrometry, Mass, Electrospray Ionization / methods; Lasers; Light
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 30, 2023
2023 article
A bottom-up proteomics workflow for a system containing multiple organisms
Bai, H., Collins, L. B. B., Andre, M. R., Breitschwerdt, E. B. B., & Williams, T. I. (2023, January 3). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol. 1.
TL;DR:
A bottom-up proteomics workflow was developed to study a system containing multiple organisms to promote a thorough understanding of how each interacts with the others and can be readily applied to other label-free proteomics work involving multiple proteomes from taxonomically distinct organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023
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