Works Published in 2010
Displaying works 61 - 80 of 99 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Mature Hair Follicles Generated from Dissociated Cells: A Universal Mechanism of Folliculoneogenesis
DEVELOPMENTAL DYNAMICS, 239(10), 2619–2626.
author keywords: hair follicle; morphogenesis; organogenesis
MeSH headings : Animals; Cell Cycle / genetics; Cell Cycle / physiology; Dogs; Hair Follicle / cytology; Hair Follicle / embryology; Humans; Opossums; Organogenesis / genetics; Organogenesis / physiology; Rats; Skin / cytology; Skin / metabolism
TL;DR:
There is essentially one way by which dissociated mammalian skin cells form a new hair follicle in vivo and that this mechanism has been highly conserved, according to Developmental Dynamics 239:2619–2626.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Manganese Bioconcentration in Aquatic Insects: Mn Oxide Coatings, Molting Loss, and Mn(II) Thiol Scavenging
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 44(23), 9182–9188.
MeSH headings : Animals; Coal Mining; Environmental Monitoring; Fresh Water / chemistry; Insecta / metabolism; Manganese / analysis; Manganese / chemistry; Manganese / metabolism; Manganese Compounds / analysis; Manganese Compounds / metabolism; Molting; Oxides / analysis; Oxides / metabolism; Sulfhydryl Compounds / chemistry; Sulfhydryl Compounds / metabolism; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / chemistry; Water Pollutants, Chemical / metabolism; Water Pollution, Chemical / statistics & numerical data
TL;DR:
It is suggested that Mn exposure results in transient physiological stress in aquatic insects which is likely relieved, in part, during the molting process, as well as increased ambient calcium concentrations.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Does proximity to coal-fired power plants influence fish tissue mercury?
ECOTOXICOLOGY, 19(8), 1601–1611.
author keywords: Mercury; Selenium; Point-source; Coal-fired power plant; Fish
MeSH headings : Animals; Coal; Environmental Monitoring / methods; Fishes / metabolism; Food Contamination / analysis; Fresh Water; Geologic Sediments / chemistry; Humans; Mercury / metabolism; Mercury / toxicity; Power Plants; Selenium / metabolism; Species Specificity; Tissue Distribution; Water Pollutants, Chemical / metabolism; Water Pollutants, Chemical / toxicity
TL;DR:
Although reduced fish tissue mercury in systems near power plants may decrease mercury-specific risks to human consumers, these benefits are highly localized and the relatively high selenium associated with these tissues may compromise ecological health.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress
JOURNAL OF CELL SCIENCE, 123(22), 3863–3871.
author keywords: HIPK2; ATF1; Phosphorylation; Ferritin; Genotoxic stress; Transcription
MeSH headings : Activating Transcription Factor 1 / genetics; Activating Transcription Factor 1 / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Growth Processes / genetics; Cell Survival / genetics; DNA Damage; Ferritins / genetics; Ferritins / metabolism; Gene Expression Regulation; Humans; Phosphorylation; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
HIPK2 (homeodomain-interacting protein kinase 2), a DNA-damage-responsive nuclear kinase, is a new ATF1 kinase involved in the regulation of ferritin H and other antioxidant detoxification genes in genotoxic stress conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 review
The pros and cons of phytoestrogens
[Review of ]. FRONTIERS IN NEUROENDOCRINOLOGY, 31(4), 400–419.
author keywords: Soy; Isoflavones; Genistein; Equol; Endocrine disruption; Estrogen; ER alpha; ER beta; Brain; Hypothalamus
MeSH headings : Animals; Brain / drug effects; Brain / growth & development; Breast Neoplasms / prevention & control; Diethylstilbestrol / adverse effects; Endocrine Disruptors / adverse effects; Endocrine Disruptors / pharmacology; Female; Genitalia / drug effects; Genitalia / growth & development; Heart Diseases / prevention & control; Humans; Male; Menopause / drug effects; Menstrual Cycle / drug effects; Mice; Osteoporosis / prevention & control; Phytoestrogens / adverse effects; Phytoestrogens / pharmacology; Puberty / drug effects; Rats; Sexual Behavior / drug effects; Soybean Proteins / adverse effects; Soybean Proteins / pharmacology
TL;DR:
As weak estrogen agonists/antagonists with molecular and cellular properties similar to synthetic endocrine disruptors such as Bisphenol A (BPA), the phytoestrogens provide a useful model to comprehensively investigate the biological impact of endocrine disruption in general.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Overexpression of Transcription Factor Sp2 Inhibits Epidermal Differentiation and Increases Susceptibility to Wound- and Carcinogen-Induced Tumorigenesis
CANCER RESEARCH, 70(21), 8507–8516.
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Blotting, Western; COS Cells; Carcinogens / toxicity; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cattle; Cell Differentiation; Chlorocebus aethiops; Disease Susceptibility; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Female; Humans; Immunoenzyme Techniques; Keratin-5 / genetics; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Sp2 Transcription Factor / physiology; Wounds and Injuries
TL;DR:
It is reported that Sp2 protein abundance in mice increases in concert with the progression of carcinogen-induced murine squamous cell carcinomas, and this results directly support the likelihood that Sp2 overexpression occurring in various human cancers has significant functional effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 article
Neuroendocrine disruption: Historical roots, current progress, questions for the future
Gore, A. C., & Patisaul, H. B. (2010, October). FRONTIERS IN NEUROENDOCRINOLOGY, Vol. 31, pp. 395–399.
MeSH headings : Animals; Endocrine Disruptors / history; Endocrine Disruptors / toxicity; Female; History, 20th Century; History, 21st Century; Humans; Male; Neurosecretory Systems / drug effects; Rats
TL;DR:
Rapidly emerging data from numerous labs conducting basic animal research, studies of inadvertent human exposures, and epidemiological analyses overwhelmingly point to the inevitable conclusion that EDC exposures are pervasive, and cause both short- and long-term harm to humans and wildlife.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Ablation of TAK1 Upregulates Reactive Oxygen Species and Selectively Kills Tumor Cells
Cancer Research, 70(21), 8417–8425.
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; Blotting, Western; Carcinogens / toxicity; Cell Proliferation; Gene Deletion; Integrases / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; RNA, Messenger / genetics; RNA, Small Interfering / pharmacology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Up-Regulation
TL;DR:
TAK1 kinase could be a new and effective molecular target for ROS-based tumor killing and is examined whether ablation of TAK1 in preexisting skin tumors could cause an increase in ROS and result in tumor cell death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2010 journal article
RSK-Mediated Phosphorylation in the C/EBP beta Leucine Zipper Regulates DNA Binding, Dimerization, and Growth Arrest Activity
MOLECULAR AND CELLULAR BIOLOGY, 30(11), 2621–2635.
MeSH headings : Amino Acid Sequence; Animals; CCAAT-Enhancer-Binding Protein-beta / chemistry; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cell Cycle / physiology; Cell Line; DNA / genetics; DNA / metabolism; Growth Substances / metabolism; Humans; Leucine Zippers; MAP Kinase Signaling System / physiology; Mice; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Phosphorylation; Protein Multimerization; Protein Processing, Post-Translational; Rats; Ribosomal Protein S6 Kinases / antagonists & inhibitors; Ribosomal Protein S6 Kinases / genetics; Ribosomal Protein S6 Kinases / metabolism; Sequence Alignment; Transcriptional Activation; ras Proteins / genetics; ras Proteins / metabolism
TL;DR:
It is shown that C/EBPβ DNA binding is autorepressed and becomes activated by the Ras-Raf-MEK-ERK-p90RSK cascade and RSK-mediated phosphorylation of a bifunctional residue in the leucine zipper that regulates DNA binding and homodimerization and thereby promotes cell cycle arrest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Predicting Residential Air Exchange Rates from Questionnaires and Meteorology: Model Evaluation in Central North Carolina
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 44(24), 9349–9356.
MeSH headings : Air Movements; Air Pollutants / analysis; Air Pollution, Indoor / analysis; Air Pollution, Indoor / statistics & numerical data; Atmosphere / chemistry; Environmental Monitoring / methods; Forecasting; Meteorological Concepts; Models, Chemical; North Carolina; Particle Size; Seasons; Surveys and Questionnaires
TL;DR:
The capability of the LBL, LBLX, and SF models could help reduce the AER uncertainty in air pollution exposure models used to develop exposure metrics for health studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos
Journal of the American Chemical Society, 132(44), 15644–15650.
MeSH headings : Animals; Cells, Cultured; Embryo, Nonmammalian / metabolism; Gene Expression; Morpholines / chemistry; Oligonucleotides / genetics; Oligonucleotides / metabolism; Ultraviolet Rays; Xenopus laevis / genetics; Xenopus laevis / metabolism; Zebrafish / genetics; Zebrafish / metabolism
TL;DR:
A novel and efficient synthetic route for incorporating photocaged monomeric building blocks directly into morpholino oligomers is reported and the utility of these caged morpholinos in the light-activated control of gene function in both cell culture and living embryos is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro
Aquatic Toxicology (Amsterdam, Netherlands), 98(3), 245–255.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Bile Acids and Salts / pharmacology; Binding Sites; Fresh Water; Genes, Reporter / genetics; Humans; Molecular Sequence Data; Oryzias / genetics; Protein Isoforms / genetics; Protein Isoforms / metabolism; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Titrimetry; Transcriptional Activation / drug effects; Transcriptional Activation / genetics; Transfection
TL;DR:
M mammalian two-hybrid studies demonstrated the ability of Fxralpha2, but not FxRALpha1, to interact with PGC-1alpha and SRC-1, and supported the results from the transient transfection reporter gene activation assays.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2010 journal article
Intracellular Conversion of Environmental Nitrate and Nitrite to Nitric Oxide with Resulting Developmental Toxicity to the Crustacean Daphnia magna
PLoS ONE, 5(8), e12453.
Ed(s): X. Pan
MeSH headings : Animals; Animals, Newborn; Daphnia / cytology; Daphnia / drug effects; Daphnia / growth & development; Daphnia / metabolism; Drosophila / cytology; Drosophila / drug effects; Drosophila / metabolism; Ecdysteroids / metabolism; Ecosystem; Endocrine System / drug effects; Endocrine System / metabolism; Environmental Monitoring; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Female; Intracellular Space / drug effects; Intracellular Space / metabolism; Nitrates / metabolism; Nitrates / toxicity; Nitric Oxide / metabolism; Nitrites / metabolism; Nitrites / toxicity; Reproduction / drug effects; Risk
TL;DR:
Results demonstrate that nitrite elicits developmental and reproductive toxicity at environmentally relevant concentrations due likely to its intracellular conversion to nitric oxide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Interactions of the crustacean nuclear receptors HR3 and E75 in the regulation of gene transcription
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 167(2), 268–278.
author keywords: Daphnia pulex; Ecdysteroids; Endocrine disruptor; Nuclear receptors
TL;DR:
The premise that HR3 is a major component of ecdysteroid signaling in some crustaceans and is under the negative regulatory control of E75 is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 personal communication
IDH1 and IDH2 hotspot mutations are not found in canine glioma
Reitman, Z. J., Olby, N. J., Mariani, C. L., Thomas, R., Breen, M., Bigner, D. D., … Yan, H. (2010, July 1).
MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / veterinary; Dogs; Glioma / genetics; Glioma / veterinary; Isocitrate Dehydrogenase / genetics; Isoenzymes / genetics; Mutation
TL;DR:
Human diffuse and anaplastic astrocytomas, well-differenti-ated and anaPLastic oligodendrogliomas and secondary glio-blastomas frequently contain somatic mutations of the R132 codon of the cytoplasmic NADPþ-dependent iso-citrate dehydrogenase (IDH1) or the corresponding R172codon in its homolog, IDH2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamine
FOOD AND CHEMICAL TOXICOLOGY, 48(8-9), 2542–2546.
author keywords: Triazines; Melamine; Ruminants; Pharmacokinetics
MeSH headings : Animals; Chromatography, High Pressure Liquid; Dairying; Female; Food Contamination; Goats / metabolism; Half-Life; Linear Models; Mass Spectrometry; Milk / chemistry; Tissue Distribution; Triazines / blood; Triazines / pharmacokinetics
TL;DR:
The pharmacokinetics of melamine in ruminants is not predictive from monogastrics and milk from similarly exposed animals should be condemned for at least 4days after the last exposure to avoid violation of proposed MRLs or safe levels for milk.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Upper thermal tolerances of early life stages of freshwater mussels
JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY, 29(3), 959–969.
author keywords: freshwater mussel; Unionidae; glochidia; juvenile; temperature; thermal tolerance; LT50; LT05
TL;DR:
The results indicate that freshwater mussels already might be living close to their upper thermal tolerances in some systems and, thus, might be at risk from rising environmental temperatures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
TGF-beta-Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium
JOURNAL OF IMMUNOLOGY, 185(8), 4729–4737.
MeSH headings : Animals; Blotting, Western; Epithelium / enzymology; Epithelium / immunology; Gene Expression; Gene Expression Regulation / immunology; Immunity, Mucosal / physiology; Immunohistochemistry; Intestinal Mucosa / enzymology; Intestinal Mucosa / immunology; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-E2-Related Factor 2 / immunology; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / immunology; Reactive Oxygen Species / immunology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction
TL;DR:
It is reported that TGF-β–activated kinase 1 (TAK1) is a key regulator of ROS in the intestinal epithelium and regulates ROS through transcription factor NF-E2–related factor 2, which is important for intestinal epithelial integrity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Regulation of Genotoxic Stress Response by Homeodomain-interacting Protein Kinase 2 through Phosphorylation of Cyclic AMP Response Element-binding Protein at Serine 271
MOLECULAR BIOLOGY OF THE CELL, 21(16), 2966–2974.
MeSH headings : Animals; Antineoplastic Agents, Phytogenic / pharmacology; Blotting, Western; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; CREB-Binding Protein / genetics; CREB-Binding Protein / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Line, Tumor; Cells, Cultured; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; DNA Damage; Embryo, Mammalian / cytology; Etoposide / pharmacology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; HEK293 Cells; Humans; K562 Cells; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; RNA Interference; Serine / genetics; Serine / metabolism; Transcription, Genetic / drug effects; Two-Hybrid System Techniques
TL;DR:
Homeodomain-interacting protein kinase 2 is a new CREB kinase for phosphorylation at Ser-271 but not Ser-133 in genotoxic stress and activates CREB transactivation function including brain-derived neurotrophic factor (BDNF) mRNA expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Impact of Plastics on Fate and Transport of Organic Contaminants in Landfills
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 44(16), 6396–6402.
Contributors: J. Saquing n, C. Saquing n, D. Knappe n & M. Barlaz n
MeSH headings : Adsorption; Cities; Diffusion; Environmental Pollutants / chemistry; Hydrophobic and Hydrophilic Interactions; Motion; Organic Chemicals / chemistry; Plastics / chemistry; Refuse Disposal; Toluene / chemistry
TL;DR:
Plastics in landfills are potential sinks of hydrophobic organic contaminants (HOCs) because of their higher affinity for HOCs compared to lignocellulosic materials and the slow desorption of H OCs from glassy plastics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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