Works Published in 2021
Displaying works 61 - 80 of 263 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 journal article
Phase I/II Trial of Vemurafenib in Dogs with Naturally Occurring, BRAF-mutated Urothelial Carcinoma
MOLECULAR CANCER THERAPEUTICS, 20(11), 2177–2188.
MeSH headings : Adolescent; Animals; Carcinoma, Transitional Cell / drug therapy; Carcinoma, Transitional Cell / pathology; Child; Disease Models, Animal; Dogs; Humans; Mutation; Proto-Oncogene Proteins B-raf / drug effects; Vemurafenib / pharmacology; Vemurafenib / therapeutic use
TL;DR:
The safety, antitumor activity, and cutaneous pharmacodynamic effects of vemurafenib, and the development of drug resistance in dogs closely mimic those reported in humans, which suggests BRAF-mutated canine InvUC offers an important complementary animal model to improve BRAf-targeted therapies in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 23, 2021
2021 journal article
Photoactivated Carbon Dots for Inactivation of Foodborne Pathogens Listeria and Salmonella
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 87(23).
author keywords: carbon dots; foodborne pathogens; photoinactivation
MeSH headings : Carbon / pharmacology; Food Contamination / prevention & control; Listeria / drug effects; Nanoparticles; Salmonella / drug effects
TL;DR:
A newly established antimicrobial nanomaterials platform, CDots coupled with visible/natural light, is reported for effective and efficient inactivation of representative foodborne bacterial pathogens.
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 23, 2021
2021 journal article
Ritalinic acid in urine: Impact of age and dose
PRACTICAL LABORATORY MEDICINE, 27.
author keywords: Methylphenidate; Ritalinic acid; LC/MSMS; Urine drug testing
TL;DR:
Study of urine drug testing for ritalinic acid, the major urinary metabolite of methylphenidate (MP), indicates that school age children under the age of 18 have much higher levels of RA than adult patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 23, 2021
2021 journal article
Harnessing Whole Genome Sequence Data for Facility-Specific Signatures for Listeria monocytogenes: A Case Study With Turkey Processing Plants in the United States
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS, 5.
author keywords: Listeria monocytogenes; inlA; whole genome sequencing; turkey processing plant; persistence; plant-specific signatures; cgMLST; wgMLST
TL;DR:
Deploying whole genome sequencing data for intra-sample strain analysis allows for a more complete environmental surveillance of L. monocytogenes in food processing facilities, reducing the risk of failing to detect strains that may be clinically relevant and potentially novel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 15, 2021
2021 journal article
Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses
BIOLOGY OF REPRODUCTION, 105(4), 876–891.
author keywords: adrenomedullin; conceptus; uterine fluid; uterus; pigs
MeSH headings : Adrenomedullin / genetics; Adrenomedullin / metabolism; Animals; Embryo, Mammalian / metabolism; Female; Receptors, Adrenomedullin / genetics; Receptors, Adrenomedullin / immunology; Spatio-Temporal Analysis; Sus scrofa / embryology; Sus scrofa / genetics; Uterus / metabolism
TL;DR:
It is suggested that adrenomedullin plays a significant role in uterine receptivity and conceptus growth and development, via the stimulation of cell proliferation and activation of MTORC1 signaling pathway in the porcine conceptus trophectoderm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 15, 2021
2021 article
Sex-specific biomechanics and morphology of the anterior cruciate ligament during skeletal growth in a porcine model
Howe, D., Cone, S. G., Piedrahita, J. A., Collins, B., Fordham, L. A., Griffith, E. H., … Fisher, M. B. (2021, November 9). JOURNAL OF ORTHOPAEDIC RESEARCH.
author keywords: anterior cruciate ligament; knee; porcine model; skeletal growth
MeSH headings : Adolescent; Aged; Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Biomechanical Phenomena; Child; Female; Humans; Joint Instability; Knee Joint; Male; Swine; Tibia
TL;DR:
A porcine model is used to investigate the sex-specific morphology and biomechanics of the ACL and its bundles throughout skeletal growth and has implications for age and sex‐specific surgical intervention strategies and suggests the need for human studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: November 15, 2021
2021 journal article
Enzyme Complexes of Ptr4CL and PtrHCT Modulate Co-enzyme A Ligation of Hydroxycinnamic Acids for Monolignol Biosynthesis in Populus trichocarpa
FRONTIERS IN PLANT SCIENCE, 12.
author keywords: protein interaction; monolignol biosynthesis; wood formation; Populus trichocarpa; BiFC; metabolic flux
TL;DR:
It is proposed that Ptr4CL/PtrHCT complexes modulate the metabolic flux of CoA ligation for monolignol biosynthesis during wood formation in P. trichocarpa.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021
2021 journal article
Key Characteristics of Cardiovascular Toxicants
ENVIRONMENTAL HEALTH PERSPECTIVES, 129(9).
MeSH headings : Air Pollutants / analysis; Air Pollution / analysis; Carcinogens; Environmental Pollutants / toxicity; Hazardous Substances / toxicity; Particulate Matter / analysis
TL;DR:
The KCs could be used to identify potential CV toxicants and to define a set of test methods to evaluate CV toxicity in a more comprehensive and standardized manner than current approaches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021
2021 journal article
Multivariate spatial prediction of air pollutant concentrations with INLA
ENVIRONMENTAL RESEARCH COMMUNICATIONS, 3(10).
author keywords: air pollution; CMAQ; geostatistical model; INLA; linear model of coregionalization
TL;DR:
A spatial multipollutant data fusion model that combines monitoring measurements and chemical transport model simulations that leverages dependence between pollutants to improve spatial prediction and provides model-based prediction error estimates is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021
2021 article
Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis
Jackson, T. W., Baars, O., & Belcher, S. M. (2021, November 7). (Vol. 11). Vol. 11.
TL;DR:
It is demonstrated that Cd can preferentially cross the female placenta, accumulate in the liver, and cause lifelong dysregulation of metal ion concentrations associated with metabolic disruption.
(via Semantic Scholar)
Source: ORCID
Added: November 8, 2021
2021 journal article
Hygiene-Eliciting Brood Semiochemicals as a Tool for Assaying Honey Bee (Hymenoptera: Apidae) Colony Resistance to Varroa (Mesostigmata: Varroidae)
JOURNAL OF INSECT SCIENCE, 21(6).
Ed(s): M. Simone-Finstrom
author keywords: hygienic behavior; social immunity; chemical communication; alkene; unhealthy brood odor
MeSH headings : Animals; Beekeeping; Bees / chemistry; Bees / parasitology; Pheromones; Varroidae
TL;DR:
The hypothesis that hygienic response to a mixture of semiochemicals associated with Varroa-infested honey bee brood can serve as an improved tool for predicting colony-level VarroA resistance is tested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 2, 2021
2021 journal article
Soybeans as a non-Bt refuge for Helicoverpa zea in maize-cotton agroecosystems
AGRICULTURE ECOSYSTEMS & ENVIRONMENT, 322.
author keywords: Bollworm; Bt-refuge; Resistance management; Risk description; Row crops
TL;DR:
Soybeans in North Carolina and southeastern U.S. likely serves as a critical non-Bt refuge for delaying H. zea resistance to Bt toxins in landscapes dominated by Bt maize and cotton, and inverse distance weighted (IDW) soybeans is the most important predictor of H.Zea abundance through time in row crop agroecosystems inNorth Carolina.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 1, 2021
2021 article
Decade Long Upsurge In Target Site Pyrethroid Resistance In Bed Bug Populations In The United States
Lewis, C. D., Levine, B. A., Schal, C., Vargo, E. L., & Booth, W. (2021, October 26).
TL;DR:
The results suggest that the persistent use of pyrethroid insecticides over the past decade continues to impose strong selection pressure on C. lectularius populations, driving the proliferation of kdr-associated mutations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: October 27, 2021
2021 review
Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways
[Review of ]. REPRODUCTION, 162(5), F111–F130.
MeSH headings : Endocrine Disruptors / toxicity; Female; Humans; Male; Neurosecretory Systems; Pregnancy; Puberty; Reproduction; Semen Analysis
TL;DR:
This review focuses on endocrine disrupting compounds (EDCs), both naturally occurring and man-made, and summarizes how they interfere with the neuroendocrine system to adversely impact pregnancy outcomes, semen quality, age at puberty, and other aspects of human reproductive health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021
2021 journal article
Natural Horizontal Gene Transfer of Antimicrobial Resistance Genes in Campylobacter spp. From Turkeys and Swine
FRONTIERS IN MICROBIOLOGY, 12.
author keywords: antimicrobial resistance; Campylobacter; transformation; turkey; swine; animal experiment; co-culture experiment; horizontal gene transfer
TL;DR:
The potential for antimicrobial resistance transfer across Campylobacter species originating from turkeys and swine, which may have implications for farms hosting both species in close proximity, is highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 26, 2021
2021 journal article
A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation
FRONTIERS IN ONCOLOGY, 11.
author keywords: angiopellosis; circulating tumor cell cluster; tumor cell extravasation; cancer exodus hypothesis; metastasis; osteosarcoma
TL;DR:
Together, the results provide a novel experimental framework to study discrete steps in the metastatic process and identify the versican/ECM network dysregulation as a potential contributor to osteosarcoma circulating tumor cell metastasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021
2021 journal article
Design and in situ biosynthesis of precision therapies against gastrointestinal pathogens
CURRENT OPINION IN PHYSIOLOGY, 23.
TL;DR:
Recent progress in understanding of small molecules that inhibit specific virulence mechanisms point to an emerging integrative approach to treatment of gastrointestinal diseases, comprising microbiologists, peptide chemists, and synthetic biologists.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021
2021 article
Amino Acids in Cell Signaling: Regulation and Function
AMINO ACIDS IN NUTRITION AND HEALTH: AMINO ACIDS IN GENE EXPRESSION, METABOLIC REGULATION, AND EXERCISING PERFORMANCE, Vol. 1332, pp. 17–33.
author keywords: Functional amino acids; Transceptor; Sensor; mTORC1; AMPK; MAPK
MeSH headings : Amino Acids; Animals; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1 / genetics; Signal Transduction
TL;DR:
This work will discuss functional amino acids in cell signaling pathways in mammals with a particular emphasis on mTORC1, AMPK, and MAPK pathways for protein synthesis, nutrient sensing, and anti-inflammatory responses, as well as cell survival, growth, and development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021
2021 journal article
Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids
BMC BIOTECHNOLOGY, 21(1).
author keywords: Human cerebral organoids; Neurodevelopment; Agarose microwells; Microfabrication; RNAseq; Mechanobiology
MeSH headings : Brain; Cell Differentiation; Gene Expression Profiling; Humans; Organoids; Transcriptome
TL;DR:
A role for spatial factors in brain region specification during hCO development is suggested and this work observed that non-spherical shapes showed signs of altered neurodevelopmental kinetics and favored the development of medial ganglionic eminence-associated brain regions and cell types over cortical regions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 26, 2021
2021 journal article
Structure, dynamics, and regulation of TRF1-TIN2-mediated trans- and cis-interactions on telomeric DNA
JOURNAL OF BIOLOGICAL CHEMISTRY, 297(3).
MeSH headings : Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; DNA / metabolism; DNA-Binding Proteins / metabolism; Humans; Microscopy, Atomic Force / methods; Models, Molecular; Multiprotein Complexes / metabolism; Protein Binding; Protein Isoforms / metabolism; Shelterin Complex / metabolism; Shelterin Complex / physiology; Telomere / metabolism; Telomere-Binding Proteins / metabolism; Telomere-Binding Proteins / physiology; Telomeric Repeat Binding Protein 1 / metabolism; Telomeric Repeat Binding Protein 1 / physiology; Telomeric Repeat Binding Protein 2 / metabolism; Telomeric Repeat Binding Protein 2 / physiology
TL;DR:
Analysis of DNA molecular structures promoted by TRF1-TIN2 interaction supports a molecular model in which protein assemblies at telomeres are heterogeneous with distinct subcomplexes and full shelterin complexes playing distinct roles in telomere protection and elongation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 26, 2021
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