Works Published in 2015
Displaying works 101 - 120 of 134 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization
CHROMOSOME RESEARCH, 23(2), 171–186.
author keywords: Canine; Oral melanoma; Cytogenetics; Array; Comparative genomic hybridization
MeSH headings : Animals; Chromosome Aberrations; Cluster Analysis; Comparative Genomic Hybridization; Computational Biology; DNA Copy Number Variations; Dogs; Female; Humans; In Situ Hybridization, Fluorescence; Male; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mouth Neoplasms / genetics; Mouth Neoplasms / pathology; Penetrance; Skin Neoplasms
TL;DR:
This study suggests that in concordance with what is known for human melanomas, canine melanomas of the oral mucosa and cutaneous epithelium are discrete and initiated by different molecular pathways.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Canine urothelial carcinoma: genomically aberrant and comparatively relevant
CHROMOSOME RESEARCH, 23(2), 311–331.
author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
MeSH headings : Animals; Biopsy; Carcinoma / veterinary; Chromosome Aberrations; Comparative Genomic Hybridization; Computational Biology / methods; DNA Copy Number Variations; Dogs; Female; Genetic Loci; Genomics / methods; Humans; In Situ Hybridization, Fluorescence; Male; Urologic Neoplasms / veterinary
TL;DR:
It is proposed that common aberrations found in primary canine UC biopsies are indicative of an evolutionarily conserved mechanism of pathogenesis and harbor genes key to urothelial neoplasia, warranting investigation for diagnostic, prognostic, and therapeutic applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Applying Biopharmaceutical Classification System (BCS) Criteria to Predict Oral Absorption of Drugs in Dogs: Challenges and Pitfalls
AAPS JOURNAL, 17(4), 948–964.
author keywords: BCS; dogs; canine; permeability; solubility
MeSH headings : Administration, Oral; Animals; Biological Availability; Biological Transport; Computer Simulation; Dogs; Drug Design; Humans; Models, Biological; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / classification; Solubility; Species Specificity
TL;DR:
The results of this assessment strongly suggest that the human BCS classification system requires substantial modification before it can be reliably applied to dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Abdominal ultrasonographic findings in acromegalic cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 17(8), 698–703.
MeSH headings : Acromegaly / pathology; Acromegaly / veterinary; Animals; Case-Control Studies; Cat Diseases / blood; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Female; Insulin-Like Growth Factor I / metabolism; Male; Reference Values; Retrospective Studies; Statistics, Nonparametric; Ultrasonography
TL;DR:
Findings indicate that compared with non-acromegalic cats, age-matched acromegaly patients have measurably larger kidneys, adrenal glands and pancreas than poorly regulated diabetic cats exhibiting organomegaly on abdominal ultrasound examination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Unique Glycan Signatures Regulate Adeno-Associated Virus Tropism in the Developing Brain
JOURNAL OF VIROLOGY, 89(7), 3976–3987.
MeSH headings : Animals; Brain / virology; Dependovirus / physiology; Mice, Inbred BALB C; Receptors, Virus / metabolism; Sialic Acids / metabolism; Transduction, Genetic; Viral Tropism
TL;DR:
It is postulate that glycan signatures associated with host development can be exploited to redirect novel AAV vectors to specific cell types in the brain and suggest that carbohydrate content can be exploiting to regulate viral transport and tropism in the head.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 personal communication
The AVMA task force for antimicrobial stewardship in companion animal practice responds
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Recovery of normal esophageal function in a kitten with diffuse megaesophagus and an occult lower esophageal stricture
JOURNAL OF FELINE MEDICINE AND SURGERY, 17(6), 557–561.
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / therapy; Catheterization / veterinary; Cats; Endoscopy / veterinary; Esophageal Achalasia / complications; Esophageal Achalasia / veterinary; Esophageal Stenosis / complications; Esophageal Stenosis / veterinary; Male; Recovery of Function
TL;DR:
Management of kittens with radiographic findings suggestive of congenital megaesophagus by means of gastrostomy tube feeding may be associated with a return of normal esophageal motility and widening of the esophagal stricture, and facilitate subsequent success of interventional dilation of the EsophageAL stricture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes
AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(7), 649–655.
MeSH headings : Animals; Azathioprine / administration & dosage; Azathioprine / pharmacology; Cell Line; Cell Survival / drug effects; Dogs; Dose-Response Relationship, Drug; Hepatocytes / drug effects; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / pharmacology; Mercaptopurine / administration & dosage; Mercaptopurine / pharmacology; Thioguanine / administration & dosage; Thioguanine / pharmacology
TL;DR:
Results indicated that thiopurines adversely affected the viability of canine hepatocytes in a time- and concentration-dependent manner but had a nonsignificant effect on the LDH and ALT activities and free glutathione depletion of those hepatocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Cellular Postconditioning Allogeneic Cardiosphere-Derived Cells Reduce Infarct Size and Attenuate Microvascular Obstruction When Administered After Reperfusion in Pigs With Acute Myocardial Infarction
CIRCULATION-HEART FAILURE, 8(2), 322–332.
author keywords: acute myocardial infarction; animal models; coronary interventions; ischemic postconditioning
MeSH headings : Animals; Coronary Vessels; Disease Models, Animal; Heart Failure / surgery; Injections, Intra-Arterial; Ischemic Postconditioning / methods; Myocardial Infarction / complications; Myocardial Infarction / therapy; Myocardial Reperfusion; Stem Cell Transplantation / methods; Swine; Swine, Miniature; Transplantation, Homologous; Ventricular Remodeling / physiology
TL;DR:
A novel cardioprotective effect, which the authors call cellular postconditioning, differs from previous strategies to reduce IS in that it works even when initiated with significant delay after reflow.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Antimicrobial stewardship in companion animal practice
Journal of the American Veterinary Medical Association, 246(3), 287–288.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain
BMC VETERINARY RESEARCH, 11.
author keywords: Nerve growth factor; Dog; Antibody; Pain; Model; Osteoarthritis; Accelerometry; Actimetry
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / therapy; Dogs; Double-Blind Method; Female; Immunotherapy / veterinary; Male; Nerve Growth Factor / immunology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary
TL;DR:
These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain, similar to that expected with an NSAID.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A VALENTINE-SHAPED CARDIAC SILHOUETTE IN FELINE THORACIC RADIOGRAPHS IS PRIMARILY DUE TO LEFT ATRIAL ENLARGEMENT
VETERINARY RADIOLOGY & ULTRASOUND, 56(3), 245–250.
author keywords: atrium; cat; cardiomegaly; radiography; valentine shaped
MeSH headings : Animals; Cardiomegaly / diagnostic imaging; Cardiomegaly / etiology; Cardiomegaly / veterinary; Cat Diseases / diagnostic imaging; Cat Diseases / etiology; Cats; Cross-Sectional Studies; Echocardiography / veterinary; Female; Heart Atria / diagnostic imaging; Male; North Carolina; Radiography; Retrospective Studies
TL;DR:
The hypothesis that a valentine-shaped cardiac silhouette in radiographs is due primarily to left atrial enlargement in cats is supported, with right atrial enlargeement only impacting the shape if concurrent with severe left atri enlargement.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 354(3), 394–405.
MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents / administration & dosage; Antipruritics / administration & dosage; Cytokines / metabolism; Dermatitis, Allergic Contact / drug therapy; Dermatitis, Allergic Contact / metabolism; Disease Models, Animal; Female; Inflammation / drug therapy; Inflammation / metabolism; Janus Kinases / antagonists & inhibitors; Lymph Nodes / drug effects; Lymph Nodes / metabolism; Mice; Mice, Inbred BALB C; Piperidines / administration & dosage; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / administration & dosage; Pyrroles / administration & dosage; Skin / drug effects; Skin / metabolism; Sulfonamides / administration & dosage
TL;DR:
Oral treatment with JAK inhibitors reduced itch behavior dramatically but had only little effect on the inflammatory response, whereas topical treatment improved both itch and inflammatory response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins
PROTEOMICS, 15(15), 2678–2690.
author keywords: Animal proteomics; Endocrine disrupting compounds; Machine learning; Plasma; Semiquantitative proteomics; Support vector machines
MeSH headings : Animals; Bass / metabolism; Blood Proteins / metabolism; Blotting, Western; Chromatography, Liquid; Estradiol / pharmacology; Estrogens / pharmacology; Female; Fish Proteins / metabolism; Kininogens / metabolism; Male; Nanotechnology / methods; Proteome / drug effects; Proteome / metabolism; Proteomics / methods; Sex Factors; Support Vector Machine; Tandem Mass Spectrometry; Vitellogenins / metabolism
TL;DR:
This is the first report that Eltd1 and Kng1 may be E2‐responsive proteins in fishes and therefore may be useful indicators of estrogen induction in fishes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Evaluation of Copper Oxide Oxidation for Quantification of Lignin in Municipal Solid Waste
ENVIRONMENTAL ENGINEERING SCIENCE, 32(6), 486–496.
author keywords: municipal solid waste; CuO oxidation; lignin
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts
Journal of Cellular and Molecular Medicine, 19(8), 1805–1813.
author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy
MeSH headings : Aging; Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Dogs; Female; Fibrosis; Heart / physiology; Heart Function Tests; Mice, SCID; Myocardium / pathology; Myocytes, Cardiac / cytology; Neovascularization, Physiologic; Paracrine Communication; Regeneration; Spheroids, Cellular / cytology
TL;DR:
It is shown that canine CDCs can be produced from adult dog hearts and display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
CT AND MRI FEATURES OF CAROTID BODY PARAGANGLIOMAS IN 16 DOGS
VETERINARY RADIOLOGY & ULTRASOUND, 56(4), 374–383.
author keywords: carotid body tumor; chemodectoma; CT; dog; MRI; paraganglioma
MeSH headings : Animals; Carotid Arteries / diagnostic imaging; Carotid Arteries / pathology; Carotid Body Tumor / veterinary; Contrast Media; Cross-Sectional Studies; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dogs; Dyspnea / veterinary; Female; Head and Neck Neoplasms / veterinary; Lymph Nodes / diagnostic imaging; Lymph Nodes / pathology; Magnetic Resonance Imaging / veterinary; Male; Neoplasm Invasiveness; Radiographic Image Enhancement / methods; Retrospective Studies; Thyroid Neoplasms / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR:
Computed tomographic and magnetic resonance imaging characteristics of confirmed carotid body tumors in a multi-institutional sample of dogs helped explain some clinical presentations such as breathing difficulties, Horner's syndrome, head tilt, or facial nerve paralysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
BRAF Mutations in Canine Cancers
PLOS ONE, 10(6).
Contributors: H. Mochizuki n , K. Kennedy n, S. Shapiro n & M. Breen n
MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Dogs; Exons / genetics; Female; Genetic Predisposition to Disease; Humans; Male; Molecular Sequence Data; Mutation / genetics; Neoplasms / genetics; Neoplasms / veterinary; Proto-Oncogene Proteins B-raf / chemistry; Proto-Oncogene Proteins B-raf / genetics; Sequence Analysis, DNA
TL;DR:
The evolutional conservation of the BRAF V600E mutation highlights the importance of MAPK pathway activation in neoplasia and may offer opportunity for molecular diagnostics and targeted therapeutics for dogs bearing BRAF-mutated cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
The use of an open-field model to assess sound-induced fear and anxiety-associated behaviors in Labrador retrievers
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 10(4), 338–345.
author keywords: military working dogs; open-field test; fear; anxiety; thunderstorm; gunfire
TL;DR:
In general, candidate IED-detection Labrador retrievers responded to sound stimuli and recovered quickly, although dogs stratified in their response to sound stimulus, suggesting that dogs habituated to the open field arena.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Pharmacokinetics of a low dose and FDA-labeled dose of diclazuril administered orally as a pelleted topdressing in adult horses
Journal of Veterinary Pharmacology and Therapeutics, 38(3), 243–248.
MeSH headings : Administration, Oral; Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / blood; Antiprotozoal Agents / cerebrospinal fluid; Antiprotozoal Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Administration Schedule / veterinary; Female; Horses / metabolism; Male; Nitriles / administration & dosage; Nitriles / blood; Nitriles / cerebrospinal fluid; Nitriles / pharmacokinetics; Triazines / administration & dosage; Triazines / blood; Triazines / cerebrospinal fluid; Triazines / pharmacokinetics
TL;DR:
Results of this study show that diclazuril pellets given at the approved label dose and a lower dose both produce similar plasma drug concentrations at steady-state and attain plasma and CSF concentrations known to inhibit Sarcocystis neurona in cell culture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
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