Works Published in 2000
Displaying works 41 - 60 of 119 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2000 journal article
Characterization of a coronavirus isolated from a diarrheic foal
Journal of Clinical Microbiology, 38(12), 4523–4526.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Cellular and molecular mechanisms of action of linuron: An antiandrogenic herbicide that produces reproductive malformations in male rats
TOXICOLOGICAL SCIENCES, 56(2), 389–399.
author keywords: androgen binding; flutamide; linuron; reproductive malformations; androgen receptor (AR) antagonists
MeSH headings : Abnormalities, Drug-Induced; Androgen Antagonists / toxicity; Animals; COS Cells; Dibutyl Phthalate / toxicity; Dihydrotestosterone / pharmacology; Dose-Response Relationship, Drug; Female; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / pathology; Herbicides / toxicity; Linuron / toxicity; Male; Pregnancy; Rats; Rats, Sprague-Dawley; Transcriptional Activation / drug effects
TL;DR:
The hypothesis that linuron is an AR antagonist both in vivo and in vitro is supported, but it remains to be determined if linuron alters sexual differentiation by additional mechanisms of action.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
C-terminal alternative splicing changes the gating properties of a human spinal cord calcium channel alpha 1A subunit
Journal of Neuroscience, 20(20), 7564–7570.
MeSH headings : Alternative Splicing; Amino Acid Substitution; Animals; Calcium Channels / genetics; Calcium Channels / metabolism; Cells, Cultured; Cerebellum / metabolism; Exons; Gene Expression; Humans; Ion Channel Gating / genetics; Membrane Potentials / physiology; Microinjections; Molecular Sequence Data; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Oocytes / metabolism; Patch-Clamp Techniques; Protein Isoforms / genetics; Protein Isoforms / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Spinal Cord / metabolism; Xenopus
TL;DR:
It is demonstrated that C-terminal structural changes alone can influence the way in which α1A subunits respond to a depolarizing stimulus and add to the developing picture of the C terminus as a critical domain in the regulation of Ca2+ channel function.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Amoxicillin pharmacokinetics in harbor seals (Phoca vitulina) and northern elephant seals (Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 23(4), 223–228.
MeSH headings : Amoxicillin / administration & dosage; Amoxicillin / blood; Amoxicillin / pharmacokinetics; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Dose-Response Relationship, Drug; Injections, Intravenous / veterinary; Seals, Earless / classification; Seals, Earless / metabolism
TL;DR:
A true physiologic difference in drug handling, possibly related to renal perfusion or tubal secretory efficiency could affect amoxicillin kinetics in these species, and longer administration intervals may be appropriate for elephant seals as compared to harbor seals when administering multiple dose amoxicalin therapy at 20 mg/kg.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Administration of ticarcillin in combination with clavulanic acid intravenously and intrauterinely to clinically normal oestrous mares
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 23(6), 373–378.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid; Clavulanic Acid / administration & dosage; Clavulanic Acid / blood; Clavulanic Acid / pharmacokinetics; Cross-Over Studies; Drug Therapy, Combination; Female; Half-Life; Horses; Injections, Intravenous; Microbial Sensitivity Tests; Penicillins / administration & dosage; Penicillins / blood; Penicillins / pharmacokinetics; Ticarcillin / administration & dosage; Ticarcillin / blood; Ticarcillin / pharmacokinetics; Tissue Distribution
TL;DR:
It appears that addition of clavulanate to the formulation for treatment of i.u. infections in mares is of questionable value based on these concentrations, which would necessitate frequent treatment in order to maintain drug concentrations above the minimum inhibitory concentrations (MIC) throughout the treatment period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Evaluation of diet as a cause of gastric ulcers in horses
AMERICAN JOURNAL OF VETERINARY RESEARCH, 61(7), 784–790.
MeSH headings : Animal Feed / adverse effects; Animal Feed / analysis; Animals; Chromatography, Gas / veterinary; Cross-Over Studies; Endoscopy, Digestive System / veterinary; Fatty Acids, Volatile / analysis; Female; Gastric Mucosa / pathology; Gastrointestinal Contents / chemistry; Horse Diseases / etiology; Horse Diseases / pathology; Horses; Hydrogen-Ion Concentration; Lactic Acid / analysis; Random Allocation; Regression Analysis; Stomach Ulcer / etiology; Stomach Ulcer / pathology; Stomach Ulcer / veterinary
TL;DR:
Concentrations of acetic, propionic, and isovaleric acid were significantly higher in gastric juice, and number and severity of nonglandular squamous gastric lesions were significantly lower in horses fed alfalfa hay-grain, whereas valeric acid concentrations and butyric acid were useful in predicting severity of those lesions in Horses fed bromegrass hay.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia
STEM CELLS, 18(5), 360–365.
author keywords: thrombocytopenia; thrombopoietin; mimetic peptide; GW395058; canine; pharmacokinetics; pharmacodynamics
MeSH headings : Animals; Carboplatin / toxicity; Dogs; Female; Injections, Intravenous; Injections, Subcutaneous; Leukocyte Count / drug effects; Male; Metabolic Clearance Rate; Molecular Mimicry; Neoplasm Proteins; Neutrophils / drug effects; Peptides / blood; Peptides / pharmacokinetics; Peptides / pharmacology; Platelet Count / drug effects; Proto-Oncogene Proteins / agonists; Proto-Oncogene Proteins / physiology; Receptors, Cytokine; Receptors, Thrombopoietin; Thrombocytopenia / blood; Thrombocytopenia / chemically induced; Thrombocytopenia / therapy; Thrombopoietin / physiology
TL;DR:
The pharmacokinetics and pharmacodynamics of GW395058 were characterized using a randomized, crossover study in a large‐animal model (dog) of chemotherapy‐induced thrombocytopenia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
The computed tomographic enhancement pattern of the normal canine pituitary gland
VETERINARY RADIOLOGY & ULTRASOUND, 41(6), 507–510.
MeSH headings : Animals; Dogs / anatomy & histology; Male; Pituitary Gland / anatomy & histology; Pituitary Gland / diagnostic imaging; Reference Values; Tomography, X-Ray Computed / veterinary
TL;DR:
Establishing the enhancement pattern in the canine pituitary gland is the precursor to the clinical application of dynamic CT of the pituitsary gland to diagnose pituitaries microadenomas and/or small macroadenomas before they become exceptionally large.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
TGF-beta 1 and fibroblast growth factor-1 modify fibroblast growth factor-2 production in type II cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 279(6), L1038–L1046.
author keywords: basic fibroblast growth factor; acidic fibroblast growth factor; alveolar epithelium; alveolar injury; pulmonary fibrosis; transforming growth factor
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Pulmonary Fibrosis / metabolism; RNA, Messenger / analysis; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases / genetics; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor / genetics; Specific Pathogen-Free Organisms; Transforming Growth Factor beta / pharmacology
TL;DR:
Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factors (TGF)-β1, an important inflammatory cytokine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Results of irradiation of infiltrative lipoma in 13 dogs
VETERINARY RADIOLOGY & ULTRASOUND, 41(6), 554–556.
author keywords: infiltrating or infiltrative lipoma; radiation therapy; canine
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Female; Lipoma / mortality; Lipoma / radiotherapy; Lipoma / veterinary; Male; North Carolina / epidemiology; Records / veterinary; Retrospective Studies; Survival Analysis; Tomography, X-Ray Computed / veterinary; Treatment Outcome
TL;DR:
It appears that dogs with infiltrative lipomas can benefit from external beam irradiation alone or in combination with surgery to effect long-term local tumor control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Insulin-like growth factor I receptor Mrna and protein expression in pig corpora lutea
Journal of Reproduction & Fertility, 120(1), 109–114.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2000 journal article
Excretion patterns of mucosally delivered antibodies to p23 in Cryptosporidium parvum infected calves
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 76(3-4), 309–317.
author keywords: cryptosporidiosis; mucosal antibodies; excretion patterns; calves; anti-p23
MeSH headings : Animals; Animals, Newborn; Antibodies, Protozoan / immunology; Antibodies, Protozoan / physiology; Cattle; Cattle Diseases / immunology; Cattle Diseases / parasitology; Cryptosporidiosis / immunology; Cryptosporidiosis / parasitology; Cryptosporidiosis / veterinary; Cryptosporidium parvum / growth & development; Cryptosporidium parvum / immunology; Feces / parasitology; Flow Cytometry / veterinary; Immunity, Mucosal / physiology; Immunoassay / veterinary; Immunoglobulin Isotypes / immunology; Immunoglobulin Isotypes / physiology; Male; Microspheres; Specific Pathogen-Free Organisms
TL;DR:
Fecal samples obtained at intervals from six calves with acute cryptosporidiosis contained antibodies of multiple isotypes to p23, and one calf that died following exposure to Cryptosporidium parvum oocysts lacked detectable anti-p23 antibodies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Effect of an intravitreal cyclosporine implant on experimental uveitis in horses
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 76(3-4), 239–255.
author keywords: uveitis; cyclosporine; intravitreal; equine; experimental
MeSH headings : Animals; Aqueous Humor / drug effects; Aqueous Humor / immunology; Aqueous Humor / metabolism; Cyclosporine / administration & dosage; Cyclosporine / immunology; Cyclosporine / pharmacokinetics; Drug Implants; Horse Diseases / drug therapy; Horse Diseases / immunology; Horses; Immunohistochemistry / veterinary; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / immunology; Immunosuppressive Agents / pharmacokinetics; Interferon-gamma / biosynthesis; Interferon-gamma / metabolism; Interleukin-2 / biosynthesis; Interleukin-2 / metabolism; Lymphocyte Count / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes / cytology; T-Lymphocytes / drug effects; Uveitis / drug therapy; Uveitis / immunology; Uveitis / veterinary
TL;DR:
CsA implants did not completely eliminate the development of a second ('recurrent') experimental inflammatory episode in these horses, but the duration and severity of inflammation, cellular infiltration, tissue destruction, and pro-inflammatory cytokines RNA transcript levels were significantly less in those eyes implanted with the CsA device.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Differential expression of c-Jun proteins during Mullerian duct growth and apoptosis: caspase-related tissue death blocked by diethylstilbestrol
CELL AND TISSUE RESEARCH, 302(3), 377–385.
author keywords: Mullerian duct; apoptosis; c-Jun proteins; caspase; diethylstilbestrol; chicken (White leghorn)
MeSH headings : Animals; Apoptosis / drug effects; Blotting, Western; Caspase 3; Caspases / metabolism; Cell Nucleus / ultrastructure; Chick Embryo; DNA Fragmentation / drug effects; Diethylstilbestrol / pharmacology; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression / drug effects; Mullerian Ducts / drug effects; Mullerian Ducts / growth & development; Mullerian Ducts / metabolism; Protein Isoforms / biosynthesis; Protein Isoforms / physiology; Proto-Oncogene Proteins c-jun / biosynthesis; Proto-Oncogene Proteins c-jun / physiology
TL;DR:
High caspase-3 activity (determined by the measurement of the fragmented 85-kDa poly ADP-ribose polymerase) was found in the RMD during apoptosis, and the apoptotic death of RMD was prevented by in vivo diethylstilbestrol treatment, which inhibited the overexpression of the 66-k Da and 45-k da proteins, the fragmentation of DNA, andThe activity of casp enzyme-3.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Comparison of virus isolation, immunohistochemistry, and reverse transcriptase-polymerase chain reaction procedures for detection of turkey coronavirus
AVIAN DISEASES, 44(3), 624–631.
author keywords: turkey coronavirus; reverse transcriptase-polymerase chain reaction
TL;DR:
The utility of both immunohistochemistry and RT-PCR for detection of TCV is demonstrated and it is indicated that RT- PCR is a highly sensitive and specific alternative to conventional diagnostic procedures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 patent
Anti-Cryptosporidium parvum preparations
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Reduction of diepoxybutane-induced sister chromatid exchanges by glutathione peroxidase and erythrocytes in transgenic Big Blue (R) mouse and rat fibroblasts
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 447(2), 267–274.
author keywords: Big Blue (R); SCE; diepoxybutane; detoxification
MeSH headings : Animals; Cells, Cultured; Cytogenetic Analysis; Dose-Response Relationship, Drug; Epoxy Compounds / adverse effects; Erythrocytes / physiology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Glutathione Peroxidase / pharmacology; Male; Mice; Mice, Transgenic; Mitotic Index / drug effects; Mutagens / adverse effects; Rats; Sister Chromatid Exchange / drug effects
TL;DR:
GSH-Px may be important in the detoxification of DEB-induced DNA damage that results in the formation of SCEs, according to the observed differences in the rodent carcinogenic response to BD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Protective immunity against feline immunodeficiency virus induced by inoculation with vif-deleted proviral DNA
VIROLOGY, 273(1), 67–79.
MeSH headings : Animals; Antibodies, Viral / immunology; Antigens, Viral / immunology; Cats; DNA, Viral / administration & dosage; DNA, Viral / analysis; DNA, Viral / genetics; Gene Deletion; Gene Products, env / immunology; Gene Products, gag / immunology; Gene Products, vif / genetics; Genome, Viral; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Lentivirus Infections / immunology; Lentivirus Infections / prevention & control; Lentivirus Infections / virology; Lymphocyte Count; Proviruses / genetics; T-Lymphocytes, Cytotoxic / immunology; Time Factors; Vaccines, DNA / genetics; Vaccines, DNA / immunology; Viral Vaccines / genetics; Viral Vaccines / immunology
TL;DR:
Findings indicate that inoculation with FIV-pPPR-Deltavif proviral DNA induced resistance to challenge with infectious FIV and that a vif deletion mutant may provide a relatively safe attenuated lentiviral vaccine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Preliminary investigation of doxycycline plasma concentrations in cockatiels (Nymphicus hollandicus) after administration by injection or in water or feed
Journal of Avian Medicine and Surgery, 14(1), 23–30.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Local 42 degrees C hyperthermia improves vascular conductance of the R3230Ac rat mammary adenocarcinoma during sodium nitroprusside infusion
RADIATION RESEARCH, 154(2), 196–201.
TL;DR:
Local 42°C tumor heating, combined with a moderate reduction in blood pressure with nitroprusside, overrides the vascular steal effect associated with reduced perfusion pressure alone and results in improved tumor perfusion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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