Works Published in 2011
Displaying works 61 - 80 of 127 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Interaction between Geminivirus Replication Protein and the SUMO-Conjugating Enzyme Is Required for Viral Infection
JOURNAL OF VIROLOGY, 85(19), 9789–9800.
MeSH headings : Amino Acid Substitution; Binding Sites; DNA Mutational Analysis; Geminiviridae / pathogenicity; Host-Pathogen Interactions; Mutagenesis, Site-Directed; Mutant Proteins / genetics; Mutant Proteins / metabolism; Protein Binding; Protein Interaction Mapping; Sequence Deletion; Tobacco / virology; Ubiquitin-Conjugating Enzymes / metabolism; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR:
The results established the importance of AL1-SCE1 interactions during geminivirus infection of plants and suggested that AL1 alters the sumoylation of selected host factors to create an environment suitable for viral infection.
(via Semantic Scholar)
jvi.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes
CHROMOSOME RESEARCH, 19(6), 685–708.
author keywords: B chromosomes; fragile breakage model; breakpoint reuse theory; fluorescence in situ hybridization; phylogenetic; Canidae
MeSH headings : Animals; Biological Evolution; Canidae / genetics; Chromosome Mapping; Chromosome Painting; Chromosomes, Artificial, Bacterial; Chromosomes, Mammalian / genetics; Cytogenetics; Dogs / genetics; Foxes / genetics; Genome; In Situ Hybridization, Fluorescence; Raccoon Dogs / genetics
TL;DR:
This work suggests that the complex karyotype rearrangements associated with speciation of the Canidae reflect unstable chromosome regions described by the fragile breakage model and provides evidence that these breakpoints are also recurrently associated with spontaneous canine cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 review
Regulation of mucin secretion and inflammation in asthma: A role for MARCKS protein?
[Review of ]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1810(11), 1110–1113.
author keywords: MARCKS; Mucin; Secretion; Asthma
MeSH headings : Animals; Asthma / etiology; Humans; Inflammation / etiology; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / physiology; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate
TL;DR:
The properties of MARCKS and how the protein may regulate mucin secretion at a cellular level will be discussed and the roles ofMARCKS in airway inflammation related to both influx of inflammatory cells into the lung and release of granules containing inflammatory mediators by these cells will be explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration
TRANSGENIC RESEARCH, 20(6), 1391–1395.
author keywords: Transgenic; Pig; Rhodopsin; Phenotype
MeSH headings : Age Factors; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Eosine Yellowish-(YS) / metabolism; Eye / pathology; Female; Hematoxylin / metabolism; Inbreeding; Inheritance Patterns; Male; Phenotype; Photoreceptor Cells, Vertebrate / metabolism; Photoreceptor Cells, Vertebrate / pathology; Retina / metabolism; Retina / pathology; Retinal Degeneration / pathology; Rhodopsin / genetics; Rhodopsin / metabolism; Staining and Labeling; Swine / genetics; Swine / metabolism; Transgenes
TL;DR:
The phenotype, based on assessment of photoreceptor degeneration, is similar to that of the first description of the transgenic animals and can be used confidently in future studies of the type of retinal degeneration seen with retinitis pigmentosa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 article
Pharmacokinetics of orally administered phenobarbital in African grey parrots (Psittacus erithacus erithacus)
Powers, L. V., & Papich, M. G. (2011, December). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 34, pp. 615–617.
MeSH headings : Administration, Oral; Animals; Anticonvulsants / administration & dosage; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Female; Fluorescence Polarization Immunoassay / veterinary; Half-Life; Male; Parrots / blood; Phenobarbital / administration & dosage; Phenobarbital / blood; Phenobarbital / pharmacokinetics
TL;DR:
This investigation was performed to examine the pharmacokinetics of orally administered phenobarbital in African grey parrots and to present this as a preliminary report that can potentially serve as a basis for further study.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 article
Leflunomide pharmacokinetics after single oral administration to dogs
Singer, L. M., Cohn, L. A., Reinero, C. R., & Papich, M. G. (2011, December). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 34, pp. 609–611.
MeSH headings : Administration, Oral; Animals; Chromatography, High Pressure Liquid / veterinary; Crotonates / blood; Crotonates / pharmacokinetics; Dogs / blood; Drug Administration Schedule / veterinary; Female; Half-Life; Hydroxybutyrates; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / blood; Immunosuppressive Agents / pharmacokinetics; Isoxazoles / administration & dosage; Isoxazoles / blood; Isoxazoles / pharmacokinetics; Leflunomide; Linear Models; Nitriles; Toluidines / blood; Toluidines / pharmacokinetics
TL;DR:
Leflunomide has been used as an adjunctive therapy for dogs refractory to traditional immunosuppressive drugs and to prevent anti-allograft immune responses and all procedures were approved by the NIH Guide for the Care and Use of Laboratory Animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Host immune responses that promote initial HIV spread
JOURNAL OF THEORETICAL BIOLOGY, 289, 17–35.
author keywords: HIV; Innate inflammatory response pathway; Regulatory response pathway; Mathematical model
MeSH headings : CD4-Positive T-Lymphocytes / immunology; Dendritic Cells / immunology; HIV / physiology; HIV Infections / immunology; HIV Infections / transmission; HIV Infections / virology; Humans; Inflammation / immunology; Inflammation / virology; Lymphocyte Activation / immunology; Models, Immunological; T-Lymphocytes, Regulatory / immunology; Virus Replication / immunology
TL;DR:
A model of the host inflammatory response to virus as well as inherent nTreg-mediated regulation of Th1 recruitment and activation is created to identify mechanisms of the natural inflammatory response that are best targeted to inhibit viral spread without compromising initial antiviral activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
EFFECTS OF INTRAMUSCULAR MELOXICAM ADMINISTRATION ON PROSTAGLANDIN E2 SYNTHESIS IN THE NORTH AMERICAN BULLFROG (RANA CATESBEIANA)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 42(4), 680–685.
author keywords: Meloxicam; nonsteroidal anti-inflammatory; prostaglandin e2; North American bullfrog; Rana catesbeiana
MeSH headings : Animals; Dinoprostone / biosynthesis; Dinoprostone / blood; Dinoprostone / genetics; Gene Expression Regulation / drug effects; Injections, Intramuscular; Meloxicam; Rana catesbeiana / metabolism; Thiazines / administration & dosage; Thiazines / pharmacology; Thiazoles / administration & dosage; Thiazoles / pharmacology
TL;DR:
It is suggested that the systemic administration of meloxicam at a dosage of 0.1 mg/kg once daily suppresses circulating serum PGE2 levels postinjury in the North American bullfrog.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart
GENES CHROMOSOMES & CANCER, 50(11), 859–874.
MeSH headings : Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Comparative Genomic Hybridization; Core Binding Factor Alpha 1 Subunit / genetics; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Gene Dosage; Genomic Instability; Humans; In Situ Hybridization, Fluorescence; Male; Membrane Proteins / genetics; Osteosarcoma / genetics; Osteosarcoma / veterinary; PTEN Phosphohydrolase / genetics; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Tumor Suppressor Proteins / genetics
TL;DR:
Large scale screening of genomic imbalance in canine OS further validates the use of the dog as a suitable model for human cancers, supporting the idea that dysregulation discovered in canine cancers will provide an avenue for complementary study in human counterparts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector
CLINICAL AND VACCINE IMMUNOLOGY, 18(11), 1834–1844.
MeSH headings : Adjuvants, Immunologic / genetics; Administration, Oral; Animals; B-Lymphocytes / immunology; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Blood / immunology; Colon / immunology; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers / administration & dosage; Female; Flagellin / genetics; Genetic Vectors; Humans; Intestinal Mucosa / immunology; Lactobacillus / genetics; Lactobacillus / immunology; Mice; Mice, Inbred BALB C; Plasmids; Toll-Like Receptor 5 / immunology
TL;DR:
In vivo studies established that treatment with L. gasseri led to a diversification of B-cell populations in the lamina propria of the murine colon and a significant decrease in the percentage of FoxP3+ colonic lymphocytes, and in vivo data clarify the interaction of L. Gasseri with the host immune system and support further investigation of the in vivo immunogenicity of the vector.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Genomic Profiling in CEPH Cell Lines Distinguishes between the Camptothecins and Indenoisoquinolines
MOLECULAR CANCER THERAPEUTICS, 10(10), 1839–1845.
MeSH headings : Antineoplastic Agents, Phytogenic / pharmacology; Camptothecin / pharmacology; Cell Line; Drug Evaluation, Preclinical / methods; Gene Expression Profiling; Genomics / methods; Humans; Isoquinolines / pharmacology; Oligonucleotide Array Sequence Analysis; Quantitative Trait Loci; Topoisomerase I Inhibitors / pharmacology
TL;DR:
In vitro sensitivity of the same panel of CEPH cell lines to the indenisoquinolones, a structurally distinct class of Top1 inhibitors, is characterized, revealing a pattern of 7 quantitative trait loci (QTL) shared by all of the camptothecins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 article
Pathology in Practice
Tobias, J. R., Barnes, H. J., & Law, J. M. H. (2011, October 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 239, pp. 1065–1067.
MeSH headings : Adenocarcinoma / pathology; Adenocarcinoma / veterinary; Animals; Chickens; Female; Liver Neoplasms / secondary; Liver Neoplasms / veterinary; Oviducts / pathology; Peritoneal Neoplasms / secondary; Peritoneal Neoplasms / veterinary; Poultry Diseases / pathology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Wood Biodegradation in Laboratory-Scale Landfills
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 45(16), 6864–6871.
TL;DR:
Wood species have unique methane yields that should be considered in the development of national inventories of methane production and carbon storage and the current assumption of uniform biodegradability is not appropriate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Two Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Paralogs are Required for Normal Development in Zebrafish
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 294(9), 1511–1524.
author keywords: MARCKS; zebrafish; development
MeSH headings : Amino Acid Sequence; Animals; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / metabolism; Molecular Sequence Data; Morpholinos / pharmacology; Multigene Family; Myristoylated Alanine-Rich C Kinase Substrate; Phenotype; Phylogeny; Sequence Homology, Amino Acid; Zebrafish / genetics; Zebrafish / growth & development
TL;DR:
It is demonstrated that Marcksa and Marcksb are required for normal zebrafish development and suggested that zebra fish are a suitable model to further study MARCKS function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 review
The Role of Imprinted Genes in Fetal Growth Abnormalities
[Review of ]. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 91(8), 682–692.
MeSH headings : Animals; Epigenesis, Genetic; Female; Fetal Development; Fetus / abnormalities; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Humans; Pregnancy; Pregnancy Complications / genetics
TL;DR:
Imprinting-associated disorders in humans and assisted reproductive technologies in animals have been shown to affect the epigenome of the early embryo and the expression of imprinted genes, and their role in disorders such as intrauterine growth restriction appears to be more complex.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
BONE, 49(3), 356–367.
author keywords: Osteosarcoma; Gene expression profiling; Cell cycle; DNA damage checkpoint; Tumor microenvironment; Canine
MeSH headings : Animals; Bone Neoplasms / classification; Bone Neoplasms / genetics; Bone Neoplasms / pathology; Cluster Analysis; Cohort Studies; Cyclin B2 / genetics; Cyclin B2 / metabolism; Dogs; Female; Gene Expression Profiling; Humans; Kaplan-Meier Estimate; Male; Oligonucleotide Array Sequence Analysis / methods; Osteosarcoma / classification; Osteosarcoma / genetics; Osteosarcoma / pathology; Prognosis; Vimentin / genetics; Vimentin / metabolism
TL;DR:
The results indicate that the narrower genetic diversity of dogs can be utilized to group complex human osteosarcoma into biologically and clinically relevant molecular subtypes, which in turn may enhance prognosis and prediction, and identify relevant therapeutic targets.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Dissimilar Properties of Two Recombinant Lactobacillus acidophilus Strains Displaying Salmonella FliC with Different Anchoring Motifs
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77(18), 6587–6596.
MeSH headings : Acids / metabolism; Antigens, Bacterial / genetics; Antigens, Bacterial / metabolism; Cells, Cultured; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers; Drug Stability; Flagellin / genetics; Flagellin / metabolism; Genetic Vectors; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Peptide Hydrolases / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Salmonella Vaccines / genetics; Salmonella Vaccines / immunology; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology
TL;DR:
Two recombinant L. acidophilus derivatives displaying Salmonella flagellin were constructed using different anchor motifs, and the surface-associated antigen was highly sensitive to simulated gastric and small intestinal juices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Development of a Brain Metastatic Canine Prostate Cancer Cell Line
PROSTATE, 71(12), 1251–1263.
author keywords: prostate cancer; brain metastasis; spinal cord metastasis; dog; canine; bone metastasis
MeSH headings : Adrenal Gland Neoplasms / epidemiology; Adrenal Gland Neoplasms / secondary; Animals; Antineoplastic Agents / pharmacology; Bone Neoplasms / epidemiology; Bone Neoplasms / secondary; Boronic Acids / pharmacology; Bortezomib; Brain Neoplasms / epidemiology; Brain Neoplasms / metabolism; Brain Neoplasms / pathology; Brain Neoplasms / secondary; Carcinogenicity Tests; Carcinoma / epidemiology; Carcinoma / metabolism; Carcinoma / pathology; Carcinoma / secondary; Cell Division; Cell Line, Tumor / drug effects; Cell Line, Tumor / pathology; Dogs; Immunohistochemistry; Incidence; Injections, Subcutaneous; Keratin-18 / metabolism; Keratin-7 / metabolism; Keratin-8 / metabolism; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Connective Tissue / secondary; Parathyroid Hormone-Related Protein / metabolism; Phenylbutyrates / antagonists & inhibitors; Prostatic Neoplasms / pathology; Pyrazines / pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord Neoplasms / epidemiology; Spinal Cord Neoplasms / secondary; Subcutaneous Tissue; Transplantation, Heterologous
TL;DR:
The goal of the study was to establish and characterize a new prostate cancer line derived from a dog with spontaneous prostate cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Specification of a Foxj1-Dependent Lineage in the Forebrain Is Required for Embryonic-to-Postnatal Transition of Neurogenesis in the Olfactory Bulb
JOURNAL OF NEUROSCIENCE, 31(25), 9368–9382.
MeSH headings : Animals; Forkhead Transcription Factors / metabolism; Mice; Mice, Knockout; Neurogenesis / physiology; Neurons / physiology; Olfactory Bulb / embryology; Olfactory Bulb / physiology; Prosencephalon / embryology; Prosencephalon / physiology
TL;DR:
For the first time, this study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Ronidazole pharmacokinetics after intravenous and oral immediate-release capsule administration in healthy cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 13(4), 244–250.
MeSH headings : Administration, Oral; Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / pharmacokinetics; Biological Availability; Cat Diseases / drug therapy; Cats / metabolism; Cross-Over Studies; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Metabolic Clearance Rate; Protozoan Infections, Animal / drug therapy; Random Allocation; Ronidazole / administration & dosage; Ronidazole / pharmacokinetics; Tritrichomonas foetus / drug effects
TL;DR:
The high oral bioavailability of RDZ and slow elimination may predispose cats to neurotoxicity with twice-daily administration, and less frequent administration should be considered for further study of effective treatment of T foetus-infected cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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