Works Published in 2009
Displaying works 81 - 100 of 148 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses
AMERICAN JOURNAL OF VETERINARY RESEARCH, 70(10), 1259–1268.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Clonixin / adverse effects; Clonixin / analogs & derivatives; Female; Gene Expression Regulation, Enzymologic / drug effects; Horse Diseases / chemically induced; Horse Diseases / drug therapy; Horses; Intestinal Diseases / chemically induced; Intestinal Diseases / veterinary; Ischemia / chemically induced; Jejunum / drug effects; Lidocaine / therapeutic use; Male; Prostaglandin-Endoperoxide Synthases / genetics; Prostaglandin-Endoperoxide Synthases / metabolism
TL;DR:
In horses with ischemia-injured jejunum, lidocaine administered IV reduced plasma prostaglandin E(2) metabolite concentration and mucosal COX-2 expression and coadministration of lidocane with flunixin ameliorated the flunxin-induced increase in mucosal neutrophil counts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Small Interfering RNAs (siRNAs) Targeting TGF-beta(1) mRNA Suppress Asbestos-Induced Expression of TGF-beta(1) and CTGF in Fibroblasts
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, 28(2), 109–119.
author keywords: interstitial lung disease; RNA interference; small interfering RNA; transforming growth factor-beta(1); connective tissue growth factor; asbestos
MeSH headings : 3T3 Cells; Animals; Asbestos, Serpentine / toxicity; Base Sequence; Connective Tissue Growth Factor / genetics; DNA Primers; Disease Models, Animal; Fibroblasts / metabolism; Gene Knockdown Techniques; Lung Diseases, Interstitial / chemically induced; Lung Diseases, Interstitial / genetics; Mice; Polymerase Chain Reaction; RNA Interference; RNA, Messenger / genetics; RNA, Small Interfering / genetics; Transforming Growth Factor beta1 / genetics
TL;DR:
It is suggested that siRNAs could be effective in preventing or possibly arresting the progression of pulmonary fibrosis, and studies are underway in vivo to test this postulate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Mycobacterium chelonae sensitisation induces CD4(+)-mediated cytotoxicity against BCG
EUROPEAN JOURNAL OF IMMUNOLOGY, 39(7), 1841–1849.
author keywords: Bacterial infections; CD4 T cells; Cytotoxicity; Host-pathogen interactions; Immune responses
MeSH headings : Animals; Antibodies / immunology; CD4-Positive T-Lymphocytes / cytology; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD56 Antigen / immunology; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Cytotoxicity, Immunologic / immunology; Fas Ligand Protein / immunology; Fas Ligand Protein / metabolism; Flow Cytometry; Interferon-gamma / immunology; Interferon-gamma / metabolism; Interleukin-10 / immunology; Interleukin-10 / metabolism; Lung / immunology; Lung / microbiology; Lung / pathology; Mice; Mice, Inbred BALB C; Mycobacterium bovis / immunology; Mycobacterium chelonae / immunology; Perforin / immunology; Perforin / metabolism; Tuberculosis / immunology; Tuberculosis / microbiology; Tuberculosis / veterinary
TL;DR:
This is the first report describing cytotoxicity against BCG‐infected cells as a mechanism underlying the influence of Env sensitisation on subsequent BCG responses, and it is postulated that it could be due to Env‐specific T cells exerting cytot toxicity againstBCG‐ Infected host cells.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Mesenchymal stem cells produce Wnt isoforms and TGF-beta(1) that mediate proliferation and procollagen expression by lung fibroblasts
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 297(5), L1002–L1011.
author keywords: peptide growth factors; pulmonary fibrosis
MeSH headings : Animals; Antibodies / pharmacology; Bone Marrow Cells / cytology; Cell Proliferation / drug effects; Coculture Techniques; Collagen Type I / genetics; Collagen Type I / metabolism; Culture Media, Conditioned / pharmacology; Fetal Blood / cytology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Regulation / drug effects; Humans; Intracellular Signaling Peptides and Proteins; Lung / cytology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Mice; Platelet-Derived Growth Factor / metabolism; Polymerase Chain Reaction; Protein Isoforms / metabolism; Proteins / pharmacology; Solubility / drug effects; Transforming Growth Factor beta1 / antagonists & inhibitors; Transforming Growth Factor beta1 / metabolism; Wnt Proteins / metabolism; beta Catenin / metabolism
TL;DR:
It is demonstrated that MSC from mice and humans produce Wnt proteins and TGF-beta1 that respectively stimulate LF proliferation and matrix production, two hallmarks of fibroproliferative lung disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 297(1), L164–L173.
author keywords: epithelium; interleukin-4; STAT6; IRS-1; IRS-2
MeSH headings : Air; Cell Differentiation / drug effects; Cell Line; Cell Movement / drug effects; DNA, Complementary / genetics; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Genes, Dominant; Humans; Insulin Receptor Substrate Proteins / metabolism; Interleukin-4 / pharmacology; Lung / cytology; Lung / pathology; Phosphorylation / drug effects; RNA, Small Interfering / metabolism; STAT6 Transcription Factor / metabolism
TL;DR:
It is demonstrated that IL-4 can accelerate migration of differentiated AEC after injury, and this reparative response does not require STAT6 activation, but rather requires IRS-1 and/or IRS-2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity
Molecular Immunology, 46(7), 1505–1516.
author keywords: Zebrafish; Mouse; rag1; Innate immunity; SCID
MeSH headings : Adaptation, Physiological / genetics; Adaptation, Physiological / immunology; Animals; Animals, Genetically Modified; Blood Coagulation Factors / genetics; Blood Coagulation Factors / metabolism; Complement C4 / genetics; Complement C4 / metabolism; Complement System Proteins / genetics; Complement System Proteins / metabolism; Female; Gene Expression Profiling; Genes, RAG-1 / physiology; Immunity / genetics; Immunity / physiology; Intestinal Mucosa / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Up-Regulation; Zebrafish
TL;DR:
It is hypothesized that the rag1(-/-) zebrafish may possess an "enhanced" innate immune response to compensate for the lack of an adaptive immune system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Assessment of clotrimazole gels for in vitro stability and in vivo retention in the frontal sinus of dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 70(5), 640–647.
MeSH headings : Animals; Antifungal Agents / chemistry; Antifungal Agents / metabolism; Antifungal Agents / pharmacokinetics; Clotrimazole / chemistry; Clotrimazole / metabolism; Clotrimazole / pharmacokinetics; Dogs / metabolism; Drug Stability; Frontal Sinus / diagnostic imaging; Frontal Sinus / metabolism; Gels / chemistry; Gels / metabolism; Male; Poloxamer / chemistry; Poloxamer / metabolism; Tomography, X-Ray Computed / veterinary
TL;DR:
Poloxamer gels had the most promise for improving drug contact within the frontal sinus of dogs, while limiting the inflammatory response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 review
Update on Genomics in Veterinary Oncology
[Review of ]. TOPICS IN COMPANION ANIMAL MEDICINE, 24(3), 113–121.
author keywords: cancer; genomics; oncology; technology; veterinary
MeSH headings : Animals; Cat Diseases / genetics; Cats; Dog Diseases / genetics; Dogs; Genomics / methods; Neoplasms / genetics; Neoplasms / veterinary; Veterinary Medicine / methods
TL;DR:
The release of an annotated human genome sequence assembly and the emergence of genomics technologies have led to significant advances in the authors' understanding of many human diseases including cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 review
Rotavirus and Reovirus Modulation of the Interferon Response
[Review of ]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 29(9), 559–567.
MeSH headings : Active Transport, Cell Nucleus; Animals; Humans; Interferon Regulatory Factors / immunology; Interferon Regulatory Factors / metabolism; Interferon Type I / genetics; Interferon Type I / immunology; Interferon Type I / metabolism; Interferon-Stimulated Gene Factor 3 / immunology; Interferon-Stimulated Gene Factor 3 / metabolism; NF-kappa B / metabolism; RNA Helicases / immunology; RNA Helicases / metabolism; Rotavirus / immunology; Rotavirus / pathogenicity; Rotavirus Infections / genetics; Rotavirus Infections / immunology; Rotavirus Infections / virology; STAT Transcription Factors / metabolism; Signal Transduction; Viral Nonstructural Proteins / immunology; Viral Nonstructural Proteins / metabolism; Virulence
TL;DR:
Members of the family Reoviridae have evolved a variety of mechanisms to subvert the host's innate protective response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 personal communication
Research on mesothelioma from brake exposure: Corporate influence remains relevant concern
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Pharmacokinetics of 4-aminopyridine derivatives in dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 32(5), 485–491.
MeSH headings : 4-Aminopyridine / analogs & derivatives; 4-Aminopyridine / blood; 4-Aminopyridine / cerebrospinal fluid; 4-Aminopyridine / pharmacokinetics; Administration, Oral; Animals; Dogs; Dose-Response Relationship, Drug; Female; Male; Potassium Channel Blockers / administration & dosage; Potassium Channel Blockers / blood; Potassium Channel Blockers / cerebrospinal fluid; Potassium Channel Blockers / pharmacokinetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
MULTISCALE IMAGE PROCESSING AND ANTISCATTER GRIDS IN DIGITAL RADIOGRAPHY
VETERINARY RADIOLOGY & ULTRASOUND, 50(6), 569–576.
author keywords: antiscatter grid; exposure dose; image processing; image quality; multifrequency; multiscale
MeSH headings : Animals; Dogs; Radiation Dosage; Radiographic Image Enhancement / methods; Radiographic Image Enhancement / standards; Radiography, Abdominal / instrumentation; Radiography, Abdominal / methods; Radiography, Abdominal / standards; Radiography, Abdominal / veterinary; Radiography, Thoracic / instrumentation; Radiography, Thoracic / methods; Radiography, Thoracic / standards; Radiography, Thoracic / veterinary; Scattering, Radiation
TL;DR:
Using a grid with digital image processing led to a slight but statistically significant increase in overall quality when compared with digitally processed images made without a grid but whether this increase in quality is clinically significant is unknown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Influence of diet and water supply on mineral content and pH within the large intestine of horses with enterolithiasis
VETERINARY JOURNAL, 182(1), 44–49.
author keywords: Horse; Enterolithiasis; Nutrition; Water; Minerals
MeSH headings : Animal Feed / adverse effects; Animal Feed / analysis; Animals; Case-Control Studies; Colon / chemistry; Female; Horse Diseases / diet therapy; Horse Diseases / etiology; Horse Diseases / metabolism; Horse Diseases / prevention & control; Horses; Hydrogen-Ion Concentration; Intestinal Diseases / etiology; Intestinal Diseases / metabolism; Intestinal Diseases / prevention & control; Intestinal Diseases / veterinary; Lithiasis / etiology; Lithiasis / metabolism; Lithiasis / prevention & control; Lithiasis / veterinary; Magnesium Compounds / analysis; Magnesium Compounds / metabolism; Male; Minerals / analysis; Minerals / metabolism; Phosphates / analysis; Phosphates / metabolism; Risk Factors; Struvite; Water Supply / analysis; Water Supply / standards
TL;DR:
Under controlled dietary and management conditions, horses with enterolithiasis have differences in colonic mineral and pH parameters that may be consistent with physiological differences between horses with and without the disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Enhanced Skin Carcinogenesis and Lack of Thymus Hyperplasia in Transgenic Mice Expressing Human Cyclin D1b (CCND1b)
MOLECULAR CARCINOGENESIS, 48(6), 508–516.
author keywords: cyclin D1; skin carcinogenesis; DMBA; TPA; transgenic mouse model
MeSH headings : Animals; Base Sequence; Cell Transformation, Neoplastic / genetics; Cyclin D1 / genetics; DNA Primers; Exons; Hyperplasia; Introns; Mice; Mice, Transgenic; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Skin Neoplasms / genetics; Thymus Gland / pathology
TL;DR:
Results show that human cyclin D1b has different biological functions than cyclinD1a and confirm its oncogenic properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Early alterations in protein and gene expression in rat kidney following bromate exposure
FOOD AND CHEMICAL TOXICOLOGY, 47(6), 1154–1160.
author keywords: Bromate; Glycolysis; Mitochondria; Renal cell carcinoma; 2D-DIGE; Gene expression
MeSH headings : Animals; Bromates / toxicity; Cell Line; Disinfection; Electrophoresis, Gel, Two-Dimensional; Energy Metabolism / drug effects; Gene Expression / drug effects; Glycolysis / drug effects; Kidney / cytology; Kidney / drug effects; Kidney / metabolism; Male; Membrane Potentials / drug effects; Mitochondria / drug effects; Mitochondria / metabolism; Mitochondrial Membranes / drug effects; Oligonucleotide Array Sequence Analysis; Proteins / metabolism; Rats; Rats, Inbred F344; Tandem Mass Spectrometry; Trypsin / chemistry; Water Supply
TL;DR:
Changes in protein and gene expression are evaluated through two-dimensional difference gel electrophoresis (2D-DIGE) and Affymetrix arrays to identify potential modes of action involved in potassium bromate carcinogenicity and provide insight into early events in renal cell physiology altered by bromates exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
EVALUATION OF THE SERRATIA MARCESCENS NUCLEASE (NucA) AS A TRANSGENIC CELL ABLATION SYSTEM IN PORCINE
ANIMAL BIOTECHNOLOGY, 20(4), 177–185.
author keywords: Ablation; DTA; Fibroblasts; NucA; Porcine
MeSH headings : Animals; Cell Separation / methods; Cells, Cultured; Electroporation / methods; Endodeoxyribonucleases / analysis; Endodeoxyribonucleases / genetics; Endodeoxyribonucleases / metabolism; Endoribonucleases / analysis; Endoribonucleases / genetics; Endoribonucleases / metabolism; Fibroblasts / metabolism; Gene Expression; Gene Transfer Techniques; Rabbits; Serratia / enzymology; Swine
TL;DR:
Gene expression analysis of surviving colonies indicated that survival is related to low or absent expression of the toxic genes, and results indicate that the NucA gene, while capable of mammalian cell ablation, is less efficient than DTA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Chlamydia trachomatis YtgA is an iron-binding periplasmic protein induced by iron restriction
Microbiology (Reading, England), 155, 2884–2894.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Characterizing eversion syndrome in captive scyphomedusa jellyfish
American Journal of Veterinary Research, 70(9), 1087–1093.
MeSH headings : Animal Feed; Animals; Digestive System Abnormalities / pathology; Digestive System Abnormalities / veterinary; Scyphozoa / anatomy & histology; Scyphozoa / physiology; Syndrome
TL;DR:
It is suggested that eversion syndrome is a complex phenomenon associated with degenerative changes of the bell matrix and Striated muscle degeneration and necrosis and extracellular matrix (mesoglea) degeneration were evident on histologic examination of affected jellyfish.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Characterization of Conserved and Nonconserved Imprinted Genes in Swine
BIOLOGY OF REPRODUCTION, 81(5), 906–920.
author keywords: assisted reproductive technology; comparative genomic imprinting; epigenetics; gene regulation; genomic imprinting; parthenogenesis; placenta; swine parthenote
MeSH headings : Animals; Female; Fetus / anatomy & histology; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Oligonucleotide Array Sequence Analysis; Organ Size; Parthenogenesis / genetics; Placenta / anatomy & histology; Polymorphism, Single Nucleotide; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Staining and Labeling; Swine / genetics
TL;DR:
To increase the understanding of imprinted genes in swine, a comprehensive analysis of this gene family was carried out using two complementary approaches: expression and phenotypic profiling of parthenogenetic fetuses, and analysis of imprinting by pyrosequencing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 personal communication
Appreciation for study on bromide administration in dogs
Source: NC State University Libraries
Added: August 6, 2018
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