Works Published in 2020
Displaying works 61 - 80 of 131 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
PTPN11mutations in canine and human disseminated histiocytic sarcoma
INTERNATIONAL JOURNAL OF CANCER, 147(6), 1657–1665.
author keywords: histiocytic sarcoma; dog; spontaneous model; PTPN11
MeSH headings : Adult; Aged; Aged, 80 and over; Animals; Biopsy; Cell Line, Tumor; Cell Proliferation / drug effects; Child; Child, Preschool; DNA Mutational Analysis; Disease Models, Animal; Dog Diseases / blood; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Drug Screening Assays, Antitumor / methods; Female; Histiocytes / pathology; Histiocytic Sarcoma / drug therapy; Histiocytic Sarcoma / genetics; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Humans; Infant; MAP Kinase Signaling System / drug effects; MAP Kinase Signaling System / genetics; Male; Middle Aged; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Mutation; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / therapeutic use; Protein Tyrosine Phosphatase, Non-Receptor Type 11 / antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics; Ribonucleases; Tumor Suppressor Proteins; Young Adult
TL;DR:
Results illustrate the relevance of naturally affected dogs in deciphering genetic mechanisms and selecting efficient targeted therapies for such rare and aggressive cancers in humans, by testing drugs targeting the MAPK pathway in eight canine HS cell lines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 10, 2020
2020 article
Clinical xenotransplantation of the heart: At the watershed
Platt, J. L., Piedrahita, J. A., & Cascalho, M. (2020, August). JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol. 39, pp. 758–760.
MeSH headings : Animals; Heart; Heart Transplantation; Primates; Swine; Transplantation, Heterologous
www.jhltonline.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 10, 2020
2020 journal article
Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling
SCIENCE ADVANCES, 6(30).
MeSH headings : Cells, Cultured; Exosomes; Hair; Hair Follicle; MicroRNAs / genetics; Regeneration; beta Catenin / genetics
TL;DR:
Results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment, and it was demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 10, 2020
2020 journal article
Algorithmically Controlled Electroporation: A Technique for Closed Loop Temperature Regulated Pulsed Electric Field Cancer Ablation
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 67(8), 2176–2186.
author keywords: Temperature control; Temperature measurement; Temperature sensors; Electric fields; Protocols; Temperature dependence; In vitro; Non-thermal high frequency irreversible electroporation; electro-thermal therapy; pulsed electric field; bioelectric; electroporation
MeSH headings : Electricity; Electroporation; Humans; Models, Theoretical; Neoplasms; Temperature
TL;DR:
The results of this study indicate ablative outcomes due to exposure to pulses on the order of one microsecond may be thermally mediated and dependent on local tissue temperatures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 10, 2020
2020 review
A tutorial review of mathematical techniques for quantifying tumor heterogeneity
[Review of ]. MATHEMATICAL BIOSCIENCES AND ENGINEERING, 17(4), 3660–3709.
author keywords: cancer heterogeneity; mathematical oncology; tumor growth; glioblastoma multiforme; virtual populations; nonlinear mixed effects; spatiotemporal data; Bayesian estimation; generative; adversarial networks; non-parametric estimation; variational autoencoders; machine learning
MeSH headings : Bayes Theorem; Humans; Machine Learning; Models, Theoretical; Neoplasms; Precision Medicine
TL;DR:
Several techniques that can be used to aid the mathematical modeller in inferring and quantifying both sources of heterogeneity from patient data are reviewed, including virtual populations, nonlinear mixed effects modeling, non-parametric estimation, Bayesian techniques, and machine learning.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 3, 2020
2020 journal article
Pharmacokinetics, sedation and hemodynamic changes following the administration of oral transmucosal detomidine gel in cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 22(12), 1184–1190.
author keywords: Detomidine gel; alpha-2 agonist; buccal; oral transmucosal; pharmacokinetics
MeSH headings : Administration, Oral; Animals; Blood Pressure / drug effects; Cats / physiology; Conscious Sedation / veterinary; Female; Gels; Heart Rate / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / pharmacokinetics; Imidazoles / administration & dosage; Imidazoles / pharmacokinetics; Male; Respiratory Rate / drug effects
TL;DR:
The pharmacokinetic profile supports short-term, minimally invasive sedation in this species and is warranted for use in debilitated cats, or prior to general anesthesia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 3, 2020
2020 journal article
Traumatic skull fractures in dogs and cats: A comparative analysis of neurological and computed tomographic features
JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(5), 1975–1985.
author keywords: canine; computed tomography; feline; skull fractures
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cats; Dog Diseases / diagnostic imaging; Dogs; Retrospective Studies; Skull / diagnostic imaging; Skull Fractures / diagnostic imaging; Skull Fractures / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR:
The cranial vault fractures were associated with neurological deficits and worse survival, and the presence of TSF alone should not be considered a negative prognostic factor because most affected animals survived the first week.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 3, 2020
2020 review
Exosome therapeutics for lung regenerative medicine
[Review of ]. JOURNAL OF EXTRACELLULAR VESICLES, 9(1).
author keywords: Exosome; regenerative medicine; lung spheroid cell; stem cell
TL;DR:
The uses of exosomes as a therapy and their roles in lung regenerative medicine, as well as current challenges in exosome therapies are underline.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 20, 2020
2020 journal article
Geographic Disparities in Clinical Characteristics of Duodenitis–Proximal Jejunitis in Horses in the United States
Journal of Equine Veterinary Science, 93, 103192.
author keywords: Gastrointestinal; Small intestine; Duodenitis-proximal jejunitis; Colic
MeSH headings : Animals; Case-Control Studies; Duodenitis / epidemiology; Duodenitis / veterinary; Horse Diseases / epidemiology; Horses; Jejunal Diseases / veterinary; Prospective Studies; Southeastern United States; United States / epidemiology
TL;DR:
Differences in clinical parameters of horses with DPJ between geographic regions were identified to corroborate anecdotal reports and support theories of differing etiologies and identify risk factors contributing toward regional differences in this disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 16, 2020
2020 journal article
Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(12), 7409–7419.
MeSH headings : Animals; Biomarkers; Dogs; Environmental Monitoring; Humans; Organophosphates; Silicones
TL;DR:
Exposures among pet dogs and their owners using silicone dog tags and wristbands were evaluated to determine if contaminant levels were correlated with validated biomarkers and the value of using silicone bands with dogs to investigate health impacts on humans from shared exposures is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: July 13, 2020
2020 journal article
Electro-thermal therapy: Microsecond duration pulsed electric field tissue ablation with dynamic temperature control algorithms
COMPUTERS IN BIOLOGY AND MEDICINE, 121.
author keywords: Cancer therapy; Irreversible electroporation; Thermal ablation; H-FIRE; NK-IRE
MeSH headings : Algorithms; Electrodes; Electroporation; Liver / surgery; Temperature
TL;DR:
The results establish ETT as a viable method for hepatic tumor treatment with ablation profiles equivalent to other energy based techniques and the single applicator and multi-applicator approaches demonstrated may enable the treatment of complex tumor geometries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: July 13, 2020
2020 journal article
Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs
MOLECULAR NEUROBIOLOGY, 57(7), 3143–3149.
author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; Amyotrophic lateral sclerosis; Degenerative myelopathy
TL;DR:
This work identified plasma NfL as a key clinical index of neuro-aging and neurodegeneration in pet dogs using an ultrasensitive single-molecule array assay to measure plasma concentrations and found it increases in an age-dependent manner and is significantly elevated in dogs diagnosed with Neurodegenerative disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 13, 2020
2020 journal article
Systematic Profiling of Full-Length Ig and TCR Repertoire Diversity in Rhesus Macaque through Long Read Transcriptome Sequencing
JOURNAL OF IMMUNOLOGY, 204(12), 3434–3444.
MeSH headings : Animals; High-Throughput Nucleotide Sequencing / methods; Humans; Immunoglobulins / genetics; Immunoglobulins / immunology; Macaca mulatta / genetics; Macaca mulatta / immunology; Receptors, Antigen, T-Cell / immunology; Transcriptome / genetics; Transcriptome / immunology
TL;DR:
New rhesus-specific assays are designed that remove the need for primers conventionally targeting variable regions and allow single cell level Ig and TCR repertoire analysis, and the first complete reference set for the constant regions of all known isotypes and chain types of rhesu Ig andTCR repertoires is constructed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020
2020 journal article
Global forensic geolocation with deep neural networks
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS, 69(4), 909–929.
author keywords: Citizen science; Machine learning; Microbiome; Non-homogeneous Poisson process; Spatial point pattern
TL;DR:
The DeepSpace algorithm makes remarkably good point predictions; for example, when applied to the microbiomes of over 1300 dust samples collected across continental USA, more than half of geolocated predictions produced by this model fall less than 100 km from their true origin, which is a 60% reduction in error from competing geolocation methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 6, 2020
2020 journal article
A mutation in MTM1 causes X-Linked myotubular myopathy in Boykin spaniels
NEUROMUSCULAR DISORDERS, 30(5), 353–359.
author keywords: Canine; Centronuclear myopathy; Myotubularin myopathy
MeSH headings : Animals; Dogs; Male; Myopathies, Structural, Congenital / genetics; Myopathies, Structural, Congenital / pathology; Myopathies, Structural, Congenital / physiopathology; Pedigree; Phenotype; Protein Tyrosine Phosphatases, Non-Receptor / genetics
TL;DR:
The purpose of this study was to report the findings of clinical and genetic evaluation of a 3-month old male Boykin spaniel that presented with progressive weakness that causes a severe form of X-linked myotubular myopathy, comparable to the human counterpart.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 29, 2020
2020 journal article
Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis
NANO RESEARCH, 13(8), 2197–2202.
author keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release
TL;DR:
A targeted and controlled release method that triggers HSC apoptosis and reverses the liver fibrosis is provided the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 29, 2020
2020 journal article
Optimization of the second internal transcribed spacer (ITS2) for characterizing land plants from soil
PLOS ONE, 15(4).
MeSH headings : Bryophyta / classification; Bryophyta / genetics; DNA Barcoding, Taxonomic / methods; DNA Barcoding, Taxonomic / standards; DNA, Intergenic / chemistry; DNA, Intergenic / genetics; DNA, Plant / chemistry; DNA, Plant / genetics; Ferns / classification; Ferns / genetics; Magnoliopsida / classification; Magnoliopsida / genetics; Metagenomics / methods; Metagenomics / standards; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / standards; Soil / chemistry
TL;DR:
The broad recoverability across land plants is determined when using published ITS2 primer pairs, and the PCR reaction constituents and cycling conditions for the best two performing primer pairs (ITS2F/ITSp4 and ITSp3/ITSu4) are optimized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 15, 2020
2020 journal article
Temperature Dependence of High Frequency Irreversible Electroporation Evaluated in a 3D Tumor Model
ANNALS OF BIOMEDICAL ENGINEERING, 48(8), 2233–2246.
author keywords: Nano-knife irreversible electroporation (NK-IRE); Electro thermal therapy; Tissue ablation; Cancer therapy; Integrated energized time (IET); Pulsed electric fields
MeSH headings : Cell Death; Cell Line, Tumor; Cell Survival; Electroporation; Glioblastoma / metabolism; Glioblastoma / pathology; Humans; Models, Biological; Temperature
TL;DR:
Results were found for pancreatic cancer cells which indicate that tissue temperature may be a significant factor affecting H-FIRE ablation size and treatment planning in vivo while lower temperatures may be useful in maintaining cell viability for transfection applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 1, 2020
2020 journal article
Use of standardized bioinformatics for the analysis of fungal DNA signatures applied to sample provenance
FORENSIC SCIENCE INTERNATIONAL, 310.
author keywords: Forensic microbiology; Bioinformatics; Metabarcoding; Sample provenance
MeSH headings : DNA Barcoding, Taxonomic; DNA, Fungal / chemistry; Demography; Forensic Sciences; Fungi; Humans; Reference Values; Soil
TL;DR:
Investigating a small-scale approach as an adaptation of a larger metabarcoding study to develop a model for global sample provenance using fungal DNA signatures collected from dust swabs to facilitate a standardized method for consistent, reproducible sample treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 26, 2020
2020 review
Engineering better stem cell therapies for treating heart diseases
[Review of ]. ANNALS OF TRANSLATIONAL MEDICINE, 8(8).
author keywords: Stem cell therapy; ischemic heart diseases; bioengineering strategies; clinical translation
TL;DR:
This review will provide a brief summary of stem cell therapies for ischemic heart disease, the investigation of mechanisms behind stem-cell based cardiac regeneration and also, what bioengineers can do and have been doing on the translational stage of stem Cell therapies for heart repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020
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