Works Published in 2022
Displaying works 61 - 80 of 151 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2022 article
Comparative Toxicogenomics Database (CTD): update 2023
Davis, A. P., Wiegers, T. C., Johnson, R. J., Sciaky, D., Wiegers, J., & Mattingly, C. J. (2022, September 28). NUCLEIC ACIDS RESEARCH, Vol. 9.
MeSH headings : Humans; Toxicogenetics; Databases, Factual; Phenotype
TL;DR:
A 20% increase in overall CTD content is reported and CTD Tetramers, a novel tool that computationally generates four-unit information blocks connecting a chemical, gene, phenotype, and disease to construct potential molecular mechanistic pathways are presented.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 11, 2022
2022 journal article
Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke
ENVIRONMENT INTERNATIONAL, 167.
author keywords: Exosomes; Extracellular vesicles; Environmental exposures; Mixtures; Systems biology; Wildfires
MeSH headings : Animals; Biomass; Extracellular Vesicles / metabolism; Female; Hypoxia; Mice; MicroRNAs; Soil; Wildfires
TL;DR:
A potential mechanism through which wildfire exposures induce cardiopulmonary responses is posited, highlighting the role of circulating plasma EVs in intercellular and systems-level communication between tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 3, 2022
2022 journal article
Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18).
author keywords: differentially methylated regions; adverse offspring outcomes; infertility
MeSH headings : Child; Clomiphene; DNA Methylation; Female; Genomic Imprinting; Humans; Male; Reproductive Techniques, Assisted / adverse effects; Retrospective Studies
TL;DR:
The results suggest that the increased risk of adverse outcomes in offspring conceived through ART may be due in part to altered methylation of ICRs, and larger studies utilizing epigenome-wide interrogation are warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 3, 2022
2022 journal article
Organotins in a food web from the Three Gorges Reservoir, China: Trophic enrichment and potential health risk
SCIENCE OF THE TOTAL ENVIRONMENT, 845.
author keywords: Organotin; Food web; Bioaccumulation; Trophic enrichment; Health risk
MeSH headings : Animals; China; Environmental Monitoring / methods; Food Chain; Organotin Compounds; Rivers; Water; Water Pollutants, Chemical / analysis
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 3, 2022
2022 article
Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters
Witchey, S. K., Doyle, M. G., Fredenburg, J. D., St Armour, G., Horman, B., Odenkirk, M. T., … Patisaul, H. B. (2022, September 8). NEUROENDOCRINOLOGY, Vol. 9.
TL;DR:
This study reveals multiple mechanisms by which the components of a common FR mixture are developmentally neurotoxic and that the OPFRs may be the compounds of greatest concern.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022
2022 article
PFAS Challenges and Novel Research A Conversation With the Editorial Board of the AWWA Water Science Topical Collection on PFAS Analytics and Treatment
Crimi, M., Speth, T. F., Chowdhury, Z. K., Dickenson, E. R. V., Knappe, D. R. U., & Liu, J. (2022, September). JOURNAL AWWA, Vol. 114, pp. 13–22.
Sources: Web Of Science, NC State University Libraries
Added: September 19, 2022
2022 journal article
Species Identification of Caterpillar Eggs by Machine Learning Using a Convolutional Neural Network and Massively Parallelized Microscope
AGRICULTURE-BASEL, 12(9).
author keywords: insect identification; Helicoverpa zea; Chloridea virescens; machine learning; microscope photography; Bt resistance; neural network; precision pest control; insect eggs
TL;DR:
This work designed, built, and validated a machine learning approach to insect egg identification with >99% accuracy using a convolutional neural architecture to classify the two species of caterpillars.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 17, 2022
2022 journal article
A resource for integrated genomic analysis of the human liver
SCIENTIFIC REPORTS, 12(1).
MeSH headings : Bayes Theorem; Genome-Wide Association Study / methods; Genomics; Humans; Liver; Polymorphism, Single Nucleotide; Quantitative Trait Loci
TL;DR:
This study generated whole-transcriptome RNA-Seq from genotyped liver samples and used existing data from the GTEx Project and previous liver eQTL studies to create an enhanced transcriptomic sequence resource in the human liver, finding that MHC genes, and especially class II genes, are enriched for liver-specific eZTL patterns.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 8, 2022
2022 journal article
Drinking Water-Associated PFAS and Fluoroethers and Lipid Outcomes in the GenX Exposure Study
ENVIRONMENTAL HEALTH PERSPECTIVES, 130(9).
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Alkanesulfonic Acids; Child; Cholesterol; Cross-Sectional Studies; Drinking Water; Environmental Pollutants; Fluorocarbons; Humans; Lipids; Middle Aged; Young Adult
TL;DR:
PFNA and PFOS were associated with higher levels of total and non-HDL cholesterol, with associations larger in magnitude among older adults, and fluoroethers appeared to be associated with HDL but not non- HDL lipid measures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 8, 2022
2022 journal article
Improve the Colorectal Cancer Diagnosis Using Gut Microbiome Data
FRONTIERS IN MOLECULAR BIOSCIENCES, 9.
author keywords: machine learning; prediction; feature engineering; colorectal cancer; mediation analysis; 16S rRNA
TL;DR:
A machine learning method for gut microbiome data to assist in diagnosing colorectal cancer, which shows an 8.7% higher prediction accuracy and 13% higher area under the receiver operator characteristic curve than other published work.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 6, 2022
2022 journal article
Grouping of UVCB Substances with Dose-Response Transcriptomics Data from Human Cell-Based Assays
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 39(3), 388–404.
MeSH headings : Biological Assay; Endothelial Cells; Humans; Induced Pluripotent Stem Cells; Petroleum; Transcriptome
TL;DR:
The results further demonstrate the value of NAMs for grouping of UVCBs, identify informative cell lines, and provide data that could be used for justifying selection of substances for further testing that may be required for registration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 29, 2022
2022 journal article
Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by eSTAT3 and C/EBP beta
TOXICOLOGY IN VITRO, 83.
author keywords: Nanoparticles; Nickel; Lipopolysaccharide; Cytokines; Cell signaling; Epithelial cells
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cell Line; Epithelial Cells; Female; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Lipopolysaccharides / pharmacology; Male; Mice; Nanoparticles; Nickel; STAT3 Transcription Factor / metabolism
TL;DR:
The data suggest that LPS and NiNPs induce IL-6 via STAT3 and C/EBPβ in BEAS-2B cells, and that these cells do not appear to be suitable for studying the effect of sex hormones.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 15, 2022
2022 article
Virtual Issue: Neurotoxicology
Sombers, L. A., & Patisaul, H. B. (2022, August 3). ACS CHEMICAL NEUROSCIENCE, Vol. 13, pp. 2238–2239.
Sources: Web Of Science, NC State University Libraries
Added: August 15, 2022
2022 journal article
Normal Table of Xenopus development: a new graphical resource
DEVELOPMENT, 149(14).
author keywords: Xenopus laevis; Normal table; Amphibian development; FETAX; EAMA; AMA; Metamorphosis; Embryo
MeSH headings : Animals; Databases, Genetic; Genomics; Humans; Metamorphosis, Biological; Reproducibility of Results; Xenopus laevis / genetics
TL;DR:
133 new, high-quality illustrations of X. laevis development from fertilization to metamorphosis are presented, with additional views that were not available in the original collection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 15, 2022
2022 journal article
Model systems and organisms for addressing inter- and intra-species variability in risk assessment
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 132.
MeSH headings : Animals; Mice; Models, Theoretical; Risk Assessment; Toxicokinetics; Uncertainty
TL;DR:
It is concluded that population-based models are now beginning to realize their potential to address long-standing data gaps in inter- and intra-species variability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 15, 2022
2022 article
Allergic and non-allergic wheeze among farm women in the Agricultural Health Study (2005-2010)
Islam, J. Y., Mohamed, A., Umbach, D. M., London, S. J., Henneberger, P. K., Freeman, L. E. B., … Hoppin, J. A. (2022, August 8). OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol. 8.
author keywords: Allergy; Pesticides; Respiratory System
TL;DR:
Use of specific pesticides and certain farm activities may contribute to wheeze among farm women, as evaluated in the Agricultural Health Study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 9, 2022
2022 journal article
Correlation Analysis of Variables From the Atherosclerosis Risk in Communities Study
FRONTIERS IN PHARMACOLOGY, 13.
author keywords: cluster analysis; systems biology; meta-analysis as topic; ARIC; cardiovascular disease
TL;DR:
The data-driven approach can facilitate data harmonization and curation efforts by providing human annotators with groups of related variables reflecting the themes present in the data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 8, 2022
2022 article
Inter-pathologist agreement on diagnosis, classification and grading of canine glioma
Krane, G. A., Shockley, K. R., Malarkey, D. E., Miller, A. D., Miller, C. R., Tokarz, D. A., … Mariani, C. L. (2022, July 30). VETERINARY AND COMPARATIVE ONCOLOGY.
author keywords: brain; cancer; dog; histopathology; immunohistochemistry
MeSH headings : Humans; Animals; Dogs; Oligodendroglioma / diagnosis; Oligodendroglioma / veterinary; Oligodendroglioma / pathology; Pathologists; Dog Diseases / diagnosis; Dog Diseases / pathology; Glioma / diagnosis; Glioma / veterinary; Glioma / pathology; Astrocytoma / veterinary; Brain Neoplasms / diagnosis; Brain Neoplasms / veterinary; Brain Neoplasms / pathology
TL;DR:
Inter‐pathologist agreement utilising CBTC guidelines for canine glioma was moderate overall but varied from fair to almost perfect between pairs of pathologists, similar for oligodendrogliomas and astrocytomas but lower for undefined gliomas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 8, 2022
2022 article
Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish (vol 10, 99, 2022)
Kassotis, C. D., LeFauve, M. K., Chiang, Y.-T. T., Knuth, M. M., Schkoda, S., & Kullman, S. W. (2022, July). TOXICS, Vol. 10.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 8, 2022
2022 article
Comparative assessment of blood mercury in American alligators (Alligator mississippiensis) from Coastal North Carolina and Florida
Belcher, S. M., Guillette, M. P., Robb, F., & Rock, K. D. (2022, August 3). ECOTOXICOLOGY, Vol. 8.
author keywords: Bioaccumulation; Biomonitoring; Ecotoxicology; Mercury; Metals; Reptile
MeSH headings : Alligators and Crocodiles; Animals; Ecosystem; Environmental Monitoring; Florida; Humans; Mercury / analysis; North Carolina
TL;DR:
It is revealed that local environmental factors greatly impact Hg bioaccumulation in alligators, and findings that reaffirm local contaminant biomonitoring in alligator populations will be critical for affective management and determination of guidelines for safe consumption of harvested alligators.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 3, 2022
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