Works Published in 2018
Displaying works 81 - 100 of 174 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 review
Platelets and their biomimetics for regenerative medicine and cancer therapies
[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 6(45), 7354–7365.
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Blood Platelets / chemistry; Blood Platelets / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Drug Carriers / chemistry; Humans; Nanoparticles / chemistry; Regenerative Medicine / methods
TL;DR:
This review will highlight the recent progress made in the development of disease-targeting platelets- and platelet-mimicking-vehicles as therapeutic platforms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 10, 2018
2018 personal communication
Response to Editor: Regarding Foster et al., Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study
Dorman, D. C. (2018, December).
author keywords: Manganese; Developmental neurotoxicity; Parkin
MeSH headings : Animals; Manganese; Mice; Mice, Inbred C57BL; Pilot Projects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 10, 2018
2018 review
Systematic reviews and meta-analyses of human and animal evidence of prenatal diethylhexyl phthalate exposure and changes in male anogenital distance
[Review of ]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 21(4), 207–226.
author keywords: Reproductive toxicity; phthalate; anogenital distance; epidemiology
MeSH headings : Animals; Diethylhexyl Phthalate / adverse effects; Environmental Pollutants / adverse effects; Female; Genitalia, Male / anatomy & histology; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / pathology
TL;DR:
There is a moderate level of evidence from human investigations and a high level of data from animal studies that in utero exposure to DEHP decreases AGD, and DEHP is presumed to be a reproductive hazard to humans on the basis of effects on AGD.
(via Semantic Scholar)
Source: Web Of Science
Added: December 3, 2018
2018 review
Polybrominated diphenyl ether (PBDE) neurotoxicity: a systematic review and meta-analysis of animal evidence
[Review of ]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 21(4), 269–289.
author keywords: Developmental neurotoxicity; systematic review; learning and memory
MeSH headings : Animals; Attention / drug effects; Environmental Exposure / analysis; Environmental Pollutants / toxicity; Female; Halogenated Diphenyl Ethers / toxicity; Learning / drug effects; Male; Memory / drug effects; Mice; Rats
TL;DR:
A systematic review and meta-analysis of human studies found an association between prenatal serum polybrominated diphenyl ethers (PBDE) concentrations and a decrease in the IQ of children and identified RoB concerns that might be remedied by better study reporting.
(via Semantic Scholar)
Source: Web Of Science
Added: December 3, 2018
2018 journal article
NIPAM-based Microgel Microenvironment Regulates the Therapeutic Function of Cardiac Stromal Cells
ACS APPLIED MATERIALS & INTERFACES, 10(44), 37783–37796.
author keywords: injectable hydrogels; NIPAM microgel; thermo-responsive microgel; cardiac stromal cells; multicellular spheroids; heart repair
MeSH headings : Acrylamides / administration & dosage; Acrylamides / chemistry; Animals; Cellular Microenvironment / drug effects; Chemokine CXCL12 / genetics; Gene Expression Regulation / drug effects; Humans; Hydrogels / administration & dosage; Hydrogels / chemistry; Hydrophobic and Hydrophilic Interactions / drug effects; Insulin-Like Growth Factor I / genetics; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Polymers / administration & dosage; Polymers / chemistry; Rats; Stromal Cells / drug effects; Stromal Cells / pathology; Succinates / chemistry; T-Lymphocytes / drug effects; Vascular Endothelial Growth Factor A / genetics
TL;DR:
The result revealed the treatment-promoted MI heart repair through angiogenesis and inhibition of apoptosis with an improved cell retention rate, which will open a door for tailoring poly( N-isopropylacrylamide)-based microgel as a delivery vehicle for CSC therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Paternity testing using massively parallel sequencing and the PowerSeq (TM) AUTO/Y system for short tandem repeat sequencing
ELECTROPHORESIS, 39(21), 2669–2673.
author keywords: Massively parallel sequencing; Paternity testing; PowerSeq (TM) AUTO/Y system; Short tandem repeat
MeSH headings : Alleles; Brazil; DNA / genetics; DNA Fingerprinting / methods; Female; High-Throughput Nucleotide Sequencing / methods; Humans; Male; Microsatellite Repeats; Paternity; Sequence Analysis, DNA / methods
TL;DR:
Advantages of implementing sequence‐based analysis, MPS, in paternity testing with improved statistical calculations and a greater resolution for the trios/families tested are shown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Clinical therapeutic efficacy of mycophenolate mofetil in the treatment of SARDS in dogs-a prospective open-label pilot study
VETERINARY OPHTHALMOLOGY, 21(6), 565–576.
author keywords: dog; mycophenolate mofetil; retina; sudden acquired retinal degeneration syndrome; treatment; vision
MeSH headings : Animals; Dog Diseases / drug therapy; Dogs; Female; Immunosuppressive Agents / therapeutic use; Male; Mycophenolic Acid / therapeutic use; Pilot Projects; Prospective Studies; Retinal Degeneration / drug therapy; Retinal Degeneration / veterinary; Vision Tests / veterinary
TL;DR:
The effect of sole-agent treatment with mycophenolate mofetil as a sole agent has no measureable positive effect on physical health, vision, or retinal structure following a 6-week trial period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy
NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.
MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
TL;DR:
It is shown that systemically delivered blood platelets decorated with anti-PD-1 antibodies and conjugated to haematopoietic stem cells reduce the growth and recurrence of leukaemia in mice and significantly augment the therapeutic efficacy of checkpoint blockade.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 26, 2018
2018 journal article
Pharmacists' Knowledge of Veterinary Pharmacotherapy and the Impact of an Educational Intervention
JOURNAL OF PHARMACY TECHNOLOGY, 34(6), 244–251.
author keywords: veterinary pharmacy; veterinary; veterinary medicine; pharmacy education
TL;DR:
It is suggested that a substantial portion of pharmacists lack the knowledge needed to process and dispense the veterinary prescriptions most commonly encountered in community pharmacies and that implementation of an educational intervention can increase pharmacists’ knowledge of core concepts necessary to safely care for animal patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 26, 2018
2018 journal article
SMALL INTESTINAL INTRAMURAL HEMATOMA SECONDARY TO A MIGRATING WIRE FOREIGN BODY IN A DOG
VETERINARY RADIOLOGY & ULTRASOUND, 59(6), E61–E65.
author keywords: foreign body; hematoma; intramural; migrating; ultrasound
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / etiology; Dog Diseases / surgery; Dogs; Duodenum / pathology; Duodenum / surgery; Female; Foreign-Body Migration / complications; Foreign-Body Migration / diagnostic imaging; Foreign-Body Migration / surgery; Foreign-Body Migration / veterinary; Hematoma / diagnostic imaging; Hematoma / etiology; Hematoma / surgery; Hematoma / veterinary; Jejunum / pathology; Jejunum / surgery; Laparotomy / veterinary; Radiography / veterinary
TL;DR:
A 12-year-old spayed female Labrador retriever was presented for a 5-day history of vomiting and inappetence and an intramural hematoma was found consistent with a foreign body.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 26, 2018
2018 journal article
Risk of nutritional deficiencies for dogs on a weight loss plan
JOURNAL OF SMALL ANIMAL PRACTICE, 59(11), 695–703.
MeSH headings : Animal Feed; Animals; Caloric Restriction / veterinary; Diet, Reducing / veterinary; Dog Diseases / etiology; Dogs; Malnutrition / etiology; Malnutrition / veterinary; Risk Assessment; Surveys and Questionnaires; Weight Loss
TL;DR:
Caution is warranted when making weight loss recommendations using commercial diets until further research on the nutrient needs of obese dogs undergoing weight loss is undertaken, as restriction of commercial diets to achieve weight loss in dogs may result in nutrient deficiencies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 26, 2018
2018 journal article
A pilot study documenting increased thrombin generation following abrupt withdrawal of heparin therapy in healthy dogs
Journal of Veterinary Emergency and Critical Care, 28(6), 518–526.
author keywords: hypercoagulable; rebound; thromboelastography
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Dogs; Heparin / administration & dosage; Heparin / pharmacology; Infusions, Intravenous / veterinary; Male; Pilot Projects; Prospective Studies; Thrombelastography / veterinary; Thrombin / biosynthesis; Thrombin / drug effects
TL;DR:
Results suggest that a transient increase in thrombin generation developed 12 hours after withdrawal of UFH therapy, which is similar to that seen in healthy dogs following abrupt cessation of unfractionated heparin (UFH) therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: November 26, 2018
2018 review
Body builder: from synthetic cells to engineered tissues
[Review of ]. CURRENT OPINION IN CELL BIOLOGY, 54, 37–42.
MeSH headings : Artificial Cells / metabolism; Humans; Models, Biological; Regenerative Medicine; Tissue Engineering / methods
TL;DR:
This review summarized recent advances in fabricating synthetic cells, with a specific focus on their application to cardiac regenerative medicine and tissue engineering, and pointed to challenges and future directions for the field.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 12, 2018
2018 journal article
Population pharmacokinetics of extended-release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide
JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(5), 1677–1683.
author keywords: antiepileptic drug; canine; drug disposition; drug interactions; seizures
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / pharmacokinetics; Anticonvulsants / therapeutic use; Delayed-Action Preparations; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Drug Interactions; Epilepsy / drug therapy; Epilepsy / veterinary; Levetiracetam / administration & dosage; Levetiracetam / pharmacokinetics; Levetiracetam / therapeutic use; Phenobarbital / administration & dosage; Phenobarbital / pharmacokinetics; Phenobarbital / therapeutic use; Zonisamide / administration & dosage; Zonisamide / pharmacokinetics; Zonisamide / therapeutic use
TL;DR:
Considerable variation exists in the pharmacokinetics of LEV‐XR in dogs with epilepsy being treated with a common dose regimen, and drug monitoring may be beneficial to determine the most appropriate dose of levetiracetam in individual dogs.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 5, 2018
2018 journal article
Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction
ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088–33096.
author keywords: microvessels; hydrodynamic focusing; cardiac stem cells; cardiomyocyte proliferation; angiogenesis; myocardial infarction
MeSH headings : Animals; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Microfluidic Analytical Techniques; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Rats; Rats, Nude; Stem Cells / cytology; Stem Cells / physiology
TL;DR:
It is shown that the endothelialized BMVs mimicked the natural architecture and function of capillaries and that the resultant vascularized cardiac patch (BMV-CSC patch) exhibited equivalent release of paracrine factors compared to those of coculture of genuine human CSCs and HUVECs after 7 days of in vitro culture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 29, 2018
2018 journal article
C/EBP beta deletion in oncogenic Ras skin tumors is a synthetic lethal event
CELL DEATH & DISEASE, 9.
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / administration & dosage; Animals; Apoptosis / drug effects; Apoptosis / genetics; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / genetics; Cell Differentiation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Knockout; Receptors, Death Domain / genetics; Receptors, Death Domain / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / administration & dosage; Tetradecanoylphorbol Acetate / analogs & derivatives; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; ras Proteins / genetics; ras Proteins / metabolism
TL;DR:
The results show that oncogenic Ras tumors display a significant DNA damage/replicative stress phenotype and these tumors have acquired a dependence on C/EBPβ for their survival, making it a promising target for future potential anticancer therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 29, 2018
2018 journal article
Daily humidity oscillation regulates the circadian clock to influence plant physiology
NATURE COMMUNICATIONS, 9.
Contributors: M. Mwimba*, S. Karapetyan *, L. Liu *, J. Marques*, E. McGinnis *, N. Buchler n, X. Dong *
MeSH headings : Arabidopsis / microbiology; Arabidopsis / physiology; Arabidopsis Proteins / genetics; Circadian Clocks / physiology; DNA-Binding Proteins / genetics; Gene Expression Regulation, Plant; Humidity; Mutation; Photoperiod; Plant Immunity; Plants, Genetically Modified; Repressor Proteins / genetics; Transcription Factors / genetics
TL;DR:
It is reported that, under constant light, circadian humidity oscillation can entrain the plant circadian clock to a period of 24 h probably through the induction of clock genes such as CIRCADIAN CLOCK ASSOCIATED 1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 29, 2018
2018 journal article
Biomimetic O-2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor
BIOMATERIALS, 178, 83–94.
author keywords: O-2-evolving; Metal-organic framework; Photodynamic therapy; Long circulation; ABC membrane
MeSH headings : Animals; Biomimetic Materials / chemistry; Cell Survival / drug effects; Erythrocytes / drug effects; Erythrocytes / metabolism; Humans; Indocyanine Green / pharmacology; MCF-7 Cells; Metal-Organic Frameworks / chemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Oxygen / chemistry; Photochemotherapy; RAW 264.7 Cells; Spheroids, Cellular / drug effects; Spheroids, Cellular / metabolism; Spheroids, Cellular / pathology; Superoxides / chemistry; Tissue Distribution; Tumor Hypoxia / drug effects
TL;DR:
Owing to the advantages of long circulation and O2 self-sufficient, the designed nanotherapeutic agent can improve the efficiency of treatment against hypoxia tumor via PDT and provides a new avenue to eliminate hypoxic tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 19, 2018
2018 journal article
The pharmacokinetics of cytarabine administered subcutaneously, combined with prednisone, in dogs with meningoencephalomyelitis of unknown etiology
Journal of Veterinary Pharmacology & Therapeutics, 41(5), 638–643.
author keywords: canine; cytarabine; MUE; Pharmacokinetics; sparse sampling; subcutaneous; canine; cytarabine; MUE; pharmacokinetics; sparse sampling; subcutaneous
MeSH headings : Animals; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / blood; Antimetabolites, Antineoplastic / pharmacokinetics; Antimetabolites, Antineoplastic / therapeutic use; Cytarabine / administration & dosage; Cytarabine / blood; Cytarabine / pharmacokinetics; Cytarabine / therapeutic use; Dog Diseases / drug therapy; Dogs; Drug Combinations; Encephalomyelitis / drug therapy; Encephalomyelitis / veterinary; Female; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / blood; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / therapeutic use; Injections, Subcutaneous; Male; Meningoencephalitis / drug therapy; Meningoencephalitis / veterinary; Prednisone / administration & dosage; Prednisone / blood; Prednisone / pharmacokinetics; Prednisone / therapeutic use
TL;DR:
The pharmacokinetics of CA in dogs with MUE after a single 50 mg/m2 SC injection in dogs was similar to what has been previously reported in healthy beagles; there was moderate variability in the population estimates in this clinical population of dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2018
2018 journal article
Relationship Between Sequence Homology, Genome Architecture, and Meiotic Behavior of the Sex Chromosomes in North American Voles
GENETICS, 210(1), 83–97.
author keywords: pseudoautosomal region; Microtus heterochromatin; telomeric repeats; meiotic synapsis
MeSH headings : Animals; Arvicolinae / genetics; Chromosome Segregation / genetics; Genomics / methods; Meiosis / genetics; North America; Pseudoautosomal Regions / genetics; Sequence Analysis, DNA / methods; Sequence Homology, Nucleic Acid; Sex Chromosomes / genetics; Telomere / genetics; Telomere-Binding Proteins / genetics; X Chromosome / genetics; Y Chromosome / genetics
TL;DR:
Key conditions required to sustain the standard program of X/Y synapsis at meiosis are suggested and an intriguing connection between heterochromatic repeat architecture and noncanonical, asynaptic mechanisms of sex chromosome segregation in voles is revealed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 19, 2018
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