Works Published in 2019
Displaying works 101 - 120 of 215 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Unique Axon-to-Soma Signaling Pathways Mediate Dendritic Spine Loss and Hyper-Excitability Post-axotomy
FRONTIERS IN CELLULAR NEUROSCIENCE, 13.
author keywords: retrograde signaling; axon-to-soma; injury model; axotomy; dendritic spine loss; hyper-excitability
TL;DR:
It is found that calcium release from axonal ER is critical for the induction of hyper-excitability and inhibition loss, and suggests that synapse loss and hyper-Excitability are uncoupled responses following axon injury.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 7, 2019
2019 journal article
Elicited Finger and Wrist Extension Through Transcutaneous Radial Nerve Stimulation
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 27(9), 1875–1882.
author keywords: Transcutaneous electrical nerve stimulation; radial nerve stimulation; hand function; hand opening; wrist extension
MeSH headings : Adult; Biomechanical Phenomena; Elbow; Electromyography; Female; Fingers / physiology; H-Reflex / physiology; Hand; Healthy Volunteers; Humans; Male; Motor Neurons / physiology; Muscle Fatigue; Muscle Fibers, Skeletal / physiology; Radial Nerve / physiology; Transcutaneous Electric Nerve Stimulation / methods; Wrist / physiology; Young Adult
TL;DR:
This paper investigated the feasibility of eliciting various hand opening and wrist extension movement patterns through a transcutaneous electrical stimulation array, which targeted the proximal segment of the radial nerve bundle proximal to the elbow.
(via Semantic Scholar)
Source: Web Of Science
Added: October 7, 2019
2019 journal article
Parametric control of fiber morphology and tensile mechanics in scaffolds with high aspect ratio geometry produced via melt electrowriting for musculoskeletal soft tissue engineering
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 99, 153–160.
author keywords: Musculoskeletal soft tissue; Additive manufacturing; Scaffold geometry; Tissue engineering
MeSH headings : Anisotropy; Biomimetics; Collagen / chemistry; Electrochemistry; Extracellular Matrix / metabolism; Materials Testing; Temperature; Tensile Strength; Tissue Engineering / instrumentation; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The need to tailor MEW process parameters in scaffolds with high aspect ratio geometry in order to consistently generate specific structural and mechanical properties is highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 30, 2019
2019 journal article
Effects of extended powered knee prosthesis stance time via visual feedback on gait symmetry of individuals with unilateral amputation: a preliminary study
JOURNAL OF NEUROENGINEERING AND REHABILITATION, 16(1).
Contributors: A. Brandt n, W. Riddick, J. Stallrich n, M. Lewek* & H. Huang*
author keywords: Gait; Amputation; Visual Feedback; Rehabilitation; Knee Prosthesis
MeSH headings : Adult; Amputation, Surgical / rehabilitation; Amputees / rehabilitation; Biomechanical Phenomena; Feedback, Sensory; Female; Gait; Humans; Knee Prosthesis; Male; Middle Aged; Walking; Young Adult
TL;DR:
Increasing the amputated-limb stance time via visual feedback significantly improved the stance time symmetry and peak propulsion symmetry of individuals walking with both prostheses, and favorably improved individuals’ temporal and propulsive symmetry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 30, 2019
2019 journal article
X-ray structure of the direct electron transfer-type FAD glucose dehydrogenase catalytic subunit complexed with a hitchhiker protein
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 75, 841–851.
author keywords: direct electron transfer; flavin adenine dinucleotide-dependent dehydrogenase complex; glucose dehydrogenase; iron-sulfur cluster; hitchhiker protein; glucose sensors; Burkholderia cepacia
MeSH headings : Burkholderia cepacia / enzymology; Catalytic Domain; Crystallography, X-Ray / methods; Electron Transport; Flavin-Adenine Dinucleotide / chemistry; Glucose Dehydrogenases / chemistry; Models, Molecular; Recombinant Proteins / chemistry
TL;DR:
The X-ray structure of the catalytic subunit of Burkholderia cepacia FAD glucose dehydrogenase complexed with a hitchhiker protein was determined as a representative molecule of direct electron transfer-type FAD-dependent dehydrogenases complexes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 23, 2019
2019 journal article
p16(Ink4a) deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence
MATRIX BIOLOGY, 82, 54–70.
author keywords: p16; p19; Ink4a; Senescence; Mouse models; Intervertebral disc degeneration; Aggrecan; Extracellular matrix; Nucleus pulposus; Aging; SASP
MeSH headings : Aggrecans / metabolism; Aging / genetics; Aging / metabolism; Animals; Cellular Senescence; Collagen / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Disease Models, Animal; Extracellular Matrix / metabolism; Gene Deletion; Homeostasis; Humans; Intervertebral Disc Degeneration / genetics; Intervertebral Disc Degeneration / metabolism; Mice; Phenotype
TL;DR:
Conditional loss of p16Ink4a reduces apoptosis, limits the SASP phenotype and alters matrix homeostasis of disc cells, and these results show that while, p 16Ink 4a is dispensable for induction and maintenance of senescence, conditional loss of cKO discs showed lower levels of SASP markers,IL-1β, IL-6, MCP1 and TGF-β1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: September 23, 2019
2019 article
Maintaining Hemostatic Balance in Treating Disseminated Intravascular Coagulation
Brown, A. C., & Levy, J. H. (2019, September). ANESTHESIOLOGY, Vol. 131, pp. 459–461.
MeSH headings : Animals; Blood Coagulation Factors; Disseminated Intravascular Coagulation; Hemostasis; Hemostatics; Swine
TL;DR:
It is demonstrated that following experimental animal trauma, administration of prothrombin complex concentrates, either alone or in combination with fibrinogen concentrate, can potentially induce hypercoagulability, but coadministration of antithrombin mitigated this effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: September 23, 2019
2019 journal article
Revisited: Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota
Food and Chemical Toxicology, 132, 110692.
author keywords: Artificial sweeteners; Gut microbiota; Sweetener toxicity; Sweetener safety
MeSH headings : Animals; Bacteria / classification; Bacteria / isolation & purification; Colony Count, Microbial; Feces / microbiology; Gastrointestinal Microbiome / drug effects; Humans; Male; Rats; Sucrose / administration & dosage; Sucrose / adverse effects; Sucrose / analogs & derivatives; Sucrose / pharmacology; Sweetening Agents / administration & dosage; Sweetening Agents / adverse effects; Sweetening Agents / pharmacology
TL;DR:
Scientific studies on the sweetener sucralose indicate that this organochlorine compound unequivocally and irrefutably disrupts the gut microbiome at doses relevant to human use.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 23, 2019
2019 journal article
Effects of polarized macrophages on the in vitro gene expression after Co-Culture of human pluripotent stem cell-derived cardiomyocytes
Journal of Immunology and Regenerative Medicine.
TL;DR:
In the present study, a cell-based system was used to study the in vitro interactions between lipopolysaccharide (LPS) and interferon-gamma (IFNγ)-activated Mϕs and human embryonic stem cell-derived cardiomyocytes (hESC-CMs).
(via Semantic Scholar)
Source: ORCID
Added: September 10, 2019
2019 review
Advances in transdermal insulin delivery
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 139, 51–70.
author keywords: Drug delivery; Transdermal delivery; Insulin; Diabetes; Iontophoresis; Electroporation; Ultrasound; Jet injection; Microneedle
MeSH headings : Administration, Cutaneous; Animals; Electroporation; Humans; Hypoglycemic Agents / administration & dosage; Insulin / administration & dosage; Iontophoresis; Microinjections; Needles; Ultrasonic Waves
TL;DR:
Different transdermal insulin delivery techniques and their respective advantages and limitations are focused on, including chemical enhancers-promoted, electrically enhanced, mechanical force-triggered, and microneedle-assisted methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 9, 2019
2019 journal article
Histological and blood chemistry examination of the rodent kidney after exposure to flash-replenishment ultrasound contrast imaging
ULTRASONICS, 98, 1–6.
author keywords: Contrast enhanced ultrasound; Ultrasound contrast agents; Microbubble; Bioeffects
MeSH headings : Animals; Blood Chemical Analysis; Blood Urea Nitrogen; Contrast Media / pharmacology; Female; Fluorocarbons / pharmacology; Kidney / diagnostic imaging; Kidney / drug effects; Microbubbles; Rats; Rats, Inbred F344; Ultrasonography
TL;DR:
In conclusion, CEUS with flash-replenishment imaging sequences did not result in kidney bioeffects observable with histology at early or late time points.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 9, 2019
2019 journal article
The precision demands of viewing distance modulate postural coordination and control
HUMAN MOVEMENT SCIENCE, 66, 425–439.
author keywords: Precision; Posture; Dynamical systems; Information
TL;DR:
The findings show that the natural act of looking to the same feature in the environment as a function of visual viewing distance can lead to quantitative and qualitative changes in the dynamics of posture, consistent with the view that postural facilitation and information availability are integrated in the perceptual-motor dynamics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 3, 2019
2019 journal article
Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy
NANO LETTERS, 19(8), 4879–4889.
author keywords: Drug delivery; immunotherapy; immune checkpoint blockade; bioresponsive; nanomedicine
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / therapeutic use; Antineoplastic Agents, Immunological / immunology; Antineoplastic Agents, Immunological / therapeutic use; CD47 Antigen / immunology; Female; Immunotherapy; Melanoma / immunology; Melanoma / therapy; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / immunology; Reactive Oxygen Species / immunology; Tumor Microenvironment / drug effects
TL;DR:
A bioresponsive ICB treatment is developed based on the reactive oxygen species (ROS)-sensitive protein complex for controlled sequential release of anti- "don't eat me" signal antibody and antiprogrammed cell death protein 1 (aPD1), by leveraging the abundant ROS in the tumor microenvironment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 3, 2019
2019 review
SIZE AND SHAPE OF THE HUMAN ANTERIOR CRUCIATE LIGAMENT AND THE IMPACT OF SEX AND SKELETAL GROWTH
[Review of ]. JBJS REVIEWS, 7(6).
MeSH headings : Anterior Cruciate Ligament / anatomy & histology; Anterior Cruciate Ligament / physiology; Anterior Cruciate Ligament Injuries / surgery; Anterior Cruciate Ligament Reconstruction / methods; Bone Development / physiology; Decision Support Techniques; Evidence-Based Medicine / classification; Graft Survival; Humans; Qualitative Research; Sex Factors
TL;DR:
The present study condenses measurements describing the geometry of the ACL, its individual bundles, and its insertion sites, accounting for common covariates when possible, to provide a resource to the clinical and scientific communities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: September 3, 2019
2019 journal article
IN VITRO SUPERHARMONIC CONTRAST IMAGING USING A HYBRID DUAL-FREQUENCY PROBE
ULTRASOUND IN MEDICINE AND BIOLOGY, 45(9), 2525–2539.
author keywords: Dual-frequency transducer; Contrast agent; Superharmonic imaging; Acoustic angiography; Plane wave
MeSH headings : Angiography / methods; Contrast Media / chemistry; In Vitro Techniques; Microbubbles; Phantoms, Imaging; Signal-To-Noise Ratio; Transducers; Ultrasonography / instrumentation
TL;DR:
A new dual-frequency probe based on array technology, specifically designed for clinical applications of acoustic angiography is reported on, including two 1.7-MHz rectangular transducers positioned one on each side of a 20-MHz 256-element array.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 journal article
Modeling and simulations of two dimensional propagation of shear shock waves in relaxing soft solids
JOURNAL OF COMPUTATIONAL PHYSICS, 395, 205–222.
author keywords: Piecewise parabolic method; Shear shock waves; Relaxation mechanisms; Traumatic brain injury
TL;DR:
A two-dimensional system of first-order equations modeling the propagation of shear shock waves in a relaxing soft solid is presented, and this system is solved numerically using the piecewise parabolic method, a high-order finite volume method.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 journal article
Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes
PHYSICAL REVIEW E, 100(2).
MeSH headings : Biological Transport; Kinetics; Models, Biological; Molecular Motor Proteins / metabolism; Monte Carlo Method; Protein Binding
TL;DR:
It is found that lowering processivity, i.e., weaker binding of motors to MTs, can improve transport flux, shed light on the relationship between processivity and transport efficiency and offer a theory for the physiological benefits of low motor processivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 journal article
ASSESSMENT OF THE SUPERHARMONIC RESPONSE OF MICROBUBBLE CONTRAST AGENTS FOR ACOUSTIC ANGIOGRAPHY AS A FUNCTION OF MICROBUBBLE PARAMETERS
ULTRASOUND IN MEDICINE AND BIOLOGY, 45(9), 2515–2524.
author keywords: Microbubble; Ultrasound; Acoustic angiography; Superharmonic; Perfluorocarbon
MeSH headings : Acoustics; Angiography / methods; Contrast Media / chemistry; Microbubbles
TL;DR:
It is suggested that microbubbles around 1 μm in diameter with perfluorocarbon cores and longer-chained lipid shells perform best for superharmonic imaging at 4 MHz, which is similar to prior studies using a narrower frequency bandwidth centered around the excitation frequency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 journal article
High-resolution imaging reveals how the spindle midzone impacts chromosome movement
JOURNAL OF CELL BIOLOGY, 218(8), 2529–2544.
MeSH headings : Anaphase; Cell Cycle Proteins / metabolism; Chromosome Segregation; Chromosomes, Human / metabolism; Fluorescence Recovery After Photobleaching; HeLa Cells; Humans; Imaging, Three-Dimensional; Microtubule-Associated Proteins / metabolism; Microtubules / metabolism; Movement; Mutation / genetics; Spindle Apparatus / metabolism
TL;DR:
The assembly dynamics of midzone microtubule bundles during anaphase are examined and how chromosome segregation is impacted by aberrant bundle assembly is examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 19, 2019
2019 journal article
Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs
SCIENCE ADVANCES, 5(7).
MeSH headings : Animals; Blood Glucose / drug effects; Diabetes Mellitus, Experimental / drug therapy; Drug Carriers / chemical synthesis; Drug Carriers / chemistry; Drug Delivery Systems; Insulin / administration & dosage; Mice; Molecular Structure; Polymers / chemical synthesis; Polymers / chemistry; Swine
TL;DR:
A new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by electrostatic interaction achieves high insulin loading efficiency and loading capacity and promotes release under hyperglycemic conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 19, 2019
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