Works Published in 2016
Displaying works 121 - 140 of 173 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
The "Fingerprint" of Cancer Extends Beyond Solid Tumor Boundaries: Assessment With a Novel Ultrasound Imaging Approach
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 63(5), 1082–1086.
author keywords: Acoustic angiography; angiogenesis; spatial heterogeneity; tortuosity; ultrasound
MeSH headings : Angiography; Animals; Image Interpretation, Computer-Assisted / methods; Imaging, Three-Dimensional / methods; Mice; Microvessels / diagnostic imaging; Neoplasms / blood supply; Neoplasms / diagnostic imaging; Neovascularization, Pathologic / diagnostic imaging; Ultrasonography / methods
TL;DR:
Visualization of abnormal vascular tortuosity may make acoustic angiography an invaluable tool for early tumor detection based on quantifying the vascular footprint of small tumors and a sensitive method for understanding changes in the vascular microenvironment during tumor progression.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Response of human macrophages to wound matrices in vitro
WOUND REPAIR AND REGENERATION, 24(3), 514–524.
MeSH headings : Acellular Dermis; Biocompatible Materials / pharmacology; Biological Dressings; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Cellular Microenvironment / drug effects; Cellular Microenvironment / physiology; Humans; Macrophages / drug effects; Macrophages / metabolism; Materials Testing; Neovascularization, Physiologic / drug effects; Neovascularization, Physiologic / physiology; Phenotype; Tissue Scaffolds; Wound Healing / drug effects; Wound Healing / physiology
TL;DR:
It was found that collagen scaffolds cross‐linked with 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide and N‐hydroxysuccinimide (EDC/NHS) promoted the least inflammatory phenotype in primary human macrophages compared with scaffoldsCross‐ linked with formaldehyde or glutaraldehyde.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Point-of-care diagnostics for niche applications
Biotechnology Advances, 34(3), 161–176.
author keywords: Point-of-care; Diagnostics; Space travel; Sports medicine; Veterinary; Emergency care; Operating room
MeSH headings : Animals; Emergency Service, Hospital / organization & administration; Humans; Operating Rooms / organization & administration; Point-of-Care Systems / statistics & numerical data; Point-of-Care Systems / trends; Space Flight; Sports Medicine; Veterinary Medicine
TL;DR:
This review discusses five areas relevant to human and animal health where increased attention could produce significant impact: veterinary medicine, space travel, sports medicine, emergency Medicine, emergency medicine, and operating room efficiency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2016 review
Platelet-mimetic strategies for modulating the wound environment and inflammatory responses
[Review of ]. EXPERIMENTAL BIOLOGY AND MEDICINE, 241(10), 1138–1148.
author keywords: Platelets; hemostasis; artificial platelets; platelet-mimetic; nanoparticles; bionanoscience
MeSH headings : Artificial Cells; Blood Platelets / physiology; Inflammation / pathology; Inflammation / physiopathology; Models, Theoretical; Wounds and Injuries / pathology; Wounds and Injuries / physiopathology
TL;DR:
Lyophilized platelets that can be freeze-dried and stored for longer periods of time and synthetic platelet-mimetic technologies that can enhance or replace the functions of natural platelets, while minimizing adverse immune responses have been explored as alternatives to transfusion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Numerical Simulation of Focused Shock Shear Waves in Soft Solids and a Two-Dimensional Nonlinear Homogeneous Model of the Brain
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 138(4).
MeSH headings : Biomechanical Phenomena; Brain / diagnostic imaging; Head Injuries, Closed; Humans; Linear Models; Models, Biological; Nonlinear Dynamics; Shear Strength; X-Ray Microtomography
TL;DR:
Under realistic loading scenarios, with nonlinear properties consistent with measurements in the brain, and when the shock wave propagation distance and focal distance coincide, nonlinear propagation can easily overcome attenuation to generate shear shocks deep inside the brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 review
Nanoparticles and direct immunosuppression
[Review of ]. EXPERIMENTAL BIOLOGY AND MEDICINE, 241(10), 1064–1073.
author keywords: Nanoparticles; immunosuppression; bionanoscience; nanotoxicology; immunotoxicity; anti-inflammatory
MeSH headings : Animals; Drug Carriers / metabolism; Humans; Immunosuppression Therapy / methods; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / pharmacology; Nanoparticles / metabolism
TL;DR:
The state-of-the-art and developments in understanding how nanoparticles induce immunosuppressive responses are summarized, the inherent properties of nanomaterials which induce these immunological reactions are compared, and the potential for using nanommaterials to modulate and control the immune system is commented on.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Muscle fatigue increases beta-band coherence between the firing times of simultaneously active motor units in the first dorsal interosseous muscle
JOURNAL OF NEUROPHYSIOLOGY, 115(6), 2830–2839.
author keywords: motor unit coherence; isometric fatigue; intramuscular coherence; beta-band coherence; short-term synchronization
MeSH headings : Electromyography; Female; Fingers / physiology; Humans; Isometric Contraction / physiology; Male; Models, Neurological; Muscle Fatigue / physiology; Muscle, Skeletal / physiology; Periodicity; Volition; Wavelet Analysis
TL;DR:
Simulation results indicated that changes in motoneuron inhibition and firing rates alone could not directly account for increased beta-band coherence postfatigue, and the observed increase is more likely to arise from an increase in the strength of correlated inputs to MUs as the muscle fatigues.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery
Advanced Materials, 28(16), 3115–3121.
MeSH headings : Animals; Blood Glucose / analysis; Blood Glucose / metabolism; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Experimental / pathology; Insulin / metabolism; Insulin Secretion; Islets of Langerhans / metabolism; Mice; Needles; Time Factors
TL;DR:
An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation that can quickly reduce the blood-sugar levels of chemically induced type-1 diabetic mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2016 journal article
Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy
ADVANCED MATERIALS, 28(17), 3313–3320.
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Hypoxia; Cell Survival / drug effects; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Drug Carriers / chemistry; HeLa Cells; Humans; Hydrogen-Ion Concentration; Light; Mice; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Neoplasms / diagnostic imaging; Neoplasms / drug therapy; Neoplasms / pathology; Optical Imaging; Polyvinyl Alcohol / chemistry; Singlet Oxygen / chemistry; Singlet Oxygen / metabolism; Transplantation, Heterologous
TL;DR:
A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen and inducing hypoxide to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Internalized compartments encapsulated nanogels for targeted drug delivery
NANOSCALE, 8(17), 9178–9184.
MeSH headings : Doxorubicin / administration & dosage; Drug Delivery Systems; Ferrous Compounds; Hyaluronic Acid; Nanoparticles; Silicon Dioxide
TL;DR:
This study illustrates the potential of utilizing an internalized compartments encapsulated formulation for targeted cancer therapy, and offers guidelines for developing a natural particulate-inspired drug delivery system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Inkjet deposition of itraconazole onto poly(glycolic acid) microneedle arrays
BIOINTERPHASES, 11(1).
MeSH headings : Animals; Antifungal Agents / chemistry; Antifungal Agents / pharmacokinetics; Antifungal Agents / pharmacology; Candida albicans / drug effects; Drug Carriers / chemistry; Itraconazole / chemistry; Itraconazole / pharmacokinetics; Itraconazole / pharmacology; Polyglycolic Acid / chemistry; Skin / chemistry; Swine
TL;DR:
Poly(glycolic acid) microneedle arrays were fabricated using a drawing lithography process; these arrays were modified with a drug release agent and an antifungal agent by piezoelectric inkjet printing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
In vitro polarization of colonoids to create an intestinal stem cell compartment
PLoS One, 11(4).
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Hypoxia-Sensitive Materials for Biomedical Applications
ANNALS OF BIOMEDICAL ENGINEERING, 44(6), 1931–1945.
author keywords: Hypoxia-responsive; Drug delivery; Bioimaging; Hypoxia inducible factor-1; Bioreductive molecule
MeSH headings : Animals; Cell Hypoxia; Humans; Hypoxia-Inducible Factor 1 / metabolism; Tissue Scaffolds / chemistry
TL;DR:
Recent progress in the development of hypoxia-responsive systems for imaging, sensing and therapy was summarized and two types of hyp oxia-sensitive systems were reviewed with comments on their advantages and limitations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
FEASIBILITY AND SAFETY OF CONTRAST-ENHANCED ULTRASOUND IN THE DISTAL LIMB OF SIX HORSES
VETERINARY RADIOLOGY & ULTRASOUND, 57(3), 282–289.
author keywords: contrast-enhanced; equine intra-arterial; ultrasound
MeSH headings : Animals; Contrast Media / administration & dosage; Contrast Media / adverse effects; Female; Hindlimb / diagnostic imaging; Horses; Injections, Intra-Arterial / veterinary; Injections, Intravenous / veterinary; Male; Muscle, Skeletal / diagnostic imaging; Pilot Projects; Prospective Studies; Ultrasonography / adverse effects; Ultrasonography / veterinary
TL;DR:
Findings from this study indicated that CEUS is a feasible and safe diagnostic test for evaluation of the equine distal limb and future studies are needed to assess the clinical utility of this test for horses with musculoskeletal diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Dual targeted nanocarrier for brain ischemic stroke treatment
JOURNAL OF CONTROLLED RELEASE, 233, 64–71.
author keywords: Stroke; Stroke homing peptide; Dual-targeting liposomes; ZL006; Neuroprotection
TL;DR:
T7&SHp-P-LPs could be used as a safe and effective dual targeted nanocarrier for ischemic stroke treatment and could enhance the ability of in vivo anti-ischemic stroke of MCAO rats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 review
Concise Review: Primary Cilia: Control Centers for Stem Cell Lineage Specification and Potential Targets for Cell-Based Therapies
[Review of ]. STEM CELLS, 34(6), 1445–1454.
author keywords: Primary cilia; Tissue regeneration; Adipose stem cells; Bone marrow stromal cells; Cell biology; Stem cell-microenvironment interactions; Cellular therapy; Progenitor cells
MeSH headings : Animals; Cell Lineage; Cilia / metabolism; Disease Models, Animal; Humans; Mechanotransduction, Cellular; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
TL;DR:
The goal of this review is to highlight the cilium's function and integrate this knowledge into the working knowledge of stem cell biologists and tissue engineers developing regenerative medicine technologies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure
REPRODUCTIVE TOXICOLOGY, 62, 92–99.
author keywords: Developmental neurotoxicology; Chemical biology; Morphology; Zebrafish; High throughput screening; ToxCast; Multiplexed assays
MeSH headings : Animals; Embryo, Nonmammalian; Entropy; Flame Retardants / toxicity; High-Throughput Screening Assays; Models, Theoretical; Phenotype; Teratogens / toxicity; Zebrafish / embryology
TL;DR:
An information-theoretic method named Aggregate Entropy (AggE) is proposed and applied to scoring multiplexed, phenotypic endpoints measured in developing zebrafish across a broad concentration-response profile for a diverse set of 1060 chemicals, identifying chemicals with significant morphological effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Adaptive windowing in contrast-enhanced intravascular ultrasound imaging
ULTRASONICS, 70, 123–135.
author keywords: Intravascular ultrasound; Contrast-enhanced ultrasound; Adaptive beamforming; Phase coherence factor; High frequency ultrasound; Superharmonic
MeSH headings : Algorithms; Animals; Atherosclerosis / diagnostic imaging; Chick Embryo; Computer Simulation; Contrast Media; Data Interpretation, Statistical; Image Enhancement / methods; Image Interpretation, Computer-Assisted / methods; Models, Statistical; Phantoms, Imaging; Reproducibility of Results; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Swine; Ultrasonography, Interventional / instrumentation; Ultrasonography, Interventional / methods; Vasa Vasorum / diagnostic imaging
TL;DR:
Applying signal processing approaches based on minimum variance (MV) beamforming and the phase coherence factor (PCF) for improving the spatial resolution and contrast-to-tissue ratio (CTR) in IVUS imaging can enhance image quality in conventional B-mode IVUS or in contrast-enhanced IVUS, where signal- to-noise ratio is relatively low and resolution is at a premium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
A Simple Model to Estimate Plantarflexor Muscle-Tendon Mechanics and Energetics During Walking With Elastic Ankle Exoskeletons
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 63(5), 914–923.
author keywords: Ankle exoskeleton; computer simulation; elastic energy storage; energetics; Hill-type muscle model; human walking; metabolic cost; muscle-tendon dynamics; plantarflexors (PF)
MeSH headings : Ankle / physiology; Biomechanical Phenomena / physiology; Exoskeleton Device; Humans; Models, Biological; Muscle, Skeletal / physiology; Tendons / physiology; Walking / physiology
TL;DR:
The combination of disrupted muscle-tendon dynamics and the need to produce compensatory forces/moments to maintain overall net ankle moment invariance could explain the “sweet spot” in metabolic performance at intermediate ankle exoskeleton stiffness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
A Novel Laser Ultrasound Transducer Using Candle Soot Carbon Nanoparticles
IEEE TRANSACTIONS ON NANOTECHNOLOGY, 15(3), 395–401.
author keywords: Broadband ultrasound; candle soot; high frequency ultrasound; nano-particles composite; optoacoustic
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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