Works Published in 2011
Displaying works 81 - 100 of 127 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Plasma Concentrations of Fluconazole After a Single Oral Dose and Administration in Drinking Water in Cockatiels (Nymphicus hollandicus)
JOURNAL OF AVIAN MEDICINE AND SURGERY, 25(1), 23–31.
author keywords: fluconazole; yeast; Candida; pharmacokinetics; compounding; avian; cockatiel; Nymphicus hollandicus
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Cockatoos / blood; Fluconazole / administration & dosage; Fluconazole / blood; Fluconazole / pharmacokinetics; Water
TL;DR:
Investigation of the disposition of fluconazole in cockatiels (Nymphicus hollandicus) after single oral dose administration and to determine if therapeutic plasma concentrations could be safely achieved by providing medicated water found it to be possible to maintain plasma concentrations in mostcockatiels that exceed the minimum inhibitory concentration of 90% or therapeutic AUC ∶ MIC of most strains of Candida albicans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
In Vitro Elution of Amikacin and Ticarcillin from a Resorbable, Self-Setting, Fiber Reinforced Calcium Phosphate Cement
VETERINARY SURGERY, 40(5), 563–570.
MeSH headings : Absorbable Implants; Amikacin / administration & dosage; Amikacin / pharmacokinetics; Amikacin / pharmacology; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Bone Cements; Calcium Phosphates; Disk Diffusion Antimicrobial Tests; Drug Carriers; Drug Combinations; Escherichia coli / drug effects; In Vitro Techniques; Klebsiella pneumoniae / drug effects; Polyglactin 910; Staphylococcus aureus / drug effects; Ticarcillin / administration & dosage; Ticarcillin / pharmacokinetics; Ticarcillin / pharmacology
TL;DR:
FRCP beads with amikacin or ticarcillin/clavulanate, but not the combination, are suitable carriers for wound implantation and underscore the importance of testing drug combinations, despite success of the combination systemically, before their use in local applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Effect and Distribution of Contrast Medium after Injection into the Anterior Suprachoroidal Space in Ex Vivo Eyes
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52(8), 5730–5736.
MeSH headings : Age Factors; Animals; Anterior Chamber / diagnostic imaging; Anterior Chamber / metabolism; Choroid / diagnostic imaging; Choroid / metabolism; Contrast Media / pharmacokinetics; Dogs; Drug Delivery Systems; Imaging, Three-Dimensional; In Vitro Techniques; Injections, Intraocular / methods; Latex / pharmacokinetics; Microbubbles; Posterior Eye Segment / diagnostic imaging; Posterior Eye Segment / metabolism; Retina / diagnostic imaging; Retina / metabolism; Swine; Ultrasonography
TL;DR:
The authors' hypothesis that a single anterior SCS injection can reach the ocular posterior segment was supported and it is suggested that the SCS can expand, in a dose-dependent manner, to accommodate various volumes of fluid and that it is possible to image theSCS with ultrasound contrast.
(via Semantic Scholar)
iovs.arvojournals.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Analysis of Manganese Tracer Kinetics and Target Tissue Dosimetry in Monkeys and Humans with Multi-Route Physiologically Based Pharmacokinetic Models
TOXICOLOGICAL SCIENCES, 120(2), 481–498.
author keywords: manganese; PBPK; inhalation exposure; risk assessment; neurotoxicity; pharmacokinetics
MeSH headings : Administration, Oral; Adult; Animals; Humans; Inhalation Exposure; Injections; Macaca mulatta; Manganese Compounds / pharmacokinetics; Metabolic Clearance Rate; Models, Biological; Organ Specificity; Physiology; Radioisotopes; Species Specificity; Time Factors; Tissue Distribution
TL;DR:
The use of this human Mn PBPK model can become a key component of future human health risk assessment, allowing the consideration of various exposure routes, natural tissue background levels, and homeostatic controls to explore exposure conditions that lead to increased target tissue levels resulting from Mn overexposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
The effects of prenatal exposure to atrazine on pubertal and postnatal reproductive indices in the female rat
Reproductive Toxicology (Elmsford, N.Y.), 32(1), 43–51.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Suppression of COX-2, IL-1 beta and TNF-alpha expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L.
FITOTERAPIA, 82(3), 414–421.
author keywords: Skin inflammation; Carnosic acid; Carnosol; Cyclooxygenase; Interleukin; Tumor necrosis factor
MeSH headings : Abietanes / pharmacology; Abietanes / therapeutic use; Animals; Cyclooxygenase 2 Inhibitors / pharmacology; Cyclooxygenase 2 Inhibitors / therapeutic use; Dose-Response Relationship, Drug; Fibronectins / genetics; Fibronectins / metabolism; Gene Expression; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / metabolism; Intercellular Adhesion Molecule-1 / genetics; Intercellular Adhesion Molecule-1 / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Macrophages / drug effects; Macrophages / metabolism; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration / drug effects; Nitric Oxide / biosynthesis; Phytotherapy; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Reverse Transcriptase Polymerase Chain Reaction; Rosmarinus / chemistry; Skin / drug effects; Skin / metabolism; Skin / pathology; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
It is shown for the first time in vivo that CA and CS differentially regulate the expression of inflammation-associated genes, thus demonstrating the pharmacological basis for the anti-inflammatory properties reported for CA andCS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Successful management of gastrointestinal pythiosis in a dog using itraconazole, terbinafine, and mefenoxam
MEDICAL MYCOLOGY, 49(5), 539–542.
author keywords: pythiosis; dogs; terbinafine; itraconazole; mefenoxam
MeSH headings : Alanine / administration & dosage; Alanine / adverse effects; Alanine / analogs & derivatives; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / adverse effects; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dogs; Duodenum / pathology; Female; Gastrointestinal Diseases / diagnosis; Gastrointestinal Diseases / drug therapy; Gastrointestinal Diseases / pathology; Gastrointestinal Diseases / veterinary; Histocytochemistry; Itraconazole / administration & dosage; Itraconazole / adverse effects; Naphthalenes / administration & dosage; Naphthalenes / adverse effects; Pythiosis / diagnosis; Pythiosis / drug therapy; Pythiosis / pathology; Pythiosis / veterinary; Pythium / isolation & purification; Terbinafine; Treatment Outcome
TL;DR:
A case of canine gastrointestinal pythiosis in which lesions were resolved through the administration of itraconazole, terbinafine, and the agricultural fungicide mefenoxam is described.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Quasi-one-dimensional antiferromagnetism and multiferroicity in CuCrO4
PHYSICAL REVIEW B, 84(1).
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Assessment of urine solute and matrix effects on the performance of an enzyme-linked immunosorbent assay for measurement of interleukin-6 in dog urine
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 23(2), 316–320.
author keywords: Cytokine; enzyme-linked immunosorbent assay; interleukin-6; matrix; urine
TL;DR:
The role of urine pH, USG, and matrix are examined while optimizing a canine-specific chemiluminescent ELISA for the measurement of IL-6 in the urine of dogs to underscores the importance of critically optimizing testing modalities for biomarkers, particularly if they are immunologic in origin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Relationship between gastrointestinal transit time and anesthetic fasting protocols in the captive chimpanzee, Pan troglodytes
JOURNAL OF MEDICAL PRIMATOLOGY, 40(3), 181–187.
author keywords: anesthesia; food deprivation; non-human primates; pre-anesthetic; pre-operative; starvation
MeSH headings : Anesthesia / veterinary; Animals; Barium / administration & dosage; Barium / pharmacokinetics; Coloring Agents / administration & dosage; Coloring Agents / pharmacokinetics; Fasting; Female; Gastric Emptying; Gastrointestinal Tract / diagnostic imaging; Gastrointestinal Tract / physiology; Gastrointestinal Transit; Male; Pan troglodytes / physiology; Polyethylene / administration & dosage; Polyethylene / pharmacokinetics; Radiography; Time Factors; Veterinary Medicine / methods
TL;DR:
This study is an initial attempt to identify a safe pre‐anesthetic fasting procedure by identifying gastric emptying time (GET) and gastrointestinal transit time (GTT) of captive chimpanzees, Pan troglodytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
RADIOGRAPHIC EVALUATION OF FELINE APPENDICULAR DEGENERATIVE JOINT DISEASE VS. MACROSCOPIC APPEARANCE OF ARTICULAR CARTILAGE
VETERINARY RADIOLOGY & ULTRASOUND, 52(3), 239–247.
author keywords: cartilage damage; cat; DJD; macroscopic; radiographs
MeSH headings : Animals; Arthrography / veterinary; Cartilage, Articular / diagnostic imaging; Cartilage, Articular / pathology; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Female; Joint Diseases / diagnostic imaging; Joint Diseases / pathology; Joint Diseases / veterinary; Joints / pathology; Male; Radiographic Image Enhancement
TL;DR:
The data support radiographic findings not relating well to cartilage degeneration, and that other modalities should be evaluated to aid in making a diagnosis of feline DJD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Intravenous and sublingual buprenorphine in horses: pharmacokinetics and influence of sampling site
VETERINARY ANAESTHESIA AND ANALGESIA, 38(4), 374–384.
author keywords: analgesia; buprenorphine; equine; opioids; pharmacokinetics; sampling site
MeSH headings : Administration, Sublingual; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Biological Availability; Blood Chemical Analysis / methods; Blood Chemical Analysis / veterinary; Buprenorphine / administration & dosage; Buprenorphine / analogs & derivatives; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Horses / metabolism; Injections, Intravenous / veterinary; Jugular Veins; Male; Prospective Studies
TL;DR:
Buprenorphine has a long plasma half-life and results in plasma concentrations that are consistent with analgesia in other species for up to 4 hours following IV administration of this dose in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
IMAGING DIAGNOSIS-MAGNETIC RESONANCE IMAGING PULSATILITY ARTIFACT IN THE CANINE CERVICAL SPINE
VETERINARY RADIOLOGY & ULTRASOUND, 52(3), 313–316.
author keywords: canine; cervical spine; MRI; pulsatility artifact
MeSH headings : Animals; Artifacts; Cervical Vertebrae; Dog Diseases / diagnosis; Dogs; Magnetic Resonance Imaging / veterinary; Pulsatile Flow; Spinal Cord / blood supply; Spinal Cord / pathology; Spinal Cord Diseases / diagnosis; Spinal Cord Diseases / veterinary
TL;DR:
Care should be exercised to avoid misdiagnosing this pulsatility artifact seen in transverse T2-weighted images of the midcervical spine in large dogs as an intramedullary lesion when T1-images or phase-swap images are not available to confirm its artifactual origin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils
Developmental & Comparative Immunology, 35(8), 872–880.
author keywords: TREM-1; TLR; Neutrophils; Sepsis; Canine
MeSH headings : Amino Acid Sequence; Animals; Cells, Cultured; Cloning, Molecular; Conserved Sequence; Cytokines / immunology; Cytokines / metabolism; Dogs / genetics; Dogs / immunology; Humans; Lipopolysaccharides / immunology; Lipopolysaccharides / pharmacology; Membrane Glycoproteins / genetics; Membrane Glycoproteins / immunology; Membrane Glycoproteins / metabolism; Molecular Sequence Data; Neutrophils / immunology; Neutrophils / metabolism; Phylogeny; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Sequence Alignment; Teichoic Acids / immunology; Teichoic Acids / pharmacology; Toll-Like Receptors / agonists; Up-Regulation / drug effects
TL;DR:
Functionally, canine TREM-1 synergistically enhances LPS-induced production of IL-8, TNF-α and a canine orthologue of CXCL1 and these data suggest that T REM-1 expression in dogs is an amplifier of pro-inflammatory responses to microbial products.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics
CLINICAL CANCER RESEARCH, 17(8), 2549–2560.
MeSH headings : Animals; Cluster Analysis; Combined Modality Therapy; Dogs; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomics / methods; Humans; Hyperthermia, Induced; Magnetic Resonance Imaging / methods; Oligonucleotide Array Sequence Analysis; Radiotherapy / methods; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma / genetics; Sarcoma / therapy
TL;DR:
This is one of the first successful attempts to link changes in gene expression and functional imaging to understand the response heterogeneity and identify compounds enhancing thermoradiotherapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Anaphylactoid reaction in a heartworm-infected dog undergoing lung lobectomy
Journal of the American Veterinary Medical Association, 238(10), 1301–1304.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
A Common MUC5B Promoter Polymorphism and Pulmonary Fibrosis
NEW ENGLAND JOURNAL OF MEDICINE, 364(16), 1503–1512.
MeSH headings : Aged; Case-Control Studies; Chromosomes, Human, Pair 11; Female; Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Idiopathic Pulmonary Fibrosis / genetics; Linkage Disequilibrium; Lung / metabolism; Lung Diseases, Interstitial / genetics; Male; Middle Aged; Mucin-5B / genetics; Mucin-5B / metabolism; Mutation; Polymorphism, Single Nucleotide; Promoter Regions, Genetic
TL;DR:
The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 review
The neuropathogenesis of feline immunodeficiency virus infection: Barriers to overcome
[Review of ]. VETERINARY JOURNAL, 188(3), 260–269.
author keywords: Feline immunodeficiency virus (Fly); Human immunodeficiency virus (HIV); Neuropathology Blood-brain barrier; CNS
MeSH headings : Animals; Blood-Brain Barrier; Brain / virology; Cats; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / virology; HIV Infections; HIV-1; Humans; Immunodeficiency Virus, Feline / pathogenicity
TL;DR:
In this review the results of both in vitro and in vivo FIV studies are assessed in an attempt to elucidate the mechanisms of viral entry into the brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
LEUKEMIA & LYMPHOMA, 52(7), 1321–1335.
author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
MeSH headings : Aneuploidy; Animals; Breeding; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Copy Number Variations / genetics; Dogs; Gene Expression Regulation, Neoplastic; Genomics; Immunophenotyping; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / pathology
TL;DR:
It is hypothesized that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Physiologically Based Pharmacokinetic Modeling of Fetal and Neonatal Manganese Exposure in Humans: Describing Manganese Homeostasis during Development
TOXICOLOGICAL SCIENCES, 122(2), 297–316.
author keywords: manganese; potentially susceptible subpopulation; environmental exposure to Mn; formula; fetus; neonate
MeSH headings : Adult; Animals; Child, Preschool; Female; Fetus / drug effects; Fetus / metabolism; Homeostasis; Humans; Infant; Inhalation Exposure; Lactation; Male; Manganese / blood; Manganese / pharmacokinetics; Manganese / toxicity; Maternal Exposure; Milk, Human / chemistry; Models, Biological; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Tissue Distribution
TL;DR:
A physiologically based pharmacokinetic model for Mn during human gestation and lactation was developed to predict Mn in fetal and neonatal brain using a parallelogram approach based upon extrapolation across life stages in rats and cross-species extrapolation to humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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