Works Published in 2019
Displaying works 41 - 60 of 113 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains
GENETICS, 213(3), 1079–1092.
author keywords: ischemic stroke; wild-derived mouse strains; neuroprotection; quantitative trait mapping
MeSH headings : Animals; Female; Genetic Predisposition to Disease; Inbreeding; Infarction, Middle Cerebral Artery / genetics; Male; Mice; Polymorphism, Single Nucleotide; Quantitative Trait Loci
TL;DR:
This study expanded the pool of allelic variation among classical inbred mouse strains by utilizing the eight founder strains of the Collaborative Cross and found a wild-derived strain, WSB/EiJ, that breaks this general rule that collateral vessel density inversely correlates with infarct volume.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 25, 2019
2019 journal article
Ozone-Induced Dysregulation of Neuroendocrine Axes Requires Adrenal-Derived Stress Hormones
TOXICOLOGICAL SCIENCES, 172(1), 38–50.
Contributors: A. Henriquez *, J. House n , S. Snow *, C. Miller *, M. Schladweiler *, A. Fisher*, H. Ren*, M. Valdez *, P. Kodavanti *, U. Kodavanti *
author keywords: ozone; brainstem; hypothalamus; pituitary; adrenalectomy; neuroendocrine hormones
TL;DR:
Findings show that short-term ozone inhalation promotes a shift in brainstem and hypothalamic gene expression that is dependent on the presence of circulating adrenal-derived stress hormones, and is likely to have profound downstream influence on systemic effects of ozone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 18, 2019
2019 journal article
C/EBP beta suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer
CARCINOGENESIS, 40(9), 1099–1109.
TL;DR:
A p53-C/E BPβ feedback loop, whereby C/EBPβ a transcriptional target of a p53 pathway, functions as a survival factor by negatively regulating p53 apoptotic activity in response to DNA damage is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 18, 2019
2019 article
Marker-Trait Complete Analysis
Zhou, Y.-H., Gallins, P., & Wright, F. (2019, November 9). (Vol. 11). Vol. 11.
TL;DR:
MTCA uses the conditional inference implicit in permutation as a motivational frame-work, but provides an option for fast screening with two novel tools: a multivariate-normal approximation for the max statistic, and the concept of eigenvalue-conditional moments for the sum statistic.
(via Semantic Scholar)
Source: ORCID
Added: November 10, 2019
2019 journal article
Ecosystem services of poplar at long‐term phytoremediation sites in the Midwest and Southeast, United States
Wiley Interdisciplinary Reviews: Energy and Environment, 8(6).
author keywords: biomass production; carbon sequestration; phytotechnologies; Populus; short rotation woody crops
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: October 28, 2019
2019 journal article
Iron-induced transferrin receptor-1 mRNA destabilization: A response to "Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation"
RNA, 25(11), 1416–1420.
MeSH headings : Iron; MicroRNAs; RNA Stability; RNA, Messenger; Receptors, Transferrin
TL;DR:
There are several critical issues contained in the article by Connell and colleagues that require further consideration and the opportunity to reply here.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 28, 2019
2019 journal article
Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study
NEUROTOXICOLOGY, 74, 139–148.
author keywords: Behavior; Estrogen; Endocrine disruption; Sexual differentiation; Neuroendocrine; Oxytocin
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Brain Chemistry / drug effects; Endocrine Disruptors / toxicity; Ethinyl Estradiol / toxicity; Female; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Oxytocin / biosynthesis; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin / biosynthesis; Septal Nuclei / drug effects; Septal Nuclei / metabolism; Sex Characteristics
TL;DR:
Prenatal exposure to BPA can eliminate sex differences in OTR expression in three hypothalamic regions, and that male O TR expression may be more susceptible, and a sexually dimorphic sub-region of the BNST not previously reported in juvenile rats is identified that is also susceptible to B PA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 21, 2019
2019 journal article
Set‐based differential covariance testing for genomics
Stat, 8(1).
author keywords: asymptotics; covariance testing; permutation
TL;DR:
A simple uniform framework to test association of covariance matrices with an experimental variable, whether discrete or continuous, and a new “connectivity” statistic that is sensitive to the changes in overall covariance magnitude is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 7, 2019
2019 article
Measuring UV Photoproduct Repair in Isolated Telomeres and Bulk Genomic DNA
DNA REPAIR: METHODS AND PROTOCOLS, Vol. 1999, pp. 295–306.
author keywords: UV photoproducts; UV irradiation; Telomeres; Immunospot blot; Telomere isolation; Radiolabeled DNA probes
MeSH headings : Antibodies / immunology; Cell Line; DNA / analysis; DNA / genetics; DNA / radiation effects; DNA Damage / radiation effects; DNA Repair; Genomic Instability; Genomics / methods; Humans; Immunoblotting / methods; Pyrimidine Dimers / analysis; Pyrimidine Dimers / genetics; Pyrimidine Dimers / radiation effects; Telomere / genetics; Telomere / immunology; Telomere / radiation effects; Telomere-Binding Proteins / immunology; Ultraviolet Rays / adverse effects
TL;DR:
A highly sensitive method for quantifying the formation and removal of UV photoproducts in telomeres isolated from UV irradiated cultured human cells is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 7, 2019
2019 journal article
Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood
SCIENTIFIC REPORTS, 9(1).
Contributors: K. Hudson n, S. Belcher n & M. Cowley n
MeSH headings : Animals; Animals, Newborn; Body Weight / drug effects; Cadmium / adverse effects; Disease Models, Animal; Female; Gene Expression Profiling / methods; Gene Expression Regulation / drug effects; Gene Regulatory Networks / drug effects; Heart / anatomy & histology; Heart / drug effects; Hypotension / chemically induced; Hypotension / genetics; Maternal Exposure / adverse effects; Metabolic Networks and Pathways / drug effects; Mice; Organ Size / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Sequence Analysis, RNA
TL;DR:
It is proposed that a maternal Cd exposure-induced iron deficiency leads to altered cellular metabolic pathways and hypoxic conditions during fetal development; this stress may contribute to increased heart weight at birth and the programming of susceptibility to hypertension in adulthood.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 7, 2019
2019 journal article
Calcium imaging of primary canine sensory neurons: Small‐diameter neurons responsive to pruritogens and algogens
Brain and Behavior.
author keywords: dorsal laminectomy dissection; dorsal root ganglia cell culture; fura-2AM; ratiometric calcium imaging
MeSH headings : Animals; Cadaver; Calcium Radioisotopes; Capsaicin / pharmacology; Cattle; Cells, Cultured; Chloroquine / pharmacology; Dogs; Ganglia, Spinal / physiopathology; Histamine / pharmacology; Humans; Laminectomy; Molecular Imaging / methods; Neurotransmitter Agents / pharmacology; Pain / physiopathology; Peptide Fragments / pharmacology; Pruritus / chemically induced; Pruritus / physiopathology; Radiopharmaceuticals; Sensory Receptor Cells / physiology; Serotonin / pharmacology; Serotonin Receptor Agonists / pharmacology; Substance P / pharmacology
TL;DR:
Rodent primary sensory neurons are commonly used for studying itch and pain neurophysiology, but translation from rodents to larger mammals and humans is not direct and requires further validation to make correlations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 1, 2019
2019 journal article
Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex
CHROMOSOME RESEARCH, 27(3), 179–202.
author keywords: Histiocytic sarcoma; Chromothripsis; MMP9; Aurora kinase; Dendritic cell sarcoma
MeSH headings : Animals; Chromosome Disorders; DNA Copy Number Variations / genetics; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Genome / genetics; Histiocytic Disorders, Malignant / diagnosis; Histiocytic Disorders, Malignant / genetics; Histiocytic Disorders, Malignant / veterinary; Humans; Immunohistochemistry / methods; Matrix Metalloproteinase 9 / metabolism; Spindle Apparatus / pathology
TL;DR:
Droplet digital PCR evaluation of these regions in numerous cancer specimens effectively discriminated HM from other common round cell tumors, including lymphoma and hemangiosarcoma, resulting in a novel, rapid diagnostic aid for veterinary medicine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: September 30, 2019
2019 journal article
Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves
PLOS ONE, 14(6).
MeSH headings : Age Factors; Animals; Area Under Curve; Bronchoalveolar Lavage Fluid / chemistry; Cattle; Cattle Diseases / drug therapy; Disaccharides / administration & dosage; Disaccharides / pharmacokinetics; Extracellular Fluid / chemistry; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / pharmacokinetics; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / pharmacokinetics; Pasteurella Infections / drug therapy; Pasteurella Infections / veterinary; Pasteurella multocida / pathogenicity; Respiration Disorders / drug therapy; Respiration Disorders / veterinary
TL;DR:
Age was determined to be a significant covariate for calves administered danofloxacin and tulathromycin for plasma PK parameters and potential reasons for age-related differences on plasma concentration–time profiles and the impact of disease on the partitioning of the drug from the blood to the lungs and ISF as a function of age are explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 30, 2019
2019 journal article
Lack of influence by endosymbiont Wolbachia on virus titer in the common bed bug, Cimex lectularius
PARASITES & VECTORS, 12(1).
author keywords: Cimex lectularius; Wolbachia; Endosymbiont; Cimicidae; Virus suppression; ssRNA
MeSH headings : Animals; Bedbugs / microbiology; Bedbugs / virology; Calicivirus, Feline / growth & development; Calicivirus, Feline / isolation & purification; Microbial Interactions; Viral Load; Wolbachia / growth & development
TL;DR:
It is suggested that other mechanisms are involved in virus suppression within bed bugs, independent of the influence of Wolbachia, and the need for future research is underscore.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 30, 2019
2019 journal article
The role of nuclear receptor E75 in regulating the molt cycle of Daphnia magna and consequences of its disruption
PLOS ONE, 14(8), e0221642.
Ed(s): C. Englert
MeSH headings : Animals; Daphnia / drug effects; Daphnia / metabolism; Daphnia / physiology; Gene Expression Regulation, Developmental / drug effects; Models, Biological; Molting / drug effects; Molting / genetics; Molting / physiology; Nitroprusside / pharmacology; RNA Interference; RNA, Double-Stranded / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear / metabolism; Signal Transduction / drug effects
TL;DR:
It is concluded that the molt cycle of daphnids is regulated in a manner similar to insects and disruption of E75 results in a lengthening of themolt cycle and a reduction the release of viable offspring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019
2019 journal article
Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.
Journal of Cell Science.
author keywords: Angiopellosis; Circulating tumor cell cluster; Tumor cell extravasation; Cancer exodus hypothesis; Metastasis
MeSH headings : Animals; Cell Count; Cell Movement / physiology; HeLa Cells; Humans; Mice; Neoplasm Metastasis; Neoplastic Cells, Circulating / metabolism
TL;DR:
Circulating tumor cell clusters spread throughout the body by using a unique method to exit blood vessels, which grants the tumor cells an increased ability to form secondary tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: September 21, 2019
2019 journal article
Retrospective Analysis of Nontuberculous Mycobacterial Infection and Monochloramine Disinfection of Municipal Drinking Water in Michigan
MSPHERE, 4(4).
Ed(s): T. Mattes
author keywords: disinfection; drinking water; infection; monochloramine; nontuberculous mycobacteria
MeSH headings : Adult; Aged; Chloramines / pharmacology; Chlorine / pharmacology; Disinfectants / pharmacology; Disinfection / methods; Drinking Water / microbiology; Female; Humans; Male; Michigan / epidemiology; Middle Aged; Mycobacterium Infections, Nontuberculous / epidemiology; Mycobacterium Infections, Nontuberculous / etiology; Nontuberculous Mycobacteria / drug effects; Retrospective Studies; Water Purification / methods; Water Purification / standards
TL;DR:
The results suggest that municipal drinking water disinfection with monochloramine compared to chlorine is not associated with higher risk of NTM infection, which is important given that regulations that limit drinking water concentrations of disinfection by-products, which are formed primarily when chlorine disinfection is used, incentivize drinking water utilities to change from chlorine disinfections to monoch chloramine disinfection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 16, 2019
2019 journal article
Novel Noninvasive Diagnostics
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 49(5), 781-+.
author keywords: Canine; Cancer; Liquid biopsy; Bladder; Prostate; BRAF; Lymphoma
MeSH headings : Animals; Carcinoma, Transitional Cell / diagnosis; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / veterinary; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / genetics; Dogs; Early Detection of Cancer / methods; Early Detection of Cancer / veterinary; Female; Humans; Leukemia / diagnosis; Leukemia / veterinary; Liquid Biopsy / methods; Liquid Biopsy / veterinary; Lymphoma / diagnosis; Lymphoma / drug therapy; Lymphoma / veterinary; Male; Molecular Targeted Therapy / veterinary; Mutation; Neoplasms / diagnosis; Neoplasms / drug therapy; Neoplasms / genetics; Neoplasms / veterinary; Urethral Neoplasms / diagnosis; Urethral Neoplasms / genetics; Urethral Neoplasms / veterinary; Urinary Bladder Neoplasms / veterinary
TL;DR:
Noninvasive/minimally invasive techniques have been described in veterinary medicine that could be referred to as liquid biopsy, which offer new opportunities for improving cancer screening, diagnosis, and monitoring the impact of therapy on the patients over time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 16, 2019
2019 journal article
Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease
Journal of Veterinary Internal Medicine.
author keywords: immunofluorescent assay; meningoencephalitis; MUE; NMDA receptor encephalitis
MeSH headings : Animals; Autoantibodies / cerebrospinal fluid; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / immunology; Central Nervous System Diseases / veterinary; Dog Diseases / cerebrospinal fluid; Dog Diseases / immunology; Dogs; Female; Fluorescent Antibody Technique, Indirect / veterinary; Humans; Male; Meningoencephalitis / cerebrospinal fluid; Meningoencephalitis / immunology; Meningoencephalitis / therapy; Neurons / immunology; Receptors, N-Methyl-D-Aspartate / immunology
TL;DR:
Defining antigenic targets associated with encephalitis in dogs might allow diagnostic categorization of MUE antemortem and further evaluation of the prevalence and clinical relevance of CSF and serum antibodies to neuronal cell surface antigens is warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: September 9, 2019
2019 journal article
Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes
Toxicology and Applied Pharmacology, 381.
Contributors: S. Burnett*, A. Blanchette*, F. Grimm*, J. House n , D. Reif n , F. Wright n, W. Chiu *, I. Rusyn *
author keywords: iPSC; In vitro; Alternative methods; Cardiotoxicity; High-content screening; Environmental chemicals
MeSH headings : Calcium / metabolism; Cardiotoxicity; Cells, Cultured; Drug Evaluation, Preclinical / methods; Female; Genotype; Humans; Induced Pluripotent Stem Cells / cytology; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Phenotype; Racial Groups; Toxicity Tests / methods
TL;DR:
This study shows the feasibility of using an organotypic population-based human in vitro model to quantitatively assess chemicals for which little cardiotoxicity information is available, and shows reproducible inter-individual variability in both baseline and chemical-induced effects on iPSC-derived cardiomyocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 30, 2019
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