Works Published in 2002
Displaying works 21 - 40 of 87 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2002 journal article
Interferon regulatory factor-1, interferon-beta, and reovirus-induced myocarditis
VIROLOGY, 298(1), 20–29.
author keywords: reovirus; double-stranded RNA (dsRNA); viral myocarditis; cardiac myocytes; interferon (IFN); interferon regulatory factor (IRF)
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / deficiency; DNA-Binding Proteins / genetics; Female; Heart / virology; Interferon Regulatory Factor-1; Interferon-beta / biosynthesis; Interferon-beta / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium / metabolism; Myocardium / pathology; Phosphoproteins / biosynthesis; Phosphoproteins / deficiency; Phosphoproteins / genetics; Reoviridae / pathogenicity; Viral Proteins / biosynthesis; Viral Proteins / genetics
TL;DR:
Surprisingly, it is found that reovirus failed to induce IRF-1 in the absence of the IFN-alpha/beta response, providing the first evidence that viruses may not induce IRf-1 directly.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
17 beta-estradiol is a hormonal regulator of mirex tumor promotion sensitivity in mice
TOXICOLOGICAL SCIENCES, 69(1), 42–48.
author keywords: mirex; skin; 17 beta-estradiol; tumor promotion; endocrine
MeSH headings : Animals; Carcinogens / toxicity; Cell Line; Chlordecone / toxicity; Drug Implants; Estradiol / administration & dosage; Estradiol / pharmacology; Female; Genes, Reporter / drug effects; Insecticides / toxicity; Luciferases / biosynthesis; Male; Mice; Mirex / toxicity; Orchiectomy; Ovariectomy; Radioimmunoassay; Sex Characteristics
TL;DR:
Collectively, these studies indicate that E2 is a major ovarian hormone responsible for mirex tumor promotion sensitivity in female mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 article
Pharmacokinetics after intravenous and oral administration of enrofloxacin in sheep
Bermingham, E. C., & Papich, M. G. (2002, July). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 63, pp. 1012–1017.
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Biological Availability; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Cross-Over Studies; Enrofloxacin; Female; Fluoroquinolones; Half-Life; Injections, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics; Sheep / blood; Sheep / metabolism
TL;DR:
Enrofloxacin administered orally to sheep has a prolonged half-life and high oral bioavailability and was sufficient to achieve a plasma concentration of 8 to 10 times the minimum inhibitory concentration of any microorganism with an MIC < or = 0.29 microg/ml.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Hypercalcemia and high parathyroid hormone-related protein concentration associated with malignant melanoma in a dog
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 221(2), 263-+.
MeSH headings : Animals; Dog Diseases / blood; Dog Diseases / etiology; Dogs; Fatal Outcome; Hypercalcemia / etiology; Hypercalcemia / veterinary; Male; Melanoma / complications; Melanoma / metabolism; Melanoma / veterinary; Mouth Neoplasms / complications; Mouth Neoplasms / metabolism; Mouth Neoplasms / veterinary; Parathyroid Hormone-Related Protein; Proteins / metabolism
TL;DR:
A 12-year-old Cocker Spaniel with an oral malignant melanoma was evaluated for progressive lethargy and anorexia, andSerum parathyroid hormone-related protein concentration was markedly high, and the melanoma had moderate to marked immunostaining for this protein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Expression of a chemokine by ciliary body epithelium in horses with naturally occurring recurrent uveitis and in cultured ciliary body epithelial cells
AMERICAN JOURNAL OF VETERINARY RESEARCH, 63(7), 942–947.
MeSH headings : Animals; Aqueous Humor / metabolism; Chemokine CCL5 / biosynthesis; Chemokine CCL5 / genetics; Chemotaxis; Ciliary Body / cytology; Ciliary Body / metabolism; Epithelial Cells / metabolism; Female; Horse Diseases / metabolism; Horses; Male; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Sequence Analysis, DNA; Uveitis / metabolism; Uveitis / veterinary
TL;DR:
Ciliary epithelium may play a role in recruitment and activation of leukocytes through expression of RANTES in horses by use of intradermal hypersensitivity testing and significant chemotaxis of equine leukocyte to rh-RANTES.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Single-tube nested PCR for detection of Tritrichomonas foetus in feline feces
JOURNAL OF CLINICAL MICROBIOLOGY, 40(11), 4126–4130.
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / parasitology; Cats; DNA Primers; DNA, Protozoan / analysis; DNA, Ribosomal / analysis; Feces / parasitology; Polymerase Chain Reaction / instrumentation; Polymerase Chain Reaction / methods; Protozoan Infections / diagnosis; Protozoan Infections / parasitology; Protozoan Infections, Animal; RNA, Ribosomal, 5.8S / genetics; Sensitivity and Specificity; Tritrichomonas foetus / genetics; Tritrichomonas foetus / isolation & purification
TL;DR:
The results demonstrate that the single-tube nested PCR is ideally suited for diagnostic testing of feline fecal samples that are found negative by direct microscopy and culturing and definitive identification of microscopically observable or cultivated organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Secretion-competent mouse tracheal epithelial cell culture from the genetically altered mouse - Pathway analysis via gene array
Chest, 121(3), 79S.
TL;DR:
This work presents a new Epithelial Repair Model of In Vitro Gene Expression in an http://chestjournal.chestpubs.org/content/121/3_suppl/79S.xhtml ( distributed without the prior written permission of the copyright holder).
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Plasma steroid concentrations in relation to size and age in juvenile alligators from two Florida lakes
Comparative Biochemistry and Physiology. A, Molecular & Integrative Physiology, 131(4), 923–930.
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Pharmacokinetics and endometrial tissue concentrations of enrofloxacin and the metabolite ciprofloxacin after i.v. administration of enrofloxacin to mares
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 25(5), 343–350.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Endometrium / metabolism; Enrofloxacin; Female; Fluoroquinolones; Horses / metabolism; Infusions, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics
TL;DR:
Endometrial tissue concentrations taken from the mares after dosing showed that enrofloxacin and ciprofloxin both penetrate this tissue adequately after systemic administration and would attain concentrations high enough in the tissue fluids to treat infections of the endometrium caused by susceptible bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 review
Newer gabaergic agents for pharmacotherapy of infantile spasms
[Review of ]. DRUGS OF TODAY, 38(10), 657–675.
MeSH headings : Adrenocorticotropic Hormone / genetics; Adrenocorticotropic Hormone / therapeutic use; Amino Acid Sequence; GABA Agents / chemistry; GABA Agents / metabolism; GABA Agents / therapeutic use; Humans; Infant; Molecular Sequence Data; Spasms, Infantile / drug therapy; Spasms, Infantile / metabolism
TL;DR:
Recent studies indicate that several newer anticonvulsant agents, which are positive allosteric modulators of GABA(A) receptors, are as effective as ACTH in acutely controlling infantile spasms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Nasal adenocarcinoma with diffuse metastases involving the orbit, cerebrum, and multiple cranial nerves in a horse
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 221(10), 1460–1463.
MeSH headings : Adenocarcinoma / diagnosis; Adenocarcinoma / secondary; Adenocarcinoma / veterinary; Animals; Brain Neoplasms / diagnosis; Brain Neoplasms / secondary; Brain Neoplasms / veterinary; Cerebrospinal Fluid / chemistry; Cranial Nerve Neoplasms / diagnosis; Cranial Nerve Neoplasms / secondary; Cranial Nerve Neoplasms / veterinary; Diagnosis, Differential; Fatal Outcome; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Male; Nose Neoplasms / diagnosis; Nose Neoplasms / pathology; Nose Neoplasms / veterinary; Orbital Neoplasms / diagnosis; Orbital Neoplasms / secondary; Orbital Neoplasms / veterinary; Prognosis; Tomography, X-Ray Computed / veterinary
TL;DR:
A 9-year-old Trakehner gelding examined because of right exophthalmus found a lack of menace response in the right eye, reduced direct and consensual right pupillary light reflexes, ventrolateral strabismus of the rightEye, mild right-sided facial asymmetry, a head tilt to the left, and increased extensor tone in theright limbs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 review
Hypoglycemia and embryonic heart development
[Review of ]. FRONTIERS IN BIOSCIENCE-LANDMARK, 7, D307–D318.
author keywords: hypoglycemia; embryo; heart; mouse; in vitro; in vivo; diabetes; morphology; function; metabolism; GRPs; hexokinase; glut-1; review
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Host DNA replication is induced by geminivirus infection of differentiated plant cells
PLANT CELL, 14(12), 2995–3007.
MeSH headings : Aphidicolin / pharmacology; Bromodeoxyuridine / metabolism; Cell Differentiation / genetics; Cell Differentiation / physiology; DNA Replication / drug effects; DNA Replication / genetics; DNA Replication / physiology; DNA, Viral / drug effects; DNA, Viral / metabolism; Geminiviridae / genetics; Geminiviridae / physiology; Hydroxyurea / pharmacology; Immunohistochemistry; In Situ Hybridization; Microscopy, Fluorescence; Tobacco / chemistry; Tobacco / genetics; Tobacco / virology
TL;DR:
5-bromo-2-deoxyuridine incorporation to examine DNA synthesis directly in infected Nicotiana benthamiana plants to determine if viral reprogramming of host replication controls had an impact on host DNA replication and demonstrate that chromosomal DNA is replicated in TGMV-infected cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Fibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 283(6), L1263–L1270.
author keywords: basal cell; perlecan; fibroblast growth factor receptor-1; rhesus monkey
MeSH headings : Aging / metabolism; Animals; Animals, Newborn / growth & development; Basement Membrane / metabolism; Collagen / metabolism; Fibroblast Growth Factor 2 / metabolism; Heparan Sulfate Proteoglycans / metabolism; Immunohistochemistry; Macaca mulatta; Male; Receptor Protein-Tyrosine Kinases / metabolism; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor / metabolism; Tissue Distribution; Trachea / anatomy & histology; Trachea / cytology; Trachea / metabolism
TL;DR:
The data indicate that development of the BMZ is a postnatal event in the rhesus monkey that involves FGF-2 and FGFR-1, and that more dynamic, functional components of the epithelial-mesenchymal trophic unit are detected in the developing BMZ.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Effects of prenatal testosterone propionate on the sexual development of male and female rats: A dose-response study
TOXICOLOGICAL SCIENCES, 65(1), 71–86.
author keywords: testosterone propionate; androgens; masculinization; prenatal exposure; sexual differentiation; anogenital distance; agenesis of the lower vagina; Sprague-Dawley rats
MeSH headings : Abnormalities, Drug-Induced / etiology; Anal Canal / abnormalities; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Genitalia, Female / abnormalities; Genitalia, Male / abnormalities; Gonadal Steroid Hormones / administration & dosage; Gonadal Steroid Hormones / physiology; Gonadal Steroid Hormones / toxicity; Male; Maternal Exposure / adverse effects; Nipples / abnormalities; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Testosterone / administration & dosage; Testosterone / physiology; Testosterone / toxicity; Toxicity Tests; Vagina / abnormalities
TL;DR:
Gestation administration of 0.5 and 1 mg TP masculinizes female offspring without greatly affecting pup viability or pregnancy of the dam, and this study provides a useful model for in utero testing of environmental androgens for their potential to induce developmental abnormalities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Association of factor H of the alternative pathway of complement with agrin and complement receptor 3 in the Alzheimer's disease brain
JOURNAL OF NEUROIMMUNOLOGY, 131(1-2), 135–146.
author keywords: Alzheimer's; factor H; heparan sulfate proteoglycan; agrin; complement receptor 3; amyloid beta
MeSH headings : Aged; Agrin / analysis; Agrin / metabolism; Alzheimer Disease / immunology; Alzheimer Disease / metabolism; Alzheimer Disease / pathology; Amyloid beta-Peptides / analysis; Amyloid beta-Peptides / metabolism; Blotting, Western; Brain / immunology; Brain / metabolism; Brain Chemistry; Complement Factor H / analysis; Complement Factor H / immunology; Complement Factor H / metabolism; Complement Pathway, Alternative; Humans; Immunohistochemistry; Macrophage-1 Antigen / analysis; Neuroglia / immunology
TL;DR:
It is proposed that CR3 receptors expressed by microglia are used for ligand binding to factor H bound to HSPGs and Abeta in plaques in the AD brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Alternative splicing of a beta(4) subunit proline-rich motif regulates voltage-dependent gating and toxin block of Ca(v)2.1 Ca2+ channels
Journal of Neuroscience, 22(21), 9331–9339.
MeSH headings : Alternative Splicing / physiology; Amino Acid Motifs / physiology; Animals; Brain / metabolism; Calcium Channel Blockers / pharmacology; Calcium Channels, N-Type / drug effects; Calcium Channels, N-Type / genetics; Calcium Channels, N-Type / metabolism; Humans; Ion Channel Gating / drug effects; Ion Channel Gating / physiology; Membrane Potentials / physiology; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins / genetics; Oocytes / metabolism; Organ Specificity; Patch-Clamp Techniques; Protein Structure, Tertiary / physiology; Protein Subunits / drug effects; Protein Subunits / genetics; Protein Subunits / metabolism; RNA, Messenger / metabolism; Sequence Deletion; Sequence Homology, Amino Acid; Spinal Cord / metabolism; Structure-Activity Relationship; Xenopus laevis; omega-Conotoxins / pharmacology
TL;DR:
The models reveal that alternative splicing of the β4 N terminus results in dramatic differences in surface charge distribution and localize the proline-rich motif of β4b to an extended arm structure that flanks what would be the equivalent of a highly modified PSD-95 carboxylate binding loop.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation
AMERICAN JOURNAL OF PATHOLOGY, 161(2), 405–411.
MeSH headings : Animals; Carcinogens / toxicity; Cell Division / genetics; Cell Transformation, Neoplastic / genetics; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases / deficiency; Cyclin-Dependent Kinases / genetics; Keratinocytes / cytology; Keratinocytes / enzymology; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins; Skin Neoplasms / enzymology; Skin Neoplasms / etiology; Skin Neoplasms / genetics; Tetradecanoylphorbol Acetate / toxicity
TL;DR:
The results suggest that therapeutic approaches to inhibit cdk4 activity could provide a target to inhibit tumor development with minimal or no effect in normal tissue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
The role of interferon regulatory factors in the cardiac response to viral infection
VIRAL IMMUNOLOGY, 15(1), 17–28.
MeSH headings : Animals; DNA-Binding Proteins / physiology; Interferon Regulatory Factor-1; Interferon Regulatory Factor-2; Interferon Regulatory Factor-3; Interferon-beta / genetics; Interferon-beta / physiology; Mice; Myocarditis / immunology; Phosphoproteins / physiology; Reoviridae Infections / immunology; Repressor Proteins; Transcription Factors / physiology; Transcription, Genetic
TL;DR:
The role of IRF-2 in regulation of IFN-beta expression is cell type-specific and differs between skeletal and cardiac muscle cells, suggesting that the heart may provide a unique environment for IRF function, critical for protection against virus-induced cardiac damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Putative drug-related pemphigus foliaceus in four dogs
VETERINARY DERMATOLOGY, 13(4), 195–202.
author keywords: adverse drug reaction; antibiotics; dogs; pemphigus foliaceus; skin lesions
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Diagnosis, Differential; Dog Diseases / chemically induced; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Drug Eruptions / diagnosis; Drug Eruptions / veterinary; Female; Immunosuppressive Agents / therapeutic use; Male; Pemphigus / diagnosis; Pemphigus / veterinary
TL;DR:
Four dogs developed cutaneous lesions following the administration of various antibiotics, Histopathology of the lesions was compatible with pemphigus foliaceus, although apoptotic cells suggestive of erythema multiforme were seen in two cases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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