Works Published in 2018
Displaying works 61 - 80 of 141 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Effect of age on plasma protein binding of several veterinary drugs in dairy Check for calves 2
RESEARCH IN VETERINARY SCIENCE, 121, 59–64.
author keywords: Protein binding; Calves; Alpha-1-acid glycoprotein; Albumin
MeSH headings : Age Factors; Animals; Blood Proteins / metabolism; Cattle / metabolism; Protein Binding; Veterinary Drugs / metabolism
TL;DR:
Findings from these calves suggest that age is not an important factor in the binding of these drugs to plasma proteins, and statistically significant age-effects on plasma protein binding were not observed for any of the drugs evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 17, 2018
2018 journal article
A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(4), 441–452.
Contributors: F. Grimm*, A. Blanchette*, J. House n , K. Ferguson *, N. Hsieh *, C. Dalaijamts *, A. Wright*, B. Anson*
MeSH headings : Cardiotoxicity / genetics; Cardiovascular Agents / pharmacology; Cardiovascular Agents / toxicity; Cell Differentiation / drug effects; Cell Differentiation / genetics; Female; Healthy Volunteers; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / drug effects; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Phenotype; Reproducibility of Results
TL;DR:
iPSC-derived cardiomyocytes exhibited reproducible donor-specific differences in baseline function and drug-induced effects, demonstrating the feasibility of using a panel of population-based organotypic cells from healthy donors as an animal replacement experimental model to quantify inter-individual variability in xenobiotic responses.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 10, 2018
2018 journal article
Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam
Proceedings of the Royal Society B: Biological Sciences, 285(1891), 20181237.
Contributors: M. Baptissart n, H. Lamb n, K. To n, C. Bradish n , J. Tehrani n, D. Reif n , M. Cowley n
MeSH headings : Animals; Animals, Newborn / physiology; Diet, High-Fat; Female; Maternal Behavior / physiology; Maternal Exposure; Mice / physiology; Mice, Inbred C57BL; Pregnancy
TL;DR:
In utero exposure to HF diet programmes physiological changes in the offspring which influence the maternal behaviours of their dam after birth are suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: December 10, 2018
2018 journal article
IR-MALDESI mass spectrometry imaging of underivatized neurotransmitters in brain tissue of rats exposed to tetrabromobisphenol A
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410(30), 7979–7986.
author keywords: IR-MALDESI; Neurotransmitters; Mass spectrometry imaging; Exposomics; Orbitrap
MeSH headings : Animals; Brain; Female; Infrared Rays; Neurotransmitter Agents / chemistry; Polybrominated Biphenyls / toxicity; Rats; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
This study serves as a demonstration of a new application of IR-MALDESI, namely that neurotransmitter distributions can be confidently and rapidly imaged without derivatization, and is used for the analysis of neurotransmitters in the brains of rats exposed to TBBPA in gestation and lactation through their mothers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018
2018 journal article
Effect of 3 phytoceutical products on elimination of bacteria in experimentally induced Streptococcus uberis clinical mastitis
JOURNAL OF DAIRY SCIENCE, 101(11), 10409–10413.
author keywords: mastitis; Streptococcus uberis; phytoceutical
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Cattle; Female; Lactation; Mammary Glands, Animal / drug effects; Mammary Glands, Animal / microbiology; Mastitis, Bovine / drug therapy; Mastitis, Bovine / microbiology; Milk / drug effects; Milk / microbiology; Plant Preparations / pharmacology; Random Allocation; Streptococcal Infections / drug therapy; Streptococcal Infections / microbiology; Streptococcal Infections / veterinary; Streptococcus / drug effects
TL;DR:
It is concluded that the phytoceuticals tested, as dosed and used in this trial, did not produce bacterial cures in S. uberis-induced mastitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 5, 2018
2018 journal article
Use of an ultrafiltration device in gland cistern for continuous sampling of healthy and mastitic quarters of lactating cattle for pharmacokinetic modeling
JOURNAL OF DAIRY SCIENCE, 101(11), 10414–10420.
MeSH headings : Administration, Intravenous / veterinary; Animals; Cattle; Chromatography, High Pressure Liquid / veterinary; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Feasibility Studies; Female; Lactation; Mammary Glands, Animal / metabolism; Mass Spectrometry / veterinary; Mastitis, Bovine / diagnosis; Milk / chemistry; Ultrafiltration / veterinary
TL;DR:
Collection of ultrafiltration samples from the mammary gland of cows provides a viable means to continuously assess drug concentrations in the milk while continuing to milk the cow normally, and demonstrates the utility of continuous sampling of milk via ultraFiltration for future pharmacokinetic studies in cattle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: NC State University Libraries
Added: November 5, 2018
2018 journal article
C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event
Cell Death & Disease, 9(11).
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / administration & dosage; Animals; Apoptosis / drug effects; Apoptosis / genetics; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / genetics; Cell Differentiation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Knockout; Receptors, Death Domain / genetics; Receptors, Death Domain / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / administration & dosage; Tetradecanoylphorbol Acetate / analogs & derivatives; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; ras Proteins / genetics; ras Proteins / metabolism
TL;DR:
The results show that oncogenic Ras tumors display a significant DNA damage/replicative stress phenotype and these tumors have acquired a dependence on C/EBPβ for their survival, making it a promising target for future potential anticancer therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: October 29, 2018
2018 journal article
Relationship Between Sequence Homology, Genome Architecture, and Meiotic Behavior of the Sex Chromosomes in North American Voles
GENETICS, 210(1), 83–97.
author keywords: pseudoautosomal region; Microtus heterochromatin; telomeric repeats; meiotic synapsis
MeSH headings : Animals; Arvicolinae / genetics; Chromosome Segregation / genetics; Genomics / methods; Meiosis / genetics; North America; Pseudoautosomal Regions / genetics; Sequence Analysis, DNA / methods; Sequence Homology, Nucleic Acid; Sex Chromosomes / genetics; Telomere / genetics; Telomere-Binding Proteins / genetics; X Chromosome / genetics; Y Chromosome / genetics
TL;DR:
Key conditions required to sustain the standard program of X/Y synapsis at meiosis are suggested and an intriguing connection between heterochromatic repeat architecture and noncanonical, asynaptic mechanisms of sex chromosome segregation in voles is revealed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 19, 2018
2018 journal article
Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip
SCIENTIFIC REPORTS, 8(1).
Contributors: C. Sakolish*, E. Weber*, E. Kelly *, J. Himmelfarb *, R. Mouneimne*, F. Grimm*, J. House n , T. Wade *
MeSH headings : Anti-Bacterial Agents / toxicity; Cell Culture Techniques / instrumentation; Cell Line; Cell Survival / drug effects; Drug Development / instrumentation; Drug Evaluation, Preclinical / instrumentation; Humans; Kidney Tubules, Proximal / cytology; Kidney Tubules, Proximal / drug effects; Kidney Tubules, Proximal / metabolism; Lab-On-A-Chip Devices; Polymyxin B / toxicity; Technology Transfer; Vitamin D / metabolism
TL;DR:
While the overall transferability of this advanced tissue chip platform was a success, the reproducibility with the original report was greatly dependent on the cell source, demonstrating critical importance of developing microphysiological platforms using renewable cell sources.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2018
2018 journal article
Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis
PLOS GENETICS, 14(9).
TL;DR:
The genomic landscape of canine melanoma is mapped through multi-platform analysis of 37 tumors and matching constitutional samples and identifies novel predominantly truncating mutations in the putative tumor suppressor gene PTPRJ, which resembles that seen in BRAF wild-type and sun-shielded human melanoma subtypes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 article
Extralabel drug use in small ruminants
Martin, K. L., Clapham, M. O., Davis, J. L., Baynes, R. E., Lin, Z., Vickroy, T. W., … Tell, L. A. (2018, October 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 253, pp. 1001–1009.
MeSH headings : Animals; Drug Residues; Goat Diseases / drug therapy; Goats; Legislation, Drug; Off-Label Use; Sheep; Sheep Diseases / drug therapy; United States; United States Food and Drug Administration; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
The purpose of this digest is to update a previous FARAD Digest2 concerning small ruminants and provide veterinarians with summary information regarding ELDU in smallRuminants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Assessment of growth, survival, and organ tissues of caged mussels (Bivalvia: Unionidae) in a river-scape influenced by coal mining in the southeastern USA
SCIENCE OF THE TOTAL ENVIRONMENT, 645, 1273–1286.
author keywords: Clinch River; Histology; Freshwater mussels; Chemical mixtures; Lipid peroxidation; Kidney lipofuscin
MeSH headings : Animals; Bivalvia / physiology; Coal Mining; Environmental Monitoring / methods; Fresh Water; Rivers; Unionidae; Water Pollutants, Chemical / analysis
TL;DR:
These results suggest that conditions continue to exist in the zone of decline that promote impacts to mussels that are at least partially associated with low concentration coal-related contaminants.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2018 journal article
Estimation of cis-eQTL effect sizes using a log of linear model
BIOMETRICS, 74(2), 616–625.
author keywords: eQTL analyses; EQTL effect size; Multiple testing; Nonlinear regression
MeSH headings : Algorithms; Alleles; Gene Expression; Humans; Linear Models; Quantitative Trait Loci; Statistics as Topic
TL;DR:
A new, log‐of‐linear model for eQTL action is proposed, termed ACME, that captures allelic contributions to cis‐acting eZTLs in an additive fashion, yielding effect size estimates that correspond to a biologically coherent model of cis‐eQTLs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2018 journal article
Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp nov.
SYSTEMATIC AND APPLIED MICROBIOLOGY, 41(5), 460–472.
author keywords: Acidovorax; Phenanthrene; Polycyclic aromatic hydrocarbons
MeSH headings : Biodegradation, Environmental; Comamonadaceae / chemistry; Comamonadaceae / classification; Comamonadaceae / genetics; Comamonadaceae / physiology; DNA, Bacterial; Genes, Bacterial; Genome, Bacterial / genetics; Metabolic Networks and Pathways / genetics; North Carolina; Phenanthrenes / metabolism; Phylogeny; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Soil Microbiology; Soil Pollutants / metabolism
TL;DR:
Four bacterial strains identified as members of the Acidovorax genus were isolated from two geographically distinct but similarly contaminated soils in North Carolina, USA, characterized, and their genomes sequenced, indicating that they likely represent a single species within the genus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Relation of contaminants to fish intersex in riverine sport fishes
SCIENCE OF THE TOTAL ENVIRONMENT, 643, 73–89.
author keywords: Endocrine active compounds; Endocrine disruption; Bass; Polycyclic aromatic hydrocarbons; Ethinylestradiol; Mercury
MeSH headings : Animals; Disorders of Sex Development / epidemiology; Disorders of Sex Development / veterinary; Environmental Monitoring; Female; Fish Diseases / epidemiology; Fishes / physiology; Male; North Carolina; Rivers / chemistry; South Carolina; Sports; Water Pollutants, Chemical / analysis; Water Pollution, Chemical / statistics & numerical data
TL;DR:
Polycyclic aromatic hydrocarbons, ethinylestradiol, and heavy metals were the most prevalent contaminants that exceeded effect levels for the protection of aquatic organisms and principal component analysis identified waterborne PAHs as the most correlated environmental contaminant with intersex occurrence and severity in black bass and sunfish.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018
2018 journal article
Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius
SCIENTIFIC REPORTS, 8.
MeSH headings : Animals; Cells, Cultured; Cellular Reprogramming / drug effects; Cellular Reprogramming / genetics; Culture Media / metabolism; Culture Media / pharmacology; Evolution, Molecular; Female; Fibroblasts; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Induced Pluripotent Stem Cells; Leukemia Inhibitory Factor / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Male; Mice / genetics; Mice, Inbred Strains / genetics; Mouse Embryonic Stem Cells; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Sex Factors; Transcription, Genetic
TL;DR:
iPSC derived in 2iS are more transcriptionally similar to ESC than EpiSC, indicating that iPSC reprogramming acts to overcome genetic background constraints, and only some M. musculus strains are permissive under LIF culture conditions suggesting that this is an evolutionarily derived characteristic in the M.Mus musculus lineage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Duality of estrogen receptor beta action in cancer progression
CURRENT OPINION IN PHARMACOLOGY, 41, 66–73.
Contributors: T. Guillette n, T. Jackson n & S. Belcher n
MeSH headings : Animals; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Cerebellar Neoplasms / metabolism; Cerebellar Neoplasms / pathology; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / metabolism; Female; Humans; Male; Medulloblastoma / metabolism; Medulloblastoma / pathology; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2018 journal article
Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways
TOXICOLOGICAL SCIENCES, 165(1), 145–156.
author keywords: phenotype; database; curation; chemical; disease; adverse outcome pathway
MeSH headings : Adverse Outcome Pathways; Animals; Databases, Factual; Drug-Related Side Effects and Adverse Reactions / genetics; Gene Ontology; Gene-Environment Interaction; Humans; Phenotype; Toxicogenetics / methods
TL;DR:
This work introduces a new chemical-phenotype module that describes how chemicals can affect molecular, cellular, and physiological phenotypes, and presents 3 diverse case studies discerning the effect of vehicle emissions on altered leukocyte migration, the role of cadmium in influencing phenotypes preceding Alzheimer disease, and the connection of arsenic-induced glucose metabolic phenotypes with diabetes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018
2018 journal article
Comparison of the pharmacokinetics of plant-based treatments in milk and plasma of USDA organic dairy cattle with and without mastitis
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 35(9), 1716–1727.
author keywords: Pharmacology; milk; organic; thymol; carvacrol; bovine; cattle
MeSH headings : Animals; Cattle; Cymenes; Dairying; Female; Food, Organic / analysis; Garlic / chemistry; Milk / chemistry; Monoterpenes / blood; Thymol / blood; United States; United States Department of Agriculture
TL;DR:
Study of the pharmacokinetics of 3 compounds used on organic both healthy and mastitic organic dairy cattle found levels remained below the limit of detection in milk and plasma and thus no withdrawal time appears to be needed for milk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Food web contaminant dynamics of a large Atlantic Slope river: Implications for common and imperiled species
SCIENCE OF THE TOTAL ENVIRONMENT, 633, 1062–1077.
author keywords: Metals; Organics; Robust redhorse; Stable isotopes; Trophic magnification factor
MeSH headings : Animals; Cypriniformes / metabolism; Endangered Species; Food Chain; Geologic Sediments / chemistry; Hydrocarbons, Chlorinated / analysis; Mercury / analysis; North Carolina; Pesticides / analysis; Polychlorinated Biphenyls / analysis; Polycyclic Aromatic Hydrocarbons / analysis; Rivers / chemistry; South Carolina; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / metabolism
TL;DR:
The aquatic food web structure and trophic transfer and accumulation of contaminants within a riverine ecosystem and potential stressors to the health of an imperiled fish, the robust redhorse and other species of conservation concern in a large Atlantic Slope (USA) river are determined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
