Works Published in 2018
Displaying works 101 - 120 of 174 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network
SCIENTIFIC REPORTS, 8.
MeSH headings : Actins / metabolism; Animals; Cytoskeleton / metabolism; Female; Male; Mice; Mice, Inbred C57BL; Microtubules / metabolism; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Neurites / metabolism; Neurons / cytology; Neurons / metabolism; Phosphorylation; Primary Cell Culture; Protein Binding; Pseudopodia / metabolism; Signal Transduction; cdc42 GTP-Binding Protein / metabolism
TL;DR:
It is proposed that MARCKS is uniquely positioned to regulate CDC42 localization and interactions within specialized cellular compartments, such as nascent neurites.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 19, 2018
2018 journal article
Veterinary Medical Students' Motivations for Exercise
JOURNAL OF VETERINARY MEDICAL EDUCATION, 45(3), 367–373.
author keywords: academic affairs; curriculum; environment; outcomes; psychology; public health; student affairs; student health and well-being
MeSH headings : Adult; Animals; Education, Veterinary; Exercise; Female; Humans; Male; Motivation; North Carolina; Students, Medical / psychology; Surveys and Questionnaires; Young Adult
TL;DR:
This study is the first to explore what motivates veterinary medical students to exercise given their unique situational and environmental factors and it is the authors' hope that the findings will help identify exercise-related wellness interventions that could be implemented in veterinary medical schools.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 19, 2018
2018 journal article
Demonstration of a basic mitochondrial enrichment method to produce the complete mitochondrial genome sequence of the endangered North Atlantic right whale (Eubalaena glacialis)
CONSERVATION GENETICS RESOURCES, 10(3), 483–486.
author keywords: Mitochondrial enrichment; Eubalaena glacialis; Mitochondrial genome; Next generation sequencing; Bioinformatics
TL;DR:
This method simultaneously allows for efficient sequencing of the mitochondrial genome, while demonstrating quality sequence coverage that is even across the genome, which illustrates a marked improvement in sequence depth compared to that achieved when performing whole genome sequencing using a standard DNA extraction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: October 19, 2018
2018 journal article
Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis
PLOS GENETICS, 14(9).
TL;DR:
The genomic landscape of canine melanoma is mapped through multi-platform analysis of 37 tumors and matching constitutional samples and identifies novel predominantly truncating mutations in the putative tumor suppressor gene PTPRJ, which resembles that seen in BRAF wild-type and sun-shielded human melanoma subtypes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Phenotypic characterization of complete CSNB in the inbred research beagle: how common is CSNB in research and companion dogs?
DOCUMENTA OPHTHALMOLOGICA, 137(2), 87–101.
author keywords: Congenital stationary night blindness; Dog; Electroretinography; Complete; Retina
MeSH headings : Adaptation, Ocular / physiology; Animals; Animals, Inbred Strains; Dark Adaptation / physiology; Dogs; Electroretinography; Eye Diseases, Hereditary / physiopathology; Genetic Diseases, X-Linked / physiopathology; Myopia / physiopathology; Night Blindness / physiopathology; Phenotype; Refraction, Ocular / physiology; Retina / physiopathology; Retinal Bipolar Cells / physiology; Retinal Rod Photoreceptor Cells / physiology; Retrospective Studies; Vision, Ocular / physiology
TL;DR:
CSNB appears to be a rare disorder in the wider beagle population, although its detection could confound studies that use retinal function as an outcome measure in research dogs, necessitating careful baseline studies to be performed prior to experimentation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Multiloculated solitary (unicameral) bone cyst in a young dog
VETERINARY CLINICAL PATHOLOGY, 47(3), 484–488.
author keywords: Canine; cytology; lytic; osseous; osteoclast; skeletal
MeSH headings : Animals; Bone Cysts / complications; Bone Cysts / diagnostic imaging; Bone Cysts / pathology; Bone Cysts / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Femur / diagnostic imaging; Femur / pathology; Lameness, Animal / etiology; Lameness, Animal / pathology; Radiography / veterinary
TL;DR:
A 20-month-old female spayed Staffordshire Terrier presented to the Orthopedic Surgery Service at North Carolina State University Veterinary Teaching Hospital for evaluation of a 6-week history of toe-touching to nonweight-bearing lameness, and amputation of the right hind limb was performed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Molecular Dynamics Simulations of Kir2.2 Interactions with an Ensemble of Cholesterol Molecules
BIOPHYSICAL JOURNAL, 115(7), 1264–1280.
Contributors: N. Barbera*, M. Ayee*, B. Akpa n & I. Levitan *
MeSH headings : Binding Sites; Cholesterol / metabolism; Elasticity; Ion Channel Gating; Molecular Dynamics Simulation; Potassium Channels, Inwardly Rectifying / chemistry; Potassium Channels, Inwardly Rectifying / metabolism; Protein Binding; Protein Conformation
TL;DR:
Martini coarse-grained simulations are used to analyze the long timescale dynamics of cholesterol with Kir2.2 channels and find that the cholesterol environment surrounding Kir channels forms a complex milieu of different short- and long-term interactions, with multiple cholesterol molecules concurrently interacting with the channel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 16, 2018
2018 journal article
Toxicity associated with ingestion of a polyacrylic acid hydrogel dog pad
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 30(5), 708–714.
author keywords: Dogs; hydrogel; neurotoxicity; poisoning; sodium polyacrylate
MeSH headings : Acrylic Resins / poisoning; Acrylic Resins / toxicity; Animals; Dog Diseases / chemically induced; Dogs; Eating; Female; Hydrogels / poisoning; Hydrogels / toxicity; Male; North Carolina; Rats; Rats, Sprague-Dawley
TL;DR:
Results from an experimental study in rats support the conclusion that some pet pad hydrogel products can induce acute neurotoxicity in animals under high-dose exposure conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius
SCIENTIFIC REPORTS, 8.
MeSH headings : Animals; Cells, Cultured; Cellular Reprogramming / drug effects; Cellular Reprogramming / genetics; Culture Media / metabolism; Culture Media / pharmacology; Evolution, Molecular; Female; Fibroblasts; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Induced Pluripotent Stem Cells; Leukemia Inhibitory Factor / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Male; Mice / genetics; Mice, Inbred Strains / genetics; Mouse Embryonic Stem Cells; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Sex Factors; Transcription, Genetic
TL;DR:
iPSC derived in 2iS are more transcriptionally similar to ESC than EpiSC, indicating that iPSC reprogramming acts to overcome genetic background constraints, and only some M. musculus strains are permissive under LIF culture conditions suggesting that this is an evolutionarily derived characteristic in the M.Mus musculus lineage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2018 journal article
Enrichment Preferences of FIV-Infected and Uninfected Laboratory-Housed Cats
VIRUSES-BASEL, 10(7).
author keywords: FIV; enrichment; welfare; feline; laboratory animal
MeSH headings : Animals; Animals, Laboratory; Cats; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / physiology
TL;DR:
Cats used in a longitudinal study of the effects of chronic feline immunodeficiency virus (FIV) infection were used and it was found that cats elected to be brushed, preferred social interaction and play with the laser to the ball, and preferred to scratch on an inclined-box toenail conditioning object compared to a horizontal, circular toenails conditioning object.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Pharmacokinetics and pharmacodynamic effects in koi carp (Cyprinus carpio) following immersion in propofol
VETERINARY ANAESTHESIA AND ANALGESIA, 45(4), 529–538.
author keywords: fish; immersion; koi carp; pharmacodynamics; pharmacokinetics; propofol
MeSH headings : Anesthesia Recovery Period; Animals; Carps / metabolism; Chromatography, High Pressure Liquid / veterinary; Deep Sedation / methods; Deep Sedation / veterinary; Heart Rate / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / blood; Hypnotics and Sedatives / pharmacokinetics; Hypnotics and Sedatives / pharmacology; Immersion; Propofol / administration & dosage; Propofol / blood; Propofol / pharmacokinetics; Propofol / pharmacology
TL;DR:
Measurable PPCs were achieved in koi carp anesthetized with propofol by immersion, but recovery time was not.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair
PLOS ONE, 13(8).
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Epithelium / injuries; Epithelium / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Ischemia / physiopathology; Jejunum / injuries; Jejunum / physiology; Recovery of Function; Swine; Vascular Diseases / pathology; Vascular Diseases / prevention & control
TL;DR:
Findings support the hypothesis that a defect in mucosal repair in neonates is due to immature repair mechanisms within the mucosal compartment, and ex vivo exogenous application of injured juvenile mucosal homogenate produced a significant increase in TEER and enhanced histological restitution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 5(135).
author keywords: Medicine; Issue 135; Porcine; intestine; ischemia-reperfusion; stem cell; enteroid; organoid
MeSH headings : Animals; Cell Culture Techniques / methods; Disease Models, Animal; Humans; Intestine, Small / cytology; Intestine, Small / metabolism; Intestine, Small / pathology; Ischemia / etiology; Mice; Stem Cells / metabolism; Swine
TL;DR:
By utilizing a porcine model, a protocol is established in which segmental loops of intestinal ischemia can be created within a single animal, enabling the study of differing time points of ischemic injury and repair in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2018 personal communication
Caudal intercostal block for abdominal surgery in horses
Gingold, B. M. C., Hassen, K. M., Milloway, M. C., Gerard, M., & Fowler, A. W. (2018, August).
MeSH headings : Anesthesia, Caudal / methods; Anesthesia, Caudal / veterinary; Animals; Horses / surgery; Intercostal Nerves; Laparotomy / veterinary; Nerve Block / veterinary; Pain, Postoperative / prevention & control; Pain, Postoperative / veterinary; Treatment Outcome
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Use of Short Animal-Themed Videos to Enhance Veterinary Students' Mood, Attention, and Understanding of Pharmacology Lectures
JOURNAL OF VETERINARY MEDICAL EDUCATION, 45(2), 188–194.
author keywords: education enhancement; video; stress reduction; emotional impact
MeSH headings : Animals; Cats; Dogs; Education, Veterinary / methods; Educational Measurement; Humans; Pharmacology, Clinical / education; Program Evaluation; Students, Medical; Surveys and Questionnaires; Video Recording
TL;DR:
Results suggest that showing short cute animal videos in the middle of class positively affected students' mood, interest in material, and self-reported understanding of material.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
The pharmacokinetics and analgesic effects of extended-release buprenorphine administered subcutaneously in healthy dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 41(4), 502–512.
author keywords: buprenorphine; dog; extended-release; pharmacodynamics; pharmacokinetics
MeSH headings : Analgesia / methods; Analgesia / veterinary; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Analgesics, Opioid / pharmacology; Animals; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Buprenorphine / pharmacology; Delayed-Action Preparations; Dogs; Female; Injections, Subcutaneous / veterinary; Male
TL;DR:
Results showed that ER-buprenorphine administered at a dose of 0.2 mg/kg resulted in prolonged and sustained plasma concentrations and antinociceptive effects up to 72 hr after drug administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Recovery of horses from general anesthesia after induction with propofol and ketamine versus midazolam and ketamine
Journal of the American Veterinary Medical Association, 253(1), 101–107.
MeSH headings : Anesthesia Recovery Period; Anesthesia, General / veterinary; Anesthetics, Intravenous / administration & dosage; Anesthetics, Intravenous / pharmacokinetics; Animals; Female; Horses / blood; Ketamine / administration & dosage; Ketamine / pharmacokinetics; Male; Midazolam / administration & dosage; Midazolam / pharmacokinetics; Propofol / administration & dosage; Propofol / pharmacokinetics; Prospective Studies; Random Allocation; Treatment Outcome
TL;DR:
It is suggested that for horses undergoing short periods of general anesthesia, recovery quality may be better following induction with propofol and ketamine, compared with midazolam and ketamines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Population pharmacokinetics of ceftazidime after a single intramuscular injection in wild turtles
Journal of Veterinary Pharmacology and Therapeutics, 41(4), 495–501.
author keywords: ceftazidime; nonlinear mixed-effects modeling; pharmacokinetics; turtles
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Ceftazidime / administration & dosage; Ceftazidime / blood; Ceftazidime / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Injections, Intramuscular / veterinary; Turtles / blood; Turtles / metabolism
TL;DR:
This investigation used a population pharmacokinetic approach to study ceftazidime in wild turtles presented for rehabilitation, and concluded that this long T½ will allow for a dose of 20 mg/kg injected IM to maintain concentrations above the MIC of most wild-type bacteria for 5 days.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2018 journal article
High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism
Proceedings of the National Academy of Sciences, 115(21), 5420–5425.
author keywords: HMGA2; dwarfism; swine; gene editing; organ size
MeSH headings : Animals; Cryptorchidism / etiology; Cryptorchidism / pathology; Dwarfism / etiology; Dwarfism / pathology; Female; Fetal Diseases / etiology; Fetal Diseases / pathology; Genotype; HMGA2 Protein / deficiency; HMGA2 Protein / genetics; Litter Size; Male; Nuclear Transfer Techniques / veterinary; Pregnancy; Reproduction; Swine; Swine Diseases / etiology; Swine Diseases / pathology
TL;DR:
The results show that the effect of HMGA2 with respect to growth regulation is highly conserved among mammals and opens up the possibility of regulating body and organ size in a variety of mammalian species including food and companion animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2018 journal article
Use of tricaine methanesulfonate or propofol for immersion euthanasia of goldfish (Carassius auratus)
Journal of the American Veterinary Medical Association, 252(12), 1555–1561.
MeSH headings : Aminobenzoates / administration & dosage; Aminobenzoates / pharmacology; Anesthetics / administration & dosage; Anesthetics / pharmacology; Animals; Euthanasia, Animal; Fishes; Myocardial Contraction / drug effects; Propofol / administration & dosage; Propofol / pharmacology; Prospective Studies; Random Allocation; Water
TL;DR:
Whether immersion in propofol at 5 times its immersion anesthesia concentration for 30 minutes is sufficient for euthanasia of goldfish, and the duration of myocardial contraction following immersion of gold fish in TMS and decapitation are quantified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
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