Biomedical Engineering

Works Published in 2015

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Displaying works 81 - 100 of 164 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2015 article

Spatiotemporal drug delivery using laser-generated-focused ultrasound system

Di, J., Kim, J., Hu, Q., Jiang, X., & Gu, Z. (2015, December 28). JOURNAL OF CONTROLLED RELEASE, Vol. 220, pp. 592–599.

By: J. Di n, J. Kim n, Q. Hu n, X. Jiang n & Z. Gu n

author keywords: Drug delivery; Photoacoustic; Nanoparticles; Microgels; Stimuli responsive
MeSH headings : Alginates / chemistry; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Chemistry, Pharmaceutical; Ciprofloxacin / administration & dosage; Ciprofloxacin / chemistry; Delayed-Action Preparations; Dimethylpolysiloxanes / chemistry; Disk Diffusion Antimicrobial Tests; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers; Equipment Design; Escherichia coli / drug effects; Escherichia coli / growth & development; Gels; Glucuronic Acid / chemistry; HeLa Cells; Hexuronic Acids / chemistry; Humans; Kinetics; Lactic Acid / chemistry; Lasers; Nanoparticles; Photoacoustic Techniques; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Soot / chemistry; Spheroids, Cellular; Technology, Pharmaceutical / instrumentation; Technology, Pharmaceutical / methods; Transducers; Ultrasonic Waves; Ultrasonics / instrumentation; Ultrasonics / methods
TL;DR: This novel LGFU-responsive drug delivery system provides a simple and remote approach to precisely control the release of therapeutics in a spatiotemporal manner and potentially suppress detrimental effects to the surrounding tissue, such as thermal ablation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Impact of guidance documents on translational large animal studies of cartilage repair

SCIENCE TRANSLATIONAL MEDICINE, 7(310).

By: C. Pfeifer *, M. Fisher n, J. Carey * & R. Mauck *

MeSH headings : Animals; Cartilage / physiopathology; Models, Animal; Translational Research, Biomedical; United States; United States Food and Drug Administration
TL;DR: A systematic review of large animal cartilage repair studies demonstrates that few investigators attend to guidance documents published by regulatory agencies, and the availability of the documents appears to have little effect on adherence by researchers to the recommendations therein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Transformable liquid-metal nanomedicine

NATURE COMMUNICATIONS, 6.

By: Y. Lu n, Q. Hu n, Y. Lin n, D. Pacardo n, C. Wang n, W. Sun n, F. Ligler n, M. Dickey  n, Z. Gu*

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Female; Gallium / chemistry; Humans; Indium / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Nanomedicine / instrumentation; Nanomedicine / methods; Neoplasms / drug therapy
TL;DR: A transformable liquid-metal nanomedicine, based on a core–shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell, providing a new strategy for engineering theranostic agents with low toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Anticancer Platelet-Mimicking Nanovehicles

ADVANCED MATERIALS, 27(44), 7043-+.

By: Q. Hu n, W. Sun n, C. Qian n, C. Wang n, H. Bomba n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Blood Platelets / cytology; Cell Line, Tumor; Cell Membrane / chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Humans; Intracellular Space / metabolism; Mice; Nanomedicine / methods; Nanostructures / chemistry; TNF-Related Apoptosis-Inducing Ligand / chemistry; TNF-Related Apoptosis-Inducing Ligand / metabolism
TL;DR: A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

The E3 ubiquitin ligase TRIM9 Is a filopodia off switch required for netrin-dependent axon guidance

Developmental Cell, 35(6), 698–712.

By: S. Menon, N. Boyer, C. Winkle, L. McClain, C. Hanlin, D. Pandey, S. Rothenfusser, A. Taylor, S. Gupton

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Human-Centered Design of Wearable Neuroprostheses and Exoskeletons

AI MAGAZINE, 36(4), 12–22.

By: J. Contreras-Vidal*, A. Kilicarslan*, H. Huang n  & R. Grossman*

Contributors: J. Contreras-Vidal*, A. Kilicarslan*, H. Huang n  & R. Grossman*

TL;DR: The human-centered approach to the design of closed-loop brain-machine interfaces to powered prostheses and exoskeletons that allow people to act beyond their impaired or diminished physical or sensory-motor capabilities is summarized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells

BIOCONJUGATE CHEMISTRY, 26(12), 2336–2349.

By: L. Karumbaiah *, S. Enam, A. Brown n, T. Saxena, M. Betancur *, T. Barker, R. Bellamkonda

MeSH headings : Animals; Brain-Derived Neurotrophic Factor / administration & dosage; Cell Proliferation; Cells, Cultured; Chondroitin Sulfates / chemistry; Fibroblast Growth Factor 2 / administration & dosage; Hydrogels / chemistry; Neural Stem Cells / cytology; Rats; Tissue Scaffolds / chemistry
TL;DR: The ability of CS-GAG based hydrogels to regulate NSC self-renewal, and facilitate growth factor enrichment locally is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Biomechanical basis of shoulder osseous deformity and contracture in a rat model of brachial plexus birth palsy

Journal of Bone and Joint Surgery-American Volume, 97A(15), 1264–1271.

By: D. Crouch, I. Hutchinson, J. Plate, J. Antoniono, H. Gong, G. Cao, Z. Li, K. Saul

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Unconstrained muscle-tendon workloops indicate resonance tuning as a mechanism for elastic limb behavior during terrestrial locomotion

Proceedings of the National Academy of Sciences of the United States of America, 112(43), E5891–5898.

By: B. Robertson & G. Sawicki

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Timing matters: tuning the mechanics of a muscle-tendon unit by adjusting stimulation phase during cyclic contractions

JOURNAL OF EXPERIMENTAL BIOLOGY, 218(19), 3150–3159.

By: G. Sawicki n, B. Robertson n, E. Azizi* & T. Roberts *

author keywords: Muscle-tendon interaction; Muscle stimulation phase; Work loop; Elastic energy storage and return; Terrestrial locomotion
MeSH headings : Animals; Biomechanical Phenomena; Locomotion / physiology; Muscle Contraction / physiology; Muscle, Skeletal / physiology; Rana catesbeiana / physiology; Tendons / physiology
TL;DR: During cyclic contractions of a muscle–tendon unit, the timing of muscle stimulation onset determines whether the muscle acts like a force producing strut, energy generating motor or energy absorbing brake. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Three Dimensional Full-wave Nonlinear Acoustic Simulations: Applications to Ultrasound Imaging

RECENT DEVELOPMENTS IN NONLINEAR ACOUSTICS, Vol. 1685.

By: G. Pinton n

TL;DR: This paper demonstrates how finite difference simulations for the nonlinear acoustic wave equation can be used to generate physically realistic two and three dimensional ultrasound images with finite differences. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots

ACS NANO, 9(9), 9407–9415.

By: J. Di n, S. Yao n, Y. Ye n, Z. Cui n, J. Yu n, T. Ghosh n , Y. Zhu n, Z. Gu n

author keywords: drug delivery; wearable devices; stimuli-responsive; nanoparticles; microdepots
MeSH headings : Animals; Drug Delivery Systems; Drug Liberation; Elastomers / chemistry; Elastomers / pharmacology; Mice; Nanoparticles / chemistry; Polymers / chemistry; Polymers / pharmacology
TL;DR: This work demonstrated that the tensile strain, applied to the stretchable device, facilitated release of therapeutics from microdepots for anticancer and antibacterial treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips

PLOS ONE, 10(11).

By: J. Andrade  n, J. Tang n, M. Hensley n, A. Vandergriff n, J. Cores n, E. Henry n, T. Allen n, T. Caranasos * ...

MeSH headings : Animals; Coronary Vessels / surgery; Disease Models, Animal; Ligation; Mice; Myocardial Infarction / etiology; Myocardial Infarction / mortality; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Surgical Instruments; Suture Techniques; Vascular Surgical Procedures
TL;DR: This new method, taking only less than 3 minutes to complete, represents an efficient myocardial infarction model in rodents and improved post-MI survival rate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Non-nutritive sweeteners in breast milk: perspective on potential implications of recent findings

Archives of Toxicology, 89(11), 2169–2171.

By: K. Rother*, A. Sylvetsky * & S. Schiffman n 

MeSH headings : Animals; Female; Humans; Lactation; Milk, Human / chemistry; Non-Nutritive Sweeteners / metabolism; Saccharin / metabolism; Sucrose / analogs & derivatives; Sucrose / metabolism; Thiazines / metabolism
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Dual-Frequency Acoustic Droplet Vaporization Detection for Medical Imaging

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 62(9), 1623–1633.

By: C. Arena n, A. Novell n, P. Sheeran n, C. Puett n, L. Moyer n & P. Dayton n

MeSH headings : Fluorocarbons / chemistry; Microbubbles; Microscopy, Acoustic / methods; Phantoms, Imaging; Transducers; Ultrasonography / methods
TL;DR: Results indicate that it is possible to generate high-sensitivity, high-contrast images of vaporization events and has the potential to be applied in combination with dropletmediated therapy to track treatment outcomes or as a standalone diagnostic system to monitor the physical properties of the surrounding environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Continuous-wave stimulated emission depletion microscope for imaging actin cytoskeleton in fixed and live cells

Sensors (Basel, Switzerland), 15(9), 24178–24190.

By: B. Neupane, T. Jin, L. Mellor, E. Loboa, F. Ligler & G. Wang

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Confinement-induced nanocrystal alignment of conjugated polymer by the soft-stamped nanoimprint lithography

CHINESE PHYSICS B, 24(10).

By: L. Xiao-Hui *, Y. Ji-Cheng  n, L. Nai-Yan *, Z. Wei-Dong *, W. Yu-Yan * & G. Zhen  n

author keywords: conjugated polymer; soft lithography; nanocrystalline material; x-ray technique
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Candle soot nanoparticles-polydimethylsiloxane composites for laser ultrasound transducers

APPLIED PHYSICS LETTERS, 107(16).

By: W. Chang n, W. Huang n, J. Kim n, S. Li n & X. Jiang n

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(41), 12029–12033.

By: W. Sun n, W. Ji n, J. Hall n, Q. Hu n, C. Wang  n, C. Beisel  n, Z. Gu n

author keywords: CRISPR-Cas9; DNA; drug delivery; genome editing; nanoparticles
MeSH headings : Animals; CRISPR-Associated Proteins / administration & dosage; CRISPR-Associated Proteins / chemistry; CRISPR-Associated Proteins / genetics; CRISPR-Cas Systems; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; DNA / administration & dosage; DNA / chemistry; DNA / genetics; Green Fluorescent Proteins / genetics; Humans; Mice, Nude; Nanoparticles / chemistry; Neoplasms / genetics; Neoplasms / therapy; RNA, Guide, Kinetoplastida / administration & dosage; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; Streptococcus pyogenes / chemistry; Streptococcus pyogenes / genetics
TL;DR: The biologically inspired vehicles were efficiently loaded with Cas9/sgRNA complexes and delivered the complexes to the nuclei of human cells, thus enabling targeted gene disruption while maintaining cell viability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Prediction of standard-dose brain PET image by using MRI and low-dose brain [F-18]FDG PET images

MEDICAL PHYSICS, 42(9), 5301–5309.

By: J. Kang*, Y. Gao *, F. Shi *, D. Lalush n, W. Lin * & D. Shen *

author keywords: positron emission tomography (PET); [F-18]FDG; brain [F-18]FDG PET prediction; regression forest
MeSH headings : Brain / diagnostic imaging; Fluorodeoxyglucose F18; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Positron-Emission Tomography / methods; Radiation Dosage
TL;DR: Both the visual and quantitative results indicate that the standard-dose brain [(18)F]FDG PET can be well-predicted using MRI and low-dose head PET images, and substantially enhanced image quality of low- doses PET and PET image. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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