Works Published in 2017
Displaying works 141 - 160 of 203 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
Do kinematic metrics of walking balance adapt to perturbed optical flow?
HUMAN MOVEMENT SCIENCE, 54, 34–40.
author keywords: Sensorimotor; Virtual reality; Gait; Vision; Visual feedback
MeSH headings : Adaptation, Physiological; Adult; Biomechanical Phenomena; Exercise Test; Female; Foot / physiology; Gait; Humans; Imaging, Three-Dimensional; Lower Extremity; Male; Motion; Postural Balance; Vision, Ocular / physiology; Visual Perception / physiology; Walking; Young Adult
TL;DR:
Investigating the propensity for visuomotor adaptation in walking balance control using prolonged exposure to optical flow perturbations suggests that subjects progressively shifted from a general anticipatory balance control strategy to a reactive, task-specific strategy using step-to-step adjustments.
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Detection of an Integrin-Binding Mechanoswitch within Fibronectin during Tissue Formation and Fibrosis
ACS NANO, 11(7), 7110–7117.
author keywords: mechano-biology; antibody phage display; integrins; fibronectin; fibrosis; angiogenesis
MeSH headings : Animals; Biomechanical Phenomena; Cell Adhesion; Extracellular Matrix / metabolism; Fibronectins / analysis; Fibronectins / metabolism; Fibrosis; Integrins / analysis; Integrins / metabolism; Lung / metabolism; Lung / pathology; Mice; Neovascularization, Physiologic; Protein Binding
TL;DR:
Direct experimental evidence is reported for the Fn integrin switch both in vitro and ex vivo using a scFv engineered to detect the transient, force-induced conformational change, representing an opportunity for detection and targeting of early molecular signatures of cell contractile forces in tissue repair and disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Analytical methods for detection of Zika virus
MRS COMMUNICATIONS, 7(2), 121–130.
TL;DR:
Three diagnostic methods for ZIKV are considered and a recently developed programmable paper-based detection approach can provide low-cost and rapid analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules
NANO RESEARCH, 10(4), 1393–1402.
author keywords: controlled drug delivery; focused ultrasound; diabetes; nanocapsule; microgel
TL;DR:
It is demonstrated that this ultrasound-triggered insulin delivery system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Systematic investigation on the intracellular trafficking network of polymeric nanoparticles
Nanoscale, 9(9), 3269–3282.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy
ADVANCED MATERIALS, 29(13).
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Biomimetic Materials / chemistry; Blood Vessels / drug effects; Blood Vessels / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Cells, Cultured; Dextrans / chemistry; Drug Delivery Systems; Human Umbilical Vein Endothelial Cells / drug effects; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Mice, Nude; Microtubules / enzymology; Microtubules / metabolism; Nanostructures / chemistry; Neoplasm Transplantation; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / metabolism; Oligopeptides / chemistry; Paclitaxel / administration & dosage; Paclitaxel / pharmacokinetics; Tumor Necrosis Factor-alpha / chemistry; Tumor Necrosis Factor-alpha / pharmacokinetics
TL;DR:
A "relay drug delivery" system based on two distinct modules that can specifically induce tumor blood vessel inflammation generation and an execution biomimetic nanocarrier B that can accumulate at the tumor site by receiving the broadcasting signals generated by NCA is developed for amplifying active tumor targeting signal and enhancing antitumor therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation
CANCER RESEARCH, 77(12), 3217–3230.
MeSH headings : Animals; Blotting, Western; Cell Proliferation; Cerebellar Neoplasms / enzymology; Cerebellar Neoplasms / pathology; Cerebellum / enzymology; Chromatography, Liquid; Humans; Immunohistochemistry; Mass Spectrometry; Medulloblastoma / enzymology; Medulloblastoma / pathology; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neural Stem Cells / enzymology; Neural Stem Cells / pathology; Neurogenesis / physiology; Polymerase Chain Reaction; Pyruvate Kinase / metabolism
TL;DR:
Findings show that distal and proximal disruptions of glycolysis have opposite effects on proliferation, and that efforts to block the oncogenic effect of aerobic glyCOlysis must target reactions upstream of PKM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 article
Polyethylenimine-mediated synthetic insertion of gold nanoparticles into mesoporous silica nanoparticles for drug loading and biocatalysis
Pandey, P. C., Pandey, G., & Narayan, R. J. (2017, March). BIOINTERPHASES, Vol. 12.
MeSH headings : Biocatalysis; Drug Carriers / chemistry; Drug Carriers / metabolism; Formaldehyde / metabolism; Gold; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Nanoparticles / metabolism; Polyethyleneimine / metabolism; Silicon Dioxide; Spectrometry, X-Ray Emission; Surface Properties; Temperature
TL;DR:
A new synthetic route for the synthesis of gold nanoparticles (AuNPs) within (1) unmodified MSNPs and (2) 3-trihydroxysilylpropyl methylphosphonate-modifiedMSNPs is reported, indicating the potential use of the AuNP-inserted MSNps in biocatalysis and drug delivery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Modular pumps as programmable hydraulic batteries for microfluidic devices
TECHNOLOGY, 5(1), 21–30.
author keywords: Paper Microfluidics; Capillary Pump; Microfluidic; Lateral Flow; Microfluidic Pump; Point of Care
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 review
Conjugated polymer nanomaterials for theranostics
[Review of ]. ACTA PHARMACOLOGICA SINICA, 38(6), 764–781.
author keywords: conjugated polymer; theranostics; biomedical imaging; photodynamic therapy; photothermal therapy; stimuli; responsive drug delivery
MeSH headings : Drug Delivery Systems; Nanostructures / chemistry; Photochemotherapy; Polymers / chemistry; Theranostic Nanomedicine
TL;DR:
This review highlights the recent advances in the utilization of CPNs in theranostics, and introduces CPN-based in vivo imaging techniques, including near-infrared (NIR), two-photon (TP) imaging, photoacoustic (PA), and multimodal (MM) imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
A Pilot Clinical Study in Characterization of Malignant Renal-cell Carcinoma Subtype with Contrast-enhanced Ultrasound
ULTRASONIC IMAGING, 39(2), 126–136.
author keywords: contrast-enhanced ultrasound; renal cell carcinoma; time intensity curve; renal perfusion; microbubbles
MeSH headings : Carcinoma, Renal Cell / diagnostic imaging; Carcinoma, Renal Cell / pathology; Contrast Media; Diagnosis, Differential; Fluorocarbons; Humans; Kidney Neoplasms / diagnostic imaging; Kidney Neoplasms / pathology; Ultrasonography / methods
TL;DR:
Results suggest that CEUS may be a feasible test for characterizing RCC subtypes and suggest that different disease subtypes have different prognoses and involve varying treatment regimens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Stimuli-Responsive Polymersomes for Biomedical Applications
BIOMACROMOLECULES, 18(3), 649–673.
MeSH headings : Biomimetic Materials / chemistry; Diagnostic Imaging; Drug Carriers / chemistry; Drug Delivery Systems; Hydrogen-Ion Concentration; Membranes, Artificial; Nanoparticles / chemistry; Polymers / chemistry; Reactive Oxygen Species / metabolism
TL;DR:
This Perspective focuses on recent advances in stimuli-responsive polymersomes and their potential biomedical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum
ACS CHEMICAL NEUROSCIENCE, 8(2), 272–280.
author keywords: Biosensor; carbon fiber microelectrode; neuroenergetics; glucose oxidase; cocaine; fast-scan cyclic voltammetry
MeSH headings : Animals; Biophysics; Cocaine / pharmacology; Corpus Striatum / cytology; Corpus Striatum / diagnostic imaging; Corpus Striatum / drug effects; Corpus Striatum / metabolism; Dopamine / metabolism; Dopamine Antagonists / pharmacology; Dopamine Uptake Inhibitors / pharmacology; Drug Combinations; Electric Stimulation; Extracellular Fluid / metabolism; Glial Fibrillary Acidic Protein / metabolism; Glucose / metabolism; Hydrogen Peroxide / metabolism; Male; Microelectrodes; Raclopride / pharmacology; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
This work evaluates several waveforms to enable the first simultaneous detection of endogenous glucose and dopamine at single recording sites, and directly demonstrates the coupling of glucose availability with increased metabolic demand.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Musculoskeletal model-based control interface mimics physiologic hand dynamics during path tracing task
JOURNAL OF NEURAL ENGINEERING, 14(3).
author keywords: electromyogram; prosthesis control; musculoskeletal model; dynamic simulation; amputation
MeSH headings : Adult; Amputees; Biomimetics / methods; Computer Simulation; Feasibility Studies; Female; Hand / physiology; Humans; Joints / innervation; Joints / physiology; Male; Middle Aged; Models, Neurological; Movement / physiology; Muscle, Skeletal / innervation; Muscle, Skeletal / physiology; Psychomotor Performance / physiology; Reproducibility of Results; Sensitivity and Specificity
TL;DR:
The result suggests that the amputee’s motor control patterns were not accustomed to the multi-joint dynamics of the wrist and hand, possibly as a result of post-amputation cortical plasticity, disuse, or sensory deficits, and is potentially a practical and effective control platform for multifunctional myoelectric prostheses that could restore more life-like hand function for individuals with upper limb amputation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Directed Differentiation of Human Pluripotent Stem Cells to Microglia
STEM CELL REPORTS, 8(6), 1516–1524.
MeSH headings : Adenosine Diphosphate / pharmacology; CX3C Chemokine Receptor 1 / metabolism; Calcium / metabolism; Cell Differentiation; Cell Line; Cytokines / metabolism; Gene Expression; Human Embryonic Stem Cells / cytology; Human Embryonic Stem Cells / metabolism; Humans; Lipopolysaccharide Receptors / metabolism; Macrophages / cytology; Macrophages / metabolism; Microglia / cytology; Microglia / drug effects; Microglia / metabolism; Pluripotent Stem Cells / cytology; Pluripotent Stem Cells / metabolism
TL;DR:
iPSC-MG were able to phagocytose and responded to ADP by producing intracellular Ca2+ transients, whereas macrophages lacked such response, and the differentiation protocol was highly reproducible across several pluripotent stem cell lines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Background Signal as an in Situ Predictor of Dopamine Oxidation Potential: Improving Interpretation of Fast-Scan Cyclic Voltammetry Data
ACS CHEMICAL NEUROSCIENCE, 8(2), 411–419.
author keywords: Carbon-fiber microelectrode; electrochemical impedance spectroscopy; electrochemistry; calibration; in vivo
MeSH headings : Analysis of Variance; Animals; Antipsychotic Agents / pharmacology; Biophysics; Brain / drug effects; Brain / metabolism; Dopamine / metabolism; Electric Stimulation; Electrochemical Techniques; Electrodes; Enzyme Inhibitors / pharmacology; Male; Neural Pathways / drug effects; Neural Pathways / metabolism; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reserpine / pharmacology; alpha-Methyltyrosine / pharmacology
TL;DR:
The model, validated both in adrenal slice and live brain tissue, enables information encoded in the shape of the background voltammogram to determine electrochemical parameters that are critical for accurate quantification, which improves data interpretation and provides a significant next step toward more automated methods for in vivo data analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Automated microraft platform to identify and collect non-adherent cells successfully gene-edited with CRISPR-Cas9
BIOSENSORS & BIOELECTRONICS, 91, 175–182.
author keywords: Microraft; Cell array; CRISPR-Cas9; Cytometry; Cell sorting
MeSH headings : Biosensing Techniques / instrumentation; Biosensing Techniques / methods; CRISPR-Cas Systems; Equipment Design; Genes, Reporter; Green Fluorescent Proteins / genetics; Humans; Image Processing, Computer-Assisted; K562 Cells; Leukemia / genetics; Mutation; Splicing Factor U2AF / genetics; Tissue Array Analysis / instrumentation; Tissue Array Analysis / methods; Transfection
TL;DR:
The automated system was used to examine the temporal variation in EGFP expression in cells transfected with CRISPR-Cas9 components for gene editing and successfully gene edited two cell colonies demonstrating the desired mutation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
A benchtop biorobotic platform for in vitro observation of muscle-tendon dynamics with parallel mechanical assistance from an elastic exoskeleton
JOURNAL OF BIOMECHANICS, 57, 8–17.
author keywords: Biomechanics; Elastic exoskeleton; Muscle-tendon mechanics; Unconstrained work loops; Biorobotics
MeSH headings : Animals; Biomechanical Phenomena; Elasticity; Gravitation; Locomotion / physiology; Muscle, Skeletal / physiology; Ranidae; Robotics / instrumentation; Tendons / physiology
TL;DR:
Findings from this study suggest that the increased natural resonant frequency of the artificially stiffened MTU+Exo system, along with invariant movement frequencies, may underlie observed limits on the benefits of exoskeleton assistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Optimizing Acoustic Activation of Phase Change Contrast Agents With the Activation Pressure Matching Method: A Review
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 64(1), 264–272.
author keywords: Acoustic droplet vaporization (ADV); activation pressure matching (APM); nanodroplet; optimized droplet activation; perfluorocarbon (PFC); phase change contrast agents (PCCAs)
MeSH headings : Animals; Contrast Media / chemistry; Fluorocarbons / chemistry; Image Processing, Computer-Assisted; Kidney / diagnostic imaging; Microbubbles; Pressure; Rats; Transducers; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR:
This paper discusses the application of this method with a Verasonics V1 Research Ultrasound System to modulate the output pressure from an ATL L11-5 transducer and demonstrates the feasibility of this approach both in vivo and in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 review
Neuroimaging of Human Balance Control: A Systematic Review
[Review of ]. FRONTIERS IN HUMAN NEUROSCIENCE, 11.
author keywords: static and dynamic balance control; temporal and spatial dynamics of brain activation; mechanical perturbation; sensory degradation; susceptibility to cognitive dual tasks; movement artifacts
TL;DR:
This review examined 83 articles using neuroimaging modalities to investigate the neural correlates underlying static and dynamic human balance control to provide evidence to support an increase in brain activation in balance control tasks, regardless of mechanical, cognitive, or sensory challenges.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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