Works Published in 2017
Displaying works 161 - 180 of 203 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
Microfabricated blood vessels undergo neoangiogenesis
BIOMATERIALS, 138, 142–152.
author keywords: Sheath-flow microfluidics; Blood vessel; Angiogenesis; Anastomoses; Perfusion
MeSH headings : Capillaries / chemistry; Coculture Techniques; Endothelial Cells / cytology; Endothelial Cells / metabolism; Extracellular Matrix Proteins / metabolism; Feeder Cells; Fibroblasts / cytology; Fibroblasts / metabolism; Gelatin / chemistry; Humans; Hydrogels / chemistry; Microfluidics / methods; Microtechnology / methods; Microvessels / growth & development; Microvessels / ultrastructure; Neovascularization, Physiologic; Perfusion; Pericytes / cytology; Pericytes / metabolism; Polyhydroxyethyl Methacrylate / chemistry; Primary Cell Culture; Tissue Engineering / methods; Umbilical Veins / cytology
TL;DR:
Ultraviolet (UV) photo-crosslinkable poly(ethylene glycol) and gelatin methacrylate polymers used in combination with sheath-flow microfluidics allow for the fabrication of small diameter blood vessels which undergo neoangiogenesis as well as other developmental processes associated with normal human blood vessel maturation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Magnetic Resonance-Derived Improvements on PET Imaging
MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA, 25(2), 257-+.
author keywords: PET-MR imaging; PET motion correction; PET partial volume correction; MR-based PET reconstruction
MeSH headings : Humans; Image Processing, Computer-Assisted / methods; Magnetic Resonance Imaging / methods; Multimodal Imaging / methods; Positron-Emission Tomography / methods
TL;DR:
Simultaneous PET-MR imaging improves deficiencies in PET images and partial volume correction or resolution improvement of PET governed by MR imaging anatomic information improves visualization of structures and quantitative accuracy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Local delivery of checkpoints antibodies
HUMAN VACCINES & IMMUNOTHERAPEUTICS, 13(1), 245–248.
author keywords: biomaterials; cancer immunotherapy; drug delivery; immune checkpoint inhibitors; microneedle
MeSH headings : Antibodies / administration & dosage; Biomedical Research / trends; Humans; Immunologic Factors / administration & dosage; Immunotherapy / methods; Molecular Targeted Therapy / methods; Neoplasms / immunology; Neoplasms / therapy
TL;DR:
Recent efforts utilizing immunoengineering for local delivery of these immune checkpoint antibodies are introduced in the field of cancer immunotherapy.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Insulin-responsive glucagon delivery for prevention of hypoglycemia
Small (Weinheim An Der Bergstrasse, Germany), 13(19).
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Immunological mechanisms of intravesical chitosan/interleukin-12 immunotherapy against murine bladder cancer
ONCOIMMUNOLOGY, 6(1).
author keywords: BCG; bladder cancer; chitosan; immunotherapy; interleukin-12; intratumoral; intravesical; MDSC; TILS; TReg
TL;DR:
The ability of properly delivered interleukin-12-based therapies to engage adaptive immunity within the tumor itself as well as throughout the body is demonstrated and the case for clinical translation of chitosan/interleuk in-12 as an intravesical treatment for bladder cancer is strengthened.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography
ANNALS OF BIOMEDICAL ENGINEERING, 45(4), 939–948.
author keywords: Ultrasound; Perfusion; Microbubble; High frequency; Low flow imaging; Quantitative imaging; Angiogenesis; Superharmonic
MeSH headings : Angiography / methods; Animals; Chick Embryo; Chorioallantoic Membrane / blood supply; Chorioallantoic Membrane / diagnostic imaging; Contrast Media / pharmacology; Microbubbles / therapeutic use; Perfusion Imaging / methods; Ultrasonography / methods
TL;DR:
The feasibility of dynamic contrast-enhanced superharmonic perfusion imaging at low flow rates is demonstrated and the feasibility of quantitatively mapping perfusion rate in 2D in a mouse model with spatial resolution of ~100 μm is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications
BIOMED RESEARCH INTERNATIONAL, 2017.
MeSH headings : Animals; Cells, Cultured; Extracellular Matrix / chemistry; Humans; Nanofibers / chemistry; Nanofibers / therapeutic use; Polyesters / chemistry; Polyesters / therapeutic use; Porosity; Printing, Three-Dimensional; Swine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The approach combining these two commonly used scaffold fabrication technologies allows for the creation of a scaffold with more close resemblance to heterogeneous tissue architecture, holding great potential for tissue engineering and regenerative medicine applications of osteochondral tissue and other heterogeneous tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer
NANO LETTERS, 17(4), 2138–2145.
author keywords: Drug delivery; liquid metal; stimuli-responsive; morphological transformation; endosomal escape
TL;DR:
A light-fueled liquid-metal transformer for effective endosomal escape-facilitated cargo delivery via a chemical-mechanical process and equipped with graphene quantum dots provides a new strategy for facilitating effective endOSomal escape to achieve spatiotemporally controlled drug delivery with enhanced efficacy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Engineering 3D-Bioplotted scaffolds to induce aligned extracellular matrix deposition for musculoskeletal soft tissue replacement
CONNECTIVE TISSUE RESEARCH, 58(3-4), 342–354.
author keywords: Biofabrication; meniscus; tissue engineering; scaffold; 3D printing
MeSH headings : Animals; Cell Count; Cell Shape; Collagen / metabolism; Extracellular Matrix / metabolism; Imaging, Three-Dimensional; Male; Musculoskeletal Physiological Phenomena; Rats, Sprague-Dawley; Regeneration / physiology; Sus scrofa; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The ability to use interstrand spacing as a means of controlling the formation of aligned collagen in vivo was demonstrated, which helps establish a design space for scaffold-based meniscus tissue engineering.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Effects of 3D-bioplotted polycaprolactone scaffold geometry on human adipose-derived stem cell viability and proliferation
RAPID PROTOTYPING JOURNAL, 23(3), 534–542.
author keywords: 3D-Bioplotting; Human adipose-derived stem cells; Polycaprolactone; Tissue engineering scaffolds
TL;DR:
The design with the lowest porosity had the highest compression modulus after 14 days of culture, but resulted in the lowest hASC viability, which provided the basis for future studies which will use this optimal scaffold design to develop constructs for hASC-based osteochondral tissue engineering applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 review
Bioresponsive materials
[Review of ]. NATURE REVIEWS MATERIALS, 2(1).
TL;DR:
This Review highlights recent advances in the design of smart materials capable of responding to the physiological environment, to biomarkers and to biological particulates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium
BIOMATERIALS, 128, 44–55.
author keywords: Scaffold; Microfabrication; Intestine; Stem cell; Crypt; Villus
MeSH headings : Animals; Cell Compartmentation; Cell Differentiation / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; Collagen / pharmacology; Cross-Linking Reagents / pharmacology; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / physiology; Intestine, Small / drug effects; Intestine, Small / physiology; Mice; Organoids / drug effects; Porosity; Rats; Tissue Culture Techniques; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
This new approach combining microengineered scaffolds, biophysical cues and chemical gradients to control the intestinal epithelium ex vivo can serve as a physiologically relevant mimic of the human small intestine, and is broadly applicable to model other tissues that rely on gradients for physiological function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Time-Dependent Model for Fluid Flow in Porous Materials with Multiple Pore Sizes
Analytical Chemistry, 89(8), 4377–4381.
TL;DR:
A new transport model is presented that incorporates a range of pore sizes to more accurately predict the capillary transport of fluid in porous materials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2017 journal article
The springs of time-limited bullfrog jumps and slow-preparation grasshopper leaps are tuned to their muscle dynamics
Integrative and Comparative Biology, 57, E390–390.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
The independent effects of speed and propulsive force on joint power generation in walking
JOURNAL OF BIOMECHANICS, 55, 48–55.
author keywords: Plantarflexor; Push-off; Aging; Gait; Biofeedback
MeSH headings : Adult; Aging / physiology; Biomechanical Phenomena; Exercise Test; Female; Humans; Joints / physiology; Knee Joint / physiology; Male; Mechanical Phenomena; Muscle, Skeletal / physiology; Walking Speed / physiology; Young Adult
TL;DR:
Visual biofeedback based on real-time FP measurements is used to decouple and investigate the interaction between joint-level coordination, whole-body FP, and walking speed in the aging population and naturally emergent joint- and limb-level biomechanical changes resemble those due to aging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
The Neuromuscular Origins of Kinematic Variability during Perturbed Walking
SCIENTIFIC REPORTS, 7.
MeSH headings : Adult; Biomechanical Phenomena; Female; Humans; Male; Muscle Contraction; Muscle, Skeletal / physiology; Postural Balance; Walking / physiology
TL;DR:
It is found that perturbations significantly increased step width, decreased step length, and elicited larger trunk sway compared to normal walking, and perturbation-induced effects on the corresponding variabilities of these measurements were much more profound.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Red Blood Cells for Glucose-Responsive Insulin Delivery
ADVANCED MATERIALS, 29(18).
MeSH headings : Erythrocytes; Glucose; Insulin
TL;DR:
This work is the first demonstration of utilizing RBC membrane to achieve smart insulin delivery with fast responsiveness and the binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of BG level in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Optimizing ultrasound molecular imaging of secreted frizzled related protein 2 expression in angiosarcoma
PLOS ONE, 12(3).
MeSH headings : Animals; Avidin / metabolism; Biomarkers, Tumor / metabolism; Cell Line, Tumor; Contrast Media / metabolism; Hemangiosarcoma / metabolism; Humans; Membrane Proteins / metabolism; Membrane Proteins / ultrastructure; Mice, Nude; Microbubbles; Molecular Imaging / methods; Neoplasm Transplantation; Ultrasonography / methods
TL;DR:
Basing the targeted contrast on NeutrAvidin™-functionalized microbubbles, using IgY antibodies for the authors' control contrast, and optimizing the imaging protocol significantly increased the SFRP2-specific signal returned from angiosarcoma vasculature, and may provide new opportunities for targeted molecular imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Electrical Cell-Substrate Impedance Spectroscopy Can Monitor Age-Grouped Human Adipose Stem Cell Variability During Osteogenic Differentiation
STEM CELLS TRANSLATIONAL MEDICINE, 6(2), 502–511.
author keywords: Electrical cell-substrate impedance spectroscopy; Adipose stem cells; Osteogenesis; Bioimpedance
MeSH headings : Adipose Tissue / cytology; Adult; Age Factors; Aged; Aged, 80 and over; Bone and Bones / cytology; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dielectric Spectroscopy / methods; Electric Impedance; Humans; Middle Aged; Osteogenesis; Phenotype; Stem Cells / metabolism; Stem Cells / physiology; Time Factors; Young Adult
TL;DR:
This is the first study to use ECIS to predict osteogenic potential of multiple hASC populations and to show that donor age may temporally control onset of osteogenesis, which could be critical for development of patient‐specific bone tissue engineering and regenerative medicine therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Comparison of simulated microgravity and hydrostatic pressure for chondrogenesis of hASC
Aerospace Medicine and Human Performance, 88(4), 377–384.
Source: NC State University Libraries
Added: August 6, 2018
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