Works Published in 2020
Displaying works 181 - 200 of 216 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function
ARCHIVES OF TOXICOLOGY, 94(2), 469–484.
author keywords: Neurotoxicity; Screening; ToxCast
MeSH headings : Animals; Cell Culture Techniques / instrumentation; Cell Culture Techniques / methods; Databases, Chemical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical / methods; Machine Learning; Microelectrodes; Nerve Net / drug effects; Neural Networks, Computer; Neurons / drug effects; Neurotoxicity Syndromes / pathology; Rats, Long-Evans; Toxicity Tests / methods
TL;DR:
It is demonstrated that multivariate MEA activity patterns can efficiently screen for diverse chemical activities relevant to neurotoxicity, and that response patterns may have predictive value related to chemical structural features.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: March 30, 2020
2020 journal article
Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs
THERANOSTICS, 10(8), 3474–3487.
author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
TL;DR:
It is demonstrated that the exosomes' ability to target the parent cancer is a phenomenon that opens up new ways to devise targeted therapies to deliver anti-tumor drugs.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 30, 2020
2020 journal article
Finger Joint Angle Estimation Based on Motoneuron Discharge Activities
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 24(3), 760–767.
author keywords: Biosignal processing; joint angle prediction; motor unit; finger movement; motor unit decomposition
MeSH headings : Adult; Algorithms; Biomechanical Phenomena / physiology; Electromyography / methods; Female; Finger Joint / physiology; Humans; Male; Motor Neurons / physiology; Signal Processing, Computer-Assisted; Young Adult
TL;DR:
The findings indicated that the neural-drive-based interface was a promising approach to reliably predict individual finger kinematics, especially during fast movements.
(via Semantic Scholar)
Source: Web Of Science
Added: March 30, 2020
2020 journal article
FAD dependent glucose dehydrogenases - Discovery and engineering of representative glucose sensing enzymes -
BIOELECTROCHEMISTRY, 132.
author keywords: Flavin adenine dinucleotide (FAD); Glucose dehydrogenase; Glucose sensor; Diabetes; Direct electron transfer (DET); Glucose oxidase
MeSH headings : Electrons; Flavin-Adenine Dinucleotide / metabolism; Fungi / enzymology; Glucose / metabolism; Glucose 1-Dehydrogenase / metabolism; Protein Engineering
TL;DR:
The two representative glucose sensing enzymes are focused on, by presenting their discovery, sources, and protein and enzyme properties, and the current engineering strategies to improve their potential in sensor applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020
2020 journal article
Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation
JCI INSIGHT, 5(4).
MeSH headings : Actin-Related Protein 2-3 Complex / antagonists & inhibitors; Actin-Related Protein 2-3 Complex / metabolism; Adaptation, Physiological; Animals; Cartilage, Articular / metabolism; Cartilage, Articular / pathology; Intervertebral Disc / metabolism; Intervertebral Disc / pathology; Mice; Mice, Mutant Strains; Osmoregulation; Transcription Factors / metabolism
TL;DR:
Findings suggest that Arp2/3 plays a critical role in cartilaginous tissues through the regulation of cell-extracellular matrix interactions and modulation of TonEBP-mediated osmoadaptation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 23, 2020
2020 journal article
Joint laxity varies in response to partial and complete anterior cruciate ligament injuries throughout skeletal growth
JOURNAL OF BIOMECHANICS, 101.
author keywords: Anterior cruciate ligament; Pediatric; Injury; Joint mechanics; Animal model
MeSH headings : Animals; Anterior Cruciate Ligament Injuries / complications; Biomechanical Phenomena; Female; Joint Instability / complications; Joint Instability / physiopathology; Rotation; Stifle / growth & development; Stifle / physiopathology; Swine
TL;DR:
At all ages, the medial collateral ligament and the medial meniscus combined to resist the majority of applied anterior tibial load following complete ACL transection, adding to the current understanding of age-specific functional properties of both healthy and injured knees during skeletal growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: March 23, 2020
2020 journal article
LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus
MUCOSAL IMMUNOLOGY, 13(5), 814–823.
MeSH headings : Animals; Antibodies, Bacterial / immunology; Disease Models, Animal; Immunoglobulin Fab Fragments / immunology; Immunoglobulin Fc Fragments / immunology; Immunoglobulin G / immunology; Intestinal Mucosa; Lipopolysaccharides / immunology; Mice; Mucus / immunology; Mucus / microbiology; Polysaccharides / immunology; Protein Binding / immunology; Salmonella Infections / immunology; Salmonella Infections / microbiology; Salmonella typhimurium / immunology
TL;DR:
The addition of anti-lipopolysaccharide IgG to GI mucus markedly reduced the progressive motility of Salmonella by lowering the swim speed and retaining individual bacteria in an undirected motion state, implicate IgG-mucin crosslinking as a broadly conserved function that reduces mucous penetration of both bacterial and viral pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: March 23, 2020
2020 journal article
Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(6), 2599–2609.
author keywords: antimicrobial; microgels; nanosilver; platelet-mimetic; wound healing
MeSH headings : Acrylic Resins / chemistry; Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Blood Platelets; Clot Retraction; Colony-Forming Units Assay; Fibrin / chemistry; Fibrin / immunology; Gels; Hemorrhage / drug therapy; Hemostasis / drug effects; Liver / injuries; Male; Metal Nanoparticles; Mice; Mice, Inbred C57BL; Microgels; Silver / administration & dosage; Silver / chemistry; Wound Healing
TL;DR:
It is found that nanosilver incorporation does not affect base PLP performance while bestowing significant antimicrobial activity and enhancing infected wound healing outcomes, and Ag-PLPs have great promise for treating hemorrhage and improving healing following trauma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 16, 2020
2020 review
Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria
[Review of ]. BIOMATERIALS SCIENCE, 8(4), 1089–1100.
MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / growth & development; Bacterial Infections / drug therapy; Biomimetic Materials / chemistry; Biomimetic Materials / pharmacology; Drug Resistance, Bacterial / drug effects; Humans; Technology, Pharmaceutical
TL;DR:
This review will discuss current antimicrobial strategies and present an overview on biomimetic antimicrobial material-based strategies for combating antibiotic resistant bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 16, 2020
2020 review
SUPER-RESOLUTION ULTRASOUND IMAGING
[Review of ]. ULTRASOUND IN MEDICINE AND BIOLOGY, 46(4), 865–891.
author keywords: Ultrasound; Microvessels; Super-resolution; Localization; Microscopy; Microbubbles; Contrast agents; Brain; Tumor
MeSH headings : Animals; Blood Vessels / diagnostic imaging; Humans; Microbubbles; Neoplasms / diagnostic imaging; Ultrasonography / methods
TL;DR:
Inspired by optical microscopy, ultrasound localization microscopy has bypassed the classic compromise between penetration and resolution in ultrasonic imaging and is being applied pre-clinically and clinically for imaging of the microvasculature of the brain, kidney, skin, tumors and lymph nodes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 10, 2020
2020 journal article
Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair
SCIENCE ADVANCES, 6(6).
MeSH headings : Animals; Apoptosis; Blood Platelets / metabolism; Cell-Derived Microparticles / metabolism; Cytokines / metabolism; Disease Models, Animal; Humans; Immunohistochemistry; Inflammation Mediators / metabolism; Interleukin-1beta / antagonists & inhibitors; Mice; Models, Biological; Myocardial Infarction / etiology; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocytes, Cardiac / metabolism; Protein Binding; Ventricular Remodeling
TL;DR:
IL1-PM is a promising cardiac detoxification agent that removes cytotoxic IL-1β during AMI and induces therapeutic cardiac repair and protects the cardiomyocytes from apoptosis by neutralizing IL–1β and decreasing IL- 1β–driven caspase-3 activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 2, 2020
2020 journal article
Matrix-Assisted Pulsed laser Evaporation-deposited Rapamycin Thin Films Maintain Antiproliferative Activity
INTERNATIONAL JOURNAL OF BIOPRINTING, 6(1), 105–111.
author keywords: Rapamycin; Drug delivery; Matrix-assisted pulsed laser evaporation; Thin film
TL;DR:
Data indicate that the antiproliferative properties of rapamycin were maintained after MAPLE deposition, and the thickness of the coating that is applied to the surface of the medical device can be tightly controlled.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 27, 2020
2020 review
Solvent-based Extrusion 3D Printing for the Fabrication of Tissue Engineering Scaffolds
[Review of ]. INTERNATIONAL JOURNAL OF BIOPRINTING, 6(1), 28–42.
TL;DR:
It is believed that a better understanding of the scaffold fabrication process and assessment methods can improve the functionality of SBE-manufactured 3D printed scaffolds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Source: Web Of Science
Added: February 27, 2020
2020 journal article
Benefits of additive manufacturing and micro and nano surface texture modifications on mechanical strength and infection resistance of skin-implant interfaces in rats
JOURNAL OF BIOMATERIALS APPLICATIONS, 34(9), 1193–1200.
author keywords: Additive manufactured implants; electron beam melting; selective laser melting; skin-implant interface; transcutaneous prostheses
MeSH headings : Alloys / chemistry; Animals; Biocompatible Materials / chemistry; Biomechanical Phenomena; Epidermis / metabolism; Equipment Design; Female; Infections / metabolism; Materials Testing; Nanostructures / chemistry; Nanotechnology; Oxygen / chemistry; Porosity; Prostheses and Implants; Rats; Rats, Sprague-Dawley; Skin / metabolism; Stress, Mechanical; Surface Properties; Titanium / chemistry
TL;DR:
Both manufacturing technique and post-manufacturing surface texture modification affected the skin-implant interface’s mechanical integration and effectiveness as a barrier to infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 27, 2020
2020 review
Clot Structure and Implications for Bleeding and Thrombosis
[Review of ]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 46(1), 96–104.
author keywords: fibrin; clot structure; atomic force microscopy; fibrinolysis; thrombosis
MeSH headings : Fibrin / metabolism; Fibrinolysis; Hemorrhage / metabolism; Hemorrhage / pathology; Humans; Thrombosis / metabolism; Thrombosis / pathology
TL;DR:
Known factors that contribute to changes in clot structure and the presence of structural clot changes in various disease states are examined to provide valuable information in forming therapeutic strategies for disease states where alterations in clotructure are observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 27, 2020
2020 journal article
Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs
NATURE BIOMEDICAL ENGINEERING, 4(5), 499–506.
MeSH headings : Animals; Blood Glucose / metabolism; Diabetes Mellitus, Experimental / blood; Disease Models, Animal; Drug Delivery Systems; Humans; Insulin / pharmacology; Insulin Secretion / drug effects; Male; Mice, Inbred C57BL; Needles; Swine; Swine, Miniature; Transdermal Patch
TL;DR:
It is shown that a single removable transdermal patch, bearing microneedles loaded with insulin and a non-degradable glucose-responsive polymeric matrix, and fabricated via in situ photopolymerization, regulated blood glucose in insulin-deficient diabetic mice and minipigs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 17, 2020
2020 journal article
The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis
PLOS PATHOGENS, 16(1).
MeSH headings : Adult; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Cervix Uteri / microbiology; Cervix Uteri / virology; Coinfection / microbiology; Coinfection / virology; Female; HIV Infections / virology; HIV-1 / physiology; Humans; Microbiota; Middle Aged; Mucus / microbiology; Mucus / virology; Vagina / microbiology; Vagina / virology; Vaginosis, Bacterial / microbiology; Young Adult
TL;DR:
Overall, it is found that HIV virions had significantly increased mobility in CVM from women with BV compared to CVMFrom women with Lactobacillus crispatus-dominant microbiota, regardless of whether symptoms were present.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: February 17, 2020
2020 journal article
Porcine Vocal Fold Lamina Propria-Derived Biomaterials Modulate TGF-β1-Mediated Fibroblast Activation in Vitro
ACS Biomaterials Science & Engineering, 6(3), 1690–1703.
author keywords: extracellular matrix; hydrogels; vocal fold lamina propria; MBVs; fibrosis
MeSH headings : Animals; Biocompatible Materials / pharmacology; Fibroblasts; Mucous Membrane; Swine; Transforming Growth Factor beta1; Vocal Cords
TL;DR:
The results provide evidence of the unique protein composition of the VFLP-ECM and the potential link between the components of the vesicles and macromolecules and the inhibition of TGF-β1 signaling observed in vitro when transformed into injectable forms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: February 13, 2020
2020 journal article
How age and surface inclination affect joint moment strategies to accelerate and decelerate individual leg joints during walking
JOURNAL OF BIOMECHANICS, 98.
author keywords: Induced acceleration analysis; Eccentric; Concentric; Gait; Aging
MeSH headings : Acceleration; Adolescent; Adult; Aged; Aged, 80 and over; Aging / physiology; Biomechanical Phenomena; Exercise Test; Female; Gait; Humans; Joints / physiology; Kinetics; Leg / physiology; Male; Surface Properties; Walking / physiology; Young Adult
TL;DR:
Results suggest that during level and uphill walking increased hip flexor mechanical output in older adults does not arise from reduced ankle moments, contrary to increased hip extensor mechanical output, and implies that preserved eccentric knee extensor function is important in maintaining knee stabilization in older age.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 10, 2020
2020 review
Preserving single cells in space and time for analytical assays
[Review of ]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 122.
author keywords: Laboratory medicine; Single-cell analysis; Sample preparation; Fixation; Preservation; Signaling; Analytical chemistry; Bioanalytical chemistry; Clinical assays
TL;DR:
Novel cell fixation techniques incorporate programmable fixation times, reversible bond formation and cleavage, chemoselective reactions, and improved analyte recovery to further the development of individualized, precision therapies for patients to yield improved clinical outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 10, 2020
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