Works Published in 2014
Displaying works 21 - 40 of 54 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting
NATURE COMMUNICATIONS, 5.
MeSH headings : Animals; Antibodies; Bone Marrow Cells / metabolism; Bone Marrow Transplantation / methods; Cell Movement; Ferrosoferric Oxide / therapeutic use; Iron; Leukocytes, Mononuclear / metabolism; Magnets; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Nanotechnology / methods; Rats; Regeneration; Stem Cells
TL;DR:
The authors use magnetic iron nanoparticles conjugated with antibodies that bind therapeutic cells and cardiomyocytes to treat myocardial ischemia/reperfusion injury in rats and show that targeting to the heart is enhanced upon local application of a magnetic field.
(via Semantic Scholar)
www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels
CELLULAR SIGNALLING, 26(12), 2702–2709.
author keywords: Hypoxia; Cobalt chloride; Hypoxia inducible factor (HIF); Iron regulatory protein (IRP); Nrf2; Ferritin
MeSH headings : Apoferritins / genetics; Cell Line, Tumor; Cobalt / pharmacology; Ferritins / genetics; Gene Expression Regulation / genetics; Humans; Hypoxia / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Iron-Regulatory Proteins / genetics; Protein Processing, Post-Translational / drug effects; Protein Processing, Post-Translational / genetics; RNA, Messenger / genetics; Transcription, Genetic / drug effects; Transcription, Genetic / genetics; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR:
It is demonstrated that hypoxia and cobalt chloride regulate ferritin heavy chain (ferritin H) expression by two distinct mechanisms through the interplay between DNA and mRNA elements at the transcriptional and post-transcriptional levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Crystallization and preliminary X-ray diffraction analysis of Hypocrea jecorina Cel7A in two new crystal forms
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 70(Pt 6), 773–776.
MeSH headings : Cellulose 1,4-beta-Cellobiosidase / chemistry; Crystallization; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Hypocrea / chemistry
TL;DR:
A preliminary analysis of the electron-density maps suggests that the linker and CBM are disordered in both crystal forms of Cel7A, which consists of a large 434-residue N-terminal catalytic domain capable of cleaving cellulose, a 27-Residue flexible linking module and a small 36- Residue C-Terminal carbohydrate-binding module.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
A simple improved-throughput xylem protoplast system for studying wood formation
NATURE PROTOCOLS, 9(9), 2194–2205.
MeSH headings : Cell Wall / metabolism; Gene Expression Regulation, Plant / genetics; Gene Regulatory Networks / genetics; Green Fluorescent Proteins; Populus / cytology; Populus / growth & development; Protoplasts / metabolism; Transfection / methods; Wood / cytology; Wood / growth & development; Xylem / chemistry
TL;DR:
A protocol for the isolation and transfection of protoplasts from wood-forming tissue, the stem-differentiating xylem (SDX), in the model woody plant Populus trichocarpa is presented.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
A robust chromatin immunoprecipitation protocol for studying transcription factor-DNA interactions and histone modifications in wood-forming tissue
NATURE PROTOCOLS, 9(9), 2180–2193.
MeSH headings : Base Sequence; Chromatin Immunoprecipitation / methods; DNA / metabolism; DNA Fragmentation; Histones / metabolism; Immunoprecipitation; Molecular Sequence Data; Populus / cytology; Populus / metabolism; Sequence Analysis, DNA; Transcription Factors / metabolism; Wood / cytology; Xylem / genetics; Xylem / metabolism
TL;DR:
This protocol is the only working ChIP system for wood-forming tissue and uses stem-differentiating xylem to identify genome-wide specific TF-DNA interactions during wood formation and histone modifications associated with regulation of wood formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Redesigning the procaspase-8 dimer interface for improved dimerization
Protein Science, 23(4), 442–453.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Live Attenuated Tetravalent Dengue Virus Host Range Vaccine Is Immunogenic in African Green Monkeys following a Single Vaccination
JOURNAL OF VIROLOGY, 88(12), 6729–6742.
MeSH headings : Animals; Antibodies, Viral / immunology; Chlorocebus aethiops; Dengue / immunology; Dengue / prevention & control; Dengue / virology; Dengue Vaccines / administration & dosage; Dengue Vaccines / genetics; Dengue Vaccines / immunology; Dengue Virus / classification; Dengue Virus / genetics; Dengue Virus / immunology; Dengue Virus / physiology; Host Specificity; Humans; Species Specificity; Vaccination; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / genetics; Vaccines, Attenuated / immunology; Viral Envelope Proteins / administration & dosage; Viral Envelope Proteins / genetics; Viral Envelope Proteins / immunology
TL;DR:
A live attenuated viral (LAV) vaccine capable of eliciting a strong immune response in African green monkeys (AGMs) in a single dose is generated, and this study suggests that viremia and antibody response in AGMs may be similar to those seen in DENV infection in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states
MOLECULAR SYSTEMS BIOLOGY, 10(1).
author keywords: growth factor receptors; mitogen-activated protein kinases; negative feedback; nucleocytoplasmic shuttling; mathematical model
MeSH headings : Active Transport, Cell Nucleus; Animals; Extracellular Signal-Regulated MAP Kinases / chemistry; Extracellular Signal-Regulated MAP Kinases / metabolism; Feedback, Physiological; Kinetics; Mice; Models, Theoretical; NIH 3T3 Cells; Phosphorylation; Protein Transport / genetics; Receptors, Growth Factor / genetics; Signal Transduction / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Coordinating subdomains of ferritin protein cages with catalysis and biomineralization viewed from the C (4) cage axes
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 19(4-5), 615–622.
author keywords: Ferritin; Protein nanocage; Ferric oxo; Di-iron protein; Nanobiomineral
MeSH headings : Catalysis; Ferric Compounds / chemistry; Ferric Compounds / metabolism; Ferritins / chemistry; Ferritins / metabolism; Iron / chemistry; Iron / metabolism; Protein Structure, Secondary
TL;DR:
Conserved amino acids facilitate dissolution of ferritin-protein-caged iron biominerals in variants with altered subunit interfaces for trimers (ion channels), E130I, and external dimer surfaces (E88A) as controls, and altered tetramer sub unit interfaces (L165I and H169F).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 review
A maize root tip system to study DNA replication programmes in somatic and endocycling nuclei during plant development
[Review of ]. JOURNAL OF EXPERIMENTAL BOTANY, 65(10), 2747–2756.
author keywords: DNA replication; EdU; endocycle; flow cytometry; high-resolution microscopy; maize; mitotic cell cycle; root development; S phase
MeSH headings : Base Sequence; Cell Nucleus / genetics; DNA Replication; DNA, Plant / biosynthesis; In Situ Hybridization, Fluorescence; Oligonucleotide Probes; Plant Roots / growth & development; Zea mays / genetics; Zea mays / growth & development
TL;DR:
A promising new system that can be used to visualize DNA replication in isolated maize root tip nuclei after in planta pulse labelling with the thymidine analogue, 5-ethynyl-2'-deoxyuridine (EdU).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
A DNA Mimic: The Structure and Mechanism of Action for the Anti-Repressor Protein AbbA
JOURNAL OF MOLECULAR BIOLOGY, 426(9), 1911–1924.
author keywords: transition state regulator; AbbA; DNA mimic; molecular docking; NMR
MeSH headings : Bacillus subtilis / chemistry; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Protein Multimerization
TL;DR:
Interestingly, it is shown that AbbA has structural and surface characteristics that closely mimic the DNA phosphate backbone, enabling it to readily carry out its physiological function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Lignin extraction from biomass with protic ionic liquids
GREEN CHEMISTRY, 16(3), 1114–1119.
TL;DR:
Biopolymer solubility tests indicate that increasing the xylansolubility in the PIL results in greater fiber disruption/penetration, which significantly enhances the effectiveness of the lignin extraction.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Decoding the massive genome of loblolly pine using haploid DNA and novel assembly strategies
GENOME BIOLOGY, 15(3).
MeSH headings : Contig Mapping / methods; DNA, Plant / genetics; Genome, Plant; Haploidy; Pinus taeda / genetics; Sequence Analysis, DNA / methods
TL;DR:
A novel strategy to sequence the genome of loblolly pine that combines unique aspects of pine reproductive biology and genome assembly methodology is developed, demonstrating a novel approach to sequencing the large and complex genomes of this important group of plants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
A role for iron and oxygen chemistry in preserving soft tissues, cells and molecules from deep time
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Systems Biology of Lignin Biosynthesis in Populus trichocarpa: Heteromeric 4-Coumaric Acid: Coenzyme A Ligase Protein Complex Formation, Regulation, and Numerical Modeling
PLANT CELL, 26(3), 876–893.
MeSH headings : Coenzyme A Ligases / genetics; Coenzyme A Ligases / metabolism; Coumaric Acids / metabolism; Immunoprecipitation; Lignin / biosynthesis; Mass Spectrometry; Models, Biological; Populus / metabolism; Propionates; RNA, Messenger / genetics; Substrate Specificity; Systems Biology
TL;DR:
This work shows that 4CL, an enzyme in monolignol biosynthesis, is found as a heterotetrameric complex of two isoforms in Populus trichocarpa, where the two 4-coumaric acid:CoA ligase (4CL) isoforms, 4CL3 and 4CL5, interact in vivo and in vitro to form a heterosymmetric protein complex.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(15), 5735–5740.
author keywords: protein sorting; regulated secretion; dense core granules; folliculogenesis
MeSH headings : Analysis of Variance; Animals; Biological Evolution; Blotting, Western; Female; Fertility / physiology; Follicle Stimulating Hormone / metabolism; Gonadotrophs / metabolism; Luteinizing Hormone / metabolism; Mice; Mice, Transgenic; Microscopy, Confocal; Microscopy, Immunoelectron; Ovarian Follicle / metabolism; Ovary / metabolism; Ovary / physiology; Ovulation / metabolism; Real-Time Polymerase Chain Reaction; Signal Transduction / physiology
TL;DR:
The rerouted FSH enhanced ovarian follicle survival, caused a dramatic increase in number of ovulations, and prolonged female reproductive lifespan, and the approach to interconvert the secretory fate of proteins in vivo has pathophysiological significance, and could explain the etiology of several hormone hyperstimulation and resistance syndromes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Moving Fe2+ from ferritin ion channels to catalytic OH centers depends on conserved protein cage carboxylates
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(22), 7925–7930.
author keywords: iron traffic; oxidoreductase enzyme activity; antioxidant; ferrihydrite; BioIron
MeSH headings : Animals; Antioxidants / chemistry; Antioxidants / metabolism; Anura; Catalysis; Conserved Sequence; Ferric Compounds / chemistry; Ferric Compounds / metabolism; Ferritins / chemistry; Ferritins / genetics; Ferritins / metabolism; Heme / chemistry; Heme / metabolism; Hydroxides / chemistry; Hydroxides / metabolism; Ion Channels / chemistry; Ion Channels / metabolism; Iron / chemistry; Iron / metabolism; Metals / chemistry; Metals / metabolism; Minerals / chemistry; Minerals / metabolism; Models, Chemical; Mutagenesis, Site-Directed; Oxidoreductases / chemistry; Oxidoreductases / metabolism; Protein Structure, Secondary; Protein Structure, Tertiary; Substrate Specificity; Sulfates / chemistry; Sulfates / metabolism
TL;DR:
M Monitoring rapid diferric peroxo formation in WT ferritin and E57 and E136 variants showed that these conserved residues are required for enzyme activity and thus are functional links betweenferritin ion channels and enzymatic sites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
In Vivo Mapping of Arabidopsis Scaffold/Matrix Attachment Regions Reveals Link to Nucleosome-Disfavoring Poly(dA:dT) Tracts
PLANT CELL, 26(1), 102–120.
MeSH headings : Arabidopsis / genetics; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Arabidopsis Proteins / physiology; Chromatin / metabolism; Gene Expression Regulation, Plant; Matrix Attachment Regions; Nucleosomes / metabolism; Nucleotide Motifs; Poly dA-dT / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription Factors / physiology
TL;DR:
This work uses tiling microarrays to map S/MARs on Arabidopsis chromosome 4, found to be spaced more closely than in the large plant and animal genomes studied to date and preferentially enriched in poly(dA:dT) tracts, sequences that resist nucleosome formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Chemical shift assignments and secondary structure prediction of the phosphorelay protein VanU from Vibrio anguillarum
BIOMOLECULAR NMR ASSIGNMENTS, 8(1), 177–179.
author keywords: VanU; NMR; Vibrio anguillarum; Phosphorelay
MeSH headings : Bacterial Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Phosphotransferases / chemistry; Protein Structure, Secondary; Vibrio / metabolism
TL;DR:
The 1H, 13C, and 15N backbone and side chain resonance assignments and secondary structure prediction for VanU from V. anguillarum are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis
BIOMOLECULAR NMR ASSIGNMENTS, 8(1), 155–158.
author keywords: NMR; SinR; Bacillus subtilis; Biofilm regulation
MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Biofilms; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary
TL;DR:
The full-length backbone and side chain chemical shift values in addition to the experimentally derived secondary structure predictions are reported as the first step towards directly studying the complex interaction dynamics between SinR and SinI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
