Works Published in 2023
Displaying works 81 - 100 of 125 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2023 journal article
Assessment of drug permeability through an ex vivo porcine round window membrane model
ISCIENCE, 26(6).
TL;DR:
An ex vivo porcine RWM model, similar in structure and thickness to the human RWM, is developed, which provides a straightforward approach to developing effective and non-invasive delivery methods to the inner ear.
(via Semantic Scholar)
www.cell.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: June 26, 2023
2023 journal article
Pharmacokinetics and pharmacodynamics of intramuscular alfaxalone in central bearded dragons (Pogona vitticeps): effect of injection site
VETERINARY ANAESTHESIA AND ANALGESIA, 50(3), 280–288.
author keywords: alfaxalone; bearded dragon; injectable anes-thesia; pharmacokinetics; Pogona vitticeps; sedation
MeSH headings : Animals; Anesthetics / pharmacology; Cross-Over Studies; Injections, Intramuscular / veterinary; Prospective Studies
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 26, 2023
2023 journal article
A novel task of canine olfaction for use in adult and senior pet dogs
SCIENTIFIC REPORTS, 13(1).
MeSH headings : Dogs; Animals; Smell; Food; Aging; Neuropsychological Tests
TL;DR:
A novel olfaction test using spontaneous search behavior in dogs to find a hidden food treat in a three-choice task with both light-phase and dark-phase conditions is described, making it feasible to compare between and within groups of pet dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 26, 2023
2023 journal article
A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus
SCIENCE ADVANCES, 9(25).
MeSH headings : Cricetinae; Animals; Humans; Mice; Influenza Vaccines; SARS-CoV-2; Influenza, Human; Influenza A Virus, H1N1 Subtype; Pandemics; COVID-19 / prevention & control; COVID-19 Vaccines; Influenza A virus
TL;DR:
The Flu-RBD VLP vaccine is a promising candidate for combating COVID-19, influenza A, and coinfection and elicited a strong neutralization activity against both SARS-CoV-2 Delta pseudovirus and wild-type influenza A H1N1 inactivated virus in mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2023
2023 article
A chromosome-level genome assembly of longnose gar, Lepisosteus osseus
Mallik, R., Carlson, K. B., Wcisel, D. J., Fisk, M., Yoder, J. A., & Dornburg, A. (2023, April 29). (N. Whiteman, Ed.). G3-GENES GENOMES GENETICS, Vol. 4.
Ed(s): N. Whiteman
author keywords: teleost genome duplication; holostei; longnose gar; chromosome level assembly; living fossil; transposable elements
MeSH headings : Humans; Animals; Evolution, Molecular; Fishes / genetics; Genome; Chromosomes / genetics; Phylogeny
TL;DR:
The first high quality reference genome assembly and annotation of the longnose gar (Lepisosteus osseus) is reported, highlighting the potential utility of holostean genomes for understanding the evolution of vertebrate repetitive elements and providing a critical reference for comparative genomic studies utilizing ray-finned fish models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 12, 2023
2023 journal article
A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease
FASEB JOURNAL, 37(6).
author keywords: APC mutation; colorectal cancer; intestine; Lgr5; porcine; stem cell; transgenic large animal
MeSH headings : Humans; Swine; Animals; Mice; In Situ Hybridization, Fluorescence; Intestines; Stem Cells; Ileum; Colon; Coleoptera; Green Fluorescent Proteins / genetics; Receptors, G-Protein-Coupled / genetics
TL;DR:
This study validates ISC isolation in a new porcine Leucine Rich Repeat Containing G Protein‐Coupled Receptor 5 (LGR5) reporter line and demonstrates the use of these pigs as a novel colorectal cancer model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023
2023 journal article
Acute radiotherapy-associated oral pain may promote tumor growth at distant sites
FRONTIERS IN ONCOLOGY, 13.
author keywords: pain; radiotherapy; sensory nerves; cancer; mouse; TRPV1
TL;DR:
This research points towards radiation-induced activation of capsaicin-responsive (TRPV1) neurons as the cause for accelerated growth of tumors at distant (unirradiated) sites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 12, 2023
2023 journal article
Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain
ISCIENCE, 26(3).
TL;DR:
Subtractive bulk ventral and dorsal forebrain deletions of Egfr uncovered significant and permanent decreases in oligodendrogenesis and myelination in the cortex and corpus callosum, and a regenerative population of gliogenic progenitors in the mouse forebrain may compensate for the missing EGFR-dependent dorsal glia in the bulk Egfr-deleted forebrain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 5, 2023
2023 journal article
COMBINe enables automated detection and classification of neurons and astrocytes in tissue-cleared mouse brains
CELL REPORTS METHODS, 3(4).
MeSH headings : Animals; Mice; Astrocytes; Excipients; Microscopy, Fluorescence; Neurons; Prosencephalon
TL;DR:
An automated workflow to map sparsely labeled neurons and astrocytes in genetically distinct mouse forebrains using mosaic analysis with double markers (MADM) is presented and the regional and subregional effects of MADM-based deletion of the epidermal growth factor receptor (EGFR) are quantitatively analyzed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 30, 2023
2023 journal article
C/EBP beta deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
INNATE IMMUNITY, 29(1-2), 14–24.
author keywords: C/EBP beta; cell death; keratinocytes; type I IFN response
MeSH headings : Animals; Mice; Caspase 3 / metabolism; Caspase 8 / metabolism; CCAAT-Enhancer-Binding Protein-beta / genetics; Immunity, Innate; Interferon Type I / metabolism; Keratinocytes; Receptors, Pattern Recognition / genetics; Receptors, Pattern Recognition / metabolism
TL;DR:
The conditional deletion of C/EBPβ transcription factor in mouse epidermis resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs) and the expression of cytosolic pattern recognition receptors (cPRRs), that recognize viral RNA and DNA, were significantly increased, and enriched in the RNAseq data set.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 30, 2023
2023 article
Presumed pituitary apoplexy in 26 dogs: Clinical findings, treatments, and outcomes
Woelfel, C. W., Mariani, C. L., Nolan, M. W., Keenihan, E. K., Topulos, S. P., Early, P. J., … Olby, N. J. (2023, April 21). JOURNAL OF VETERINARY INTERNAL MEDICINE.
author keywords: adenoma; carcinoma; endocrionopathy; hemorrhage; magnetic resonance imaging; suprasellar; survival
MeSH headings : Dogs; Animals; Pituitary Apoplexy / therapy; Pituitary Apoplexy / veterinary; Pituitary Apoplexy / diagnosis; Pituitary Neoplasms / complications; Pituitary Neoplasms / diagnostic imaging; Pituitary Neoplasms / therapy; Pituitary Neoplasms / veterinary; Retrospective Studies; Hydrocephalus / veterinary; Infarction / veterinary; Magnetic Resonance Imaging / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / therapy
TL;DR:
Dogs with pituitary apoplexy present with a variety of acute signs of neurological disease and inconsistent endocrine dysfunction and dogs that survive to discharge can have a favorable outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 22, 2023
2023 journal article
Effects of age, seasonality, and reproductive status on the gut microbiome of Southern White Rhinoceros (Ceratotherium simum simum) at the North Carolina zoo
ANIMAL MICROBIOME, 5(1).
author keywords: Gut microbiome; Southern white rhinoceros; Temporal dynamics
TL;DR:
The results increase the understanding of age and season related microbial variation in southern white rhinoceros at the North Carolina Zoo and have identified a potential microbial biomarker for reproductive concern within managed female southern white rhinoceros.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: May 22, 2023
2023 journal article
Retrospective analysis of postoperative complications following surgical treatment of ileal impaction in horses managed with manual decompression compared to jejunal enterotomy
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: colic; ileum; impaction; enterotomy; manual decompression
TL;DR:
It was showed that there were no significant differences in post-operative complications and survival to discharge in horses undergoing distal jejunal enterotomy versus manual decompression for correction of ileal impaction, and pre-operative PCV and duration of surgery were found to be the only predictive factors of survival to discharged.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 22, 2023
2023 journal article
Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption
PLOS GENETICS, 19(4).
MeSH headings : Dogs; Animals; Humans; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / veterinary; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / veterinary; Proto-Oncogene Proteins B-raf / genetics; Exome Sequencing; Mutation; MAP Kinase Kinase 1 / genetics
TL;DR:
It is suggested that short in-frame deletions within BRAF exon 12 and MAP2K1 exons 2 and 3 in UDV595E cases are alternative MAPK-pathway activating events that may have significant therapeutic implications for selecting first-line treatment for canine UC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 15, 2023
2023 journal article
General anesthesia does not induce ultrasonographic changes in the pleura of healthy adult horses anesthetized for elective magnetic resonance imaging
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(4), 500–504.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 9, 2023
2023 journal article
Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation
ELIFE, 12.
author keywords: endothelial cells; nuclear LINC complex; SUN1; microtubules; adherens junctions; blood vessels; GEF-H1; Nesprin-1; angiogenesis; Rho; contractility; Endothelial cell; Mouse; Zebrafish
MeSH headings : Animals; Mice; Microtubule-Associated Proteins / metabolism; Endothelial Cells / metabolism; Zebrafish / metabolism; Nuclear Proteins / metabolism; Microtubules / metabolism; Intercellular Junctions / metabolism
TL;DR:
It is shown that the nuclear-localized LINC complex protein SUN1 regulates vascular sprouting and barrier function via effects on endothelial cell-cell junction morphology and function and long-range communication from the nucleus to the cell periphery is important for vascular development and function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: May 1, 2023
2023 article
Using FastID to analyze complex SNP mixtures from indoor dust
Meiklejohn, K. A., Scheible, M. K. R., Boggs, L. M., Dunn, R. R., & Ricke, D. O. (2023, April 3). JOURNAL OF FORENSIC SCIENCES.
author keywords: FastID; indoor dust; interpretation of DNA mixtures; investigative leads; massively parallel sequencing; MPS; single nucleotide polymorphisms; SNPs
MeSH headings : Humans; Polymorphism, Single Nucleotide; DNA Fingerprinting / methods; Genotype; DNA / analysis; Software; High-Throughput Nucleotide Sequencing / methods; Sequence Analysis, DNA; Microsatellite Repeats
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 1, 2023
2023 review
Asthma: The Use of Animal Models and Their Translational Utility
[Review of ]. CELLS, 12(7).
author keywords: asthma; animal model; inflammation
MeSH headings : Humans; Mice; Rats; Animals; Guinea Pigs; Sheep; Horses; Dogs; Disease Models, Animal; Asthma / drug therapy; Proteins; Inflammation
TL;DR:
This review aims to discuss the animal models most available for asthma investigation, with an emphasis on describing the inciting antigen/allergen, inflammatory response induced, and its translation to human asthma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 1, 2023
2023 journal article
Gallbladder microbiota in healthy dogs and dogs with mucocele formation
PLOS ONE, 18(2).
MeSH headings : Dogs; Animals; Gallbladder / pathology; Mucocele / veterinary; RNA, Ribosomal, 16S / genetics; Bile / microbiology; Gallbladder Diseases / veterinary; Microbiota / genetics; Bile Duct Diseases; Dog Diseases / diagnosis
TL;DR:
Results of this study do not support existence of a core microbiome in the bile of healthy dogs or gallbladder mucus from dogs with mucocele formation, and document how contaminating sequences can significantly contribute to the results of sequencing analysis when performed on samples with low bacterial biomass.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 24, 2023
2023 article
Uterine histotroph and conceptus development: III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway
Liu, B., Paudel, S., Flowers, W. L., Piedrahita, J. A., & Wang, X. (2023, April 10). AMINO ACIDS.
author keywords: Adrenomedullin; Trophectoderm cells; MTOR; Pigs; Implantation
MeSH headings : Pregnancy; Female; Swine; Animals; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Adrenomedullin / pharmacology; Signal Transduction; TOR Serine-Threonine Kinases / genetics; TOR Serine-Threonine Kinases / metabolism; Cell Proliferation; Sirolimus / pharmacology
TL;DR:
Results suggest that porcine ADM in histotroph acts on its receptor component CALCRL to activate AKT-TSC2-MTOR, particularly MTORC1 signaling cascade, leading to elongation, migration and attachment of conceptuses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 24, 2023
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